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1. 发明授权

US08475808B2 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

2. 发明申请

US20070092538A1 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US20070092538A1
公开(公告)日：2007-04-26
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86 , C07K14/18 , C12N5/08 , C12N5/06
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

3. 发明申请

US20060281106A1 Telomerase promoter sequences for screening telomerase modulators 有权
标题翻译：用于筛选端粒酶调节剂的端粒酶启动子序列
公开(公告)号：US20060281106A1
公开(公告)日：2006-12-14
申请号：US11411604
申请日：2006-04-25
申请人： William Andrews , Gregg Morin , Serge Lichtsteiner , Alain Vasserot , Robert Adams , Lisa Cardoza , Jane Lebkowski
发明人： William Andrews , Gregg Morin , Serge Lichtsteiner , Alain Vasserot , Robert Adams , Lisa Cardoza , Jane Lebkowski
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote transcription in cells that express telomerase reverse transcriptase (TERT). The disclosure also provides systems using TERT promoter sequences for identifying compounds that can be used to modulate telomerase expression
摘要翻译：端粒酶逆转录酶是负责维持端粒长度和增加祖细胞复制能力的端粒酶复合物的一部分。端粒酶活性在成熟分化细胞中被关闭，但在包括许多癌症在内的增生性疾病中又重新开始。本公开提供了在表达端粒酶逆转录酶（TERT）的细胞中促进转录的调节元件。本公开还提供了使用TERT启动子序列鉴定可用于调节端粒酶表达的化合物的系统

4. 发明申请

US20050146129A1 Fringed splash guards and trim 审中-公开
标题翻译：装满飞溅的防护装置和装饰
公开(公告)号：US20050146129A1
公开(公告)日：2005-07-07
申请号：US10752049
申请日：2004-01-06
申请人： William Andrews
发明人： William Andrews
IPC分类号： B62B9/14 , B62B9/16 , B62D25/18 , B62J15/00 , B62J15/04
CPC分类号： B62B9/16 , B62D25/18 , B62J15/00 , B62J15/04
摘要： A fringed splash guard used to decoratively protect a vehicle against materials which may be thrown from a vehicles tire. A fringed splash guard can be used on vehicles such as tractor tralers trucks, pick up trucks, vans, cars, and motorcycles. Also provided is a fringed trim and used on a vehicle as a decoration. This fringed trim can also be used as a small splash guard and used to accommodate small vehicles such as motorcycles, a cart, trailers, all terrain, and bicycles.
摘要翻译：一个边缘的防溅罩用于装饰保护车辆免受可能从车辆轮胎抛出的物料。拖拉机，卡车，货车，汽车和摩托车等车辆可以使用边缘防溅罩。还提供了一个边缘的修剪，并用于车辆作为装饰。这种边缘装饰也可以用作小型防溅罩，用于容纳小型车辆，如摩托车，推车，拖车，全地形和自行车。

5. 发明授权

US08429600B2 Distributed collaborative environment definition system and method 有权
标题翻译：分布式协同环境定义系统和方法
公开(公告)号：US08429600B2
公开(公告)日：2013-04-23
申请号：US12878369
申请日：2010-09-09
申请人： William Andrews , Darren Humphrey , Joe Swinski , Benjamin Baker , Chris Van Duyne , Derek Minton
发明人： William Andrews , Darren Humphrey , Joe Swinski , Benjamin Baker , Chris Van Duyne , Derek Minton
IPC分类号： G06F9/44
CPC分类号： G06F8/71
摘要： A system and method for generating a reusable virtual environment item to be integrated into a visual computer simulation using data gathered from a plurality of developers, comprising a centralized knowledge management module, a plurality of distributed workspaces, a content repository, and a content production tool.
摘要翻译：一种用于使用从多个开发者收集的数据来生成可集成到视觉计算机模拟中的可重用虚拟环境项目的系统和方法，包括集中式知识管理模块，多个分布式工作区，内容存储库和内容制作工具。

6. 发明申请

US20100218451A1 STRUCTURAL MEMBERS WITH GRIPPING FEATURES AND JOINING ARRANGEMENTS THEREFOR 有权
标题翻译：具有传送特征的结构性成员及其接合安排
公开(公告)号：US20100218451A1
公开(公告)日：2010-09-02
申请号：US12537397
申请日：2009-08-07
申请人： William Andrews
发明人： William Andrews
IPC分类号： E04B1/19 , E04H12/00
CPC分类号： E04B2/767 , E04B2/7459 , Y10T403/46 , Y10T403/7043
摘要： A joining arrangement is provided for use in the construction of stud frame which includes a releasable attachment/detachment feature. The first member (plate) includes in at least one side wall a formation which, when members are joined, engages a corresponding formation in at least one wall of the second member (stud). The formation, such as a V-shaped protrusion, is/are disposed at an angle to the longitudinal axis of the member and the formation on the second member is disposed generally parallel to its longitudinal axis such that upon engagement of the first and second members, the respective formations in the first and second members engage such that they are in alignment, thereby, securing the first member to the second. Additionally, a plurality of protrusions, which provide a gripping feature, may be formed on the upper surface of web for inhibiting the stud from sliding, slipping, moving and/or migrating within the plate.
摘要翻译：提供了一种用于构造螺柱框架的接合装置，其包括可释放的附接/拆卸特征。第一构件（板）在至少一个侧壁中包括当构件接合时与第二构件（螺柱）的至少一个壁中的对应地层接合的构件。诸如V形突起之类的结构被设置成与构件的纵向轴线成一定角度，并且第二构件上的结构大致平行于其纵向轴线设置，使得在第一和第二构件，第一和第二构件中的相应构造使得它们对齐，从而将第一构件固定到第二构件。此外，提供抓握特征的多个突起可以形成在幅材的上表面上，以防止螺柱在板内滑动，滑动，移动和/或迁移。

