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1. 发明授权

US07371251B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07371251B2
公开(公告)日：2008-05-13
申请号：US11143052
申请日：2005-06-02
申请人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
发明人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. A stretch resistant embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. The engagement member engages a retaining ring on the embolic device. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.
摘要翻译：一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。弹性阻塞栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括接合构件，该接合构件附接到推动器构件的远端并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。接合构件接合栓塞装置上的保持环。当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

2. 发明授权

US08313504B2 Foam matrix embolization device 有权
标题翻译：泡沫基质栓塞装置
公开(公告)号：US08313504B2
公开(公告)日：2012-11-20
申请号：US11171560
申请日：2005-06-30
申请人： Hiep Q. Do , Richard Champion Davis, III , Donald K. Jones , Juan A. Lorenzo , Vladimir Mitelberg , Darren R. Sherman , Murty Vyakarnam
发明人： Hiep Q. Do , Richard Champion Davis, III , Donald K. Jones , Juan A. Lorenzo , Vladimir Mitelberg , Darren R. Sherman , Murty Vyakarnam
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12181 , A61B17/1219 , A61B2017/0053 , A61B2017/1205 , A61L31/10 , A61L31/146 , A61L2430/36 , C08L67/04
摘要： The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.
摘要翻译：本发明涉及一种用于放置在人体通道内的预定位置处的医疗装置，更具体地涉及一种柔性栓塞装置，其可以由导管递送到血管内的预选位置，从而栓塞血管或血管缺损，例如动脉瘤或瘘。具体地，栓塞装置包括具有内腔的细长线圈，线圈和内腔至少部分地嵌入细长的泡沫构件，其在一些实施例中包括具有栓塞的柔性，可生物降解的水不溶性，开放的互连泡沫材料特征，并且能够允许细胞增殖进入开孔泡沫内部。

3. 发明授权

US07344558B2 Embolic device delivery system 有权
标题翻译：栓塞装置输送系统
公开(公告)号：US07344558B2
公开(公告)日：2008-03-18
申请号：US11364462
申请日：2006-02-28
申请人： Juan A. Lorenzo , Vladimir Mitelberg , Donald K. Jones
发明人： Juan A. Lorenzo , Vladimir Mitelberg , Donald K. Jones
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12054
摘要： A vascular occlusion device deployment system for deploying an occlusion device at a preselected site within the vasculature of a patient. The deployment system includes a pusher which has a constrictor located at the distal end portion of the pusher. The constrictor has a channel which receives a portion of the occlusion device. The constrictor has a proximal end portion and a distal end portion wherein the proximal end portion can be moved relative to the distal end portion to reduce the size of the channel. When the channel size is reduced, the constrictor grasps the portion of the occlusion device located within the channel. When it is desired to deploy the coil, the constrictor is moved in the opposite direction to increase the size of the channel and release the coil's grasp of the occlusion device.
摘要翻译：一种用于在患者的脉管系统内的预选位置部署闭塞装置的血管闭塞装置展开系统。所述展开系统包括推杆，所述推动器具有位于所述推动器的远端部分的收缩部。收缩器具有接收遮挡装置的一部分的通道。收缩器具有近端部分和远端部分，其中近端部分可以相对于远端部分移动以减小通道的尺寸。当通道尺寸减小时，收缩器抓住位于通道内的遮挡装置的部分。当需要展开线圈时，收缩器沿相反的方向移动以增加通道的尺寸并释放线圈对遮挡装置的把持。

4. 发明授权

US07377932B2 Embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机构的栓塞线圈输送系统
公开(公告)号：US07377932B2
公开(公告)日：2008-05-27
申请号：US11143051
申请日：2005-06-02
申请人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
发明人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B2017/00477 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.
摘要翻译：一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。栓塞装置通过机械互锁机构保持在输送导管内，该联动机构包括接合构件，该接合构件附接到推动器构件的远端并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

