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1. 发明授权

US06796303B2 Pulmonary aerosol delivery device and method 失效
标题翻译：肺气雾剂输送装置及方法
公开(公告)号：US06796303B2
公开(公告)日：2004-09-28
申请号：US10161545
申请日：2002-06-03
申请人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
发明人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译：一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个的多个放电电极下游的参考电极。

2. 发明授权

US06397838B1 Pulmonary aerosol delivery device and method 失效
标题翻译：肺气雾剂输送装置及方法
公开(公告)号：US06397838B1
公开(公告)日：2002-06-04
申请号：US09469042
申请日：1999-12-21
申请人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
发明人： William C. Zimlich, Jr. , James E. Dvorsky , David R. Busick , Richard D. Peters
IPC分类号： A61M1100
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
摘要翻译：一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置和方法。紧凑且方便的装置包括这样的尺寸的壳体，使得其可以在使用者的一只手中保持在壳体中的出口，用于将气溶胶引导到使用者的嘴部。壳体包围用于容纳要雾化的液体并将其输送到电动力学装置的分配系统和用于使液体雾化并将气溶胶输送到出口的电动液压装置。电动力学装置产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。雾化装置包括多个喷射部位，每个喷射部分具有尖端，喷射部位与电荷源配合，以产生从至少一个末端到下游的多个放电电极的雾化喷雾，以及多个的多个放电电极下游的参考电极。

3. 发明授权

US06454193B1 High mass transfer electrosprayer 失效
标题翻译：高质量转移电喷雾器
公开(公告)号：US06454193B1
公开(公告)日：2002-09-24
申请号：US09553541
申请日：2000-04-20
申请人： David R. Busick , James E. Dvorsky , Gregory A. Trees , James H. Saunders
发明人： David R. Busick , James E. Dvorsky , Gregory A. Trees , James H. Saunders
IPC分类号： B05B500
CPC分类号： A61L9/14 , A61M1/265 , A61M15/02 , B05B5/0255
摘要： A electrohydrodynamic aerosol sprayer wherein a gas flow deflector is used for creating a gas flow past the spray nozzle to stabilize the Taylor cone and to transport at least a portion of the aerosol away from the region downstream of the spray nozzle. This stabilization of the cone and transport of aerosol improves the droplet size and distribution and may also reduce the deposit of droplets on the internal components of the device.
摘要翻译：一种电动液体喷雾器，其中气体导流器用于产生通过喷嘴的气流，以稳定泰勒锥并将至少一部分气溶胶运送到远离喷雾喷嘴下游的区域。锥体的稳定化和气溶胶的输送改善了液滴的尺寸和分布，并且还可以减少液滴在装置的内部部件上的沉积。

4. 发明授权

US07849850B2 Nozzle for handheld pulmonary aerosol delivery device 有权
标题翻译：喷枪用于手持式肺气溶胶输送装置
公开(公告)号：US07849850B2
公开(公告)日：2010-12-14
申请号：US10375957
申请日：2003-02-28
申请人： William G. Atterbury , Chad E. Bouton , David R. Busick , James E. Dvorsky , Peter A. Gaydos , David A. Holley , Daniel D. Meek , Gregory A. Trees
发明人： William G. Atterbury , Chad E. Bouton , David R. Busick , James E. Dvorsky , Peter A. Gaydos , David A. Holley , Daniel D. Meek , Gregory A. Trees
IPC分类号： A61M11/00 , B05B5/00 , F23D11/32
CPC分类号： A61M15/02 , A61M11/001 , B05B1/18 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/1691
摘要： An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.
摘要翻译：特别适用于手持式肺气溶胶吸入器的改进的电动力学（EHD）喷嘴通过减少或消除通过屏蔽放电电极的润湿来增加治疗液体的一致和有效的分配。一些版本进一步消除了润湿，同时通过环绕环绕气溶胶的离子的电晕放电来增强气溶胶的中和。将具有一致的压降的改进的液体分布结合到每个EHD喷嘴尖端允许水平分配，并且通过使用具有低表面能的介电喷嘴尖端，从而避免分配之间的芯吸，并且有利地减少分配时可实现的粒度。某些版本具有增强的卡扣配合和其他可制造性优势。 EHD喷嘴的独特特征之一是实现高剂量率（微升/分钟），具有低润湿和小粒径（1.0-5微米），尽管这些性质倾向于相互排斥。此外，这些属性被并入到便利的小型手持设备中。

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