专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5385911A Anti-herpes castanospermine esters 失效
标题翻译：抗疱睾丸素酯
公开(公告)号：US5385911A
公开(公告)日：1995-01-31
申请号：US41532
申请日：1993-04-01
申请人： Sai P. Sunkara , Paul S. Liu , A. Stanley Tyms , Debra L. Taylor
发明人： Sai P. Sunkara , Paul S. Liu , A. Stanley Tyms , Debra L. Taylor
IPC分类号： A61K31/435 , A61K31/40 , A61K31/44 , A61P31/12 , A61P31/22 , C07D471/04 , G07D211/46
CPC分类号： A61K31/40 , A61K31/44 , Y10S514/934
摘要： Certain Castanospermine ester derivatives of the formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1-14 alkanoyl, C.sub.1-14 alkenoyl, cyclohexanecarbonyl, C.sub.1-8 alkoxyacetyl, ##STR2## naphthalenecarbonyl optionally substituted by methyl or halogen; phenyl (C.sub.2-6 alkanoyl) wherein the phenyl is optionally substituted by methyl or halogen; cinnamoyl; pyridinecarbonyl optionally substituted by methyl or halogen; dihydropyridine carbonyl optionally substituted by C.sub.1 -C.sub.10 alkyl; thiophenecarbonyl optionally substituted by methyl or halogen; or furancarbonyl optionally substituted by methyl or halogen; Y is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, trifluoromethyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylmercapto, cyano or dimethylamino; Y' is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or it is combined with Y to give 3,4-methylenedioxy; Y" is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or halogen; with R, R.sub.1 and R.sub.2 being selected in such a way that at least one of them, but not more than two of them, is hydrogen; are disclosed to be effective in treating diseases caused by Herpes Simplex Virus (HSV) Types 1 and 2.
摘要翻译：其中R，R 1和R 2各自独立地为氢，C 1-14烷酰基，C 1-14链烯酰基，环己烷羰基，C 1-8烷氧基乙酰基，任选被甲基或卤素取代的萘甲酰基的某些蓖麻精酯衍生物。苯基（C 2-6烷酰基），其中苯基任选被甲基或卤素取代; 肉桂酰; 任选被甲基或卤素取代的吡啶羰基; 任选被C 1 -C 10烷基取代的二氢吡啶羰基; 任选被甲基或卤素取代的噻吩羰基; 或任选被甲基或卤素取代的呋喃羰基; Y是氢，C 1-4烷基，C 1-4烷氧基，卤素，三氟甲基，C 1-4烷基磺酰基，C 1-4烷基巯基，氰基或二甲基氨基; Y'是氢，C 1-4烷基，C 1-4烷氧基，卤素，或与Y结合，得到3,4-亚甲二氧基; Y“是氢，C 1-4烷基，C 1-4烷氧基或卤素; 其中R，R 1和R 2以这样的方式进行选择，使得它们中的至少一个，但不超过其中之一为氢; 被公开以有效治疗由1型和2型单纯疱疹病毒（HSV）引起的疾病。

2. 发明授权

US5190957A Treatment of multi-drug resistant tumors with quinolyl-and isoquinolyloxazole-2-ones 失效
标题翻译：用喹诺酮和异喹啉酮-2-酮治疗多药耐药性肿瘤
公开(公告)号：US5190957A
公开(公告)日：1993-03-02
申请号：US852922
申请日：1992-03-13
申请人： Sai P. Sunkara , Winton D. Jones
发明人： Sai P. Sunkara , Winton D. Jones
IPC分类号： A61K31/47 , A61K31/475 , A61K38/14 , C07D413/04
CPC分类号： C07D413/04 , A61K31/47 , A61K31/475 , A61K31/70 , A61K38/14
摘要： This invention relates to quinolyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The quinoloyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
摘要翻译：本发明涉及可用于治疗多重耐药性肿瘤的喹喔啉-2-酮。喹诺卡唑-2-酮用于预防耐药性，从而允许常规的化学治疗剂杀死肿瘤细胞，就好像耐药性不存在一样。

