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1. 发明申请

US20070055302A1 VASO-OCCLUSIVE DELIVERY DEVICE WITH KINK RESISTANT, FLEXIBLE DISTAL END 有权
标题翻译： VASO-OCCLUSIVE交付装置，具有抗振动，灵活的远端
公开(公告)号：US20070055302A1
公开(公告)日：2007-03-08
申请号：US11423934
申请日：2006-06-13
申请人： William Henry , Charles Daly , Russell Ford , Michael Williams , Hanh Duong , Hughie Devaney , Kamal Ramzipoor , Clifford Teoh , Richard Murphy , Andrew Huffmaster , Scott McGill
发明人： William Henry , Charles Daly , Russell Ford , Michael Williams , Hanh Duong , Hughie Devaney , Kamal Ramzipoor , Clifford Teoh , Richard Murphy , Andrew Huffmaster , Scott McGill
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61M25/09 , A61M2025/09133
摘要： A device for delivering an occlusive element includes an elongate sheath having a lumen therein. An elongate core member is disposed within the lumen and is formed from a proximal portion and distal portion connected via a joint. The distal portion of the elongate member includes a severable junction secured to the occlusive element. A marker coil is coaxially arranged around the distal portion of the elongate core member and is partially disposed inside the sheath lumen. A coil member is coaxially arranged around the distal portion of the elongate core member and coaxially arranged around at least a portion of the marker coil extending outside the lumen of the sheath. The coil member is secured at a distal end thereof to the distal portion of the elongate core member. The device resists axial compression while allowing for radial bending.
摘要翻译：用于递送闭塞元件的装置包括其中具有内腔的细长护套。细长的芯构件设置在内腔内，并且由通过接头连接的近端部分和远端部分形成。细长构件的远端部分包括固定到闭塞元件的可分开的连接点。标记线圈围绕细长芯构件的远端部分同轴布置，并且部分地设置在鞘腔内。线圈构件围绕细长芯构件的远侧部分同轴地布置，并且围绕标记线圈的至少一部分同轴地布置，该标记线圈延伸到护套内腔的外侧。线圈构件在其远端固定到细长芯构件的远端部分。该装置抵抗轴向压缩同时允许径向弯曲。

2. 发明申请

US20130150302A1 CONJUGATED BLOOD COAGULATION FACTOR VIII 审中-公开
标题翻译：凝血因子凝血因子VIII
公开(公告)号：US20130150302A1
公开(公告)日：2013-06-13
申请号：US13643287
申请日：2011-04-28
申请人： William Henry
发明人： William Henry
IPC分类号： C07K14/755 , A61K45/06 , A61K38/37
CPC分类号： C07K14/755 , A61K38/37 , A61K45/06 , A61K47/60
摘要： The present invention provides a biocompatible polymer conjugated to FVIII via one or more cysteine residues, suitably via a linker across a reduced disulphide bond in FVIII, and pharmaceutical compositions comprising such conjugated forms of FVIII.
摘要翻译：本发明提供了通过一种或多种半胱氨酸残基缀合至FVIII的生物相容性聚合物，适当地通过在FVIII中通过还原二硫键的连接体和包含这种缀合形式的FVIII的药物组合物。

3. 发明申请

US20100249027A1 CRF CONJUGATES WITH EXTENDED HALF-LIVES 审中-公开
标题翻译： CRF与扩展的半身人士联合
公开(公告)号：US20100249027A1
公开(公告)日：2010-09-30
申请号：US12601714
申请日：2008-05-27
申请人： William Henry
发明人： William Henry
IPC分类号： A61K38/35 , C07K14/00 , A61P7/10
CPC分类号： C07K14/57509 , A61K31/56 , A61K47/60 , A61K2300/00
摘要： The present invention relates to conjugates of CRF that have been modified to include a moiety that protects CRF from degradation and prolongs the half-life of CRF. The CRF conjugates of the invention have an increased half-life which results in a dose-sparing effect and less frequent administration
摘要翻译：本发明涉及已被修饰以包括保护CRF免于降解并延长CRF半衰期的部分的CRF缀合物。本发明的CRF缀合物具有增加的半衰期，其导致剂量节省效应和较不频繁的给药

