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1. 发明授权

US08710209B2 Modulation of HSP47 expression 有权
标题翻译：调节HSP47表达
公开(公告)号：US08710209B2
公开(公告)日：2014-04-29
申请号：US12963600
申请日：2010-12-08
申请人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
发明人： Xiaomei Jin , Lei Yu , Hirokazu Takahashi , Yasunobu Tanaka , Yoshiro Niitsu , Elena Feinstein , Sharon Avkin-Nachum , Hagar Kalinski , Igor Mett , Shai Erlich , Elizabeth C. Squiers , Ning Chen
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

2. 外观设计

USD973900S1 Sterilization cassette 有权
公开(公告)号：USD973900S1
公开(公告)日：2022-12-27
申请号：US29776998
申请日：2021-04-01
申请人： Ning Chen , Si Chen
设计人： Ning Chen , Si Chen

3. 发明授权

US09467823B2 Method and device for processing value-added service for short message service 有权
标题翻译：处理短信服务增值业务的方法和设备
公开(公告)号：US09467823B2
公开(公告)日：2016-10-11
申请号：US12557652
申请日：2009-09-11
申请人： Xiaolong Hou , Ning Chen
发明人： Xiaolong Hou , Ning Chen
IPC分类号： H04W4/12 , H04W88/18
CPC分类号： H04W4/12 , H04W88/184
摘要： The present invention discloses a value-added service for short message service, VAS-SMS, processing method and a VAS-SMS processing center, which include: the VAS-SMS processing center receives an original short message forwarded from the short message service center, generates a value-added service short message associated with the original short message in accordance with data of VAS-SMS subscribed by the calling and called parities of the original short message, submits the value-added service short message to the short message service center, and receives a delivery status report returned from the short message service center, and the value-added service for short message service processing center takes the delivery result of the value-added service short message as that of the associated original short message and sends a delivery result notification of the original short message to the short message service center.
摘要翻译：本发明公开了一种短消息服务，VAS-SMS，处理方法和VAS-SMS处理中心的增值业务，其中包括：VAS-SMS处理中心收到短消息业务中心转发的原始短消息，根据原始短消息的主叫和被叫号码的VAS-SMS的数据，生成与原始短消息相关联的增值业务短消息，向短消息业务中心提交增值业务短消息，并收到短消息服务中心返回的发送状态报告，短消息业务处理中心的增值业务将增值业务短消息的发送结果作为相关原始短消息的发送结果，并发送原始短信的结果通知给短信服务中心。

4. 发明申请

US20140197898A1 High Sensitivity Micro-Piezoelectric Tunable Resonator 审中-公开
标题翻译：高灵敏度微压电可调谐谐振器
公开(公告)号：US20140197898A1
公开(公告)日：2014-07-17
申请号：US13744064
申请日：2013-01-17
申请人： Ying Hsu , Mike Tracy , Brian Bircumshaw , Ning Chen , Salah Uddin
发明人： Ying Hsu , Mike Tracy , Brian Bircumshaw , Ning Chen , Salah Uddin
IPC分类号： H03B5/32
CPC分类号： H03H9/2463 , H03H2009/02165
摘要： A highly sensitive micro-piezoelectric tunable resonator element and device that uses a tapered transition region from the actuator and sensor elements to the resonator beam to permit maximum mechanical energy transfer to the beam. A dual-resonator beam embodiment with a shared tuning element is provided in an alternative embodiment.
摘要翻译：一种高灵敏度的微压电可调谐谐振器元件和器件，其使用来自致动器和传感器元件的锥形过渡区域到谐振器束，以允许最大的机械能量传递到光束。具有共享调谐元件的双谐振器波束实施例在替代实施例中提供。

