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1. 发明申请

US20110029070A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 审中-公开
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20110029070A1
公开(公告)日：2011-02-03
申请号：US12906295
申请日：2010-10-18
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/82 , B05D7/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

2. 发明申请

US20110027368A1 POLYMERIC COMPOSITIONS COMPRISING THERAPEUTIC AGENTS IN CRYSTALLINE PHASES, AND METHODS OF FORMING THE SAME 有权
标题翻译：在晶体相中包含治疗剂的聚合物组合物及其形成方法
公开(公告)号：US20110027368A1
公开(公告)日：2011-02-03
申请号：US12905186
申请日：2010-10-15
申请人： Robert Burgermeister , Vipul Dave
发明人： Robert Burgermeister , Vipul Dave
IPC分类号： A61K9/14 , A61K31/196 , A61K31/436 , A61K31/7076 , A61K31/454
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04
摘要： The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
摘要翻译：本发明涉及包含至少一种包封在至少一种生物相容性聚合物中的治疗剂的含药聚合物组合物，其中该聚合物组合物中至少一部分治疗剂是结晶的。所述至少一种生物相容性聚合物可以形成基本上连续的聚合物基质，所述至少一种治疗剂包封在其中。或者，所述至少一种生物相容性聚合物可以形成聚合物颗粒，其中包封有至少一种治疗剂。

3. 发明授权

US07842312B2 Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same 有权
标题翻译：包含结晶相中的治疗剂的聚合物组合物及其形成方法
公开(公告)号：US07842312B2
公开(公告)日：2010-11-30
申请号：US11321255
申请日：2005-12-29
申请人： Robert Burgermeister , Vipul Dave
发明人： Robert Burgermeister , Vipul Dave
IPC分类号： A61K9/50
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04
摘要： The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
摘要翻译：本发明涉及包含至少一种包封在至少一种生物相容性聚合物中的治疗剂的含药聚合物组合物，其中该聚合物组合物中至少一部分治疗剂是结晶的。所述至少一种生物相容性聚合物可以形成基本上连续的聚合物基质，所述至少一种治疗剂包封在其中。或者，所述至少一种生物相容性聚合物可以形成聚合物颗粒，其中包封有至少一种治疗剂。

4. 发明申请

US20100152841A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 有权
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20100152841A1
公开(公告)日：2010-06-17
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

5. 发明申请

US20090287300A1 EXTRACTION OF SOLVENTS FROM DRUG CONTAINING POLYMER RESERVOIRS 有权
标题翻译：从含有聚合物储备的药物中提取溶剂
公开(公告)号：US20090287300A1
公开(公告)日：2009-11-19
申请号：US12122995
申请日：2008-05-19
申请人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： A process for reducing solvent contents in drug-containing polymeric compositions may be utilized to reduce the solvent content in implantable medical device wherein the compositions are in reservoirs. Specifically, the solvent contents in the drug-containing polymeric compositions are first reduced by one or more conventional drying methods, to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.
摘要翻译：可以使用用于降低含药聚合物组合物中溶剂含量的方法来降低可植入医疗装置中的溶剂含量，其中组合物在储存器中。具体来说，含药聚合物组合物中的溶剂含量首先通过一种或多种常规的干燥方法还原，至聚合物组合物总重量的约0.5重量％至约10重量％。随后，通过低温干燥方法进一步处理含药物的聚合物组合物，以进一步降低溶剂含量。

6. 发明申请

US20080085297A1 BIOABSORBABLE DEVICE HAVING ENCAPSULATED ADDITIVES FOR ACCELERATING DEGRADATION 有权
标题翻译：具有加速降解的加入添加剂的生物可降解装置
公开(公告)号：US20080085297A1
公开(公告)日：2008-04-10
申请号：US11539393
申请日：2006-10-06
申请人： Vipul Dave , George Landau
发明人： Vipul Dave , George Landau
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/06 , A61L31/129 , A61L31/148 , A61L31/18 , A61L2300/604 , A61L2400/12 , B23K2103/42 , B23K2103/50 , C08L67/04
摘要： A medical device has a structure made of one biodegradable and/or bioabsorbable material. A degradation additive is encapsulated by another biodegradable and/or bioabsorbable material forming a nanoparticle or microparticle. The nanoparticle or microparticle is together with the one biodegradable and/or bioabsorbable material of the structure. The other biodegradable and/or bioabsorbable material of the nanoparticle or microparticle has a degradation rate that is faster than a degradation rate of the one biodegradable and/or bioabsorbable material. The structure experiences a period of accelerated degradation upon release of the degradation additive from the nanoparticle or microparticle.
摘要翻译：医疗装置具有由一种可生物降解和/或生物可吸收材料制成的结构。降解添加剂被形成纳米颗粒或微粒的另一生物可降解和/或生物可吸收材料包封。纳米颗粒或微粒与结构的一种可生物降解和/或生物可吸收的材料一起。纳米颗粒或微粒的另一种可生物降解和/或生物可吸收的材料具有比一种生物可降解和/或生物可吸收材料的降解速率快的降解速率。该结构在从纳米颗粒或微粒释放降解添加剂时经历加速降解的时期。

