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1. 发明申请

US20070249964A1 POLYMER COATED GUIDE WIRE 有权
标题翻译：聚合物涂层指导线
公开(公告)号：US20070249964A1
公开(公告)日：2007-10-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
发明人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

2. 发明申请

US20070162071A1 Locking component for an embolic filter assembly 有权
标题翻译：栓塞过滤器组件的锁定部件
公开(公告)号：US20070162071A1
公开(公告)日：2007-07-12
申请号：US11698549
申请日：2007-01-26
申请人： David Burkett , Robert Esselstein , Kathern Lind , Pablito Buan , Robert Hazelden , Thomas Tokarchik , Ryan Grandfield , Aaron Baldwin , Wayne Cornish , Philip Yip
发明人： David Burkett , Robert Esselstein , Kathern Lind , Pablito Buan , Robert Hazelden , Thomas Tokarchik , Ryan Grandfield , Aaron Baldwin , Wayne Cornish , Philip Yip
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.
摘要翻译：用于将医疗装置锁定在导丝上的锁定部件。这样的医疗装置包括例如用于捕获栓塞材料的栓塞过滤器组件，其可以在支架置入或血管成形术程序期间产生并释放到患者的脉管系统中。栓塞过滤器组件沿着导丝跟踪，并且被输送到其被锁定就位并展开的治疗部位。锁定组件使过滤器组件能够锁定到任何标准导丝上，并且不需要具有专门设计的接头或止挡件的改进的导丝来实现锁定功能。

3. 发明申请

US20070255217A1 TEXTURED POLYMER COATED GUIDE WIRE AND METHOD OF MANUFACTURE 审中-公开
标题翻译：纹理聚合物涂层指导线和制造方法
公开(公告)号：US20070255217A1
公开(公告)日：2007-11-01
申请号：US11762617
申请日：2007-06-13
申请人： David Burkett , Kevin Britton , Ryan Grandfield , Peter D'Aquanni , David Wrolstad , Edwin Mahieu , Wayne Cornish , Mark Richardson
发明人： David Burkett , Kevin Britton , Ryan Grandfield , Peter D'Aquanni , David Wrolstad , Edwin Mahieu , Wayne Cornish , Mark Richardson
IPC分类号： A61M5/178
CPC分类号： A61M25/09 , A61B17/12145 , A61F2/95 , A61F2/958 , A61M25/0043 , A61M2025/006 , A61M2025/0062 , A61M2025/09108 , A61M2025/09133 , B29C48/05 , B29C48/12 , B29C48/155
摘要： A guide wire for advancing a medical device such as a catheter through a patient's body lumen which has an elongated core with proximal and distal core section, a flexible tubular member such as a coil on the distal end. The wire core includes surface textures that are translated into the overlying coating. Alternatively, the coating has its own surface texture. The surface textures include randomly or non-randomly spaced bumps, divots, ridges, helical grooves, longitudinal grooves, undulations, etc.
摘要翻译：一种用于使诸如导管的医疗装置通过患者体腔前进的导丝，所述导管具有具有近端和远侧芯部的细长芯，在远端上具有诸如线圈的柔性管状构件。线芯包括被翻译成上覆涂层的表面纹理。或者，涂层具有其自己的表面纹理。表面纹理包括随机或非随机间隔的凸块，凸纹，凸脊，螺旋槽，纵向凹槽，起伏等。

4. 发明授权

US06599557B2 Method and apparatus for polymer application to intracorporeal device 有权
公开(公告)号：US06599557B2
公开(公告)日：2003-07-29
申请号：US10161786
申请日：2002-06-04
申请人： David Burkett , Emmanuel Biagtan
发明人： David Burkett , Emmanuel Biagtan
IPC分类号： B05D118
CPC分类号： B05C3/12 , A61M2025/09108
摘要： A method and apparatus for applying a polymer coating on an elongated substrate, preferably an elongate intracorporeal device in the form of a guidewire. An extrudable polymer cartridge is moved by a cartridge advancement mechanism into a guide chamber which is heated at an end with a die or orifice through which a desired portion of a guidewire may pass and be coated. Parameters such as guide chamber temperature, pull speed and force exerted by the cartridge advancement mechanism may be controlled with a computer program in order to achieve repeatable results. The guide chamber, extrudable polymer cartridge, die, and push tube may all be made from polymer components which can be reused or disposed of after a single use. The extrudable polymer cartridge may have a variety of configurations including multiple layers of different materials, eccentric shapes, multiple lumens for multiple elements to be drawn through and coated and asymmetric disposition of different materials with respect to the longitudinal axis as viewed in a transverse cross section which can give bending properties having a preferred direction in the coated guidewire or device.