4. 发明申请

US20050259985A1 Spherical enclosure for a camera 有权
标题翻译：相机的球形外壳
公开(公告)号：US20050259985A1
公开(公告)日：2005-11-24
申请号：US11088736
申请日：2005-03-25
申请人： Christopher Mulvey , Russell Mullins , William Henry
发明人： Christopher Mulvey , Russell Mullins , William Henry
IPC分类号： G03B17/08 , G03B17/56 , G03B39/00
CPC分类号： G03B17/08 , G03B17/56 , G03B17/565
摘要： A spherical enclosure for a camera, has in some examples, an optically transmitting wall, a highly-reflective external surface, a coated internal surface, a collapsible internal lining, and a support tube. The wall may have a region of varying wall thickness providing a lens. The collapsible internal liner is made of a material that obscures the camera's silhouette, and is inserted through an opening in the wall while folded, and then expands into position. The inner surface of the enclosure may be coated with a material that reduces internal reflections. The camera, when mounted in the enclosure has the optical center of the camera coincident with the geometric center of the spherical enclosure, so that distortion of the camera image is minimized.
摘要翻译：在一些示例中，用于相机的球形外壳在光学透射壁，高反射性外表面，涂覆内表面，可折叠内衬和支撑管中具有。壁可以具有提供透镜的变化壁厚的区域。可折叠的内衬由遮蔽相机轮廓的材料制成，并且在折叠时插入壁中的开口，然后扩展到位。外壳的内表面可以涂覆有减少内部反射的材料。相机在安装在外壳中时，相机的光学中心与球形外壳的几何中心重合，从而使相机图像的失真最小化。

5. 发明申请

US20050165352A1 Stent delivery catheter 失效
标题翻译：支架输送导管
公开(公告)号：US20050165352A1
公开(公告)日：2005-07-28
申请号：US10764054
申请日：2004-01-23
申请人： William Henry , John Ortiz
发明人： William Henry , John Ortiz
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61M29/00
CPC分类号： A61F2/97 , A61F2/95 , A61F2/966
摘要： A self-expanding stent delivery assembly includes a shaft having a proximal end, a distal end, a distal region, a lumen, and a longitudinal axis. A retractable sheath having an outer surface, a proximal end and a distal end is co-axially disposed around the shaft distal region. A stent is disposed co-axially between the shaft and the retractable sheath. A tubular tapered tip is affixed to the retractable sheath distal end. The tubular tapered tip has an elongate region predisposed to fracturing. Methods of delivering a self-expanding stent are also described.
摘要翻译：自扩张支架输送组件包括具有近端，远端，远侧区域，内腔和纵向轴线的轴。具有外表面，近端和远端的可伸缩护套共轴地设置在轴远侧区域周围。支架同轴地设置在轴和可缩回护套之间。管状锥形尖端固定到可缩回护套远端。管状锥形尖端具有易于断裂的细长区域。还描述了递送自扩张支架的方法。

6. 发明授权

US09309507B2 Conjugated blood coagulation factor VIIa 有权
标题翻译：共轭凝血因子VIIa
公开(公告)号：US09309507B2
公开(公告)日：2016-04-12
申请号：US13643504
申请日：2011-04-28
申请人： William Henry
发明人： William Henry
IPC分类号： A61K38/00 , C12N9/96 , A61K47/48 , A61K38/48 , A61K45/00
CPC分类号： C12N9/96 , A61K38/4846 , A61K45/00 , A61K47/60
摘要： The present invention provides a biocompatible polymer conjugated to FVIIa via one or more cysteine residues, suitably via a linker across a reduced disulphide bond in FVIIa, and pharmaceutical compositions comprising such conjugated forms of FVIIa.
摘要翻译：本发明提供了通过一种或多种半胱氨酸残基缀合至FVIIa的生物相容性聚合物，合适地经由FVIIa中的还原二硫键的连接体以及包含这种缀合形式的FVIIa的药物组合物。

7. 发明申请

US20130129698A1 CONJUGATED BLOOD COAGULATION FACTOR VIIA 有权
标题翻译：凝血因子凝血因子VIIA
公开(公告)号：US20130129698A1
公开(公告)日：2013-05-23
申请号：US13643504
申请日：2011-04-28
申请人： William Henry
发明人： William Henry
IPC分类号： C12N9/96 , A61K45/00 , A61K38/48
CPC分类号： C12N9/96 , A61K38/4846 , A61K45/00 , A61K47/60
摘要： The present invention provides a biocompatible polymer conjugated to FVIIa via one or more cysteine residues, suitably via a linker across a reduced disulphide bond in FVIIa, and pharmaceutical compositions comprising such conjugated forms of FVIIa.
摘要翻译：本发明提供了通过一种或多种半胱氨酸残基缀合至FVIIa的生物相容性聚合物，合适地经由FVIIa中的还原二硫键的连接体以及包含这种缀合形式的FVIIa的药物组合物。