7. 发明申请

US20070154554A1 Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same 有权
标题翻译：包含结晶相中的治疗剂的聚合物组合物及其形成方法
公开(公告)号：US20070154554A1
公开(公告)日：2007-07-05
申请号：US11321255
申请日：2005-12-29
申请人： Robert Burgermeister , Vipul Dave
发明人： Robert Burgermeister , Vipul Dave
IPC分类号： A61K9/14
CPC分类号： A61K31/65 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/427 , A61K31/436 , A61K31/454 , A61K31/4745 , A61K31/485 , A61K31/565 , A61K47/6957 , A61L27/18 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61L2300/63 , Y10S977/904 , Y10S977/906 , C08L67/04
摘要： The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
摘要翻译：本发明涉及包含至少一种包封在至少一种生物相容性聚合物中的治疗剂的含药聚合物组合物，其中该聚合物组合物中至少一部分治疗剂是结晶的。所述至少一种生物相容性聚合物可以形成基本上连续的聚合物基质，所述至少一种治疗剂包封在其中。或者，所述至少一种生物相容性聚合物可以形成聚合物颗粒，其中包封有至少一种治疗剂。

8. 发明申请

US20070142903A1 Laser cut intraluminal medical devices 审中-公开
标题翻译：激光切割管腔内医疗器械
公开(公告)号：US20070142903A1
公开(公告)日：2007-06-21
申请号：US11304372
申请日：2005-12-15
申请人： Vipul Dave
发明人： Vipul Dave
IPC分类号： A61F2/88 , B23K26/38 , B23K26/12
CPC分类号： B23K26/0823 , B23K26/064 , B23K26/0648 , B23K26/066 , B23K26/08 , B23K26/123 , B23K2101/04 , B23K2103/42 , B23K2103/50
摘要： Laser cut bioabsorbable intraluminal devices or stents and methods for forming such an intraluminal device or stent. A precursor sheet or tube of bioabsorbable material is laser cut in the presence of an inert gas to form an intraluminal medical device or stent having a desired geometry or pattern. The device or stent may comprise a helical, or other shape, having the laser cut geometry or pattern imparted thereon. The device or stent may further comprise drugs or bio-active agents incorporated into or onto the device or stent in greater percentages than conventional devices or stents. Radiopaque materials may be incorporated into, or coated onto, the intraluminal device or stent. Precise geometries or patterns are simply and readily achievable using the laser cutting methods in the presence of an inert gas while minimizing damage to the precursor materials.
摘要翻译：激光切割生物可吸收的管腔内装置或支架以及用于形成这种管腔内装置或支架的方法。生物可吸收材料的前体片或管在惰性气体的存在下被激光切割以形成具有期望的几何形状或图案的管腔内医疗装置或支架。装置或支架可以包括螺旋形或其它形状，其具有赋予其上的激光切割几何形状或图案。装置或支架可以进一步包含以比传统装置或支架更大的百分比掺入装置或支架中或其上的药物或生物活性剂。不透射线的材料可以结合到腔内装置或支架上或涂覆在管腔内装置或支架上。使用激光切割方法在存在惰性气体同时最小化对前体材料的损害的情况下，可以简单且容易地实现精确的几何形状或图案。

9. 发明申请

US20070135905A1 Polymeric stent having modified molecular structures in selected regions of the hoops 审中-公开
标题翻译：聚合物支架在箍的选定区域中具有改变的分子结构
公开(公告)号：US20070135905A1
公开(公告)日：2007-06-14
申请号：US11301367
申请日：2005-12-13
申请人： Robert Burgermeister , Vipul Dave , Pallassana Narayanan , David Overaker
发明人： Robert Burgermeister , Vipul Dave , Pallassana Narayanan , David Overaker
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61L31/04
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics.
摘要翻译：生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。可以使用聚合材料来制造包括支架在内的任何这些装置。支架可以是球囊扩张或自扩张。通过聚合物的优先机械变形，聚合物链可以被取向以获得某些所需的性能特征。

10. 发明申请

US20070135893A1 Polymeric stent having modified molecular structures in the flexible connectors and the radial arcs of the hoops 审中-公开
标题翻译：在柔性连接器中具有改进的分子结构的聚合物支架和环的径向弧
公开(公告)号：US20070135893A1
公开(公告)日：2007-06-14
申请号：US11301514
申请日：2005-12-13
申请人： Robert Burgermeister , Vipul Dave , Pallassana Narayanan , David Overaker
发明人： Robert Burgermeister , Vipul Dave , Pallassana Narayanan , David Overaker
IPC分类号： A61F2/86
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2210/0004 , A61F2230/0013 , A61F2250/0018 , A61F2250/0028 , A61L31/04 , A61L31/14
摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics.
摘要翻译：生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。可以使用聚合材料来制造包括支架在内的任何这些装置。支架可以是球囊扩张或自扩张。通过聚合物的优先机械变形，聚合物链可以被取向以获得某些所需的性能特征。

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