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1. 发明授权

US4721717A .alpha.-(aminoalkylaminomethyl)phenylmethanols, composition containing them, and use thereof to treat certain heart and circulatory diseases 失效
标题翻译： α-（氨基烷基氨基甲基）苯基甲醇，含有它们的组合物及其用于治疗某些心脏和循环系统疾病的用途
公开(公告)号：US4721717A
公开(公告)日：1988-01-26
申请号：US760128
申请日：1985-07-29
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Erwin Bohm , Klaus Strein
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Erwin Bohm , Klaus Strein
IPC分类号： A61K31/135 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P9/00 , C07C67/00 , C07C213/00 , C07C213/04 , C07C215/30 , C07C215/60 , C07C301/00 , C07C303/40 , C07C311/08 , C07C313/00 , C07C315/04 , C07C317/32 , C07C317/36 , C07C317/48 , C07D209/30 , C07D231/38 , C07D231/56 , C07D235/04 , C07D239/54 , C07D235/30 , C07D239/10
CPC分类号： C07D231/38 , C07D231/56
摘要： The present invention provides aminoalcohols of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be same or different, are hydrogen atoms, hydroxyl groups, C.sub.1 -C.sub.4 -alkoxy, benzyloxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.1 -C.sub.4 -alkanesulphonylamino, C.sub.1 -C.sub.4 -alkanesulphinyl or C.sub.1 -C.sub.4 -alkanesulphonyl radicals, m is 2, 3 or 4, X and Y, which can be the same or different, are hydrogen atoms or benzyl radicals and R.sub.3 is a phenyl radical substituted twice by C.sub.1 -C.sub.6 -alkyl radicals, a nitrophenyl radical, an aminophenyl radical, a 1,3,5-tri-C.sub.1 -C.sub.6 -alkyl-2,4-dioxo-1H,3H-pyrimidin-6-yl radical, an indolyl radical, an indazolyl radical, a benzimidazolyl radical, a 1,4-di-C.sub.1 -C.sub.6 -alkylpyrazol-5-yl radical or a radical of the general formula: ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different, are C.sub.1 -C.sub.4 -alkyl radicals and R.sub.6 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, phenyl or benzyl radical; and the pharmacologically acceptable salts there, as well as methods for making and using these compounds and compositions containing them. There are useful as cardiovascular medicaments.
摘要翻译：本发明提供以下通式的氨基醇：其中R 1和R 2可以相同或不同，为氢原子，羟基，C 1 -C 4 - 烷氧基，苄氧基，C 1 -C 4 - 烷氧基羰基，C 1 C 1-4烷基磺酰基氨基，C 1 -C 4烷基亚磺酰基或C 1 -C 4烷基磺酰基，m为2,3或4，X和Y可相同或不同，为氢原子或苄基，R 3为苯基由C 1 -C 6烷基取代两次，硝基苯基，氨基苯基，1,3,5-三-C1- C6-烷基-2,4-二氧代-1H，3H-嘧啶-6-基，吲哚基，吲唑基，苯并咪唑基，1,4-二-C1- C6烷基吡唑-5-基或通式如下的基团：其中R4和R5可以是 C 1 -C 4 - 烷基，R 6是C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，苯基或苄基; 和其中的药理学上可接受的盐，以及制备和使用这些化合物和含有它们的组合物的方法。有用的心血管药物。

