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1. 发明授权

US08293490B2 Method for high spatial resolution stochastic examination of a sample structure labeled with a substance 有权
标题翻译：用物质标记的样品结构的高空间分辨率随机检验方法
公开(公告)号：US08293490B2
公开(公告)日：2012-10-23
申请号：US12632639
申请日：2009-12-07
申请人： Volker Seyfried , Jochen Sieber
发明人： Volker Seyfried , Jochen Sieber
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N21/6428 , G01N21/6458
摘要： A method for high spatial resolution stochastic examination of a biological sample structure labeled with a labeling substance is described. The method comprises providing a biological sample structure; choosing such a labeling substance that has molecules present in a first state and in a second state, and the first and second states differ from one another in at least one photophysical property such that there is sufficient probability that one portion of the molecules of the substance will be in the first state and another portion of the molecules will be in the second state and within which labeling substance a change of the state of the molecules can occur spontaneously between the two states in both directions; and labeling the biological sample structure with the substance.
摘要翻译：描述了用标记物质标记的生物样品结构的高空间分辨率随机检查方法。该方法包括提供生物样品结构; 选择具有以第一状态和第二状态存在的分子的这种标记物质，并且第一和第二状态在至少一种光物理性质上彼此不同，使得物质分子的一部分有足够的可能性将处于第一状态，并且分子的另一部分将处于第二状态，并且标记物质内的分子状态的变化可以在两个方向的两个状态之间自发地发生; 并用物质标记生物样品结构。

2. 发明授权

US08373853B2 Device and method for providing a predeterminable concentration of at least one component in a liquid medium 有权
标题翻译：在液体介质中提供至少一种组分的预定浓度的装置和方法
公开(公告)号：US08373853B2
公开(公告)日：2013-02-12
申请号：US12617049
申请日：2009-11-12
申请人： Jochen Sieber , Marcus Dyba , Volker Seyfried
发明人： Jochen Sieber , Marcus Dyba , Volker Seyfried
IPC分类号： G01N1/38 , G01N21/64
CPC分类号： G01N1/38 , G01N1/10 , G01N21/64 , G01N35/1097 , G05D11/138
摘要： A method and a device for providing a predeterminable concentration of at least one component in a microscopic sample liquid medium are described. The device includes a feeding device for the at least one component. Measurement data are determined, measuring a predeterminable parameter using a microscopic method. The concentration of the at least one component is adjusted or controlled via the feeding device based on the basis of measurement data.
摘要翻译：描述了在微观样品液体介质中提供至少一种组分的可预定浓度的方法和装置。该装置包括用于至少一个部件的进给装置。确定测量数据，使用微观方法测量可预定参数。基于测量数据的基础，通过进给装置调节或控制至少一个部件的浓度。

3. 发明申请

US20100160613A1 METHOD FOR HIGH SPATIAL RESOLUTION STOCHASTIC EXAMINATION OF A SAMPLE STRUCTURE LABELED WITH A SUBSTANCE 有权
标题翻译：用于物质标记的样品结构的高空间分辨率STOCHASTIC检验方法
公开(公告)号：US20100160613A1
公开(公告)日：2010-06-24
申请号：US12632639
申请日：2009-12-07
申请人： Volker Seyfried , Jochen Sieber
发明人： Volker Seyfried , Jochen Sieber
IPC分类号： C07K1/13
CPC分类号： G01N21/6428 , G01N21/6458
摘要： A method for high spatial resolution stochastic examination of a biological sample structure labeled with a labeling substance is described. The method comprises providing a biological sample structure; choosing such a labeling substance that has molecules present in a first state and in a second state, and the first and second states differ from one another in at least one photophysical property such that there is sufficient probability that one portion of the molecules of the substance will be in the first state and another portion of the molecules will be in the second state and within which labeling substance a change of the state of the molecules can occur spontaneously between the two states in both directions; and labeling the biological sample structure with the substance.
摘要翻译：描述了用标记物质标记的生物样品结构的高空间分辨率随机检查方法。该方法包括提供生物样品结构; 选择具有以第一状态和第二状态存在的分子的这种标记物质，并且第一和第二状态在至少一种光物理性质上彼此不同，使得物质分子的一部分有足够的可能性将处于第一状态，并且分子的另一部分将处于第二状态，并且标记物质内的分子状态的变化可以在两个方向的两个状态之间自发地发生; 并用物质标记生物样品结构。

