专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08591953B2 Drug carrier and drug carrier kit for inhibiting fibrosis 有权
公开(公告)号：US08591953B2
公开(公告)日：2013-11-26
申请号：US13439330
申请日：2012-04-04
申请人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
发明人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
IPC分类号： A61K9/127 , A61K9/14 , A61K31/07 , C12N15/11 , A61K38/18
摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

2. 发明申请

US20130136789A1 AGENT FOR TREATING RENAL FIBROSIS 审中-公开
公开(公告)号：US20130136789A1
公开(公告)日：2013-05-30
申请号：US13704437
申请日：2011-06-17
申请人： Yoshiro Niitsu , Keiko Kajiwara , Yasunobu Tanaka , Miyono Miyazaki
发明人： Yoshiro Niitsu , Keiko Kajiwara , Yasunobu Tanaka , Miyono Miyazaki
IPC分类号： A61K9/127 , A61K47/10 , A61K31/7088 , A61K48/00
CPC分类号： C12N15/113 , A61K9/127 , A61K31/07 , A61K31/7088 , A61K31/713 , A61K47/10 , A61K47/542 , A61K47/6911 , A61K47/6919 , A61K47/6921 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to a substance delivery carrier for extracellular matrix-producing cells in the kidney, the carrier including a retinoid as a targeting agent, an agent for treating renal fibrosis utilizing the carrier, a process for producing them, a production kit, a method for treating renal fibrosis using the agent for treating renal fibrosis, etc.

3. 发明申请

US20130022665A1 CATIONIC LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS 有权
标题翻译：用于治疗药物递送配方的阳离子脂肪
公开(公告)号：US20130022665A1
公开(公告)日：2013-01-24
申请号：US13492650
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Zheng Hou , John A. Gaudette , Violetta Akopian , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Yasunobu Tanaka , Priya Karmali , Sridhar C. Nagarajan
IPC分类号： A61K31/225 , A61K9/127 , A61K31/7052 , C07C69/34
CPC分类号： C07C237/08 , A61K9/0019 , A61K9/10 , A61K9/1271 , A61K31/713 , A61K47/186 , A61K47/543 , C07C323/60 , C07C333/04 , C12N15/113
摘要： Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent; wherein Y is selected from —(CH2)n—S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4; wherein a=1-4; wherein b=1-4; wherein c=1-4; and wherein Z is a counterion; as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents; and methods of using these compositions and formulations.
摘要翻译：这里描述的是式I化合物：其中R 1和R 2独立地选自C 10至C 18烷基，C 12至C 18烯基和油基; 其中R3和R4独立地选自C1-C6烷基和C2-C6链烷醇; 其中X选自-CH 2 - ， - S-和-O-或不存在; 其中Y选自 - （CH 2）n -S（CH 2）n，-O（CH 2）n - ，噻吩，-SO 2（CH 2）n - 和酯，其中n = 1-4; 其中a = 1-4; 其中b = 1-4; 其中c = 1-4; 并且其中Z是抗衡离子; 以及包含可用于递送治疗剂的式I化合物的组合物和药物制剂; 以及使用这些组合物和制剂的方法。

4. 发明申请

US20120328694A1 THERAPEUTIC AGENT FOR FIBROID LUNG 审中-公开
标题翻译： FIBROID LUNG治疗药物
公开(公告)号：US20120328694A1
公开(公告)日：2012-12-27
申请号：US13585736
申请日：2012-08-14
申请人： Yoshiro Niitsu , Rishu Takimoto
发明人： Yoshiro Niitsu , Rishu Takimoto
IPC分类号： A61K47/10 , A61P11/00 , A61K31/713 , C07C35/18 , A61K9/127
CPC分类号： A61K47/10 , A61K9/007 , A61K9/127 , A61K31/7088 , A61K31/713 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/3515 , C12N2320/30 , C12N2320/32
摘要： Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for fibroid lung, which utilized the carrier; and a preparation kit of the therapeutic agent.
摘要翻译：披露的是：向肺中细胞外基质产生细胞的物质转移载体，其包含类视黄醇; 使用载体的纤维瘤肺治疗剂; 和治疗剂的制剂试剂盒。

5. 发明授权

US08178124B2 Drug carrier and drug carrier kit for inhibiting fibrosis 有权
公开(公告)号：US08178124B2
公开(公告)日：2012-05-15
申请号：US13249072
申请日：2011-09-29
申请人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
发明人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
IPC分类号： A61K9/127 , A61K9/14 , A61K31/07 , C12N15/11
CPC分类号： A61K31/07 , A61K9/0019 , A61K9/127 , A61K9/14 , A61K31/7088 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K45/06 , A61K47/6911 , Y10S514/893 , Y10T428/2982 , A61K2300/00
摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

