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1. 发明授权

US07286873B2 Method of optimizing mechanical heart rate during delivery of coupled or paired pacing 失效
标题翻译：耦合或配对起搏期间机械心率优化的方法
公开(公告)号：US07286873B2
公开(公告)日：2007-10-23
申请号：US11096388
申请日：2005-03-31
申请人： William J. Havel , Paul G. Krause , Karen J. Kleckner , D. Curtis Deno
发明人： William J. Havel , Paul G. Krause , Karen J. Kleckner , D. Curtis Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/37
摘要： A method of operating a cardiac pacing device that optimizes the mechanical heart rate using coordinated potentiation therapy while maximizing the opportunity for intrinsic AV conduction to occur. The method may include adjusting the timing of extra stimulus intervals during coupled or paired pacing to promote AV conduction and to effect changes in rate according to certain embodiments of the invention. Other embodiments may include adjusting the atrial pacing rate to achieve a desired target rate consistent with AV conduction. A mode switch to a dual-chamber pacing mode may be provided according to certain embodiments of the invention to ensure a ventricular rate that meets or exceeds a minimum mechanical rate.
摘要翻译：一种操作心脏起搏装置的方法，其使用协同增强疗法优化机械心率，同时最大限度地发挥固有AV传导的机会。该方法可以包括根据本发明的某些实施例在耦合或配对起搏期间调整额外刺激间隔的时间以促进AV传导并且实现速率变化。其他实施例可以包括调整心房起搏速率以实现与AV传导一致的期望目标速率。可以根据本发明的某些实施例提供到双室起搏模式的模式切换，以确保满足或超过最小机械速率的心室率。

2. 发明授权

US07957799B2 Non-invasive cardiac potentiation therapy 有权
标题翻译：非侵入性心脏增强疗法
公开(公告)号：US07957799B2
公开(公告)日：2011-06-07
申请号：US11742063
申请日：2007-04-30
申请人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
发明人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
IPC分类号： A61N1/39
CPC分类号： A61N1/3625 , A61B5/02028 , A61B5/029 , A61B5/7217 , A61N1/3627 , A61N1/3925
摘要： An external cardiac medical device for delivering Cardiac Potentiation Therapy (CPT). Techniques used with the device include initial diagnosis of the patient, delivery of the CPT, and configuration of the external device, so that CPT can be effectively and efficiently provided. In particular, these techniques include initially determining whether a patient should receive CPT, how to set the coupling interval for delivering CPT, how to configure the external medical device to deliver CPT stimulation pulses while not adversely affecting the device's ability to sense a patient's cardiac parameters and/or signals.
摘要翻译：用于输送心脏增强疗法（CPT）的外部心脏医疗装置。与该装置一起使用的技术包括患者的初始诊断，CPT的传递和外部设备的配置，使得可以有效和高效地提供CPT。具体地说，这些技术包括最初确定患者是否应该接受CPT，如何设定用于递送CPT的耦合间隔，如何配置外部医疗设备以递送CPT刺激脉冲，同时不会不利地影响设备感测患者心脏参数的能力和/或信号。

3. 发明申请

US20080269818A1 Non-Invasive Cardiac Potentiation Therapy 有权
标题翻译：非侵入性心脏电位治疗
公开(公告)号：US20080269818A1
公开(公告)日：2008-10-30
申请号：US11742063
申请日：2007-04-30
申请人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
发明人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3625 , A61B5/02028 , A61B5/029 , A61B5/7217 , A61N1/3627 , A61N1/3925
摘要： An external cardiac medical device for delivering Cardiac Potentiation Therapy (CPT). Techniques used with the device include initial diagnosis of the patient, delivery of the CPT, and configuration of the external device, so that CPT can be effectively and efficiently provided. In particular, these techniques include initially determining whether a patient should receive CPT, how to set the coupling interval for delivering CPT, how to configure the external medical device to deliver CPT stimulation pulses while not adversely affecting the device's ability to sense a patient's cardiac parameters and/or signals.
摘要翻译：用于输送心脏增强疗法（CPT）的外部心脏医疗装置。与该装置一起使用的技术包括患者的初始诊断，CPT的传递和外部设备的配置，使得可以有效和高效地提供CPT。具体地说，这些技术包括最初确定患者是否应该接受CPT，如何设定用于递送CPT的耦合间隔，如何配置外部医疗设备以递送CPT刺激脉冲，同时不会不利地影响设备感测患者心脏参数的能力和/或信号。