5. 发明申请

US20140057577A1 Radio Communication Transmission System and Method Based on Software Defined Radio 有权
标题翻译：基于软件定义无线电的无线电通信传输系统和方法
公开(公告)号：US20140057577A1
公开(公告)日：2014-02-27
申请号：US14005437
申请日：2011-05-31
申请人： Ning Chen , Bingxin Tian
发明人： Ning Chen , Bingxin Tian
IPC分类号： H04B1/00
CPC分类号： H04B1/0003 , H04B1/0007
摘要： The disclosure discloses a Software Defined Radio (SDR)-based radio communication transmission system. A front-end analog interface unit, a Digital-to-Analog (D/A) and Analog-to-Digital (A/D) conversion unit, a core processing unit and a storage unit adopt the universal bus for interconnection and interworking. The core processing unit is configured to acquire the front-end processed data from the front-end analog interface unit, and to choose to transmit the front-end processed data to the D/A and A/D conversion unit by the control of the universal bus according to whether the radio communication standard of the current data accords with the current working mode. The disclosure further discloses an SDR-based radio communication transmission method, which includes that: the core processing unit chooses to transmit the front-end processed data to the D/A and A/D conversion unit by the control of the universal bus according to whether the radio communication standard of the current data accords with the current working mode. The system and method of the disclosure can adapt to the coexistence of multiple radio communication standards and complement the advantages of each structure at the same time.
摘要翻译：本公开公开了一种基于软件无线电（SDR）的无线电通信传输系统。前端模拟接口单元，数模（D / A）和模数（A / D）转换单元，核心处理单元和存储单元采用通用总线进行互连和互通。核心处理单元被配置为从前端模拟接口单元获取前端处理的数据，并且通过控制前端处理数据的控制来选择将前端处理的数据发送到D / A和A / D转换单元通用总线根据当前数据的无线电通信标准是否符合当前工作模式。本公开进一步公开了一种基于SDR的无线电通信传输方法，其包括：核心处理单元选择通过根据通用总线的控制将前端处理数据发送到D / A和A / D转换单元当前数据的无线电通信标准是否符合当前工作模式。本公开的系统和方法可以适应多个无线电通信标准的共存，同时补充每个结构的优点。

6. 发明授权

US08467801B2 Channel sounding techniques for a wireless communication system 有权
标题翻译：无线通信系统的通道探测技术
公开(公告)号：US08467801B2
公开(公告)日：2013-06-18
申请号：US13437852
申请日：2012-04-02
申请人： James W. McCoy , Ning Chen
发明人： James W. McCoy , Ning Chen
IPC分类号： H04W72/00
CPC分类号： H04W24/06 , H04W24/10
摘要： A technique for channel sounding in a wireless communication system includes determining respective geometries of multiple subscriber stations with respect to a serving base station. Respective time periods for sounding a channel between the multiple subscriber stations and the serving base station are then set based on the respective geometries of the multiple subscriber stations.
摘要翻译：用于无线通信系统中的信道探测的技术包括确定多个用户站相对于服务基站的相应几何形状。然后，基于多个用户站的各自的几何形状来设定用于在多个用户站和服务基站之间发送信道的相应时间段。

7. 发明授权

US08098744B2 Reducing a peak-to-average ratio of a signal using filtering 有权
标题翻译：使用滤波降低信号的峰均比
公开(公告)号：US08098744B2
公开(公告)日：2012-01-17
申请号：US11649076
申请日：2007-01-03
申请人： Ning Chen , Jeffrey Keating , James W. McCoy
发明人： Ning Chen , Jeffrey Keating , James W. McCoy
IPC分类号： H04K1/10
CPC分类号： H04L27/2614
摘要： Methods and corresponding systems for reducing a peak-to-average signal ratio include determining peak and null samples of a symbol. Thereafter, an error signal is calculated that is responsive to the peak and null samples. In one embodiment the error signal has values corresponding to differences between the peak samples and a high threshold and the null samples and a low threshold. In response to the error signal, the samples are filtered to produce a filtered symbol having a reduced peak-to-average signal ratio. The error signal can also be used to calculate reserved tones on reserved subcarriers, which are combined with multi-tone subcarriers in a multi-carrier transmitter.
摘要翻译：降低峰均信号比率的方法和相应系统包括确定符号的峰值和空样本。此后，计算响应于峰值和空样本的误差信号。在一个实施例中，误差信号具有对应于峰值采样和高阈值与空采样和低阈值之间的差异的值。响应于误差信号，对样本进行滤波以产生具有降低的峰值与平均信号比的滤波符号。误差信号还可用于计算在多载波发射机中与多音调副载波组合的保留副载波上的保留音调。

