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1. 发明授权

US07294123B2 Activatable bioactive vascular occlusive device and method of use 有权
标题翻译：可活化生物活性血管闭塞装置及其使用方法
公开(公告)号：US07294123B2
公开(公告)日：2007-11-13
申请号：US10738473
申请日：2003-12-17
申请人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Donald K. Jones , Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12186 , A61B2017/00004 , A61B2017/00831
摘要： A vascular occlusive device which includes a support structure and a bioactive coating disposed onto the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive agent and bodily fluids until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种血管闭塞装置，其包括支撑结构和设置在支撑结构上的生物活性涂层和外部阻隔涂层，其用于防止生物活性剂和体液之间的反应，直到外部屏障通过将外部剂施用于外部屏障。

2. 发明授权

US07247159B2 Activatable bioactive vascular occlusive device 有权
标题翻译：可活化生物活性血管闭塞装置
公开(公告)号：US07247159B2
公开(公告)日：2007-07-24
申请号：US10820967
申请日：2004-04-08
申请人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B2017/00004 , A61B2017/00336 , A61B2017/00831
摘要： A vascular occlusive device, such as an embolic coil, having thrombogenic fibers extending from the coil and having an outer barrier which encapsulates and flattens the fibers along the sides of the embolic coil for preventing activation of the coil until the outer barrier has been dissolved, or removed, from the embolic coil.
摘要翻译：血管闭塞装置，例如栓塞线圈，具有从线圈延伸的血栓形成纤维，并且具有外阻挡件，其沿着栓塞线圈的侧面封装并平坦化纤维，以防止线圈激活直到外屏障已经溶解，或从栓塞线圈移除。

3. 发明授权

US07244261B2 Activatable bioactive vascular occlusive device 有权
标题翻译：可活化生物活性血管闭塞装置
公开(公告)号：US07244261B2
公开(公告)日：2007-07-17
申请号：US10874023
申请日：2004-06-22
申请人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
发明人： Juan A. Lorenzo , Mark L. Pomeranz , Darren Sherman
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B2017/00004 , A61B2017/00336 , A61B2017/00831
摘要： A vascular occlusive device, such as an embolic coil, having thrombogenic fibers extending from the coil and having an outer barrier which encapsulates fibers extending from the embolic coil for preventing activation of the fibers until the outer barrier has been dissolved, or removed, from the embolic coil.
摘要翻译：血管闭塞装置，例如栓塞线圈，具有从线圈延伸的血栓形成纤维，并且具有封闭从栓塞线圈延伸的纤维的外屏障，用于防止纤维的活化，直到外部屏障已经被溶解或去除栓塞线圈

4. 发明授权

US6010500A Telescoping apparatus and method for linear lesion ablation 失效
标题翻译：用于线性病变消融的伸缩装置和方法
公开(公告)号：US6010500A
公开(公告)日：2000-01-04
申请号：US897567
申请日：1997-07-21
申请人： Darren Sherman , Mark L. Pomeranz , Troy J. Chapman , N. Parker Willis , Dale Rieb , Robert B. West
发明人： Darren Sherman , Mark L. Pomeranz , Troy J. Chapman , N. Parker Willis , Dale Rieb , Robert B. West
IPC分类号： A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B2018/1472 , A61B2218/002
摘要： A catheter device for creating linear lesions in endocardial tissue or other body tissue is described. The catheter includes an inner shaft telescopically received within an outer shaft. The inner shaft has one or more spaced apart electrodes along its distal section. The outer shaft member includes a fluid permeable window positionable to selectively overlay some or all of the electrodes when the relative positioning of the inner and outer shaft members is adjusted. During use, the window is positioned adjacent to the body tissue which is to be ablated and at least a portion of the electrodes are exposed through the window. RF energy is delivered to the electrodes while saline or other conductive fluid is simultaneously delivered through the infusion tube. The conductive fluid passes into contact with the electrodes, and through the window into contact with the body tissue, thereby improving the coupling of the RF energy from the electrodes to the tissue and improving the efficiency of the ablation of the tissue.
摘要翻译：描述了用于在心内膜组织或其他身体组织中产生线性损伤的导管装置。导管包括可伸缩地容纳在外轴内的内轴。内轴沿其远端部分具有一个或多个间隔开的电极。外轴构件包括可流体渗透的窗口，其可调节内和外轴构件的相对定位时可选择地覆盖部分或全部电极。在使用期间，窗口被定位成邻近待烧蚀的身体组织，并且至少一部分电极通过窗户暴露。 RF能量被传送到电极，而盐水或其它导电流体同时通过输液管输送。导电流体与电极接触并且通过窗口与身体组织接触，从而改善从电极到组织的RF能量的耦合并提高组织消融的效率。

