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1. 发明申请

US20050065434A1 Polymeric marker with high radiopacity for use in medical devices 审中-公开
标题翻译：具有高放射性不透性的聚合物标记用于医疗器械
公开(公告)号：US20050065434A1
公开(公告)日：2005-03-24
申请号：US10748016
申请日：2003-12-29
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
IPC分类号： A61B5/05 , A61B5/107 , A61B19/00 , A61F2/06 , A61F2/84 , A61K49/04 , A61L29/18 , A61L31/18 , A61M25/01
CPC分类号： A61M25/0108 , A61B5/1076 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61K49/0419 , A61L29/18 , A61L31/18
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution, and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guide wire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有特定粒度分布的均匀成形颗粒的粉末状的不透射线剂和润湿剂，在聚合物标记物中实现高的射线不透性。生产标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定就位。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量病变，同时球囊导管的标记允许气囊相对于病变适当定位。

2. 发明申请

US20050255317A1 Polymeric marker with high radiopacity for use in medical devices 审中-公开
公开(公告)号：US20050255317A1
公开(公告)日：2005-11-17
申请号：US11148058
申请日：2005-06-07
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
IPC分类号： A61B5/05 , A61B5/107 , A61B19/00 , A61F2/958 , A61K49/04 , A61L31/18 , A61M25/01
CPC分类号： A61L31/18 , A61B5/1076 , A61B90/39 , A61B2562/17 , A61F2250/0098 , A61K49/0409 , A61K49/0419 , A61M25/0108 , Y10T428/2933
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution, and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guide wire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.

3. 发明申请

US20070123930A1 Embolic filtering devices 审中-公开
标题翻译：栓塞过滤装置
公开(公告)号：US20070123930A1
公开(公告)日：2007-05-31
申请号：US11652167
申请日：2007-01-11
申请人： Scott Huter , John Papp , Douglas Gesswein , Wayne Cornish , Peter D'Aquanni , Thomas Tokarchik , Andy Denison , Kevin Magrini , Benjamin Huter , Charles Peterson , William Boyle , Mark Richardson , Ryan Grandfield , Kathern Lind
发明人： Scott Huter , John Papp , Douglas Gesswein , Wayne Cornish , Peter D'Aquanni , Thomas Tokarchik , Andy Denison , Kevin Magrini , Benjamin Huter , Charles Peterson , William Boyle , Mark Richardson , Ryan Grandfield , Kathern Lind
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The expandable frame and filtering element can be mounted on a filter support structure, such as a coiled wire, and mounted on a guide wire. The expandable frames includes an articulation region which helps to distribute the strain which can be developed when the frame moves between an expanded and deployed position. The expandable frame may include further strain distributing bends which help distribute strain and increase the bendability of the frame.
摘要翻译：用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架第二控制臂通过部分回路。部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。可膨胀框架和过滤元件可以安装在诸如线圈的过滤器支撑结构上，并且安装在导丝上。可扩展框架包括铰接区域，其有助于分布当框架在展开位置和展开位置之间移动时可展开的应变。可扩展框架可以包括进一步的应变分布弯曲，其有助于分布应变并增加框架的可弯曲性。

4. 发明申请

US20070255217A1 TEXTURED POLYMER COATED GUIDE WIRE AND METHOD OF MANUFACTURE 审中-公开
标题翻译：纹理聚合物涂层指导线和制造方法
公开(公告)号：US20070255217A1
公开(公告)日：2007-11-01
申请号：US11762617
申请日：2007-06-13
申请人： David Burkett , Kevin Britton , Ryan Grandfield , Peter D'Aquanni , David Wrolstad , Edwin Mahieu , Wayne Cornish , Mark Richardson
发明人： David Burkett , Kevin Britton , Ryan Grandfield , Peter D'Aquanni , David Wrolstad , Edwin Mahieu , Wayne Cornish , Mark Richardson
IPC分类号： A61M5/178
CPC分类号： A61M25/09 , A61B17/12145 , A61F2/95 , A61F2/958 , A61M25/0043 , A61M2025/006 , A61M2025/0062 , A61M2025/09108 , A61M2025/09133 , B29C48/05 , B29C48/12 , B29C48/155
摘要： A guide wire for advancing a medical device such as a catheter through a patient's body lumen which has an elongated core with proximal and distal core section, a flexible tubular member such as a coil on the distal end. The wire core includes surface textures that are translated into the overlying coating. Alternatively, the coating has its own surface texture. The surface textures include randomly or non-randomly spaced bumps, divots, ridges, helical grooves, longitudinal grooves, undulations, etc.
摘要翻译：一种用于使诸如导管的医疗装置通过患者体腔前进的导丝，所述导管具有具有近端和远侧芯部的细长芯，在远端上具有诸如线圈的柔性管状构件。线芯包括被翻译成上覆涂层的表面纹理。或者，涂层具有其自己的表面纹理。表面纹理包括随机或非随机间隔的凸块，凸纹，凸脊，螺旋槽，纵向凹槽，起伏等。

