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1. 发明授权

US06796303B2 Pulmonary aerosol delivery device and method 失效
标题翻译：肺气雾剂输送装置及方法
公开(公告)号：US06796303B2
公开(公告)日：2004-09-28
申请号：US10161545
申请日：2002-06-03
申请人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
发明人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译：一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个的多个放电电极下游的参考电极。

2. 发明授权

US06397838B1 Pulmonary aerosol delivery device and method 失效
标题翻译：肺气雾剂输送装置及方法
公开(公告)号：US06397838B1
公开(公告)日：2002-06-04
申请号：US09469042
申请日：1999-12-21
申请人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
发明人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译：一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个的多个放电电极下游的参考电极。

3. 发明授权

US06368079B2 Piezoelectric micropump 失效
标题翻译：压电微型泵
公开(公告)号：US06368079B2
公开(公告)日：2002-04-09
申请号：US09220310
申请日：1998-12-23
申请人： Richard D. Peters , Chad E. Bouton , William C. Zimlich, Jr.
发明人： Richard D. Peters , Chad E. Bouton , William C. Zimlich, Jr.
IPC分类号： F04B1700
CPC分类号： F04B43/046
摘要： A piezoelectric micropump is disclosed for pumping fluid from a container to a delivery point in low volumes and at controlled flow rates. The pumping action is created by movement of two or three diaphragms. The movement of each diaphragm is caused by expansion and contraction of an attached piezoelectric actuator. Coordination of the movement of the diaphragms creates unidirectional flow of the fluid. The piezoelectric actuators are cantilevered between the pump body and the diaphragms to provide greater deflection of the diaphragms. The piezoelectric actuators preferably are piezoelectric bimorphs such that the diaphragms can function as both seals and pumps.
摘要翻译：公开了一种用于将流体从容器中以低体积和受控流速泵送到输送点的压电微型泵。通过两个或三个隔膜的移动产生泵送动作。每个隔膜的移动是由附着的压电致动器的膨胀和收缩引起的。隔膜的运动的协调产生流体的单向流动。压电致动器在泵体和隔膜之间悬臂以提供更大的隔膜偏转。压电致动器优选地是压电双晶片，使得隔膜可以用作密封件和泵两者。

4. 发明授权

US5288647A Method of irradiating biological specimens 失效
标题翻译：辐射生物标本的方法
公开(公告)号：US5288647A
公开(公告)日：1994-02-22
申请号：US686491
申请日：1991-04-17
申请人： William C. Zimlich, Jr. , Joseph A. Sorge
发明人： William C. Zimlich, Jr. , Joseph A. Sorge
IPC分类号： C07K17/00 , C12Q1/68 , G01J1/04
CPC分类号： C07K17/00 , C12Q1/68 , Y10T436/25
摘要： A method of irradiating a biological specimen with ultraviolet, in particular a polynucleotide specimen selected from DNA or RNA, or optionally a protein. In the case where the specimen is DNA or RNA, or potentially proteins, the specimen is irradiated to cross-link the specimen to a substrate. In the case where the specimen is DNA, the specimen can also be irradiated to form thymine dimers. The method uses an apparatus which permits relatively precise control of the total ultraviolet dose received by the specimen, despite any changes of ultraviolet flux from the lamps which may occur from during any one experiment, or between a number of experiments. Thus, the method allows relatively highly reproducible results to be obtained.
摘要翻译：用紫外线照射生物样本的方法，特别是选自DNA或RNA的多核苷酸标本，或任选的蛋白质。在标本是DNA或RNA或潜在的蛋白质的情况下，照射样品以将样品交联到基底上。在标本为DNA的情况下，也可以照射样品以形成胸腺嘧啶二聚体。该方法使用允许相对精确地控制由样品接收的总紫外线剂量的装置，尽管在任何一个实验期间或在多个实验之间可能发生来自灯的紫外线通量的任何变化。因此，该方法允许获得相对高度可重复的结果。

