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1. 发明授权

US08313504B2 Foam matrix embolization device 有权
标题翻译：泡沫基质栓塞装置
公开(公告)号：US08313504B2
公开(公告)日：2012-11-20
申请号：US11171560
申请日：2005-06-30
申请人： Hiep Q. Do , Richard Champion Davis, III , Donald K. Jones , Juan A. Lorenzo , Vladimir Mitelberg , Darren R. Sherman , Murty Vyakarnam
发明人： Hiep Q. Do , Richard Champion Davis, III , Donald K. Jones , Juan A. Lorenzo , Vladimir Mitelberg , Darren R. Sherman , Murty Vyakarnam
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12181 , A61B17/1219 , A61B2017/0053 , A61B2017/1205 , A61L31/10 , A61L31/146 , A61L2430/36 , C08L67/04
摘要： The present invention relates to a medical device for placement at a predetermined location within a passageway of the human body, and more particularly, relates to a flexible embolization device which may be delivered by a catheter to a pre-selected position within a blood vessel to thereby embolize a blood vessel or a blood vessel defect, such as an aneurysm or fistula. Specifically, the embolization device comprises an elongated coil having a lumen, the coil and lumen being at least partially embedded in an elongated foam member comprising, in some embodiments, a flexible, biodegradable, water insoluble, open, interconnecting-cell foam material having embolic characteristics, and capable of allowing cell proliferation into the open cell foam interior.
摘要翻译：本发明涉及一种用于放置在人体通道内的预定位置处的医疗装置，更具体地涉及一种柔性栓塞装置，其可以由导管递送到血管内的预选位置，从而栓塞血管或血管缺损，例如动脉瘤或瘘。具体地，栓塞装置包括具有内腔的细长线圈，线圈和内腔至少部分地嵌入细长的泡沫构件，其在一些实施例中包括具有栓塞的柔性，可生物降解的水不溶性，开放的互连泡沫材料特征，并且能够允许细胞增殖进入开孔泡沫内部。

2. 发明授权

US07670353B2 Modified headpiece for hydraulic coil deployment system 有权
标题翻译：液压线圈展开系统改装头
公开(公告)号：US07670353B2
公开(公告)日：2010-03-02
申请号：US11423525
申请日：2006-06-12
申请人： Richard Champion Davis, III , Donald K. Jones , Vladimir Mitelberg
发明人： Richard Champion Davis, III , Donald K. Jones , Vladimir Mitelberg
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/1214 , A61B17/1219 , A61B2017/00539 , A61B2017/1205 , A61B2017/12054
摘要： A vascular occlusion device for use with a hydraulic deployment catheter is provided. The vascular occlusion device includes a headpiece that has a deformable interference element which changes from an initial configuration to a deformed configuration upon an increase of hydraulic pressure within the deployment catheter. When the interference element is in the initial configuration, the headpiece is secured to the deployment catheter, and when the interference element is in the deformed configuration, the headpiece can be removed from the deployment catheter for deployment of the occlusion device.
摘要翻译：提供了一种与液压展开导管一起使用的血管闭塞装置。血管闭塞装置包括具有可变形干扰元件的头盔，该可变形干涉元件在展开导管内的液压增加时从初始构型变化到变形构型。当干涉元件处于初始构造时，头盔被固定到展开导管，并且当干涉元件处于变形构型时，头盔可以从用于展开遮挡装置的展开导管移除。

3. 发明授权

US07371252B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07371252B2
公开(公告)日：2008-05-13
申请号：US11301664
申请日：2005-12-13
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A91F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00867 , A61B2017/12054
摘要： A medical device for placing an embolic device, such as an embolic coil at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes a deflectable engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. When the detachment member is withdrawn from the aperture of the engagement member the engagement member deflects to release the embolic device.
摘要翻译：一种用于将栓塞装置（例如栓塞线圈）放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械联锁机构包括附接到推动器构件的远端的可偏转接合构件，并且延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。当分离构件从接合构件的孔中取出时，接合构件偏转以释放栓塞装置。

