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1. 发明申请

US20070208374A1 EMBOLIC PROTECTION DEVICES 审中-公开
标题翻译：嵌入式保护装置
公开(公告)号：US20070208374A1
公开(公告)日：2007-09-06
申请号：US11747459
申请日：2007-05-11
申请人： William Boyle , Andy Denison , Benjamin Huter , Scott Huter , Richard Stack , Kent Stalker , Christopher Tarapata , John Whitfield
发明人： William Boyle , Andy Denison , Benjamin Huter , Scott Huter , Richard Stack , Kent Stalker , Christopher Tarapata , John Whitfield
IPC分类号： A61F2/01 , A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

2. 发明申请

US20070167975A1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US20070167975A1
公开(公告)日：2007-07-19
申请号：US11651667
申请日：2007-01-10
申请人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
发明人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

3. 发明申请

US20070156169A1 Embolic filtering devices 有权
公开(公告)号：US20070156169A1
公开(公告)日：2007-07-05
申请号：US11654426
申请日：2007-01-17
申请人： Andy Denison , William Harrison , Benjamin Huter , Scott Huter , John Papp , Steven Saville , Kent Stalker
发明人： Andy Denison , William Harrison , Benjamin Huter , Scott Huter , John Papp , Steven Saville , Kent Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.

4. 发明申请

US20050021125A1 Stent delivery catheter and method of use 审中-公开
标题翻译：支架输送导管及使用方法
公开(公告)号：US20050021125A1
公开(公告)日：2005-01-27
申请号：US10925784
申请日：2004-08-24
申请人： Richard Stack , Udayan Patel , William Boyle , Kent Stalker , Paul Muller
发明人： Richard Stack , Udayan Patel , William Boyle , Kent Stalker , Paul Muller
IPC分类号： A61F2/06 , A61F2/84 , A61M25/12
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： A deformable sheath is attached to a catheter and introduced intravascularly to be expanded against an arterial wall and entrap plaque therebetween. A stent is subsequently deployed within the expanded sheath and the sheath is then withdrawn from within the vasculature to leave the stent expanded against the arterial wall with the plaque entrapped therebetween.
摘要翻译：可变形护套附着在导管上，血管内引入以相对于动脉壁扩张并在其间夹带斑块。随后将支架部署在扩张的护套内，然后从脉管系统中撤出护套，以使支架膨胀抵靠动脉壁，其间夹有斑块。

5. 发明申请

US20140012364A1 EXPANDABLE DEVICES 有权
公开(公告)号：US20140012364A1
公开(公告)日：2014-01-09
申请号：US13819846
申请日：2011-08-30
申请人： Andy Edward Denison , Kent Stalker , Mark Bates
发明人： Andy Edward Denison , Kent Stalker , Mark Bates
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/04 , A61F2/82 , A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2230/0069
摘要： An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (1 10) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first relatively stiff portion and first and second intermediate ends (160a, 160b) of the second relatively flexible portion. The first intermediate end (152a) of the relatively stiff portion is connected to the first intermediate end (160a) of the relatively flexible portion so as to create a first inward apex (170), the second intermediate end (152b) of the relatively stiff portion is connected to the second intermediate end (160b) of the relatively flexible portion so as to create a second inward apex (172), and the stent structure is configured such that, in a collapsed configuration, the first inward apex (170) is in contact with the second inward apex (172) and, in an expanded configuration, the first inward apex is biased to move in a first circumferential direction and the second inward apex is biased to move in a second circumferential direction that is different than the first circumferential direction.

6. 发明申请

US20120016297A1 Interventional Devices Including Dilute Nanotube-Polymer Compositions, and Methods of Making and Using Same 审中-公开
标题翻译：含稀释纳米管 - 聚合物组合物的介入装置及其制造和使用方法
公开(公告)号：US20120016297A1
公开(公告)日：2012-01-19
申请号：US13051351
申请日：2011-03-18
申请人： Peter John D'Aquanni , Mark C. Bates , Kent Stalker , Jason Phillips
发明人： Peter John D'Aquanni , Mark C. Bates , Kent Stalker , Jason Phillips
IPC分类号： A61M25/10 , B29C47/08 , B29C65/00 , B82Y30/00 , B82Y40/00
CPC分类号： A61L29/126 , A61L2400/12 , Y10T156/1002
摘要： Under one aspect, an interventional device includes a balloon having a flexible wall. The flexible wall includes a composition including between 0.005 wt. % and 0.20 wt. % of carbon nanotubes dispersed in a polymer. Under another aspect, a method of making an interventional device includes contacting a plurality of polymer particles with a plurality of nanotubes; extruding the polymer particles and the nanotubes to form a composition comprising the polymer and the nanotubes; and blow-casting the composition into a balloon.
摘要翻译：在一个方面，介入装置包括具有柔性壁的气囊。柔性壁包括包含0.005wt。％和0.20wt。％的碳纳米管分散在聚合物中。在另一方面，制备介入装置的方法包括使多个聚合物颗粒与多个纳米管接触; 挤出聚合物颗粒和纳米管以形成包含聚合物和纳米管的组合物; 并将组合物吹塑成气球。

7. 发明申请

US20060086440A1 Nitinol alloy design for improved mechanical stability and broader superelastic operating window 审中-公开
标题翻译：镍钛诺合金设计提高了机械稳定性和更宽的超弹性操作窗口
公开(公告)号：US20060086440A1
公开(公告)日：2006-04-27
申请号：US11019495
申请日：2004-12-20
申请人： John Boylan , Zhicheng Lin , Kent Stalker
发明人： John Boylan , Zhicheng Lin , Kent Stalker
IPC分类号： A61F2/82 , C22C14/00
CPC分类号： C22C30/00 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098 , A61L31/022 , A61L31/18 , A61L2400/16 , C22C14/00 , C22C19/00 , C22F1/006
摘要： A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron, aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expressed as UP=(0.66 ksi/° C.)(T)+σ0, with R2≧0.98, wherein σ0 is the upper plateau stress of the alloy at about 0° C., R2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.
摘要翻译：具有大的，超弹性的工作温度窗口或范围的镍钛合金。镍 - 钛合金至少包括一种额外的元素，例如铂，钯，锰，硼，铝，钨和/或锆。当通过热处理和面积还原步骤进行加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66 ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口）+σσ0，其中R 2≥0.98，其中σ0是在约0℃的合金的上平台应力。 R 2是确定系数，UP是合金的上平台应力。

8. 发明申请

US20070249964A1 POLYMER COATED GUIDE WIRE 有权
标题翻译：聚合物涂层指导线
公开(公告)号：US20070249964A1
公开(公告)日：2007-10-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
发明人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

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