5. 发明申请

US20070162071A1 Locking component for an embolic filter assembly 有权
标题翻译：栓塞过滤器组件的锁定部件
公开(公告)号：US20070162071A1
公开(公告)日：2007-07-12
申请号：US11698549
申请日：2007-01-26
申请人： David Burkett , Robert Esselstein , Kathern Lind , Pablito Buan , Robert Hazelden , Thomas Tokarchik , Ryan Grandfield , Aaron Baldwin , Wayne Cornish , Philip Yip
发明人： David Burkett , Robert Esselstein , Kathern Lind , Pablito Buan , Robert Hazelden , Thomas Tokarchik , Ryan Grandfield , Aaron Baldwin , Wayne Cornish , Philip Yip
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.
摘要翻译：用于将医疗装置锁定在导丝上的锁定部件。这样的医疗装置包括例如用于捕获栓塞材料的栓塞过滤器组件，其可以在支架置入或血管成形术程序期间产生并释放到患者的脉管系统中。栓塞过滤器组件沿着导丝跟踪，并且被输送到其被锁定就位并展开的治疗部位。锁定组件使过滤器组件能够锁定到任何标准导丝上，并且不需要具有专门设计的接头或止挡件的改进的导丝来实现锁定功能。

6. 发明授权

US06450975B1 Ultrasonic transmission guide wire 有权
标题翻译：超声波传输导丝
公开(公告)号：US06450975B1
公开(公告)日：2002-09-17
申请号：US09475521
申请日：1999-12-30
申请人： Lawrence Brennan , Douglas Gesswein , Wayne Cornish , Robert J. Siegel
发明人： Lawrence Brennan , Douglas Gesswein , Wayne Cornish , Robert J. Siegel
IPC分类号： A61B500
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/22018 , A61B2017/320084 , A61B2017/320088 , G10K11/24
摘要： The ultrasonic angioplasty transmission guide wire has regions of reduced cross-sectional diameter to improve flexibility and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the guide wire. The guide wire has a core of ultrasonic transmission material and an outer jacket surrounding a usable portion of the elongated shaft. The outer jacket is formed of a shrink tubing. At the proximal end are disposed threads configured to connect to a connecting device for an ultrasound transducer. The distal end comprises a smooth ball tip for atraumatic application of ultrasound energy to biological tissue. In one embodiment, the guide wire is formed of stainless steel. In another, the guide wire is formed at least partially of a superelastic metal alloy and in one case is formed at least partially of a shape memory alloy that exhibits superelastic properties when in its martensitic state. In one preferred embodiment, the guide wire is formed of a nickel-titanium alloy.
摘要翻译：超声波血管成形术传输导线具有减小的横截面直径的区域，以改善柔性并补偿由于沿导丝长度的声学损失引起的纵向位移的退化。引导线具有超声波传输材料的芯和围绕细长轴的可用部分的外护套。外套由收缩管形成。在近端处设置有被配置成连接到用于超声换能器的连接装置的螺纹。远端包括用于将生物组织超声能量无创应用的平滑球头。在一个实施例中，导丝由不锈钢形成。另一方面，所述导丝至少部分地由超弹性金属合金形成，并且在一种情况下至少部分地形成在其马氏体状态下表现出超弹性特性的形状记忆合金。在一个优选实施例中，导丝由镍 - 钛合金形成。