4. 发明授权

US07367987B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07367987B2
公开(公告)日：2008-05-06
申请号：US11301865
申请日：2005-12-12
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , Darren R. Sherman , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00862 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。推动器构件从推动器构件的远端延伸并且被偏压以便将保持环从接合构件提起，以确保当分离构件从接合构件的孔中取出时栓塞装置的释放。

5. 发明授权

US07377932B2 Embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机构的栓塞线圈输送系统
公开(公告)号：US07377932B2
公开(公告)日：2008-05-27
申请号：US11143051
申请日：2005-06-02
申请人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
发明人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B2017/00477 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.
摘要翻译：一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。栓塞装置通过机械互锁机构保持在输送导管内，该联动机构包括接合构件，该接合构件附接到推动器构件的远端并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

6. 发明授权

US07344558B2 Embolic device delivery system 有权
标题翻译：栓塞装置输送系统
公开(公告)号：US07344558B2
公开(公告)日：2008-03-18
申请号：US11364462
申请日：2006-02-28
申请人： Juan A. Lorenzo , Vladimir Mitelberg , Donald K. Jones
发明人： Juan A. Lorenzo , Vladimir Mitelberg , Donald K. Jones
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12054
摘要： A vascular occlusion device deployment system for deploying an occlusion device at a preselected site within the vasculature of a patient. The deployment system includes a pusher which has a constrictor located at the distal end portion of the pusher. The constrictor has a channel which receives a portion of the occlusion device. The constrictor has a proximal end portion and a distal end portion wherein the proximal end portion can be moved relative to the distal end portion to reduce the size of the channel. When the channel size is reduced, the constrictor grasps the portion of the occlusion device located within the channel. When it is desired to deploy the coil, the constrictor is moved in the opposite direction to increase the size of the channel and release the coil's grasp of the occlusion device.
摘要翻译：一种用于在患者的脉管系统内的预选位置部署闭塞装置的血管闭塞装置展开系统。所述展开系统包括推杆，所述推动器具有位于所述推动器的远端部分的收缩部。收缩器具有接收遮挡装置的一部分的通道。收缩器具有近端部分和远端部分，其中近端部分可以相对于远端部分移动以减小通道的尺寸。当通道尺寸减小时，收缩器抓住位于通道内的遮挡装置的部分。当需要展开线圈时，收缩器沿相反的方向移动以增加通道的尺寸并释放线圈对遮挡装置的把持。

7. 发明授权

US07371251B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07371251B2
公开(公告)日：2008-05-13
申请号：US11143052
申请日：2005-06-02
申请人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
发明人： Vladimir Mitelberg , Donald K. Jones , Juan A. Lorenzo
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. A stretch resistant embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. The engagement member engages a retaining ring on the embolic device. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.
摘要翻译：一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。弹性阻塞栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括接合构件，该接合构件附接到推动器构件的远端并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。接合构件接合栓塞装置上的保持环。当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

8. 发明申请

US20080195136A1 Thin Film Devices for Temporary or Permanent Occlusion of a Vessel 有权
标题翻译：用于临时或永久闭塞血管的薄膜装置
公开(公告)号：US20080195136A1
公开(公告)日：2008-08-14
申请号：US11662816
申请日：2005-09-16
申请人： Frederick Feller , Donald K. Jones , Darren R. Sherman
发明人： Frederick Feller , Donald K. Jones , Darren R. Sherman
IPC分类号： A61M29/02
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： Thin film devices implantable within a human subject for occlusion of an aneurysm or body vessel are provided. The devices are movable from an elongated, collapsed configuration for delivery to a deployed configuration within the body. Open slots in selected portions of the device telescope as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while also decreasing in porosity for preventing blood flow. Closed slits in other portions of the device open as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while remaining open for fluid flow or endothelialization. The occlusion devices may be either self-supporting or supported by a strut structure. Additionally, the occlusion devices may comprise a plurality of mesh layers having unaligned pore systems which further reduce porosity in desired portions of the deployed configuration.
摘要翻译：提供了植入人体受试者内用于闭塞动脉瘤或体内血管的薄膜装置。这些装置可以从细长的，折叠的构型移动，以便输送到主体内的展开构型。当设备移动到其展开的构型时，在设备望远镜的选定部分中开放狭槽，这导致相关部分纵向缩短并且径向膨胀，同时孔隙度也降低以防止血液流动。当装置移动到其展开构型时，装置的其它部分中的封闭狭缝打开，这导致相关部分纵向缩短并径向膨胀，同时保持开放以用于流体流动或内皮化。闭塞装置可以是自支撑的或由支柱结构支撑。另外，闭塞装置可以包括具有未对准孔系统的多个网眼层，其进一步降低展开构型的期望部分中的孔隙率。

