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    • 1. 发明授权
    • 5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines
    • 5-(任选取代的苯基)-6H-1,3,4-噻二嗪-2-胺
    • US4272532A
    • 1981-06-09
    • US71954
    • 1979-09-04
    • Winton D. JonesFrancis P. Miller
    • Winton D. JonesFrancis P. Miller
    • C07D285/16A61K31/54
    • C07D285/16
    • A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl;R.sub.2 is phenyl or phenyl substituted with F, Cl, Br, NO.sub.2, C.sub.1-5 straight or branched chain alkyl, C.sub.1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; andR.sub.3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl; ora pharmaceutically acceptable acid addition salt thereof.
    • 诱导患者镇静的方法包括向需要镇静的患者施用有效诱导下式化合物镇静的量,其中R为H,或C 1-5或7-直链或支链烷基 R1为H,C1-5或7-直链或支链烷基或烯丙基; R2是苯基或被F,Cl,Br,NO2,C1-5直链或支链烷基,C1-5直链或支链烷氧基,2,4-二Cl,2,4-di-F或2 ,4-二-Br,条件是当苯基被F单取代时,F原子不在o位; 且R 3为H或C 1-5直链或支链烷基,条件是当R 3为直链或支链烷基时,R 2为未取代的苯基; 或其药学上可接受的酸加成盐。