5. 发明申请

US20080046092A1 Coil embolization device with stretch resistance fiber 审中-公开
标题翻译：具有拉伸阻力纤维的线圈栓塞装置
公开(公告)号：US20080046092A1
公开(公告)日：2008-02-21
申请号：US11506083
申请日：2006-08-17
申请人： Richard Champion Davis , Donald K. Jones , Juan A. Lorenzo
发明人： Richard Champion Davis , Donald K. Jones , Juan A. Lorenzo
IPC分类号： A61F2/02
CPC分类号： A61B17/12022 , A61B17/12154 , A61B2017/1205
摘要： A vasoocclusive embolic device deployment system for use in the placement of an embolic coil at a treatment site within a vessel. The embolic coil includes an elongated stretch resistant fiber having its distal end attached to the distal end of the embolic coil. The stretch resistant fiber extends cylindrically around the outer surface of the coil and the proximal end of the stretch resistant fiber is attached to the proximal end of the coil. The stretch resistant fiber preferably takes the form of a loosely wound helical coil and may also be attached to the embolic coil at additional points between the proximal and distal ends of the embolic coil. Additionally, a headpiece is mounted at the proximal end of the embolic coil for coupling the coil to a coil deployment device.
摘要翻译：一种用于在血管内的治疗部位放置栓塞线圈的血管闭塞栓塞装置部署系统。栓塞线圈包括细长的抗拉纤维，其远端连接到栓塞线圈的远端。抗拉纤维围绕线圈的外表面圆柱形延伸，并且抗拉纤维的近端附接到线圈的近端。抗拉伸纤维优选采取松散缠绕的螺旋线圈的形式，并且还可以在栓塞线圈的近端和远端之间的附加点附接到栓塞线圈。此外，头端安装在栓塞线圈的近端处，用于将线圈耦合到线圈展开装置。

6. 发明授权

US07294123B2 Activatable bioactive vascular occlusive device and method of use 有权
标题翻译：可活化生物活性血管闭塞装置及其使用方法
公开(公告)号：US07294123B2
公开(公告)日：2007-11-13
申请号：US10738473
申请日：2003-12-17
申请人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12186 , A61B2017/00004 , A61B2017/00831
摘要： A vascular occlusive device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种血管闭塞装置，其包括支撑结构和设置在支撑结构上的生物活性涂层和外部阻隔涂层，其用于防止生物活性剂和体液之间的反应，直到外部屏障通过将外部剂施用于外部屏障。

7. 发明授权

US09155540B2 Embolic coil detachment mechanism with heating element and kicker 有权
标题翻译：带加热元件和踢球器的栓塞线圈脱离机构
公开(公告)号：US09155540B2
公开(公告)日：2015-10-13
申请号：US13436289
申请日：2012-03-30
申请人： Juan A. Lorenzo
发明人： Juan A. Lorenzo
IPC分类号： A61M37/00 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B2017/00951 , A61B2017/1205 , A61B2017/12054 , A61B2017/12068
摘要： Provided herein are a system, method, and apparatus for delivering a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. A heating element is disposed in the delivery tube that can be actuated remotely, and a layer of low temperature adhesive is applied at the heating element to retain the therapeutic device. The kicker in the form of, for example, a compressed spring is mounted within the delivery tube so as to be in contact with the therapeutic device for applying a constant ejector force that is countered by the adhesive force of the low temperature adhesive. When the heating element is actuated, the spring's ejector force overcomes the softened adhesive's adhesive force to force the therapeutic device out of the delivery tube.
摘要翻译：本文提供了一种用于递送治疗装置的系统，方法和装置，例如，来自患者体内目标部位的输送管的栓塞线圈。加热元件设置在可远程致动的输送管中，并且在加热元件处施加一层低温粘合剂以保持治疗装置。例如，压缩弹簧形式的踢球器安装在输送管内，以便与治疗装置接触，以施加由低温粘合剂的粘合力抵消的恒定的推出力。当加热元件被致动时，弹簧的推出力克服软化的粘合剂的粘合力，以迫使治疗装置离开输送管。

8. 发明授权

US09149278B2 Occlusive device delivery system with mechanical detachment 有权
标题翻译：闭合装置输送系统具有机械分离
公开(公告)号：US09149278B2
公开(公告)日：2015-10-06
申请号：US13802101
申请日：2013-03-13
申请人： Robert R. Slazas , Juan A. Lorenzo
发明人： Robert R. Slazas , Juan A. Lorenzo
IPC分类号： A61B17/12 , A61B17/00 , A61B19/00
CPC分类号： A61B17/1214 , A61B17/12113 , A61B17/12154 , A61B2017/00309 , A61B2017/12054 , A61B2090/037
摘要： A delivery system for an embolic coil including a delivery tube having a lumen. A proximal coil junction is disposed between the delivery tube and the embolic coil. Insertable through the lumen and extending proximally beyond the proximal end of the delivery tube is a detachable wire with a terminating feature disposed on its distal end. At least one stretch resistant member is disposed within a lumen formed by the embolic coil. A distal end of each of the at least one stretch resistant members is secured to a distal end of the embolic coil, while each of the at least one stretch resistant members is also secured proximate the proximal end of the embolic coil. The distal end of the delivery tube is retained by the wire physically against without being attached in any way to the proximal junction.
摘要翻译：一种用于栓塞线圈的输送系统，包括具有内腔的输送管。近端线圈结设置在输送管和栓塞线圈之间。可插入内腔并向近端延伸超过输送管的近端，是具有设置在其远端上的端接特征的可拆卸线。至少一个抗拉构件设置在由栓塞线圈形成的内腔内。至少一个抗拉构件中的每一个的远端固定到栓塞线圈的远端，而至少一个抗拉构件中的每一个也固定在栓塞线圈的近端附近。输送管的远端由金属丝保持物理地抵靠而不以任何方式附接到近端连接处。