5. 发明申请

US20070239196A1 Heat Detachable Coil 有权
标题翻译：热分离线圈
公开(公告)号：US20070239196A1
公开(公告)日：2007-10-11
申请号：US11688172
申请日：2007-03-19
申请人： Mark L. Pomeranz
发明人： Mark L. Pomeranz
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12068
摘要： An embolic coil deployment system for placing a coil at a preselected site within a vessel of the human body is provided. The deployment system includes a heating element at the distal end of a detachment member and a heat-responsive coupling attached to a delivery member for holding the coil during positioning of the coil. The heating element is heated to reduce the strength of and sever the heat-responsive coupling for releasing the coil at a desired position within the body vessel.
摘要翻译：提供一种用于将线圈放置在人体容器内的预选位置的栓塞线圈展开系统。展开系统包括在分离构件的远端处的加热元件和附接到输送构件的热响应联接件，用于在线圈的定位期间保持线圈。加热元件被加热以降低强度并切断用于将线圈释放到身体容器内的期望位置处的热响应耦合。

6. 发明授权

US06241666B1 Ablation catheter tip with a buffer layer covering the electrode 失效
标题翻译：消融导管尖端带有覆盖电极的缓冲层
公开(公告)号：US06241666B1
公开(公告)日：2001-06-05
申请号：US08887731
申请日：1997-07-03
申请人： Mark L. Pomeranz , N. Parker Willis , Richard E. Riley
发明人： Mark L. Pomeranz , N. Parker Willis , Richard E. Riley
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/1472 , A61B2218/002 , A61N1/06
摘要： An ablative catheter assembly whose electrode is completely covered by a buffer layer. The buffer layer prevents areas of high current density at the surface of the catheter tip, which helps to reduce popping and clotting. The buffer layer may be in the form of a conductive fluid (such as saline solution) pumped into a cavity surrounding the electrode. In this case, the conductive fluid couples the electrode to the surrounding tissue so that RF energy will pass from the electrode to the tissue, thereby effecting ablation. Also, the buffer layer may be in the form of a porous coating which covers an electrode tip. In this case, blood or fluid which infuses the porous coating couples the electrode tip to the surrounding tissues to be ablated.
摘要翻译：消融导管组件，其电极被缓冲层完全覆盖。缓冲层防止导管尖端表面处的高电流密度区域，这有助于减少爆发和凝结。缓冲层可以是被泵送到围绕电极的空腔中的导电流体（例如盐水溶液）的形式。在这种情况下，导电流体将电极耦合到周围组织，使得RF能量从电极传递到组织，从而进行消融。此外，缓冲层可以是覆盖电极尖端的多孔涂层的形式。在这种情况下，输注多孔涂层的血液或流体将电极尖端耦合到周围组织以便烧蚀。

7. 发明授权

US6119041A Apparatus and method for linear lesion ablation 有权
标题翻译：线性损伤消融的装置和方法
公开(公告)号：US6119041A
公开(公告)日：2000-09-12
申请号：US128877
申请日：1998-08-04
申请人： Mark L. Pomeranz , Troy J. Chapman , Darren R. Sherman , Mir Imran
发明人： Mark L. Pomeranz , Troy J. Chapman , Darren R. Sherman , Mir Imran
IPC分类号： A61B18/04 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61N1/05 , A61N1/06 , A61B17/39
CPC分类号： A61B17/00234 , A61B18/1492 , A61N1/056 , A61N1/06 , A61B18/12 , A61B2017/00243 , A61B2018/00005 , A61B2018/00011 , A61B2018/00065 , A61B2018/00083 , A61B2018/00113 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00821 , A61B2018/1407 , A61B2018/1437 , A61B2018/1467 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： An apparatus for ablating body tissue, and particularly for creating linear lesions within a chamber of a patient's heart, includes an elongate member having an ablation section. The ablation section includes an infusion tube and a plurality of spaced electrodes. The infusion tube and electrodes are covered by a fluid permeable foam material, and the foam material is covered by a fluid impermeable covering having a plurality of holes formed in it. During use, the ablation section is positioned against tissue to be ablated. Radiofrequency energy is delivered to he electrodes while saline or other conductive fluid is delivered to the infusion tube. The fluid exits the infusion tube at the ablation section, contacts the electrodes, and carries RF energy from the electrodes through the foam, through the holes in the covering and into contact with the body tissue to form a burn in the body tissue.
摘要翻译：用于烧蚀身体组织，特别是用于在患者心脏的腔室内产生线性损伤的装置包括具有消融部分的细长部件。消融部分包括输注管和多个间隔开的电极。输液管和电极被流体可渗透的泡沫材料覆盖，并且泡沫材料被其中形成有多个孔的不透液体的覆盖物覆盖。在使用过程中，将消融部分放置在要消融的组织上。将射频能量输送到电极，同时将盐水或其它导电流体输送到输注管。流体在消融部分离开输注管，接触电极，并且将来自电极的RF能量通过泡沫穿过覆盖物中的孔并与身体组织接触以在身体组织中形成烧伤。