5. 发明授权

US06695915B2 Method and apparatus for polymer application to intracorporeal device 有权
标题翻译：聚合物应用于体内器械的方法和装置
公开(公告)号：US06695915B2
公开(公告)日：2004-02-24
申请号：US10196673
申请日：2002-07-15
申请人： David Burkett , Emmanuel Biagtan
发明人： David Burkett , Emmanuel Biagtan
IPC分类号： B05C1102
CPC分类号： B05C3/12 , A61M2025/09108
摘要： A method and apparatus for applying a polymer coating on an elongated substrate, preferably an elongate intracorporeal device in the form of a guidewire. An extrudable polymer cartridge is moved by a cartridge advancement mechanism into a guide chamber which is heated at an end with a die or orifice through which a desired portion of a guidewire may pass and be coated. Parameters such as guide chamber temperature, pull speed and force exerted by the cartridge advancement mechanism may be controlled with a computer program in order to achieve repeatable results. The guide chamber, extrudable polymer cartridge, die, and push tube may all be made from polymer components which can be reused or disposed of after a single use. The extrudable polymer cartridge may have a variety of configurations including multiple layers of different materials, eccentric shapes, multiple lumens for multiple elements to be drawn through and coated and asymmetric disposition of different materials with respect to the longitudinal axis as viewed in a transverse cross section which can give bending properties having a preferred direction in the coated guidewire or device.
摘要翻译：一种用于将聚合物涂层施加在细长衬底上，优选呈导线形式的细长体内器件的方法和装置。可挤出聚合物盒通过盒前进机构移动到引导室中，引导室在一端被加热的模具或孔口，导丝的所需部分可通过该模具或孔口穿过并被涂覆。可以用计算机程序来控制诸如引导室温度，拉速度和由盒前进机构施加的力的参数，以实现可重复的结果。引导室，可挤出聚合物盒，模具和推管均可由聚合物组分制成，其可以在单次使用后重复使用或处理。可挤压聚合物盒可以具有各种构造，包括多层不同材料，偏心形状，用于多个要被拉伸和涂覆的元件的多个腔，以及横向截面中观察到的不同材料相对于纵向轴线的不对称布置其可以在涂覆的导丝或装置中产生具有优选方向的弯曲性质。

6. 发明申请

US20090041923A1 MEDICAL DEVICE HAVING A LUBRICIOUS COATING WITH A HYDROPHILIC COMPOUND IN AN INTERLOCKING NETWORK 审中-公开
标题翻译：在互联网络中具有疏水化合物的润滑涂层的医疗装置
公开(公告)号：US20090041923A1
公开(公告)日：2009-02-12
申请号：US11834164
申请日：2007-08-06
申请人： Tung-Liang Lin , Jeong S. Lee , Emmanuel Biagtan , David Burkett
发明人： Tung-Liang Lin , Jeong S. Lee , Emmanuel Biagtan , David Burkett
IPC分类号： B05D5/08 , A61K31/616 , C08F2/46 , C08F22/02 , A61M5/00
CPC分类号： A61L29/16 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/16 , A61L2300/42 , A61L2400/10 , C08L39/06
摘要： A medical device having a lubricious coating on at least a section of the medical device, and a method of coating a medical device, the lubricious coating being a network of a hydrophilic compound cross-linked to itself and interlocked with a network of a cross-linked polymerized multifunctional monomer or polymer. The coating can include one or more agents which provide enhanced adhesion of the coating on the device, or which provide faster hydration of the coating and/or improved lubricity. Additionally, the lubricious coating can be provided with one or more therapeutic or diagnostic agents, and in one embodiment the agent elutes relatively quickly in a concentrated release from the lubricious coating upon hydration of the coating.
摘要翻译：一种在医疗装置的至少一部分上具有光滑涂层的医疗装置以及涂覆医疗装置的方法，所述光滑涂层是与其自身交联并与交联的网络互锁的亲水性化合物的网络，连接的聚合多官能单体或聚合物。涂层可以包括一种或多种提供涂层在装置上的粘附性，或提供涂层更快水化和/或改善的润滑性的试剂。另外，光滑涂层可以配备一种或多种治疗剂或诊断剂，并且在一个实施方案中，所述药剂在所述涂层水合时从所述润滑涂层的浓缩释放中相对较快地洗脱。