3. 发明授权

US5061715A Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones 失效
标题翻译：通过喹啉基和异喹唑啉-2-区预防糖蛋白包膜病毒感染
公开(公告)号：US5061715A
公开(公告)日：1991-10-29
申请号：US590523
申请日：1990-10-03
申请人： Sai P. Sunkara , Winton D. Jones
发明人： Sai P. Sunkara , Winton D. Jones
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： This invention relates to quinolyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
摘要翻译：本发明涉及由于其作为蛋白激酶C抑制剂的能力而是有用的抗包膜病毒剂的喹喔啉-2-酮。这些衍生物被公开以有效地治疗包括HIV感染的包膜病毒感染，因此可用于治疗AIDS和ARC。

4. 发明授权

US4863968A Methods of treating gout with chalcone derivatives 失效
标题翻译：用查耳酮衍生物治疗痛风的方法
公开(公告)号：US4863968A
公开(公告)日：1989-09-05
申请号：US285331
申请日：1988-12-14
申请人： Michael L. Edwards , Sai P. Sunkara , David M. Stemerick
发明人： Michael L. Edwards , Sai P. Sunkara , David M. Stemerick
IPC分类号： A61K31/165
CPC分类号： A61K31/165
摘要： Certain chalcone derivatives are reported to inhibit the polymerization of tubulin to form microtubules and are therefore antimitotic agents which can be used as antigout agents. The chalcone derivatives are also reported to inhibit the destruction of the myelin sheath in the central nervous system of multiple sclerosis patients and are thus useful in controlling the progressive nature of the disease.
摘要翻译：据报道某些查耳酮衍生物抑制微管蛋白的聚合形成微管，因此可以用作抗突变剂的抗有丝分裂剂。据报道，查耳酮衍生物可抑制多发性硬化患者的中枢神经系统中的髓鞘的破坏，因此可用于控制疾病的进行性质。

5. 发明授权

US5648365A Diarylalkyl piperidines useful as multi-drug resistant tumor agents 失效
标题翻译：二芳基烷基哌啶可用作多药耐药肿瘤剂
公开(公告)号：US5648365A
公开(公告)日：1997-07-15
申请号：US481538
申请日：1996-03-11
申请人： Sai P. Sunkara , Jules Freedman
发明人： Sai P. Sunkara , Jules Freedman
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/451 , A61K31/4525 , A61K31/454 , A61P35/00 , A61P43/00 , C07D211/16 , C07D211/18 , C07D211/22 , C07D401/06 , C07D405/06 , A61K31/40
CPC分类号： C07D405/06 , C07D211/16
摘要： Diarylalkyl piperidines of formula (1) ##STR1## reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
摘要翻译： PCT No.PCT / US93 / 12300 Sec。 371日期：1996年3月11日 102（e）1996年3月11日PCT PCT 1993年12月17日PCT公布。出版物WO94 / 17040 日期1994年8月4日式（1）的芳基烷基哌啶类似于（1）多药耐药性肿瘤中的抗药性。这些化合物显然通过抑制在晚期肿瘤发展中变得活化的p-糖蛋白泵起作用，并且其在某些来源的肿瘤中固有存在。

6. 发明授权

US5523304A Reversal of multi-drug resistance by tetraarylethylenes 失效
标题翻译：四联乙烯逆转多药耐药
公开(公告)号：US5523304A
公开(公告)日：1996-06-04
申请号：US357361
申请日：1994-12-15
申请人： Sai P. Sunkara
发明人： Sai P. Sunkara
IPC分类号： C07D295/08 , A61K31/135 , A61K31/138 , A61K31/40 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P35/00 , C07D213/24 , A61K31/435
CPC分类号： A61K31/138 , A61K31/135 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535
摘要： Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
摘要翻译：某些四烯乙烯逆转多药耐药性肿瘤中的耐药性。这些化合物显然通过抑制在晚期肿瘤发展中变得活化的p-糖蛋白泵起作用，并且其在某些来源的肿瘤中固有存在。