2. 发明授权

US4780474A Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them 失效
标题翻译：使用亚烷基二胺衍生物治疗血流紊乱和含有它们的药物组合物
公开(公告)号：US4780474A
公开(公告)日：1988-10-25
申请号：US6275
申请日：1987-01-20
申请人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
发明人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
IPC分类号： C07D295/20 , A61K31/135 , A61K31/165 , A61K31/22 , A61K31/33 , A61K31/415 , A61K31/505 , A61K31/535 , A61K31/5375 , A61P7/00 , A61P9/00 , C07C67/00 , C07C213/00 , C07C217/84 , C07C231/00 , C07C233/25 , C07C233/78 , C07C235/44 , C07C235/46 , C07C235/50 , C07C237/22 , C07C237/34 , C07C239/00 , C07C241/00 , C07C253/00 , C07C255/54 , C07C275/00 , C07C313/00 , C07C323/36 , C07C323/60 , C07D231/38 , C07D231/56 , C07D239/54 , C07D521/00 , A61K31/40 , A61K31/405 , A61K31/41
CPC分类号： A61K31/505 , A61K31/135 , A61K31/165 , A61K31/415
摘要： The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R.sub.6 and R.sub.7 are hydrogen or lower alkyl, X is an alkylene chain containing up to 6 carbon atoms, Y is a valency bond or a >C.dbd.O group and B is an optionally substituted phenyl or heteroaromatic radical, as well as of their pharmacologically acceptable salts for the treatment of blood flow disturbances. The present invention also provides pharmaceutical compositions which contain these compounds.
摘要翻译：本发明涉及以下通式的化合物的用途：其中A是任选取代的苯基或杂芳族基团，R 6和R 7是氢或低级烷基，X是含有至多6个亚烷基的亚烷基链碳原子，Y是价键或> C = O基团，B是任选取代的苯基或杂芳族基团，以及它们的药理学上可接受的盐用于治疗血流紊乱。本发明还提供含有这些化合物的药物组合物。

3. 发明授权

US4880805A Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them 失效
标题翻译：使用亚烷基二胺衍生物治疗血流紊乱和含有它们的药物组合物
公开(公告)号：US4880805A
公开(公告)日：1989-11-14
申请号：US222215
申请日：1988-07-21
申请人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
发明人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
IPC分类号： C07D295/20 , A61K31/135 , A61K31/165 , A61K31/22 , A61K31/33 , A61K31/415 , A61K31/505 , A61K31/535 , A61K31/5375 , A61P7/00 , A61P9/00 , C07C67/00 , C07C213/00 , C07C217/84 , C07C231/00 , C07C233/25 , C07C233/78 , C07C235/44 , C07C235/46 , C07C235/50 , C07C237/22 , C07C237/34 , C07C239/00 , C07C241/00 , C07C253/00 , C07C255/54 , C07C275/00 , C07C313/00 , C07C323/36 , C07C323/60 , C07D231/38 , C07D231/56 , C07D239/54 , C07D521/00
CPC分类号： A61K31/505 , A61K31/135 , A61K31/165 , A61K31/415
摘要： The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R.sub.6 and R.sub.7 are hydrogen or lower alkyl, X is an alkylene chain containing up to 6 carbon atoms, Y is a valency bond or a >C.dbd.O group and B is an optionally substituted phenyl or heteroaromatic radical, as well as of their pharmacologically acceptable salts for the treatment of blood flow disturbances. The present invention also provides pharmaceutical compositions which contain these compounds.
摘要翻译：本发明涉及以下通式的化合物的用途：其中A是任选取代的苯基或杂芳族基团，R 6和R 7是氢或低级烷基，X是含有至多6个亚烷基的亚烷基链碳原子，Y是价键或> C = O基团，B是任选取代的苯基或杂芳族基团，以及它们的药理学上可接受的盐用于治疗血流紊乱。本发明还提供含有这些化合物的药物组合物。

