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1. 发明授权

US07298474B2 Plasmonic and/or microcavity enhanced optical protein sensing 有权
标题翻译：等离子体和/或微腔增强的光学蛋白质感测
公开(公告)号：US07298474B2
公开(公告)日：2007-11-20
申请号：US11102346
申请日：2005-04-08
申请人： Vladimir P. Drachev , Vladimir Shalaev , Dongmao Zhang , Dor Ben-Amotz
发明人： Vladimir P. Drachev , Vladimir Shalaev , Dongmao Zhang , Dor Ben-Amotz
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N15/1434 , G01N27/44721 , G01N30/74 , G01N33/54373 , G01N2030/027
摘要： Instruments for molecular detection at the nano-molar to femto-molar concentration level include a longitudinal capillary column (10) of known wall thickness and diameter. The column (10) contains a medium (24) including a target molecule (30) and a plurality of optically interactive dielectric beads (26) on the order of about 10−6 meters up to about 10−3 meters and/or metal nanoparticles (31) on the order of 1-500 nm. A flow inducer (34) causes longitudinal movement of the target molecule within the column (10). A laser (14) introduces energy laterally with respect to the column (10) at a wavelength and in a direction selected to have a resonant mode within the capillary column wall (12) and couple to the medium (24). A detector (40) is positioned to detect Raman scattering occurring along the column (10) due to the presence of the target molecule.
摘要翻译：在纳摩尔至毫摩尔浓度水平下用于分子检测的仪器包括具有已知壁厚和直径的纵向毛细管柱（10）。柱（10）包含包含目标分子（30）和大约10 -6毫米至约10微米的多个光学交互的电介质珠（26）的介质（24）和/或大约1-500nm的金属纳米粒子（31）。流动诱导器（34）引起靶分子在柱（10）内的纵向运动。激光器（14）相对于柱（10）在波长和选择为在毛细管柱壁（12）内具有共振模式并耦合到介质（24）的方向上横向引入能量。定位探测器（40）以检测由于靶分子的存在而沿塔（10）发生的拉曼散射。

2. 发明申请

US20050221503A1 Plasmonic and/or microcavity enhanced optical protein sensing 有权
标题翻译：等离子体和/或微腔增强的光学蛋白质感测
公开(公告)号：US20050221503A1
公开(公告)日：2005-10-06
申请号：US11102346
申请日：2005-04-08
申请人： Vladimir Drachev , Vladimir Shalaev , Dongmao Zhang , Dor Ben-Amotz
发明人： Vladimir Drachev , Vladimir Shalaev , Dongmao Zhang , Dor Ben-Amotz
IPC分类号： G01N15/14 , G01N21/65 , G01N27/447 , G01N30/02 , G01N30/74 , G01N33/543
CPC分类号： G01N21/658 , G01N15/1434 , G01N27/44721 , G01N30/74 , G01N33/54373 , G01N2030/027
摘要： Instruments for molecular detection at the nano-molar to femto-molar concentration level include a longitudinal capillary column (10) of known wall thickness and diameter. The column (10) contains a medium (24) including a target molecule (30) and a plurality of optically interactive dielectric beads (26) on the order of about 10−6 meters up to about 10−3 meters and/or metal nanoparticles (31) on the order of 1-500 nm. A flow inducer (34) causes longitudinal movement of the target molecule within the column (10). A laser (14) introduces energy laterally with respect to the column (10) at a wavelength and in a direction selected to have a resonant mode within the capillary column wall (12) and couple to the medium (24). A detector (40) is positioned to detect Raman scattering occurring along the column (10) due to the presence of the target molecule.
摘要翻译：在纳摩尔至毫摩尔浓度水平下用于分子检测的仪器包括具有已知壁厚和直径的纵向毛细管柱（10）。柱（10）包含包含目标分子（30）和大约10 -6毫米至约10微米的多个光学交互的电介质珠（26）的介质（24）和/或大约1-500nm的金属纳米粒子（31）。流动诱导器（34）引起靶分子在柱（10）内的纵向运动。激光器（14）相对于柱（10）在波长和选择为在毛细管柱壁（12）内具有共振模式并耦合到介质（24）的方向上横向引入能量。定位探测器（40）以检测由于靶分子的存在而沿塔（10）发生的拉曼散射。

3. 发明申请

US20050244977A1 Adaptive metal films for detection of biomolecules 审中-公开
标题翻译：用于检测生物分子的适应性金属膜
公开(公告)号：US20050244977A1
公开(公告)日：2005-11-03
申请号：US11087262
申请日：2005-03-23
申请人： Vladimir Drachev , Mark Thoreson , Vishal Nashine , Meena Narsimhan , Eldar Khaliullin , Dor Ben-Amotz , Vladimir Shalaev , Vincent Davisson
发明人： Vladimir Drachev , Mark Thoreson , Vishal Nashine , Meena Narsimhan , Eldar Khaliullin , Dor Ben-Amotz , Vladimir Shalaev , Vincent Davisson
IPC分类号： G01N33/00 , G01N33/543 , G01N33/553
CPC分类号： G01N33/553
摘要： An adaptive surface for supporting an analyte to be examined, includes a support layer, a metal island layer, and an adhesive layer by which the metal island layer is attached to the support layer, the adhesive layer and metal island layer being interactive with an analyte containing solution to permit movement of at least some of the islands on the adhesive layer into increasingly close proximity during drying of the analyte solution.
摘要翻译：用于支撑待检测分析物的自适应表面包括支撑层，金属岛层和粘附层，金属岛层通过该粘合层附着到支撑层，粘合层和金属岛层与分析物相互作用允许在分析物溶液的干燥期间允许粘合剂层上的至少一些岛的移动变得越来越紧密。