7. 发明授权

US5447911A Ghilanten antimetastatic principle from the south american leech, Haementeria ghilianii 失效
标题翻译： Ghilanten反转录原理来自南美水蛭，Haementeria ghilianii + B
公开(公告)号：US5447911A
公开(公告)日：1995-09-05
申请号：US224096
申请日：1994-04-06
申请人： Alan D. Cardin , Sai P. Sunkara
发明人： Alan D. Cardin , Sai P. Sunkara
IPC分类号： A61K38/00 , A61K31/00 , A61K35/62 , A61P35/00 , A61P35/04 , C07K14/435 , C07K14/44 , C07K14/815 , A61K38/58 , A61K38/17
CPC分类号： C07K14/815 , A61K38/00 , Y10S530/856 , Y10S530/858
摘要： A method for the inhibition of tumor metastases is described herein. The method makes use of the administration of an antimetastatic factor isolated from the leech Haementeria ghilianii.
摘要翻译：本文描述了抑制肿瘤转移的方法。该方法利用从水蛭Haementeria ghilianii分离的抗转录因子的施用。

8. 发明授权

US5077315A Aryloxy alkanols as anti-retrovirus agents 失效
标题翻译：芳氧基链烷醇作为抗逆转录病毒剂
公开(公告)号：US5077315A
公开(公告)日：1991-12-31
申请号：US541868
申请日：1990-06-21
申请人： Roger A. Parker , Sai P. Sunkara
发明人： Roger A. Parker , Sai P. Sunkara
IPC分类号： A61K31/085 , A61K31/22
CPC分类号： A61K31/085 , A61K31/22
摘要： Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.
摘要翻译：具有式Ar-O（CH 2）n OH的芳氧基烷醇衍生物，其中n为3-8的整数，Ar为（1）1-或2-萘基，（2）任选被1至3个C 1-4低级烷基取代的苯基基团，或（3）结构为“IMAGE”的二苯基部分，其中Y为键，CH 2或CH 2 O，其酯具有抗逆转录病毒活性，并且在逆转录病毒感染的治疗方法中是有效的。

9. 发明授权

US5004746A Anti-retroviral castanospermine esters 失效
标题翻译：抗逆转录病毒castanospermine酯
公开(公告)号：US5004746A
公开(公告)日：1991-04-02
申请号：US102070
申请日：1987-09-29
申请人： Paul S. Liu , Sai P. Sunkara , Terry L. Bowlin
发明人： Paul S. Liu , Sai P. Sunkara , Terry L. Bowlin
IPC分类号： A61K31/445 , A61K31/435 , A61P31/12 , A61P31/18 , C07D471/04
CPC分类号： C07D471/04
摘要： Certain Castanospermine ester derivatives are disclosed to be effective in treating retroviral infections including HIV infections and are thus useful in the treatment of AIDS and ARC.

10. 发明授权

US5002879A Treatment of tumors with autologous LAK cells, interleukin-2 and an ornithine decarboxylase inhibitor 失效
标题翻译：用自体LAK细胞，白细胞介素-2和鸟氨酸脱羧酶抑制剂治疗肿瘤
公开(公告)号：US5002879A
公开(公告)日：1991-03-26
申请号：US449288
申请日：1989-12-05
申请人： Terry L. Bowlin , Sai P. Sunkara
发明人： Terry L. Bowlin , Sai P. Sunkara
IPC分类号： A61K31/13 , A61K31/195 , A61K38/20
CPC分类号： A61K31/195 , A61K31/13 , A61K38/2013
摘要： Ornithine decarboxylase inhibitors when administered in conjunction with autologous LAK cells and interleukin-2 provide for an enhanced treatment of neoplastic disease states. This enhancement is provided by the ability of an ornithine decarboxylase inhibitor to reduce tumor load and to enhance interleukin-2 production in T helper cells.
摘要翻译：当与自体LAK细胞和白介素-2联合给药时，鸟氨酸脱羧酶抑制剂提供对肿瘤疾病状态的增强治疗。该增强由鸟氨酸脱羧酶抑制剂降低肿瘤负荷并增强T辅助细胞中白细胞介素-2产生的能力提供。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式