4. 发明申请

US20050032895A1 Medicament for the treatment of viral skin and tumour diseases 有权
标题翻译：用于治疗病毒性皮肤和肿瘤疾病的药物
公开(公告)号：US20050032895A1
公开(公告)日：2005-02-10
申请号：US10495889
申请日：2002-11-18
申请人： Yunik Chang , Robert Lathrop , Erwin Bohm , Irene Gander-Meisterernst , Ulrich Moebius , Johanna Holldack , Ulrich Moebius
发明人： Yunik Chang , Robert Lathrop , Erwin Bohm , Irene Gander-Meisterernst , Ulrich Moebius , Johanna Holldack , Ulrich Moebius
IPC分类号： A61K31/12 , A61K31/20 , A61K31/23 , A61K31/25 , A61K31/353 , A61K36/18 , A61K45/00 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/14 , A61P15/00 , A61P17/00 , A61P17/12 , A61P31/12 , A61P31/20 , A61P31/22
CPC分类号： A61K9/0014 , A61K31/23 , A61K31/353 , A61K47/06 , A61K47/10 , A61K47/14 , Y10S514/934 , Y10S514/947 , Y10S514/967 , Y10S514/969 , A61K2300/00
摘要： The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m==1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2-(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumour diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.
摘要翻译：本发明涉及含有通式（1）化合物的药物，其中R1独立地为直链或支链的饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1〜5，m = 1〜5，优选m = 1〜3，-CH 2 - [CH-（OH）] p [CH 2 - （R 3）] - 基，其中R 3 =独立的H或OH，p = 1至7，优选p = 1至4，戊糖基或己糖基团，作为治疗活性剂，单独或与一种或几种其它药剂组合，作为用于治疗病毒的组合制剂特别是由人乳头瘤病毒（HPV）和/或疱疹病毒引起的皮肤疾病和/或肿瘤疾病以及局部作用的药物制剂及其用途。

5. 发明授权

US5414088A 2-bicyclobenzimidazoles, processes for their preparation and medicaments containing these compounds 失效
标题翻译： 2-二环苯并咪唑，它们的制备方法和含有这些化合物的药物
公开(公告)号：US5414088A
公开(公告)日：1995-05-09
申请号：US847060
申请日：1992-04-14
申请人： Wolfgang Von Der Saal , Harald Zilch , Erwin Bohm
发明人： Wolfgang Von Der Saal , Harald Zilch , Erwin Bohm
IPC分类号： A61K31/415 , A61K31/47 , A61P7/02 , C07D401/04 , C07D403/04 , C07D487/04 , C07D215/227 , C07D235/18
CPC分类号： C07D401/04 , C07D403/04 , C07D487/04
摘要： The invention concerns compounds of formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.3 -C.sub.7 -cycloalkyl, R.sup.2 is C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, cyano, carboxy [carbonyl substituted by hydroxyl], C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino or hydrazino or R.sup.1 and R.sup.2 together are C.sub.2 -C.sub.6 -alkylidene or C.sub.3 -C.sub.6 -cycloalkylidene or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, form a C.sub.3 -C.sub.7 -spirocycle, n is 0 or 1, R.sup.3 is hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, C.sub.3 -C.sub.7 -cycloalkyl, benzyl, carboxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyloxycarbonyl-C.sub.1 -C.sub.6 -alkyl or di-C.sub.1 -C.sub.6 -alkyloxophosphinyl-C.sub.1 -C.sub.6 -alkyl and R.sup.4 -R.sup. 6 are as in the specification. These compounds of formula I serve for the preparation of medicaments to inhibit erythrocyte and thrombocyte aggregation. Therefore, these compounds are useful for the treatment of diseases where these aggregations occur such as arterial occlusive or ischaemic conditions, venous insufficiency or diabetes mellitus.
摘要翻译： PCT No.PCT / EP90 / 01663 Sec。 371日期：1992年4月14日 102（e）日期1992年4月14日PCT 1990年9月4日PCT PCT。出版物WO91 / 04974 1991年4月18日，本发明涉及式I化合物（Ⅰ）其中R1是氢，C1-C6-烷基，C2-C6-烯基或C3-C7-环烷基，R2是C1-C6-烷基，C 2 -C 6 - 烯基，氰基，羧基[被羟基取代的羰基]，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6烷基氨基或肼基或R 1和R 2 一起是C 2 -C 6亚烷基或C 3 -C 6亚环烷基或R 1和R 2与它们连接的碳原子一起形成C 3 -C 7 - 螺环，n是0或1，R 3是氢，C 1 -C 8 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，C 3 -C 7 - 环烷基，苄基，羧基-C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基羰基-C 1 -C 6烷基或二-C 1 -C 6烷氧基氧膦 -C 1 -C 6烷基和R 4 -R 6如说明书中所述。这些式I化合物用于制备抑制红细胞和血小板聚集的药物。因此，这些化合物可用于治疗发生这些聚集的疾病，例如动脉闭塞或缺血性疾病，静脉功能不全或糖尿病。

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