4. 发明申请

US20100122588A1 DEVICE AND METHOD FOR PROVIDING A PREDETERMINABLE CONCENTRATION OF AT LEAST ONE COMPONENT IN A LIQUID MEDIUM 有权
标题翻译：用于提供液体介质中至少一个组分的可预测浓度的装置和方法
公开(公告)号：US20100122588A1
公开(公告)日：2010-05-20
申请号：US12617049
申请日：2009-11-12
申请人： Jochen Sieber , Marcus Dyba , Volker Seyfried
发明人： Jochen Sieber , Marcus Dyba , Volker Seyfried
IPC分类号： G01N1/14 , B01L3/02
CPC分类号： G01N1/38 , G01N1/10 , G01N21/64 , G01N35/1097 , G05D11/138
摘要： A method and a device for providing a predeterminable concentration of at least one component in a microscopic sample liquid medium are described. The device includes a feeding device for the at least one component. Measurement data are determined, measuring a predeterminable parameter using a microscopic method. The concentration of the at least one component is adjusted or controlled via the feeding device based on the basis of measurement data.
摘要翻译：描述了在微观样品液体介质中提供至少一种组分的可预定浓度的方法和装置。该装置包括用于至少一个部件的进给装置。确定测量数据，使用微观方法测量可预定参数。基于测量数据的基础，通过进给装置调节或控制至少一个部件的浓度。

5. 发明授权

US08718414B2 Acousto-optical tunable filter element 有权
标题翻译：声光可调谐滤光片
公开(公告)号：US08718414B2
公开(公告)日：2014-05-06
申请号：US13366670
申请日：2012-02-06
申请人： Hilmar Gugel , Volker Seyfried
发明人： Hilmar Gugel , Volker Seyfried
IPC分类号： G02F1/335 , G02F1/11
CPC分类号： G02F1/116 , G02B3/0087 , G02B21/0032 , G02B21/0064 , G02B21/16 , G02B27/0927 , G02B27/42 , G02B27/46 , G02F1/00 , G02F1/01 , G02F1/03 , G02F1/11 , G02F1/29 , G02F1/33 , G02F1/353 , G02F2201/305 , G02F2202/32 , G02F2203/12 , G02F2203/18 , G02F2203/24
摘要： An acousto-optical filter element (114) is provided which has an acousto-optical crystal (118) having an acoustic signal transmitter (120) for generating acoustic signals in the acousto-optical crystal (118). The acousto-optical crystal (118) is designed to selectively spatially deflect light of a target wavelength from an input light beam (116) entering into the acousto-optical crystal (118), as a function of a high frequency applied to the acoustic signal transmitter (120), and to thereby produce a target light beam (126) having the target wavelength. In addition, the acousto-optical filter element (114) includes a spatial filter element (132) which is located in the target light beam (126) and is designed to selectively suppress the intensity of the target light beam (126) in a plane perpendicular to the propagation direction of the target light beam (126).
摘要翻译：提供一种声光滤波器元件（114），其具有声光晶体（118），该声光晶体具有用于在声光晶体（118）中产生声信号的声信号发射器（120）。声光晶体（118）被设计为根据进入声光晶体（118）的输入光束（116）选择性地空间偏转目标波长的光，作为施加到声信号的高频的函数发射器（120），从而产生具有目标波长的目标光束（126）。此外，声光滤波器元件（114）包括位于目标光束（126）中的空间滤光元件（132），并被设计成选择性地抑制平面中的目标光束（126）的强度垂直于目标光束（126）的传播方向。