8. 发明授权

US08033916B2 Grip pressure sensor 失效
标题翻译：夹紧压力传感器
公开(公告)号：US08033916B2
公开(公告)日：2011-10-11
申请号：US11733145
申请日：2007-05-04
申请人： Theodore Caldwell , Ning Chen
发明人： Theodore Caldwell , Ning Chen
IPC分类号： A63F13/00 , A63B67/02
CPC分类号： A63B69/0002 , A63B69/3608 , A63B69/38 , A63B2060/464 , A63B2071/0627 , A63B2071/0661 , A63B2071/0663 , A63B2209/10 , A63B2220/56 , A63B2220/836
摘要： Grip pressure is monitored by a collection of battery powered components embodied in an assembly analogous to an ordinary wrist watch, that is a watch housing or casement and a stretchable band. The system, which we shall refer to as a swing monitor, is worn on the wrist and deployed in such a way that the back of the housing or casement is cinched securely to the back or underside of the wrist. A pressure plate on the back of the watch makes contact with the pulse region of the wrist. The flexing and relaxing of the muscles and tendons of the wearer is read by an electronic pressure sensing device, a piezo sensor. A tighter grip will register greater pressure and a looser grip, less pressure. The device records grip pressure associated with the swing of a golf club, tennis racquest or baseball bat, among other articles of sports equipment meant to be swung. The grip pressure determined to be optimal, that is giving the desired result, can be SAVED in the memory of the swing monitor system. Subsequent swings and their associated grip pressures are compared with the SAVED value of the optimal or best swing. An audible signal alerts the wearer if the grip pressure departs from that registered on the optimal or best swing.
摘要翻译：握把压力由类似于普通手表的组件体现的电池供电部件的集合来监控，普通手表是手表壳体或窗扇和可拉伸带。将我们称为摇摆监视器的系统佩戴在手腕上，并以这样的方式展开，使得外壳或窗扇的背部牢固地固定在手腕的背面或下侧。手表背面的压板与手腕的脉冲区域接触。通过电子压力感测装置，压电传感器读取佩戴者的肌肉和腱的弯曲和松弛。更紧的抓地力将会增加压力和松动的抓地力，减少压力。该装置记录与高尔夫球杆，网球赛或棒球蝙蝠的秋千相关的握力，以及旨在摆动的其他运动器材制品。在摆动监视器系统的存储器中可以保持被确定为最佳的握手压力，即给出期望的结果。随后的摆动及其相关的抓地力压力与最佳或最佳摆动的SAVED值进行比较。如果握把压力偏离了在最佳或最佳摆动上登记的压力，则可听见的信号警告佩戴者。

9. 发明申请

US20110096707A1 Channel Sounding Techniques for a Wireless Communication System 有权
标题翻译：无线通信系统的通道探测技术
公开(公告)号：US20110096707A1
公开(公告)日：2011-04-28
申请号：US12981423
申请日：2010-12-29
申请人： James W. McCoy , Ning Chen
发明人： James W. McCoy , Ning Chen
IPC分类号： H04W52/00
CPC分类号： H04W52/08 , H04B17/27 , H04B17/336 , H04W24/10 , H04W52/367
摘要： A technique of operating a wireless communication system includes determining respective geometries of multiple subscriber stations, which include a first subscriber station and a second subscriber station, with respect to a serving base station. Respective channel sounding bandwidths for sounding the channel between the multiple subscriber stations and the serving base station are then scheduled, based on the respective geometries. The respective channel sounding bandwidths include a first channel sounding bandwidth (associated with the first subscriber station) and a second channel sounding bandwidth (associated with the second subscriber station). The first channel sounding bandwidth is greater than or equal to the second channel sounding bandwidth and the first subscriber station has a lower geometry than the second subscriber station.
摘要翻译：操作无线通信系统的技术包括相对于服务基站确定包括第一用户站和第二用户站的多个用户站的相应几何。然后，基于各自的几何结构来调度用于对多个用户站和服务基站之间的信道进行探测的相应信道探测带宽。相应的信道探测带宽包括第一信道探测带宽（与第一用户站相关联）和第二信道探测带宽（与第二用户站相关联）。第一声道探测带宽大于或等于第二声道探测带宽，并且第一用户台具有比第二用户台更低的几何形状。

10. 发明授权

US07754717B2 Bis-aryl amide compounds and methods of use 失效
标题翻译：双芳基酰胺化合物及其使用方法
公开(公告)号：US07754717B2
公开(公告)日：2010-07-13
申请号：US11503551
申请日：2006-08-11
申请人： Erin F. Dimauro , Jean E. Bemis , Stuart C. Chaffee , Ning Chen , Essa Hu , Roxanne Kunz , Matthew W. Martin , David C. McGowan , Shannon Rumfelt
发明人： Erin F. Dimauro , Jean E. Bemis , Stuart C. Chaffee , Ning Chen , Essa Hu , Roxanne Kunz , Matthew W. Martin , David C. McGowan , Shannon Rumfelt
IPC分类号： A01N43/60 , A01N43/54 , A01N43/42 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/4965 , A61K31/51 , A61K31/47 , C07D239/42 , C07D401/04 , C07D237/30 , C07D401/00
CPC分类号： C07D213/75 , C07D215/38 , C07D239/42 , C07D239/48 , C07D239/50 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, L, R1, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of the present invention, methods of use such as treatment of Lck and/or c-Kit kinase mediated diseases by administering the compounds of the invention, or compositions including one or more compounds of the invention, and intermediates and processes useful for the preparation of compounds of the present invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括自身免疫疾病和炎症的化合物。在一个实施方案中，化合物具有通式I，其中A1，A2，A3，A4，L，R1，R2和R3如本文所定义。本发明还包括药物组合物，其包含一种或多种本发明化合物，通过施用本发明化合物来治疗Lck和/或c-Kit激酶介导的疾病的使用方法，或包含一种或多种本发明化合物的组合物发明，以及可用于制备本发明化合物的中间体和方法。

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