8. 发明申请

US20120100171A1 HAPTEN-CARRIER CONJUGATES WITH BACTERIAL TOXINS HAVING A SIGNAL PEPTIDE AS CARRIER AND THEIR USE IN IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：具有作为载体的信号肽及其在免疫组成中的使用的细菌毒素的携带载体
公开(公告)号：US20120100171A1
公开(公告)日：2012-04-26
申请号：US13255262
申请日：2010-03-09
申请人： William Henry
发明人： William Henry
IPC分类号： A61K39/385 , A61P37/04 , A61P25/30 , C07K14/28
CPC分类号： A61K31/55 , A61K31/465 , A61K47/6415 , A61K47/646 , Y02A50/471 , A61K2300/00
摘要： This invention relates to immunogenic compositions for inducing an immune response against an antigen of interest. In particular, the invention provides immunogenic compositions comprising an antigen-carrier conjugate, wherein the carrier is a bacterial toxin that contains a signal peptide. The invention also provides methods of generating immunogenic compositions with enhanced immunogenicity, comprising adding a signal peptide to the bacterial carrier in an antigen-carrier conjugate, such as a hapten-carrier conjugate. The invention also provides methods for inducing an immune response to a hapten in a subject using these immunogenic compositions.
摘要翻译：本发明涉及用于诱导针对感兴趣的抗原的免疫应答的免疫原性组合物。特别地，本发明提供包含抗原 - 载体缀合物的免疫原性组合物，其中载体是含有信号肽的细菌毒素。本发明还提供了产生具有增强的免疫原性的免疫原性组合物的方法，包括在抗原 - 载体缀合物例如半抗原 - 载体缀合物中向细菌载体添加信号肽。本发明还提供了使用这些免疫原性组合物诱导受试者中半抗原免疫应答的方法。

9. 发明申请

US20080075830A1 Flavor application on edible substrates 审中-公开
标题翻译：香料在食用基质上的应用
公开(公告)号：US20080075830A1
公开(公告)日：2008-03-27
申请号：US11903633
申请日：2007-09-24
申请人： Lu Fang Wen , William Henry , Robert Swaine
发明人： Lu Fang Wen , William Henry , Robert Swaine
IPC分类号： A23L1/22
CPC分类号： A23L5/42 , A21D13/47 , A23G3/50 , A23G4/20 , A23L19/18 , A23L27/00 , A23P20/18
摘要： Edible substrates printed with flavors, aroma, seasonings, and images. The edible substrates can be printed with two or more distinct flavors and in different colors so that they are visible to the consumer. Preferably each distinct flavor has a different color, and even more preferably the distinct flavors having different colors are deposited in a pattern. Moreover, the distinct flavors can be deposited in a pattern that corresponds to areas on the tongue where different taste buds are located. And the two or more distinct flavors can be deposited by different deposition apparatuses or by different nozzles within the same deposition apparatus.
摘要翻译：可食用的底物印有口味，香气，调味料和图像。可食用的基材可以印有两种或更多种不同的香料和不同的颜色，使得它们对消费者是可见的。优选地，每种不同的风味具有不同的颜色，并且甚至更优选地，具有不同颜色的不同风味以图案沉积。此外，可以以对应于不同味蕾位于舌头上的区域的图案沉积不同的风味。并且两种或更多种不同的味道可以通过不同的沉积设备或在相同的沉积设备中的不同喷嘴沉积。

10. 发明授权

US08491524B2 Needleless injector drug capsule and a method for filling thereof 有权
标题翻译：无针注射器药物胶囊及其填充方法
公开(公告)号：US08491524B2
公开(公告)日：2013-07-23
申请号：US13495390
申请日：2012-06-13
申请人： William Henry , Andrew Lewis
发明人： William Henry , Andrew Lewis
IPC分类号： A61M5/30 , A61M37/00
CPC分类号： A61M5/30 , B01D19/0005
摘要： A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
摘要翻译：一种用液体药物研磨无针注射器胶囊的方法，其中药物内的溶解气体被较不易溶的气体代替，以减少气泡的包含，或防止气泡在储存过程中生长，从而防止胶囊的破裂。

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