6. 发明授权

US08681412B2 Acousto-optical system, microscope and method of use of the acousto-optical system 有权
标题翻译：声光系统，显微镜和声光系统的使用方法
公开(公告)号：US08681412B2
公开(公告)日：2014-03-25
申请号：US13151055
申请日：2011-06-01
申请人： Bernd Widzgowski , Holger Birk , Volker Seyfried
发明人： Bernd Widzgowski , Holger Birk , Volker Seyfried
IPC分类号： G02F1/33 , G02F1/11
CPC分类号： G02F1/113 , G02B21/0032 , G02B21/0076
摘要： An acousto-optical system is described comprising at least one acousto-optical element having at least one transducer that is attached to a crystal, a driver unit for generating at least one acoustic signal for driving acousto-optical elements modifying light transmitted through the acousto-optical element and comprising at least one digital data processing unit, at least one digital-to-analog converter transforming the digital combination signal into an initial analog driver signal, and an amplifier for amplifying the initial analog driver signal to become said analog electronic driver signal. Further, a microscope and a method of operating the acousto-optical element is are described. Various objectives are achieved like more flexibility, real time compensation for non-linearity and reducing the number, size, costs and energy consumption of electronic components.
摘要翻译：描述了一种声光学系统，其包括至少一个具有至少一个连接到晶体的换能器的声光元件，驱动单元，用于产生用于驱动声光元件的至少一个声信号，所述声光信号修改透过声 - 光学元件，并且包括至少一个数字数据处理单元，将数字组合信号变换为初始模拟驱动器信号的至少一个数模转换器，以及用于放大初始模拟驱动器信号以成为所述模拟电子驱动器信号的放大器。此外，描述了显微镜和操作声光元件的方法。实现了各种目标，如更灵活，非线性的实时补偿和减少电子元件的数量，尺寸，成本和能耗。

7. 发明申请

US20130222568A1 Method and Device for Light-Microscopic Imaging of a Sample Structure 有权
标题翻译：用于样品结构的光显微镜成像的方法和装置
公开(公告)号：US20130222568A1
公开(公告)日：2013-08-29
申请号：US13806047
申请日：2011-06-27
申请人： Marcus Dyba , Volker Seyfried
发明人： Marcus Dyba , Volker Seyfried
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G01N21/6428 , G01N21/6458 , G02B21/16 , G02B21/367 , G02B27/58
摘要： A method for light-microscopy imaging of a sample structure (2, 34) is described, having the following steps: preparing the sample structure (2, 34) with markers that are transferrable into a state imageable by light microscopy, generating a sequence of individual-image data sets by sequential imaging of the sample structure (2, 34), in such a way that for each image, only a subset of the totality of the markers is in each case transferred into the state imageable by light microscopy, the markers of the respective subset having an average spacing from one another which is greater than the resolution limit of light-microscopy imaging which determines the extent of a light distribution representing one of the respectively imaged markers, generating at least two data blocks in which multiple successive individual-image data sets are respectively combined, superposing the individual-image data sets contained in the respective data block to yield a superposed-image data set, identifying an image offset between the superposed-image data sets, correcting the individual-image data sets that are contained in at least one of the superposed-image data sets on the basis of the identified image offset, determining center point positions of the light distributions representing the imaged markers, and assembling the center point positions into an offset-corrected overall image.
摘要翻译：描述了一种用于样品结构（2,34）的光学显微镜成像的方法，具有以下步骤：用可转移到可通过光学显微镜成像的状态的标记物制备样品结构（2,34），产生序列通过对样本结构（2,34）进行顺序成像，通过对每个图像进行顺序成像的单个图像数据集，只有标记的全部子集在每种情况下都转移到通过光学显微镜可成像的状态，相应子集的标记具有彼此之间的平均间隔，其大于光学显微镜成像的分辨率极限，其确定表示分别成像的标记之一的光分布的程度，生成至少两个数据块，其中多个连续分别组合各个图像数据集，将包含在各个数据块中的各个图像数据集叠加以产生叠加图像数据集，识别叠加图像数据组之间的图像偏移，基于所识别的图像偏移来校正包含在至少一个叠加图像数据集中的各个图像数据集，确定表示所述图像偏移的光分布的中心点位置成像标记，以及将中心点位置组装成偏移校正的整体图像。