7. 发明授权

US06733819B2 Method and apparatus for polymer application to intracorporeal device 有权
公开(公告)号：US06733819B2
公开(公告)日：2004-05-11
申请号：US10452614
申请日：2003-06-02
申请人： David Burkett , Emmanuel Biagtan
发明人： David Burkett , Emmanuel Biagtan
IPC分类号： B05D118
CPC分类号： B05C3/12 , A61M2025/09108
摘要： A method and apparatus for applying a polymer coating on an elongated substrate, preferably an elongate intracorporeal device in the form of a guidewire. An extrudable polymer cartridge is moved by a cartridge advancement mechanism into a guide chamber which is heated at an end with a die or orifice through which a desired portion of a guidewire may pass and be coated. Parameters such as guide chamber temperature, pull speed and force exerted by the cartridge advancement mechanism may be controlled with a computer program in order to achieve repeatable results. The guide chamber, extrudable polymer cartridge, die, and push tube may all be made from polymer components which can be reused or disposed of after a single use. The extrudable polymer cartridge may have a variety of configurations including multiple layers of different materials, eccentric shapes, multiple lumens for multiple elements to be drawn through and coated and asymmetric disposition of different materials with respect to the longitudinal axis as viewed in a transverse cross section which can give bending properties having a preferred direction in the coated guidewire or device.

8. 发明授权

US06419745B1 Method and apparatus for polymer application to intracorporeal device 有权
公开(公告)号：US06419745B1
公开(公告)日：2002-07-16
申请号：US09441695
申请日：1999-11-16
申请人： David Burkett , Emmanuel Biagtan
发明人： David Burkett , Emmanuel Biagtan
IPC分类号： B05C1102
CPC分类号： B05C3/12 , A61M2025/09108
摘要： A method and apparatus for applying a polymer coating on an elongated substrate, preferably an elongate intracorporeal device in the form of a guidewire. An extrudable polymer cartridge is moved by a cartridge advancement mechanism into a guide chamber which is heated at an end with a die or orifice through which a desired portion of a guidewire may pass and be coated. Parameters such as guide chamber temperature, pull speed and force exerted by the cartridge advancement mechanism may be controlled with a computer program in order to achieve repeatable results. The guide chamber, extrudable polymer cartridge, die, and push tube may all be made from polymer components which can be reused or disposed of after a single use. The extrudable polymer cartridge may have a variety of configurations including multiple layers of different materials, eccentric shapes, multiple lumens for multiple elements to be drawn through and coated and asymmetric disposition of different materials with respect to the longitudinal axis as viewed in a transverse cross section which can give bending properties having a preferred direction in the coated guidewire or device.

9. 发明申请

US20070167975A1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US20070167975A1
公开(公告)日：2007-07-19
申请号：US11651667
申请日：2007-01-10
申请人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
发明人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

10. 发明授权

US4836752A Partial restriction detector 失效
标题翻译：部分限制检测器
公开(公告)号：US4836752A
公开(公告)日：1989-06-06
申请号：US115702
申请日：1987-11-02
申请人： David Burkett
发明人： David Burkett
IPC分类号： A61M5/00 , A61M5/142 , A61M5/168
CPC分类号： A61M5/16859
摘要： A device for detecting partial restriction in a fluid line connecting a fluid source with an IV infusion pump comprises a gauge mounted on the pump and operatively associated with the line to determine fluid pressure therein. The pump also comprises a peristable finger to conditionally occlude the line and a miroprocessor, upon occlusion of the line, to establish fluid pressure parameters within which the indication is that there is no partial restriction in the line. The pump also uses the microprocessor to compare actual pressure measured by the gauge during an occlusion with the established parameters to determine whether pump operation is to be continued.

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