专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4358457A Tetrahydro-7a-(optionally substituted phenyl)-1H-pyrrolo[1,2-b][1,2,4]-triazole-2(3H)-thiones 失效
标题翻译：四氢-7a-（任选取代的苯基）-1H-吡咯并[1,2-b] [1,2,4] - 三唑-2（3H） - 硫杂
公开(公告)号：US4358457A
公开(公告)日：1982-11-09
申请号：US286950
申请日：1981-07-27
申请人： Winton D. Jones , John M. Kane , Francis P. Miller
发明人： Winton D. Jones , John M. Kane , Francis P. Miller
IPC分类号： C07D471/04 , A61K31/41 , C07D487/04
CPC分类号： C07D471/04
摘要： Compounds of the formula ##STR1## wherein R is H or C.sub.1-5 straight or branched chain alkyl; R.sub.1 is H, C.sub.1-10 straight or branched chain alkyl, allyl or phenyl; and R.sub.2 is phenyl or phenyl substituted with F, Cl, C.sub.1-5 straight or branched chain alkyl, di-F, di-Cl or di-Br; and the pharmaceutically acceptable acid addition salts thereof; are useful as muscle relaxants, anticonvulsants and analgesics.
摘要翻译：其中R为H或C 1-5直链或支链烷基的式IMAMA的化合物; R1是H，C1-10直链或支链烷基，烯丙基或苯基; R 2为苯基或被F，Cl，C 1-5直链或支链烷基取代的苯基，二-F，二-C1或二-Br; 及其药学上可接受的酸加成盐; 可用作肌肉松弛剂，抗惊厥药和镇痛药。

2. 发明授权

US4272532A 5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines 失效
标题翻译： 5-（任选取代的苯基）-6H-1,3,4-噻二嗪-2-胺
公开(公告)号：US4272532A
公开(公告)日：1981-06-09
申请号：US71954
申请日：1979-09-04
申请人： Winton D. Jones , Francis P. Miller
发明人： Winton D. Jones , Francis P. Miller
IPC分类号： C07D285/16 , A61K31/54
CPC分类号： C07D285/16
摘要： A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl;R.sub.2 is phenyl or phenyl substituted with F, Cl, Br, NO.sub.2, C.sub.1-5 straight or branched chain alkyl, C.sub.1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; andR.sub.3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl; ora pharmaceutically acceptable acid addition salt thereof.
摘要翻译：诱导患者镇静的方法包括向需要镇静的患者施用有效诱导下式化合物镇静的量，其中R为H，或C 1-5或7-直链或支链烷基 R1为H，C1-5或7-直链或支链烷基或烯丙基; R2是苯基或被F，Cl，Br，NO2，C1-5直链或支链烷基，C1-5直链或支链烷氧基，2,4-二Cl，2,4-di-F或2 ，4-二-Br，条件是当苯基被F单取代时，F原子不在o位; 且R 3为H或C 1-5直链或支链烷基，条件是当R 3为直链或支链烷基时，R 2为未取代的苯基; 或其药学上可接受的酸加成盐。

3. 发明授权

US4289767A 5-(Chlorophenyl)-6H-1,3,4-thiadiazine-2-amines 失效
标题翻译： 5-（氯苯基）-6H-1,3,4-噻二嗪-2-胺
公开(公告)号：US4289767A
公开(公告)日：1981-09-15
申请号：US71952
申请日：1979-09-04
申请人： Winton D. Jones , Francis P. Miller
发明人： Winton D. Jones , Francis P. Miller
IPC分类号： A61K31/54 , A61P25/08 , A61P25/18 , A61P25/20 , C07D285/16
CPC分类号： C07D285/16
摘要： Compounds of the formula ##STR1## wherein R is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl and R.sub.1 is H or Cl andthe pharmacologically acceptable acid addition salts thereof are pharmacologically active as anticonvulsant and anxiolytic agents.
摘要翻译：其中R是H，C 1-5或7-直链或支链烷基或烯丙基，R 1是H或Cl，其药理学上可接受的酸加成盐作为抗惊厥药和抗焦虑剂具有药理学活性。

4. 发明授权

US6004959A Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors 失效
标题翻译：烷氧基氨基取代的芴酮及其作为蛋白激酶C抑制剂的用途
公开(公告)号：US6004959A
公开(公告)日：1999-12-21
申请号：US844209
申请日：1997-04-18
申请人： Winton D. Jones , Fred L. Ciske , Robert J. Dinerstein , Keith A. Diekema
发明人： Winton D. Jones , Fred L. Ciske , Robert J. Dinerstein , Keith A. Diekema
IPC分类号： C07C217/24 , C07C225/22 , C07D295/092 , A61K31/40 , A61K31/535 , C07D295/116
CPC分类号： C07D295/088 , C07C217/24 , C07C225/22 , C07C2103/18
摘要： The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
摘要翻译：本发明描述了抑制蛋白激酶C的某些烷氧基氨基取代的芴酮，以及包括这些化合物的药物组合物以及使用这些化合物控制哺乳动物（包括人）中的蛋白激酶C活性的方法。更具体地，本发明化合物可用于治疗肿瘤性疾病状态，与异常血流（包括高血压，缺血，动脉粥样硬化，凝血障碍）和炎性疾病（包括免疫疾病，哮喘，肺纤维化和牛皮癣）相关的疾病，。