6. 发明申请

US20120076852A1 DRUG CARRIER AND DRUG CARRIER KIT FOR INHIBITING FIBROSIS 有权
标题翻译：用于抑制纤维化的药物载体和药物载体工具包
公开(公告)号：US20120076852A1
公开(公告)日：2012-03-29
申请号：US13249072
申请日：2011-09-29
申请人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
发明人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
IPC分类号： A61K47/10 , A61P1/16 , A61P1/18 , C07C35/18 , A61P11/04 , A61K31/7088 , A61K48/00 , A61K9/127 , A61P35/00
CPC分类号： A61K31/07 , A61K9/0019 , A61K9/127 , A61K9/14 , A61K31/7088 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K45/06 , A61K47/6911 , Y10S514/893 , Y10T428/2982 , A61K2300/00
摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
摘要翻译：含有类视黄醇衍生物和/或维生素A类似物作为成分的星形胶质细胞特异性药物载体; 一种使用该药物的药物递送方法; 含有该药物的药物; 以及使用该药物的治疗方法。通过将药物载体与维生素A或维生素A类似物的类视黄醇衍生物结合或将其包封在药物载体中，用于治疗用途的药物可以特异性递送至星形胶质细胞。结果，可以有效地有效地抑制或预防星形胶质细胞相关疾病，同时尽量减少副作用。作为抑制星形胶质细胞活性或生长的药物，例如可以将作为胶原特异性分子伴侣的HSP47的siRNA包封在药物载体中。因此，可以同时抑制I型至IV型胶原的分泌，从而可以有效地抑制纤维化。

7. 发明申请

US20110257249A1 DRUG CARRIERS 审中-公开
标题翻译：药物承运人
公开(公告)号：US20110257249A1
公开(公告)日：2011-10-20
申请号：US13170967
申请日：2011-06-28
申请人： Yoshiro Niitsu , Lei Yu , Jian Liu , Gang Zhao , Nianchun Ma , Sang Van
发明人： Yoshiro Niitsu , Lei Yu , Jian Liu , Gang Zhao , Nianchun Ma , Sang Van
IPC分类号： A61K47/48 , A61P19/04 , A61K31/713 , A61P35/00 , B82Y5/00
CPC分类号： A61K31/337 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K47/6455
摘要： Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：本文公开了可以包括阳离子聚合物载体，靶向剂和治疗剂的组合物。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

8. 发明授权

US5298393A Monoclonal antibody for human acid-glutathione S-transferase and process for preparation thereof 失效
标题翻译：人酸 - 谷胱甘肽S-转移酶的单克隆抗体及其制备方法
公开(公告)号：US5298393A
公开(公告)日：1994-03-29
申请号：US759808
申请日：1991-09-16
申请人： Ichiro Urushizaki , Yoshiro Niitsu , Hiroshi Maruyama , Hideaki Suzuki , Kenji Hosoda , Hitomi Honda , Yasuhiko Masuho
发明人： Ichiro Urushizaki , Yoshiro Niitsu , Hiroshi Maruyama , Hideaki Suzuki , Kenji Hosoda , Hitomi Honda , Yasuhiko Masuho
IPC分类号： A61K39/395 , C07K16/40 , C12P21/08 , G01N33/573 , G01N33/577 , G01N33/53
CPC分类号： C07K16/40
摘要： A monoclonal antibody for human acid glutathion S-transferase. This monoclonal antibody can be utilized as a diagnostic for cancers such as cancer of liver, gastric cancer, and cancer of the blood.
摘要翻译： PCT No.PCT / JP86 / 00592 Sec。 371日期1987年7月21日 102（e）1987年7月21日PCT PCT 1986年11月19日PCT公布。第WO87 / 03377号公报日期：1987年6月4日。用于人酸性谷胱甘肽S-转移酶的单克隆抗体。该单克隆抗体可用作癌症如肝癌，胃癌和血液癌的诊断。

9. 发明授权

US08741867B2 Retinoid-liposomes for treating fibrosis 有权
标题翻译：维甲酸脂质体用于治疗纤维化
公开(公告)号：US08741867B2
公开(公告)日：2014-06-03
申请号：US13492594
申请日：2012-06-08
申请人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人： Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号： C12N15/11
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
摘要翻译：描述的是包含包含有义链和反义链的双链核酸分子的药物组合物，其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸（SEQ ID NO：60和127），SERPINH1_45a（SEQ ID NO： NOS：98和165）和SERPINH1_51（SEQ ID NO：101和168）和包含类视黄醇和脂质囊泡的混合物的药物载体，以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法，包括纤维化。

10. 发明授权

US08652526B2 Drug carrier and drug carrier kit for inhibiting fibrosis 有权
标题翻译：用于抑制纤维化的药物载体和药物载体试剂盒
公开(公告)号：US08652526B2
公开(公告)日：2014-02-18
申请号：US13439330
申请日：2012-04-04
申请人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
发明人： Yoshiro Niitsu , Junji Kato , Yasushi Sato
IPC分类号： A61K9/127 , A61K9/14 , A61K31/07 , C12N15/11 , A61K38/18
CPC分类号： A61K31/07 , A61K9/0019 , A61K9/127 , A61K9/14 , A61K31/7088 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K45/06 , A61K47/6911 , Y10S514/893 , Y10T428/2982 , A61K2300/00
摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
摘要翻译：含有类视黄醇衍生物和/或维生素A类似物作为成分的星形胶质细胞特异性药物载体; 一种使用该药物的药物递送方法; 含有该药物的药物; 以及使用该药物的治疗方法。通过将药物载体与维生素A或维生素A类似物的类视黄醇衍生物结合或将其包封在药物载体中，用于治疗用途的药物可以特异性递送至星形胶质细胞。结果，可以有效地有效地抑制或预防星形胶质细胞相关疾病，同时尽量减少副作用。作为抑制星形胶质细胞活性或生长的药物，例如可以将作为胶原特异性分子伴侣的HSP47的siRNA包封在药物载体中。因此，可以同时抑制I型至IV型胶原的分泌，从而可以有效地抑制纤维化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式