8. 发明授权

US5993462A Shapable catheter using exchangeable core and method of use 失效
标题翻译：可换尿布使用可交换核心和使用方法
公开(公告)号：US5993462A
公开(公告)日：1999-11-30
申请号：US49342
申请日：1998-03-27
申请人： Mark L. Pomeranz , Darren R. Sherman , Troy J. Chapman , Peter Park
发明人： Mark L. Pomeranz , Darren R. Sherman , Troy J. Chapman , Peter Park
IPC分类号： A61B18/14 , A61M25/00 , A61N1/05 , A61B5/04
CPC分类号： A61B18/1492 , A61M25/0041 , A61M25/0102 , A61N1/056 , A61B2017/00867 , A61B2018/00065 , A61B2018/00113 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61B2018/1472 , A61M2205/0266 , C08L2201/12
摘要： In a shapable catheter and method for positioning a shapable catheter within a body cavity, a core wire is provided which includes a pre-shaped region bent into a predetermined shape. A catheter is provided which includes a lumen proportioned to slidably receive the core wire. The catheter includes a rigid proximal section and a flexible distal section. A pull wire may additionally be provided to allow the user to cause deflection at a distal portion of the catheter.
摘要翻译：在可成型的导管和将成形导管定位在体腔内的方法中，提供了芯线，其包括弯曲成预定形状的预成形区域。提供导管，其包括与可滑动地接收芯线线成比例的管腔。导管包括刚性近端部分和柔性远端部分。另外可以提供牵引线以允许使用者在导管的远端部分引起偏转。

9. 发明授权

US5201316A Guide wire receptacle for catheters having rigid housings 失效
标题翻译：具有刚性外壳的导管的导线插座
公开(公告)号：US5201316A
公开(公告)日：1993-04-13
申请号：US672069
申请日：1991-03-18
申请人： Mark L. Pomeranz , Stephen M. Salmon , Pat A. Gingell
发明人： Mark L. Pomeranz , Stephen M. Salmon , Pat A. Gingell
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4488 , A61M2025/0183
摘要： An ultrasonic imaging catheter comprises a flexible catheter body having a rigid housing at its distal end. A tapered flexible end piece is secured to the distal end of the rigid housing, and a flexible guide wire tube extends in parallel to both the housing and the flexible end piece from the catheter body. The guide wire tube defines a guide wire lumen capable of receiving a movable guide wire, and the combined structure of the housing, flexible end piece, and flexible guide wire tube minimize constriction of the guide wire as it passes through the guide wire lumen.
摘要翻译：超声成像导管包括在其远端具有刚性壳体的柔性导管主体。锥形柔性端件固定到刚性壳体的远端，并且柔性导丝管从导管主体平行于壳体和柔性端件平行延伸。导丝管限定能够接收可移动导丝的导丝管腔，并且当引导丝穿过导丝管腔时，引导线的收缩最小化，壳体，柔性端部件和柔性引导线管的组合结构最小化。

10. 发明授权

US06014579A Endocardial mapping catheter with movable electrode 失效
标题翻译：具有可动电极的心内膜导管
公开(公告)号：US06014579A
公开(公告)日：2000-01-11
申请号：US897657
申请日：1997-07-21
申请人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
发明人： Mark L. Pomeranz , Susan M. Pietroski , Harold A. Heitzmann , Robert F. Bencini , Edward M. Gillis
IPC分类号： A61B5/042 , A61B5/0408 , A61N1/05
CPC分类号： A61B5/6858 , A61B5/0422 , A61B2562/0209 , A61B2562/043
摘要： An endocardial mapping catheter for introduction into a chamber of a heart formed by a wall. The flexible elongate tubular member has proximal and distal extremities and extends along a longitudinal axis. A plurality of longitudinally-extending spaced-apart members are carried by the distal extremity of the flexible elongate tubular member and have proximal extremities and interconnected distal extremities. Certain of the plurality of longitudinally-extending members are arms of a basket-like assembly and are movable between contracted positions and expanded positions in which the arms bow outwardly from the longitudinal axis. A plurality of longitudinally spaced-apart electrodes are carried by each of the arms. Electrical conductors extend through the flexible elongate tubular member and are connected to the electrodes for performing electrical functions with respect to the electrodes. At least one additional electrode is slidably mounted on one of the longitudinally-extending members.
摘要翻译：用于引入由壁形成的心脏室的心内膜定位导管。柔性细长管状构件具有近端和远端，并且沿着纵向轴线延伸。多个纵向延伸的间隔开的构件由柔性细长管状构件的远端承载并且具有近端和相互连接的远端。多个纵向延伸的构件中的某些是篮状组件的臂，并且可以在收缩位置和扩展位置之间移动，在该位置中臂从纵向轴线向外伸出。多个纵向间隔开的电极由每个臂承载。电导体延伸穿过柔性细长管状构件并且连接到电极以相对于电极执行电功能。至少一个附加电极可滑动地安装在一个纵向延伸部件上。

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