4. 发明授权

US07184832B2 Refractory period tracking and arrhythmia detection 有权
$Refractory period tracking and arrhythmia detection$
标题翻译：难治期跟踪和心律失常检测
公开(公告)号：US07184832B2
公开(公告)日：2007-02-27
申请号：US10680528
申请日：2003-10-07
申请人： D. Curtis Deno , Ruth N. Klepfer , William J. Havel , David M. Schneider , Vincent E. Splett
发明人： D. Curtis Deno , Ruth N. Klepfer , William J. Havel , David M. Schneider , Vincent E. Splett
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： Techniques and apparatus for estimating the temporal refractory period of a heart, for adjusting a parameter for delivery of extra-systolic stimulation (ESS) therapy and for detecting an arrhythmia during delivery of ESS therapy In some aspects, probe pulses are periodically delivered to estimate the location of the end boundary of the refractory period, and accordingly estimate its length. In some embodiments, the parameter is adjusted based on estimated length of the refractory period. For example, an extra-systolic interval (ESI) for delivery of ESS is adjusted to be a fixed interval longer than estimated lengths of the refractory period. In other aspects, the parameter is adjusted based on a measured delay (or latency) between delivery of an ESS pulse and detection of an evoked response resulting from the pulse. Also, delays between delivery of an ESS pulse and detection of a subsequent depolarization are monitored to detect an arrhythmia.
摘要翻译：用于估计心脏的时间不应期的技术和装置，用于调整用于递送收缩期刺激（ESS）治疗的参数和用于在递送ESS治疗期间检测心律失常的一些方面，定期递送探针脉冲以估计不应期结束边界的位置，并据此估计其长度。在一些实施例中，基于估计的不应期的长度来调整参数。例如，用于递送ESS的收缩期间期（ESI）被调整为比不应期的估计长度更长的固定间隔。在其他方面，基于在递送ESS脉冲和从脉冲产生的诱发响应的检测之间的测量延迟（或等待时间）来调整参数。此外，监测递送ESS脉冲和检测随后的去极化之间的延迟以检测心律失常。

5. 发明授权

US07096064B2 Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation 有权
标题翻译：用于通过电刺激治疗心脏机械功能障碍的植入式医疗装置
公开(公告)号：US07096064B2
公开(公告)日：2006-08-22
申请号：US10232792
申请日：2002-08-28
申请人： D. Curtis Deno , William J. Havel , Tommy D. Bennett , Paul M. Stein , David E. Euler
发明人： D. Curtis Deno , William J. Havel , Tommy D. Bennett , Paul M. Stein , David E. Euler
IPC分类号： A61N1/362
CPC分类号： A61N1/3956 , A61N1/36014 , A61N1/36114 , A61N1/3625 , A61N1/3627 , A61N1/36585 , A61N1/3706
摘要： The disclosure provides methods and apparatus of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants thereof. According to the disclosure monitoring and therapy delivery for a wide variety of acute and chronic cardiac dysfunctions are described and depicted. Various forms of paired or coupled pacing therapy delivery provided alone or in combination with neurostimulation therapy delivered by both implantable and external apparatus, including defibrillation therapy are also provided herein.
摘要翻译：本公开提供了对患有心力衰竭，包括心脏功能障碍，慢性HF等的患者及其所有变体的患者特别有益的方法和装置。根据公开的监测和治疗方案，描述和描述了各种急性和慢性心脏功能障碍。本文还提供各种形式的配对或联合起搏治疗递送，其单独地或与由可植入和外部装置（包括除颤治疗）递送的神经刺激治疗组合提供。

6. 发明授权

US08473057B2 Shunt-current reduction housing for an implantable therapy system 有权
标题翻译：用于植入式治疗系统的分流电流还原壳体
公开(公告)号：US08473057B2
公开(公告)日：2013-06-25
申请号：US12609901
申请日：2009-10-30
申请人： William T. Donofrio , William J. Havel , Chris C. Christiansen , Paul G. Krause
发明人： William T. Donofrio , William J. Havel , Chris C. Christiansen , Paul G. Krause
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.
摘要翻译：用于最小化治疗系统的第一和第二医疗装置之间的干扰的技术可以包括提供用于至少一个医疗装置的外壳，其包括在至少导电部分（例如，导电层）上形成的电绝缘层，或者提供围绕至少第一医疗装置的导电外壳的电绝缘袋。电绝缘层或电绝缘袋可以减少甚至消除通过外壳流入医疗装置的分流电流。分流电流可以通过第二医疗装置的电刺激的传递来产生。在一些示例中，所述技术还可以包括分流电流缓解电路，其帮助最小化或甚至消除通过电连接到第一医疗设备的一个或多个电极馈入第一医疗设备的分流电流。