7. 发明申请

US20090099645A1 Radiopaque markers and medical devices comprising binary alloys of titanium 失效
标题翻译：不透射线标记物和包含钛二元合金的医疗器械
公开(公告)号：US20090099645A1
公开(公告)日：2009-04-16
申请号：US12153254
申请日：2008-05-15
申请人： John A. Simpson , John F. Boylan , Wayne Cornish
发明人： John A. Simpson , John F. Boylan , Wayne Cornish
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2250/0098
摘要： There is disclosed medical devices, such as stents, guidewires and embolic filters, comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed a radiopaque marker comprising the disclosed binary alloy, as well as medical devices having the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosure also disclosed.
摘要翻译：公开了包括钛的二元合金和选自铂，钯，铑和金的一种二元元素的医疗装置，例如支架，导丝和栓塞过滤器。还公开了一种包括所公开的二元合金的不透射线标记，以及具有附着于其上的不透射线标记的医疗装置。另外还公开了将不透射线标记物附接到医疗装置的方法，例如通过焊接。

8. 发明申请

US20070249964A1 POLYMER COATED GUIDE WIRE 有权
标题翻译：聚合物涂层指导线
公开(公告)号：US20070249964A1
公开(公告)日：2007-10-25
申请号：US11768794
申请日：2007-06-26
申请人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
发明人： Mark Richardson , David Anderson , Emmanuel Biagtan , Lawrence Brennan , David Burkett , Wayne Cornish , Robert Esselstein , James Jacobs , Marc Jalisi , Daryush Mirzaee , Olin Palmer , John Schreiner , Kent Stalker
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61L31/10 , A61L31/18 , A61M25/0045 , A61M25/0054 , A61M2025/09083 , A61M2025/09133 , A61M2025/09166
摘要： A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.
摘要翻译：具有芯构件等的导丝或其一部分具有多个具有锥形角度的相邻锥形段的构造，以在该装置的纵向部分上产生线性的刚度变化。该装置还可以具有连续变化的锥角的芯部，以产生曲线轮廓，其被配置成在装置的纵向部分上产生芯的刚度的线性变化。一个实施例具有多个不透射线的元件，其可以是间歇的，连续的或以螺旋带的形式，用于在荧光成像下对体内结构进行缩放测量。另一个实施方案在装置的远端上具有至少一层聚合物。

9. 发明申请

US20060047223A1 Apparatus and method for joining stainless steel guide wire portion to nitinol portion, without a hypotube 审中-公开
标题翻译：将不锈钢导丝部分连接到镍钛诺部分的装置和方法，没有海波管
公开(公告)号：US20060047223A1
公开(公告)日：2006-03-02
申请号：US10930458
申请日：2004-08-31
申请人： Ryan Grandfield , Wayne Cornish
发明人： Ryan Grandfield , Wayne Cornish
IPC分类号： A61M25/00
CPC分类号： A61M25/0905 , A61M2025/09108
摘要： An intravascular guide wire having two core materials joined together without the use of a connector tube or sleeve, the core materials being stainless steel and psuedoelastic metal alloy, nitinol. The core materials are joined to each other through an intermediate transition piece made essentially of nickel, which is welded on either side to the two core materials. In alternative embodiments, the intermediate piece may have different shapes to provide different strengths and advantages as may be required.
摘要翻译：一种血管内导丝，其两芯结合在一起，而不使用连接管或套筒，芯材为不锈钢和伪弹性金属合金，镍钛诺。核心材料通过基本上由镍制成的中间过渡件相互连接，该中间过渡件在两侧焊接到两个芯材上。在替代实施例中，中间件可以具有不同的形状以提供可能需要的不同的强度和优点。

10. 发明授权

US06612998B2 Guide wire with marker sleeve 有权
公开(公告)号：US06612998B2
公开(公告)日：2003-09-02
申请号：US09997811
申请日：2001-11-28
申请人： Brandon Gosiengfiao , Douglas Gesswein , Wayne Cornish , Sharon Y. Wong , Pablito Buan , Mark T. Richardson
发明人： Brandon Gosiengfiao , Douglas Gesswein , Wayne Cornish , Sharon Y. Wong , Pablito Buan , Mark T. Richardson
IPC分类号： A61B500
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09166
摘要： An intracorporeal device such as a guide wire with an elongated core having a radiopaque and optionally MRI-compatible markers embedded in a polymer sleeve disposed on a distal section of the elongated core is disclosed. The marker sleeve may be secured to a tapered portion of the distal core section or a constant diameter portion of the distal core section. Individual markers may be formed by radiopaque ribbons, bands, or strips, or may be in the form of a helical coil.

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