4. 发明申请

US20090053818A1 Quantitative proteomics with isotopic substituted raman active labeling 审中-公开
标题翻译：定量蛋白质组学与同位素取代拉曼活性标记
公开(公告)号：US20090053818A1
公开(公告)日：2009-02-26
申请号：US11663862
申请日：2005-09-26
申请人： Dongmao Zhang , Jo V. Davisson , Dor Ben-Amotz , Yong Xie , Kumar Shirshendu Deb
发明人： Dongmao Zhang , Jo V. Davisson , Dor Ben-Amotz , Yong Xie , Kumar Shirshendu Deb
IPC分类号： G01N33/68 , C07D311/82 , G01N33/50
CPC分类号： G01N33/54373 , Y10T436/143333
摘要： A labeling reagent having a distinct Raman, or surface enhanced Raman, spectral signature is used for the control and analysis samples. The labeling reagents can be fluorescent dyes with different isotopic substituents, such as the substitution of some hydrogen atoms for deuterium atoms. Such labeling does not have any detectable effect on separation retention. Raman spectroscopy is used for detection purposes. By combining SERS and SERRS, a concentration ratio prediction error of less than 3% can be obtained over four orders of magnitude of total concentration with up to a factor of 3 concentration ratio range. The method is reliable, reproducible and more sensitive than methods based on absolute SERS/SERRS intensity correlations, with no internal standard, or using a different molecule (rather than an IEIS) as a SERS/SERRS internal standard.
摘要翻译：具有不同拉曼或表面增强拉曼光谱特征的标记试剂用于对照和分析样品。标记试剂可以是具有不同同位素取代基的荧光染料，例如用一些氢原子取代氘原子。这种标记对分离保留没有任何可检测的影响。拉曼光谱用于检测目的。通过组合SERS和SERRS，可以获得总浓度四个数量级以上的浓度比预测误差小于3％，达到3倍浓度比范围。该方法比基于绝对SERS / SERRS强度相关性无内标或使用不同分子（而不是IEIS）作为SERS / SERRS内标的方法可靠，可重现和更灵敏。

5. 发明授权

US07283228B2 Process and apparatus for segregation and testing by spectral analysis of solid deposits derived from liquid mixtures 有权
标题翻译：通过对来自液体混合物的固体沉积物的光谱分析进行分离和测试的方法和装置
公开(公告)号：US07283228B2
公开(公告)日：2007-10-16
申请号：US10821231
申请日：2004-04-08
申请人： Dongmao Zhang , Dor Ben-Amotz , Yong Xie , Vincent J. Davisson , Melissa Mrozek , Corasi Ortiz
发明人： Dongmao Zhang , Dor Ben-Amotz , Yong Xie , Vincent J. Davisson , Melissa Mrozek , Corasi Ortiz
IPC分类号： G01J3/44 , G01N21/65 , G01N1/00
CPC分类号： G01N21/3563 , B82Y30/00 , G01N21/658 , G01N2001/4027 , G01N2021/3595
摘要： Micro-droplets of liquid confining organic molecules of interest are dried on selected planar solvo-phobic substrates under conditions facilitating segregated precipitation of the larger, less soluable analytes toward edge portions of the deposit. Micro-spectrometer imaging using white light and FTIR false color can identify points of interest, and the same optics generally directed perpendicularly to the substrates selectively captures normal Raman spectra from selected points in the deposit. The spectra are manipulated using various data techniques to extract reliable information concerning analytes present at pico-Molar levels. The selected spots can also be subjected to FTIR spectroscopy followed by MALDI mass spectroscopy to obtain a variety of information from the identical specimen.
摘要翻译：限制有目标有机分子的液滴微粒在有选择的平面溶剂基底上干燥，条件是使较大的较少溶解性分析物朝向沉积物的边缘部分分离析出。使用白光和FTIR假色的微光谱仪成像可以识别感兴趣的点，并且通常垂直于衬底定向的相同光学器件选择性地从沉积物中的选定点捕获正常的拉曼光谱。使用各种数据技术来操作光谱，以提取关于以微微摩尔浓度存在的分析物的可靠信息。所选择的点也可以进行FTIR光谱，然后进行MALDI质谱，从相同的样品获得各种信息。

