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1. 发明申请

US20100161039A1 ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES 审中-公开
公开(公告)号：US20100161039A1
公开(公告)日：2010-06-24
申请号：US12342465
申请日：2008-12-23
申请人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.

2. 发明授权

US07819914B2 Adhesion promoting primer for coated surfaces 有权
标题翻译：涂层表面的粘合促进底漆
公开(公告)号：US07819914B2
公开(公告)日：2010-10-26
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

3. 发明授权

US08927049B2 Adhesion promoting temporary mask for coated surfaces 有权
标题翻译：粘附促进涂层表面的临时掩模
公开(公告)号：US08927049B2
公开(公告)日：2015-01-06
申请号：US12854463
申请日：2010-08-11
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06 , A61L33/00 , B05D3/00 , B05D1/32 , A61L31/16 , A61F2/91 , A61L31/10
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

4. 发明申请

US20100304007A1 ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES 审中-公开
标题翻译：粘合促进涂层表面的临时掩模
公开(公告)号：US20100304007A1
公开(公告)日：2010-12-02
申请号：US12854463
申请日：2010-08-11
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61L33/00
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的代理保持固定到设备以及彼此之间，可以利用掩蔽和去掩蔽处理。

5. 发明申请

US20110029070A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 审中-公开
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20110029070A1
公开(公告)日：2011-02-03
申请号：US12906295
申请日：2010-10-18
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/82 , B05D7/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

6. 发明申请

US20100152841A1 ADHESION PROMOTING PRIMER FOR COATED SURFACES 有权
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：US20100152841A1
公开(公告)日：2010-06-17
申请号：US12335741
申请日：2008-12-16
申请人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized.
摘要翻译：可扩张医疗装置包括多个细长的支柱，形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。

7. 发明申请

US20110113728A1 E BEAM STERILIZATION OF MEDICAL DEVICES COMPRISING BIOACTIVE COATING 有权
标题翻译： E包含生物涂料的医疗装置的束灭菌
公开(公告)号：US20110113728A1
公开(公告)日：2011-05-19
申请号：US12619118
申请日：2009-11-16
申请人： Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： B65B55/08 , B65B31/04
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.
摘要翻译：本发明提供了一种用于生物活性肝素涂层在包含用于医疗装置例如导管，组织工程支架或药物递送载体材料中的肝素的材料和生物材料上的单步末端灭菌方法。这可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的任何医疗装置或植入物。其它相关装置实例可包括肝素或肝素衍生物涂层支架以减少凝血和再狭窄，牙科或眼科植入物。这些材料可以包含另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生的材料的医疗装置的其它基底上。

8. 发明授权

US08887477B2 E beam sterilization of medical devices comprising bioactive coating 有权
标题翻译：包括生物活性涂层的医疗装置的E束灭菌
公开(公告)号：US08887477B2
公开(公告)日：2014-11-18
申请号：US12619118
申请日：2009-11-16
申请人： Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Robert Falotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： B65B31/00 , B65B55/00 , B65B55/16 , A61L2/08 , B65D81/26
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： The invention provides a method for single-step terminal sterilization process for bio-active heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative coated stents to reduce clotting and restenosis, dental or ophthalmological implants. These materials may comprise additional polymeric compositions such as polyethyleneimine, dextran sulfate or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics or biologically derived materials.
摘要翻译：本发明提供了一种用于生物活性肝素涂层在包含用于医疗装置例如导管，组织工程支架或药物递送载体材料中的肝素的材料和生物材料上的单步末端灭菌方法。这可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的任何医疗装置或植入物。其它相关装置实例可包括肝素或肝素衍生物涂层支架以减少凝血和再狭窄，牙科或眼科植入物。这些材料可以包含另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生的材料的医疗装置的其它基底上。

9. 发明授权

US07058909B2 Method of generating an efficient stuck-at fault and transition delay fault truncated scan test pattern for an integrated circuit design 失效
标题翻译：产生集成电路设计的有效卡住故障和转换延迟故障截断扫描测试图案的方法
公开(公告)号：US07058909B2
公开(公告)日：2006-06-06
申请号：US10728036
申请日：2003-12-03
申请人： Cam L. Lu , Robert B. Benware , Thai M. Nguyen
发明人： Cam L. Lu , Robert B. Benware , Thai M. Nguyen
IPC分类号： G06F17/50
CPC分类号： G01R31/318328
摘要： A method of generating a truncated scan test pattern for an integrated circuit design includes steps of: (a) receiving as input an integrated circuit design; (b) estimating a number of transition delay fault test patterns and a corresponding number of top-off stuck-at fault patterns to achieve maximum stuck-at fault and transition delay fault coverage; (c) truncating the estimated number of transition delay fault patterns to generate a truncated set of transition delay fault patterns so that the truncated set of transition delay fault patterns and the corresponding number of top-off stuck-at fault patterns achieve maximum stuck-at fault and transition delay fault coverage within a selected scan memory limit; and (d) generating as output the truncated set of transition delay fault patterns and the corresponding number of top-off stuck-at fault patterns.
摘要翻译：生成用于集成电路设计的截头扫描测试图案的方法包括以下步骤：（a）接收作为输入的集成电路设计; （b）估计过渡延迟故障测试模式的数量和相应数量的顶点卡住故障模式，以实现最大卡住故障和转换延迟故障覆盖; （c）截断估计的转移延迟故障模式数，以产生截断的一组过渡延迟故障模式，使得截断的过渡延迟故障模式集合和相应数量的最大持续故障模式实现最大卡住所选扫描存储限制内的故障和转换延迟故障覆盖; 和（d）产生截断的过渡延迟故障模式集合的输出以及相应数量的顶部卡住故障模式。

10. 发明授权

US06888367B1 Method and apparatus for testing integrated circuit core modules 失效
标题翻译：集成电路核心模块的测试方法和装置
公开(公告)号：US06888367B1
公开(公告)日：2005-05-03
申请号：US10767314
申请日：2004-01-28
申请人： Thai M. Nguyen , James T. Ngo , William Shen
发明人： Thai M. Nguyen , James T. Ngo , William Shen
IPC分类号： G01R31/26 , G01R31/317 , G01R31/3185
CPC分类号： G01R31/31723 , G01R31/31721 , G01R31/318558 , G01R31/318563
摘要： A method of testing a core module includes steps of: (a) providing a core module of an integrated circuit design; (b) connecting an end user input and a core module test input to separate I/O pins of the core module to isolate logic associated with an end user signal from that associated with a core module test signal; and (c) multiplexing the end user signal and the core module test signal in the core module in response to a core module test mode signal.
摘要翻译：核心模块的测试方法包括以下步骤：（a）提供集成电路设计的核心模块; （b）将最终用户输入和核心模块测试输入连接到核心模块的独立I / O引脚，以将与终端用户信号相关联的逻辑与与核心模块测试信号相关联的逻辑隔离; 以及（c）响应于核心模块测试模式信号，将核心模块中的最终用户信号和核心模块测试信号复用。

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