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1. 发明授权

US07819914B2 Adhesion promoting primer for coated surfaces 有权
标题翻译：涂层表面的粘合促进底漆
公开(公告)号：US07819914B2
公开(公告)日：2010-10-26
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

2. 发明授权

US08927049B2 Adhesion promoting temporary mask for coated surfaces 有权
标题翻译：粘附促进涂层表面的临时掩模
公开(公告)号：US08927049B2
公开(公告)日：2015-01-06
申请号：US12854463
申请日：2010-08-11
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06 , A61L33/00 , B05D3/00 , B05D1/32 , A61L31/16 , A61F2/91 , A61L31/10
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

3. 发明申请

US20100304007A1 ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES 审中-公开
标题翻译：粘合促进涂层表面的临时掩模
公开(公告)号：US20100304007A1
公开(公告)日：2010-12-02
申请号：US12854463
申请日：2010-08-11
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61L33/00
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

4. 发明申请

US20110029070A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 审中-公开
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20110029070A1
公开(公告)日：2011-02-03
申请号：US12906295
申请日：2010-10-18
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/82 , B05D7/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

5. 发明申请

US20100152841A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 有权
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20100152841A1
公开(公告)日：2010-06-17
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

6. 发明申请

US20100161039A1 ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES 审中-公开
公开(公告)号：US20100161039A1
公开(公告)日：2010-06-24
申请号：US12342465
申请日：2008-12-23
申请人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.

7. 发明授权

US08273404B2 Extraction of solvents from drug containing polymer reservoirs 有权
标题翻译：从含有药物的聚合物储存器中提取溶剂
公开(公告)号：US08273404B2
公开(公告)日：2012-09-25
申请号：US12122995
申请日：2008-05-19
申请人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
IPC分类号： A61L33/00 , A61K9/28 , A61K6/083 , A61M25/00 , A41D19/00 , A61F13/02 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.
摘要翻译：可以使用用于降低含药聚合物组合物中溶剂含量的方法来降低可植入医疗装置中的溶剂含量，其中组合物在储存器中。具体来说，含药聚合物组合物中的溶剂含量首先通过一种或多种常规的干燥方法还原，至聚合物组合物总重量的约0.5重量％至约10重量％。随后，通过低温干燥方法进一步处理含药物的聚合物组合物，以进一步降低溶剂含量。

8. 发明申请

US20090287300A1 EXTRACTION OF SOLVENTS FROM DRUG CONTAINING POLYMER RESERVOIRS 有权
标题翻译：从含有聚合物储备的药物中提取溶剂
公开(公告)号：US20090287300A1
公开(公告)日：2009-11-19
申请号：US12122995
申请日：2008-05-19
申请人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.
摘要翻译：可以使用用于降低含药聚合物组合物中溶剂含量的方法来降低可植入医疗装置中的溶剂含量，其中组合物在储存器中。具体来说，含药聚合物组合物中的溶剂含量首先通过一种或多种常规的干燥方法还原，至聚合物组合物总重量的约0.5重量％至约10重量％。随后，通过低温干燥方法进一步处理含药物的聚合物组合物，以进一步降低溶剂含量。

9. 发明授权

US08617611B2 Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same 有权
标题翻译：包含结晶相中的治疗剂的聚合物组合物及其形成方法
公开(公告)号：US08617611B2
公开(公告)日：2013-12-31
申请号：US12905186
申请日：2010-10-15
申请人： Robert Burgermeister , Vipul Dave
发明人： Robert Burgermeister , Vipul Dave
IPC分类号： A61K9/50
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04
摘要： The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
摘要翻译：本发明涉及包含至少一种包封在至少一种生物相容性聚合物中的治疗剂的含药聚合物组合物，其中该聚合物组合物中至少一部分治疗剂是结晶的。所述至少一种生物相容性聚合物可以形成基本上连续的聚合物基质，所述至少一种治疗剂包封在其中。或者，所述至少一种生物相容性聚合物可以形成聚合物颗粒，其中包封有至少一种治疗剂。

10. 发明申请

US20080086199A1 BIOABSORBABLE DEVICE HAVING COMPOSITE STRUCTURE FOR ACCELERATING DEGRADATION 有权
标题翻译：具有加速降解的复合结构的生物可降解装置
公开(公告)号：US20080086199A1
公开(公告)日：2008-04-10
申请号：US11539355
申请日：2006-10-06
申请人： Vipul Dave , George Landau
发明人： Vipul Dave , George Landau
IPC分类号： B32B27/18 , A61F2/02 , A61F2/82
CPC分类号： B32B27/32 , A61F2/82 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , Y10T428/31725 , Y10T428/31786 , C08L67/04
摘要： A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material. The first biodegradable and/or bioabsorbable material has a degradation rate that is faster than a degradation rate of the second biodegradable and/or bioabsorbable material. And, the structure experiences a period of accelerated degradation upon exposure of the first biodegradable and/or bioabsorbable material.
摘要翻译：医疗装置具有由第一可生物降解和/或生物可吸收材料和第二可生物降解和/或生物可吸收材料制成的结构。第一可生物降解和/或生物可吸收材料具有比第二可生物降解和/或生物可吸收材料的降解速度更快的降解速率。而且，该结构在第一种可生物降解和/或生物可吸收材料暴露时经历一个加速退化的时期。

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