6. 发明申请

US20050275837A1 Process and apparatus for segregation and testing by spectral analysis of solid deposits derived from liquid mixtures 有权
标题翻译：通过对来自液体混合物的固体沉积物的光谱分析进行分离和测试的方法和装置
公开(公告)号：US20050275837A1
公开(公告)日：2005-12-15
申请号：US10821231
申请日：2004-04-08
申请人： Dongmao Zhang , Dor Ben-Amotz , Yong Xie , Vincent Davisson , Melissa Mrozek , Corasi Ortiz
发明人： Dongmao Zhang , Dor Ben-Amotz , Yong Xie , Vincent Davisson , Melissa Mrozek , Corasi Ortiz
IPC分类号： G01N21/65 , G01J3/44
CPC分类号： G01N21/3563 , B82Y30/00 , G01N21/658 , G01N2001/4027 , G01N2021/3595
摘要： Micro-droplets of liquid confining organic molecules of interest are dried on selected planar solvo-phobic substrates under conditions facilitating segregated precipitation of the larger, less soluable analytes toward edge portions of the deposit. Micro-spectrometer imaging using white light and FTIR false color can identify points of interest, and the same optics generally directed perpendicularly to the substrates selectively captures normal Raman spectra from selected points in the deposit. The spectra are manipulated using various data techniques to extract reliable information concerning analytes present at pico-Molar levels. The selected spots can also be subjected to FTIR spectroscopy followed by MALDI mass spectroscopy to obtain a variety of information from the identical specimen.
摘要翻译：限制有目标有机分子的液滴微粒在有选择的平面溶剂基底上干燥，条件是使较大的较少溶解性分析物朝向沉积物的边缘部分分离析出。使用白光和FTIR假色的微光谱仪成像可以识别感兴趣的点，并且通常垂直于衬底定向的相同光学器件选择性地从沉积物中的选定点捕获正常的拉曼光谱。使用各种数据技术来操作光谱，以提取关于以微微摩尔浓度存在的分析物的可靠信息。所选择的点也可以进行FTIR光谱，然后进行MALDI质谱，从相同的样品获得各种信息。

7. 发明授权

US06483581B1 Raman system for rapid sample indentification 失效
标题翻译：拉曼系统快速样品识别
公开(公告)号：US06483581B1
公开(公告)日：2002-11-19
申请号：US09446673
申请日：1999-12-22
申请人： Dor Ben-Amotz , Yanan Jiang , Edward R. Grant , Ken Haber , George M. Laurence, Jr.
发明人： Dor Ben-Amotz , Yanan Jiang , Edward R. Grant , Ken Haber , George M. Laurence, Jr.
IPC分类号： G01J344
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/0289 , G01J3/0291 , G01J3/44 , G01N21/85 , G01N2021/656
摘要： A hand-held material identification apparatus 10 uses a spectrograph and detector array detecting a Raman spectrum produced by a sample illuminated by a laser source to recognize a variety of materials with a command to recognition time cycle of about one second or less. The width of the spectrum detected by each detector in the array is less than ¼th the excitation source wavelength deviation to permit smoothing of the spectrum detected by the discrete spectral elements to eliminate pixel noise without loss of Raman spectral information. The Raman spectra are produced by materials illuminated by an inexpensive near-infrared multimode laser operated in a pulse mode to deliver between 0.05 and 0.5 joules of photon energy, with the Raman spectra being detected before any significant heating of the sample occurs. The identification apparatus 10 qualitatively determines the chemical composition of reinforced and unreinforced copolymers and composites such as ABS, polypropylene, talc-filled polypropylene, polycarbonate, PMMA, polyethylene, and PVC, from samples of different colors and textures with a high degree of success without the need for special positioning or sample preparation.
摘要翻译：手持材料识别装置10使用检测由激光源照射的样品产生的拉曼光谱的光谱仪和检测器阵列，以识别大约1秒以下的识别时间周期的指令来识别各种材料。由阵列中的每个检测器检测到的光谱的宽度小于激发源波长偏差的1/4，以允许平滑由离散光谱元素检测的光谱，以消除像素噪声而不损耗拉曼光谱信息。拉曼光谱由以脉冲模式操作的便宜的近红外多模激光器照射的材料产生，以传递0.05至0.5焦耳的光子能量，在样品发生任何显着加热之前，检测拉曼光谱。识别装置10从不同颜色和纹理的样品定性地确定增强和非增强共聚物和复合材料如ABS，聚丙烯，填充滑石的聚丙烯，聚碳酸酯，PMMA，聚乙烯和PVC的化学组成，而没有需要特殊定位或样品制备。

8. 发明授权

US08043602B2 Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology 有权
标题翻译：叶酸靶向增强肿瘤和叶酸受体阳性组织光学成像技术
公开(公告)号：US08043602B2
公开(公告)日：2011-10-25
申请号：US10360001
申请日：2003-02-06
申请人： Karim N. Jallad , Michael D. Kennedy , Philip S. Low , Dor Ben-Amotz
发明人： Karim N. Jallad , Michael D. Kennedy , Philip S. Low , Dor Ben-Amotz
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0032 , A61K49/0043 , G01N21/6486 , G01N33/57484 , G01N33/57496 , G01N33/82
摘要： A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.
摘要翻译：公开了一种区分肿瘤与健康细胞组织的方法。该方法包括提供标记 - 叶酸缀合物的步骤，将标志物 - 叶酸缀合物置于与组织接触并观察组织。

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