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1. 发明授权

US08475808B2 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

2. 发明申请

US20070092538A1 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US20070092538A1
公开(公告)日：2007-04-26
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86 , C07K14/18 , C12N5/08 , C12N5/06
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

3. 发明申请

US20120141529A1 NOROVIRUS AND SAPOVIRUS ANTIGENS 审中-公开
标题翻译： NOROVIRUS和SAPOVIRUS抗原
公开(公告)号：US20120141529A1
公开(公告)日：2012-06-07
申请号：US13355192
申请日：2012-01-20
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , C12P21/06 , C12N15/63 , C12N1/19 , C12N15/40 , A61P31/14
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

4. 发明授权

US08142793B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US08142793B2
公开(公告)日：2012-03-27
申请号：US12383425
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

5. 发明申请

US20110014652A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20110014652A1
公开(公告)日：2011-01-20
申请号：US12383419
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： C12P21/02
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

6. 发明申请

US20100291129A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20100291129A1
公开(公告)日：2010-11-18
申请号：US12383420
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , A61K39/295 , A61P31/14 , A61P31/00 , A61K39/12
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

7. 发明授权

US07527801B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US07527801B2
公开(公告)日：2009-05-05
申请号：US11603913
申请日：2006-11-22
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74 , A61K39/187
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

8. 发明授权

US08124104B2 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US08124104B2
公开(公告)日：2012-02-28
申请号：US12383420
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

9. 发明申请

US20090087447A1 Novel HCV non-structural polypeptide 有权
标题翻译：新型HCV非结构多肽
公开(公告)号：US20090087447A1
公开(公告)日：2009-04-02
申请号：US12287006
申请日：2008-10-03
申请人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
发明人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译：公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。

10. 发明授权

US06986892B1 Immunogenic Hepatitis C virus non-structural polypeptides 有权
标题翻译：免疫原性丙型肝炎病毒非结构多肽
公开(公告)号：US06986892B1
公开(公告)日：2006-01-17
申请号：US09721479
申请日：2000-11-22
申请人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
发明人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
IPC分类号： A61K39/29 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupt the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译：公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。

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