5. 发明授权

US06805118B2 Pulmonary dosing system and method 失效
标题翻译：肺给药系统及方法
公开(公告)号：US06805118B2
公开(公告)日：2004-10-19
申请号：US09921331
申请日：2001-08-02
申请人： Michael J. Brooker , John E. Frye , Paul T. Kotnik , Michael B. Mosholder , Michael E. Placke , William C. Zimlich, Jr.
发明人： Michael J. Brooker , John E. Frye , Paul T. Kotnik , Michael B. Mosholder , Michael E. Placke , William C. Zimlich, Jr.
IPC分类号： A61M1500
CPC分类号： A61M15/0065 , A61M15/008 , A61M16/009 , A61M16/0093 , A61M16/0833 , A61M16/1055 , A61M16/107
摘要： A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material. The system comprises a patient interface to introduce the material into the patient's lungs. The patient interface is connected to a flexible inhalation tube and a flexible exhalation tube. The exhalation tube is connected to a filter having an outlet connected to atmosphere. The inhalation tube is connected to an apparatus for providing pulsed amounts of the material entrained in filtered atmospheric air. A control unit operates the pulmonary dosing system in accordance with operator inputs regarding the number of patent exhales between pulses, and pulse length. The exhaust filter and the apparatus for providing pulsed amounts of the therapeutically active material may be enclosed in a containment case and the patient's interface may comprise a mouth tube-mask combination when the therapeutically active material comprises at least one toxic drug.
摘要翻译：一种肺给药系统和方法，用于向患者提供预定量的可呼吸的治疗活性物质。该系统包括将材料引入患者肺部的患者接口。患者界面连接到柔性吸入管和柔性呼气管。呼气管连接到具有连接到大气的出口的过滤器。吸入管连接到用于提供脉冲量的夹带在过滤的大气中的材料的装置。控制单元根据关于脉冲之间的专利呼出数和脉冲长度的操作者输入来操作肺部给药系统。排气过滤器和用于提供脉冲量的治疗活性材料的装置可以封闭在容纳壳体中，并且当治疗活性材料包含至少一种毒性药物时，患者的界面可以包括口罩 - 面罩组合。

6. 发明授权

US5395591A Apparatus of irradiating biological specimens 失效
标题翻译：照射生物标本的装置
公开(公告)号：US5395591A
公开(公告)日：1995-03-07
申请号：US999434
申请日：1992-12-30
申请人： William C. Zimlich, Jr. , Joseph A. Sorge
发明人： William C. Zimlich, Jr. , Joseph A. Sorge
IPC分类号： C07K17/00 , C12Q1/68 , G05D25/02
CPC分类号： C07K17/00 , C12Q1/68 , Y10T436/25
摘要： A method of irradiating a biological specimen with ultraviolet, in particular a polynucleotide specimen selected from DNA or RNA, or optionally a protein. In the case where the specimen is DNA or RNA, or potentially proteins, the specimen is irradiated to cross-link the specimen to a substrate. In the case where the specimen is DNA, the specimen can also be irradiated to form thymine dimers. The method uses an apparatus which permits relatively precise control of the total ultraviolet dose received by the specimen, despite any changes of ultraviolet flux from the lamps which may occur from during any one experiment, or between a number of experiments. Thus, the method allows relatively highly reproducible results to be obtained.
摘要翻译：用紫外线照射生物样本的方法，特别是选自DNA或RNA的多核苷酸标本，或任选的蛋白质。在标本是DNA或RNA或潜在的蛋白质的情况下，照射样品以将样品交联到基底上。在标本为DNA的情况下，也可以照射样品以形成胸腺嘧啶二聚体。该方法使用允许相对精确地控制由样品接收的总紫外线剂量的装置，尽管在任何一个实验期间或在多个实验之间可能发生来自灯的紫外线通量的任何变化。因此，该方法允许获得相对高度可重复的结果。