9. 发明申请

US20130261713A1 EMBOLIC COIL DETACHMENT MECHANISM WITH FLEXIBLE DISTAL MEMBER AND RESISTIVE ELECTRICAL HEATING ELEMENT 有权
标题翻译：具有柔性半导体元件和电阻式电加热元件的嵌入式线圈分离机构
公开(公告)号：US20130261713A1
公开(公告)日：2013-10-03
申请号：US13436430
申请日：2012-03-30
申请人： Juan A. Lorenzo
发明人： Juan A. Lorenzo
IPC分类号： A61F7/12
CPC分类号： A61B17/1214 , A61B2017/12077 , A61B2090/037
摘要： An embolic coil detachment system includes an elongated, flexible polymer tube having a tubular wall with an inner surface defining an interior lumen. A distal portion of the tubular wall has a score line, and a resistive heating element is located near the score line and in immediate contact with a surface of a distal portion of the tubular wall, to provide direct heating of the distal portion of the flexible polymer tube adjacent to the score line. A therapeutic embolic coil includes a headpiece that is releasably attached within the distal portion of the flexible polymer tube, and that is releasable by heating of the distal portion of the tubular shaft to cause the distal portion of the tubular wall to split along the score line.
摘要翻译：栓塞线圈分离系统包括细长的柔性聚合物管，其具有带有限定内腔的内表面的管状壁。管状壁的远侧部分具有刻痕线，并且电阻加热元件位于刻痕线附近并与管状壁的远端部分的表面立即接触，以提供柔性的远端部分的直接加热聚合物管毗邻刻痕线。治疗性栓塞线圈包括可释放地附接在柔性聚合物管的远侧部分内的头盔，并且其可通过加热管状轴的远端部分而释放，以使管状壁的远端部分沿着刻痕线分开。

10. 发明申请

US20130261658A1 EMBOLIC COIL DETACHMENT MECHANISM WITH FLEXIBLE DISTAL MEMBER, RESISTIVE ELECTRICAL HEATING ELEMENT AND SHAPE MEMORY POLYMER ELEMENT 有权
标题翻译：具有柔性半导体元件，电阻式电加热元件和形状记忆聚合物元件的嵌入式线圈分离机构
公开(公告)号：US20130261658A1
公开(公告)日：2013-10-03
申请号：US13436376
申请日：2012-03-30
申请人： Juan A. Lorenzo , Kirk Johnson
发明人： Juan A. Lorenzo , Kirk Johnson
IPC分类号： A61M29/00
CPC分类号： A61B17/1214 , A61B2017/00867 , A61B2017/00871 , A61B2017/00951 , A61B2017/1205 , A61B2017/12054 , A61B2017/12068 , A61B2017/12077
摘要： An embolic coil detachment system includes an elongated, flexible shape memory polymer tube having an inner wall surface defining an interior lumen. A distal portion of the shape memory polymer tube has an enlarged and reduced diameter configurations. An embolic coil is releasably mounted to the shape memory polymer tube by a headpiece releasably attached within a distal portion of the shape memory polymer tube. A resistive heating element disposed longitudinally along and in immediate contact with the inner wall surface of the distal tubular wall of the shape memory polymer tube provides direct, even heating to release the headpiece and embolic coil attached thereto when the resistive heating element is energized.
摘要翻译：栓塞线圈分离系统包括细长的柔性形状记忆聚合物管，其具有限定内腔的内壁表面。形状记忆聚合物管的远端部分具有扩大和缩小的直径构型。栓状线圈通过可释放地附接在形状记忆聚合物管的远端部分中的头盔可释放地安装到形状记忆聚合物管。在形状记忆聚合物管的远端管状壁的内壁表面纵向并纵向接触设置的电阻加热元件，当电阻加热元件通电时，提供直接均匀的加热以释放附着于其上的头盔和栓塞线圈。

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