7. 发明授权

US07732402B2 Mammalian telomerase 失效
标题翻译：哺乳动物端粒酶
公开(公告)号：US07732402B2
公开(公告)日：2010-06-08
申请号：US10359935
申请日：2003-02-07
申请人： Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
发明人： Bryant Villeponteau , Junli Feng , Walter Funk , William Andrews
IPC分类号： A61K31/70 , C12Q1/68
CPC分类号： C12N15/11 , A01K2217/05 , A61L29/041 , A61L29/14 , A61M25/0045 , C12N9/1241 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/121 , C12N2310/13 , C12N2310/15 , C12N2310/315 , C12N2310/321 , C12Q1/68 , C12Q1/6806 , C12Q1/6841 , C12Q1/6886 , C12Q2600/158 , C12Y207/07049 , C12N2310/3521 , C08L27/18
摘要： Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
摘要翻译：包含哺乳动物端粒酶的RNA组分的核酸可用作药物，治疗和诊断试剂。

8. 发明申请

US20100035234A1 VACCINE ASSAYS 审中-公开
标题翻译：疫苗测定
公开(公告)号：US20100035234A1
公开(公告)日：2010-02-11
申请号：US12468779
申请日：2009-05-19
申请人： John Donnelly , Ping Wu , George Santos , Marzia Monica Giuliani , William Andrews , Jie Chen
发明人： John Donnelly , Ping Wu , George Santos , Marzia Monica Giuliani , William Andrews , Jie Chen
IPC分类号： C12Q1/70 , G01N33/569 , G01N33/574 , G01N33/571
CPC分类号： G01N33/569 , G01N33/53 , G01N2333/205 , G01N2333/22 , G01N2333/245 , G01N2333/285 , G01N2333/31 , G01N2333/315
摘要： The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen.
摘要翻译：本发明涉及用于实施用于评估多组分疫苗中各个组分的功效并用于评估针对病原体的疫苗的功效的这些方法和测定的方法，测定和组合物。在一个方面，评估疫苗针对病原体的功效的方法是测试与功效相关的活性的快速测定，例如在ELISA中的结合，而不是需要检测实际杀菌活性的测定的时间和费用。另一方面，用于测试多组分疫苗中单个组分的功效的方法包括从接种多组分疫苗的受试者获得免疫样品; 阻止识别个体成分的免疫样品的部分，例如通过加入各个组分，以及测试免疫样品对病原体的反应的功效。

9. 发明申请

US20070107369A1 Method of production of joining profiles for structural members 有权
标题翻译：生产结构件接头型材的方法
公开(公告)号：US20070107369A1
公开(公告)日：2007-05-17
申请号：US11483714
申请日：2006-07-10
申请人： William Andrews , Geoffrey Darmody , Albert Hill
发明人： William Andrews , Geoffrey Darmody , Albert Hill
IPC分类号： E04B1/00
CPC分类号： E04B2/761 , E04B1/5818 , E04B2/766 , Y10T29/49623 , Y10T29/5125 , Y10T403/7043
摘要： A method for forming a joining profile in a structural member comprises providing an assembly having a base member, a forming body and a pair of side anvils having profiles formed therewithin. The method further comprises mounting the structural member on the base member, advancing the forming body toward the structural member such that the structural member is clamped to the base member, urging the side anvils toward flanges of the structural member, forming a profile in each of the flanges, and engaging protrusions of the side anvils with the web such that opposing portions of the web are forced upwardly by the protrusions at locations adjacent to each one of the flange profiles in order to accommodate formation of the flange profiles in the structural member. Formation of the joining profiles in the structural members allows for detachable engagement thereof with another member having a corresponding mating profile.
摘要翻译：一种在结构构件中形成接合轮廓的方法包括提供具有基部构件，成形体和具有在其中形成的轮廓的一对侧面砧座的组件。该方法还包括将结构构件安装在基座构件上，使成形体朝向结构构件前进，使得结构构件被夹紧到基座构件上，将侧砧推向结构构件的凸缘，所述凸缘和所述侧砧与所述腹板的接合突起使得所述腹板的相对部分被所述突起在与每个所述凸缘轮廓相邻的位置处被向上推动，以便适应所述结构构件中的凸缘轮廓的形成。在结构构件中形成接合轮廓允许其与具有相应配合轮廓的另一构件的可拆卸接合。

10. 发明申请

US20060199171A1 Assays for TERT promoter modulatory agents 审中-公开
标题翻译：测定TERT启动子调节剂
公开(公告)号：US20060199171A1
公开(公告)日：2006-09-07
申请号：US11349734
申请日：2006-02-07
申请人： William Andrews
发明人： William Andrews
IPC分类号： C12Q1/00 , C12Q1/68
CPC分类号： G01N33/5023 , C12Q1/48 , C12Q1/6897 , G01N33/573
摘要： Methods and compositions for assaying an agent for TERT promoter modulatory activity are provided. In the subject methods, an agent is contacted with a normal cell under assay conditions that provide for a detectable phenotype, e.g., cell death, upon modulation of TERT promoter transcription control activity. Also provided are compositions, systems and kits thereof, as well as devices, that find use in practicing the subject methods. The subject invention finds use in assaying agents for TERT promoter modulatory activity, such as in a high throughput format.
摘要翻译：提供了用于测定TERT启动子调节活性的试剂的方法和组合物。在本发明方法中，在调节TERT启动子转录控制活性时，在提供可检测表型（例如细胞死亡）的测定条件下，将试剂与正常细胞接触。还提供了组合物，系统和试剂盒以及用于实践本发明方法的装置。本发明用于测定TERT启动子调节活性的测定剂，例如以高通量形式。

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