7. 发明授权

US06269810B1 Pulmonary dosing system and method 失效
标题翻译：肺给药系统及方法
公开(公告)号：US06269810B1
公开(公告)日：2001-08-07
申请号：US09263986
申请日：1999-03-05
申请人： Michael J. Brooker , John E. Frye , Paul T. Kotnik , Michael B. Mosholder , Michael E. Placke , William C. Zimlich, Jr.
发明人： Michael J. Brooker , John E. Frye , Paul T. Kotnik , Michael B. Mosholder , Michael E. Placke , William C. Zimlich, Jr.
IPC分类号： A61M1500
CPC分类号： A61M15/0065 , A61M15/008 , A61M16/009 , A61M16/0093 , A61M16/0833 , A61M16/1055 , A61M16/107
摘要： A pulmonary dosing system and method for supplying to a patient a predetermined amount of respirable therapeutically active material. The system comprises a patient interface to introduce the material into the patient's lungs. The patient interface is connected to a flexible inhalation tube and a flexible exhalation tube. The exhalation tube is connected to a filter having an outlet connected to atmosphere. The inhalation tube is connected to an apparatus for providing pulsed amounts of the material entrained in filtered atmospheric air. A control unit operates the pulmonary dosing system in accordance with operator inputs regarding the number of patent exhales between pulses, and pulse length. The exhaust filter and the apparatus for providing pulsed amounts of the therapeutically active material may be enclosed in a containment case and the patient's interface may comprise a mouth tube-mask combination when the therapeutically active material comprises at least one toxic drug.
摘要翻译：一种肺给药系统和方法，用于向患者提供预定量的可呼吸的治疗活性物质。该系统包括将材料引入患者肺部的患者接口。患者界面连接到柔性吸入管和柔性呼气管。呼气管连接到具有连接到大气的出口的过滤器。吸入管连接到用于提供脉冲量的夹带在过滤的大气中的材料的装置。控制单元根据关于脉冲之间的专利呼出数和脉冲长度的操作者输入来操作肺部给药系统。排气过滤器和用于提供脉冲量的治疗活性材料的装置可以封闭在容纳壳体中，并且当治疗活性材料包含至少一种毒性药物时，患者的界面可以包括口罩 - 面罩组合。

8. 发明授权

US5814523A Method of irradiating biological specimens 失效
标题翻译：辐射生物标本的方法
公开(公告)号：US5814523A
公开(公告)日：1998-09-29
申请号：US896717
申请日：1997-07-18
申请人： William C. Zimlich, Jr. , Joseph A. Sorge
发明人： William C. Zimlich, Jr. , Joseph A. Sorge
IPC分类号： C07K17/00 , C12Q1/68 , G01J1/04
CPC分类号： C07K17/00 , C12Q1/68 , Y10T436/25
摘要： A method of irradiating a biological specimen with ultraviolet, in particular a polynucleotide specimen selected from DNA or RNA, or optionally a protein. In the case where the specimen is DNA or RNA, or potentially proteins, the specimen is irradiated to cross-link the specimen to a substrate. In the case where the specimen is DNA, the specimen can also be irradiated to form thymine dimers. The method uses an apparatus which permits relatively precise control of the total ultraviolet dose received by the specimen, despite any changes of ultraviolet flux from the lamps which may occur from during any one experiment, or between a number of experiments. Thus, the method allows relatively highly reproducible results to be obtained.
摘要翻译：用紫外线照射生物样本的方法，特别是选自DNA或RNA的多核苷酸标本，或任选的蛋白质。在标本是DNA或RNA或潜在的蛋白质的情况下，照射样品以将样品交联到基底上。在标本为DNA的情况下，也可以照射样品以形成胸腺嘧啶二聚体。该方法使用允许相对精确地控制由样品接收的总紫外线剂量的装置，尽管在任何一个实验期间或在多个实验之间可能发生来自灯的紫外线通量的任何变化。因此，该方法允许获得相对高度可重复的结果。

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