7. 发明申请

US20100114205A1 SHUNT-CURRENT REDUCTION HOUSING FOR AN IMPLANTABLE THERAPY SYSTEM 有权
标题翻译：用于可植入治疗系统的分流电流减少外壳
公开(公告)号：US20100114205A1
公开(公告)日：2010-05-06
申请号：US12609901
申请日：2009-10-30
申请人： William T. Donofrio , William J. Havel , Chris C. Christiansen , Paul G. Krause
发明人： William T. Donofrio , William J. Havel , Chris C. Christiansen , Paul G. Krause
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.
摘要翻译：用于最小化治疗系统的第一和第二医疗装置之间的干扰的技术可以包括提供用于至少一个医疗装置的外壳，其包括在至少导电部分（例如，导电层）上形成的电绝缘层，或者在至少第一医疗装置的导电外壳周围提供电绝缘袋。电绝缘层或电绝缘袋可以减少甚至消除通过外壳流入医疗装置的分流电流。分流电流可以通过第二医疗装置的电刺激的传递来产生。在一些示例中，所述技术还可以包括分流电流缓解电路，其帮助最小化或甚至消除通过电连接到第一医疗设备的一个或多个电极馈入第一医疗设备的分流电流。

8. 发明授权

US09308107B2 Endoluminal prosthesis and delivery device 有权
标题翻译：腔内假体和输送装置
公开(公告)号：US09308107B2
公开(公告)日：2016-04-12
申请号：US13595636
申请日：2012-08-27
申请人： William J. Havel
发明人： William J. Havel
IPC分类号： A61F2/06 , A61F2/954 , A61F2/966
CPC分类号： A61F2/954 , A61F2/07 , A61F2/966 , A61F2002/065 , A61F2002/067
摘要： A system for treating a body vessel may include a delivery device and a prosthesis retained on the delivery device. The prosthesis may include a main body and first and second legs each extending from the main body. The main body may include a lumen, and the first leg may include a lumen in fluid communication with the lumen of the main body. The second leg may include a tubular graft body and a stent attached to the graft body. The prosthesis may have a predeployment configuration in which the graft body of the second leg is inverted into and positioned within the lumen of the first leg, and the stent is positioned outside of the inverted graft body. The prosthesis may have a deployed configuration in which the second leg extends outward from the main body, and the stent is positioned within a lumen of the graft body.
摘要翻译：用于治疗身体血管的系统可以包括输送装置和保留在输送装置上的假体。假体可以包括主体以及从主体延伸的第一和第二腿。主体可以包括腔，并且第一腿可以包括与主体的内腔流体连通的内腔。第二腿部可以包括管状移植体和附接到移植物体的支架。假体可以具有预部署构造，其中第二腿的移植物体被倒置并位于第一腿的内腔内，并且支架位于倒置的移植物体的外侧。假体可以具有展开构造，其中第二腿从主体向外延伸，并且支架位于移植物主体的内腔内。

9. 发明授权

US09101389B2 Apparatus for guiding the placement of a subcutaneous device 有权
标题翻译：用于引导皮下装置的放置的装置
公开(公告)号：US09101389B2
公开(公告)日：2015-08-11
申请号：US12431926
申请日：2009-04-29
申请人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
发明人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
IPC分类号： A61B17/34 , A61N1/04 , A61M5/42 , A61M5/158 , A61B17/00 , A61B17/30 , A61B17/32 , A61N1/05
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： An apparatus for guiding the placement of a subcutaneous device that includes a strap having an indentation configured for a fold of skin and fat layer to be positioned within the indentation as the subcutaneous device is advanced to a desired implantation site.
摘要翻译：一种用于引导皮下装置的放置的装置，所述装置包括当皮下装置前进到期望的植入部位时具有构造成用于皮肤和脂肪层的折叠的凹陷的带以定位在凹陷内。

10. 发明授权

US08630708B2 Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权
标题翻译：使用组织氧合测量进行休克后评估的方法和装置
公开(公告)号：US08630708B2
公开(公告)日：2014-01-14
申请号：US12845818
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

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