8. 发明申请

US20130003172A1 SCANNING MICROSCOPE AND METHOD FOR OPTICALLY SCANNING ONE OR MORE SAMPLES 有权
标题翻译：扫描显微镜和光学扫描一个或多个样品的方法
公开(公告)号：US20130003172A1
公开(公告)日：2013-01-03
申请号：US13578607
申请日：2011-02-11
申请人： Bernd Widzgowski , Holger Birk , Volker Seyfried
发明人： Bernd Widzgowski , Holger Birk , Volker Seyfried
IPC分类号： G02B21/08 , G02B21/36
CPC分类号： G02B21/0036
摘要： A device in the form of a scanning microscope, a device in the form of a structural unit for a microscope and a method and a device for optically scanning one or more samples. A device in the form of a scanning microscope has a light source (42), which emits an illuminating light beam (32). A focusing lens system (34) focuses the illuminating light beam (32) on a region to be examined of a sample (36). An actuator arrangement moves the focusing lens system (34) according to a prescribed scanning pattern transversely in relation to a center axis of the illuminating light beam (32) and/or in relation to a housing of a structural unit (20) that encloses the focusing lens system (34).
摘要翻译：呈扫描显微镜形式的装置，用于显微镜的结构单元形式的装置以及用于光学扫描一个或多个样品的方法和装置。扫描显微镜形式的装置具有发射照明光束（32）的光源（42）。聚焦透镜系统（34）将照明光束（32）聚焦在被检样品（36）的区域上。致动器装置根据规定的扫描图案相对于照明光束（32）的中心轴线横向移动聚焦透镜系统（34）和/或相对于包围该照明光束的结构单元（20）的壳体移动聚焦透镜系统聚焦透镜系统（34）。

9. 发明授权

US07817271B2 Confocal microscope and method for detecting by means of a confocal microscope 有权
标题翻译：共聚焦显微镜和共聚焦显微镜检测方法
公开(公告)号：US07817271B2
公开(公告)日：2010-10-19
申请号：US12044951
申请日：2008-03-08
申请人： Volker Seyfried , Frank Schreiber
发明人： Volker Seyfried , Frank Schreiber
IPC分类号： G01J3/28
CPC分类号： G02B21/0064
摘要： The invention relates to a confocal microscope which illuminates a sample (15) by means of at least one light source. A detection light beam (17) is emitted from the sample (15). The detection light beam (17) is spectrally split up in a spatial manner by the dispersive element (20) and subsequently formed on a photosensor chip (19) by means of a detection optical system (22). At least one expanding optical system (23) is arranged in front of the dispersive element (20) in the direction of the detection light beam (17). The expanding optical system (23) is embodied in such a manner that the numerical aperture of the detection optical system (22) is independent from the numerical aperture of the detection light beam (17) on the detection apertured diaphragm (18).
摘要翻译：本发明涉及通过至少一个光源照射样品（15）的共聚焦显微镜。从样品（15）发射检测光束（17）。检测光束（17）通过色散元件（20）以空间方式进行光谱分离，随后通过检测光学系统（22）形成在光电传感器芯片（19）上。至少一个扩展光学系统（23）沿着检测光束（17）的方向布置在色散元件（20）的前面。扩展的光学系统（23）以使得检测光学系统（22）的数值孔径独立于检测孔径隔膜（18）上的检测光束（17）的数值孔径的方式实现。

10. 发明申请

US20100134793A1 OPTICAL EVALUATION METHOD BY MEANS OF LASER PULSES AND CORRESPONDING APPARATUS 有权
标题翻译：激光脉冲和相关装置的光学评估方法
公开(公告)号：US20100134793A1
公开(公告)日：2010-06-03
申请号：US12626057
申请日：2009-11-25
申请人： Vishnu Vardhan Krishnamachari , William C. Hay , Volker Seyfried , Bernd Widzgowski
发明人： Vishnu Vardhan Krishnamachari , William C. Hay , Volker Seyfried , Bernd Widzgowski
IPC分类号： G01J3/30 , G01J3/44
CPC分类号： G01N21/63
摘要： An optical evaluation method and an apparatus for performing said method are described. First laser pulses of a first type and second laser pulses of a second type that differs from the first type are sent onto a sample to be examined. The sample is hit with first incident light from the two laser pulses in at least one manner of simultaneously, within a very short time lag between the two laser pulses, and a time-correlated manner of the two laser pulses, thereby generating a first optical signal, and hit with second incident light from the two laser pulses, thereby generating a second optical signal. The generated first and second optical signals are detected with at least one detector; and an electronic difference between the first and second optical signals is generated.
摘要翻译：描述了用于执行所述方法的光学评估方法和装置。第一类型的第一激光脉冲和第二类型的与第一类型不同的第二激光脉冲被发送到要检查的样品上。在两个激光脉冲之间的非常短的时间间隔内，以两个激光脉冲的时间相关方式，以至少一种方式同时来自两个激光脉冲的第一入射光和第二激光脉冲的时间相关方式，信号，并用来自两个激光脉冲的第二入射光击中，从而产生第二光信号。产生的第一和第二光信号用至少一个检测器检测; 并且产生第一和第二光信号之间的电子差异。

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