9. 发明授权

US07811300B2 Thin film devices for temporary or permanent occlusion of a vessel 有权
标题翻译：用于暂时或永久闭塞血管的薄膜装置
公开(公告)号：US07811300B2
公开(公告)日：2010-10-12
申请号：US11662816
申请日：2005-09-16
申请人： Frederick Feller, III , Donald K. Jones , Darren R. Sherman
发明人： Frederick Feller, III , Donald K. Jones , Darren R. Sherman
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： Thin film devices implantable within a human subject for occlusion of an aneurysm or body vessel are provided. The devices are movable from an elongated, collapsed configuration for delivery to a deployed configuration within the body. Open slots in selected portions of the device telescope as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while also decreasing in porosity for preventing blood flow. Closed slits in other portions of the device open as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while remaining open for fluid flow or endothelialization. The occlusion devices may be either self-supporting or supported by a strut structure. Additionally, the occlusion devices may comprise a plurality of mesh layers having unaligned pore systems which further reduce porosity in desired portions of the deployed configuration.
摘要翻译：提供了植入人体受试者内用于闭塞动脉瘤或体内血管的薄膜装置。这些装置可以从细长的，折叠的构型移动，以便输送到主体内的展开构型。当设备移动到其展开的构型时，在设备望远镜的选定部分中开放狭槽，这导致相关部分纵向缩短并且径向膨胀，同时孔隙度也降低以防止血液流动。当装置移动到其展开构型时，装置的其它部分中的封闭狭缝打开，这导致相关部分纵向缩短并径向膨胀，同时保持打开以用于流体流动或内皮化。闭塞装置可以是自支撑的或由支柱结构支撑。另外，闭塞装置可以包括具有未对准孔系统的多个网眼层，其进一步降低展开构型的期望部分中的孔隙率。

10. 发明申请

US20080161936A1 Remodeling Device for Aneurysms 有权
标题翻译：动脉瘤改造装置
公开(公告)号：US20080161936A1
公开(公告)日：2008-07-03
申请号：US11663489
申请日：2005-10-14
申请人： Frederick Feller , Donald K. Jones , Darren R. Sherman
发明人： Frederick Feller , Donald K. Jones , Darren R. Sherman
IPC分类号： A61F2/02
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/12172 , A61B2017/12054 , A61F2002/823
摘要： A method of occluding a defect in the wall of a body vessel is provided. An outlet portion of a microcatheter is delivered to the defect, then at least a body portion of a thin film occlusion device is radially expanded from a collapsed orientation to a deployed orientation for engaging the microcatheter and covering at least a portion of the defect. Thereafter, an embolic media is released into the defect from the microcatheter for facilitating thrombosis. The body portion of the occlusion device is substantially porous in the collapsed orientation, but substantially non-porous in the deployed orientation for preventing prolapse of the embolic media into the body vessel.
摘要翻译：提供了一种在身体容器的壁中闭塞缺陷的方法。微导管的出口部分被输送到缺陷，然后薄膜闭塞装置的至少主体部分从收缩方向径向扩张到展开方向，以便与微导管接合并覆盖缺陷的至少一部分。此后，栓塞介质从微导管释放到缺陷中以便于血栓形成。闭塞装置的主体部分在塌缩方向上基本上是多孔的，但是在展开方向上基本上是无孔的，以防止栓塞介质向身体容器脱垂。

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