5. 发明授权

US5182293A Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones 失效
标题翻译：用吡哆唑-2-酮治疗多药耐药性肿瘤
公开(公告)号：US5182293A
公开(公告)日：1993-01-26
申请号：US590524
申请日：1990-10-03
申请人： Sai P. Sunkara , Winton D. Jones
发明人： Sai P. Sunkara , Winton D. Jones
IPC分类号： A61K31/44 , A61K31/475 , A61K38/14
CPC分类号： A61K31/70 , A61K31/44 , A61K31/475 , A61K38/14 , Y10S514/922
摘要： This invention relates to pyridinyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The pyridinyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
摘要翻译：本发明涉及可用于治疗多重耐药性肿瘤的吡啶基恶唑-2-酮。吡啶基恶唑-2-酮用于预防耐药性，从而允许常规化学治疗剂杀死肿瘤细胞，就好像耐药性不存在一样。

6. 发明授权

US4999431A Process for preparing quinoline aldehyde and ketone derivatives 失效
标题翻译：制备喹啉醛和酮衍生物的方法
公开(公告)号：US4999431A
公开(公告)日：1991-03-12
申请号：US483831
申请日：1990-02-23
申请人： Winton D. Jones , Richard C. Dage , George P. Claxton , Hsien C. Cheng , Phillip J. Robinson
发明人： Winton D. Jones , Richard C. Dage , George P. Claxton , Hsien C. Cheng , Phillip J. Robinson
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
摘要翻译：本发明涉及可用作治疗高血压和哮喘的蛋白激酶C抑制剂的新型喹喔啉-2-酮。本发明还包括一种制备涉及溴 - 喹啉化合物与丁基锂反应的中间体酮化合物的新方法，并进一步使锂化化合物与N-甲基-N-甲氧基烷酰胺反应。

7. 发明授权

US4886811A Qunolyloxazole-2-ones useful as proteinkinase C inhibitors 失效
标题翻译：可用作蛋白酶C抑制剂的Qunolyloxazole-2
公开(公告)号：US4886811A
公开(公告)日：1989-12-12
申请号：US261435
申请日：1988-10-24
申请人： Winton D. Jones , George P. Claxton , Richard C. Dage , Hsien C. Cheng , Phillip J. Robinson
发明人： Winton D. Jones , George P. Claxton , Richard C. Dage , Hsien C. Cheng , Phillip J. Robinson
IPC分类号： A61K31/47 , A61P9/08 , A61P9/12 , A61P11/08 , A61P43/00 , C07D215/14 , C07D413/04
CPC分类号： C07D413/04
摘要： This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.

8. 发明授权

US4803210A Cardiotonic tricyclic oxazolones 失效
标题翻译：强心型三环恶唑酮
公开(公告)号：US4803210A
公开(公告)日：1989-02-07
申请号：US183537
申请日：1988-04-14
申请人： Winton D. Jones , Richard A. Schnettler , George P. Claxton , Richard C. Dage
发明人： Winton D. Jones , Richard A. Schnettler , George P. Claxton , Richard C. Dage
IPC分类号： C07D498/04 , A61K31/42
CPC分类号： C07D498/04
摘要： Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
摘要翻译：三环恶唑酮增强心肌收缩力，可用作心力衰竭治疗心力衰竭。

9. 发明授权

US4568751A 5-Acyl-2-(1H)-pyridinones 失效
标题翻译： 5-酰基-2-（1H） - 吡啶酮
公开(公告)号：US4568751A
公开(公告)日：1986-02-04
申请号：US490081
申请日：1983-04-29
申请人： Winton D. Jones , Richard C. Dage , Richard A. Schnettler
发明人： Winton D. Jones , Richard C. Dage , Richard A. Schnettler
IPC分类号： C07D213/64 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/455 , A61P9/04 , A61P9/06 , C07C67/00 , C07C213/00 , C07C225/14 , C07C225/16 , C07D213/60 , C07D213/85 , C07D213/73 , C07D401/06 , C07D405/06 , C07D409/06
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译：新型5-酰基-2-（1H）吡啶酮及其作为强心剂的用途。典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈惰性有机溶剂。

10. 发明授权

US5428045A 5-acyl-2-(1H)-pyridinoes 失效
标题翻译： 5-酰基-2-（1H） - 吡啶基
公开(公告)号：US5428045A
公开(公告)日：1995-06-27
申请号：US111814
申请日：1993-08-25
申请人： Winton D. Jones , Richard C. Dage , Richard A. Schnettler
发明人： Winton D. Jones , Richard C. Dage , Richard A. Schnettler
IPC分类号： C07D213/85 , A61K31/44 , C07D213/55 , C07D213/56 , C07D213/57
CPC分类号： C07D213/85
摘要： Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
摘要翻译：新型5-酰基-2-（1H）吡啶酮及其作为强心剂的用途。典型的化合物是通过将阴离子氰基乙酰胺与3 - [（二甲基氨基）亚甲基] -2,4-戊二酮缩合而制备的5-乙酰基-1,2-二氢-6-甲基-2-氧代-3-吡啶腈惰性有机溶剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式