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1. 发明申请

WO2017044562A1 KNOWLEDGE-BASED SPATIAL DOSE METRICS AND METHODS TO GENERATE BEAM ORIENTATIONS IN RADIOTHERAPY 审中-公开
标题翻译：基于知识的空间剂量度量和放射治疗中生成光束方位的方法
公开(公告)号：WO2017044562A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050674
申请日：2016-09-08
申请人： VARIAN MEDICAL SYSTEMS, INC. , VARIAN MEDICAL SYSTEMS INTERNATIONAL AG.
发明人： ZANKOWSKI, Corey , NORD, Janne , MARCOS, Maria Isabel, Cordero , HARTMAN, Joona , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A system for estimating a dose from a radiation therapy plan includes a memory that stores machine- readable instructions and a processor communicatively coupled to the memory, the processor operable to execute the instructions to subdivide a representation of a volume of interest into voxels. The processor also determines distances between a planned radiation field origin and each respective voxel. The processor further computes geometry-based expected (GED) metrics based on the distances, a plan parameter, and a field strength parameter. The processor sums the metrics to yield an estimated dose received by the volume of interest from the planned radiation field.
摘要翻译：用于从放射治疗计划估计剂量的系统包括存储机器可读指令的存储器和通信地耦合到存储器的处理器，所述处理器可操作以执行指令以将兴趣体积的表示细分为体素。处理器还确定计划辐射场原点与每个相应体素之间的距离。处理器还基于距离，计划参数和场强参数来计算基于几何的预期（GED）度量。处理器对指标进行总和，以产生由计划辐射场感兴趣的体积所接收的估计剂量。

2. 发明授权

EP3434328B1 APPARATUS TO FACILITATE THE ADMINISTRATION OF A KNOWLEDGE-BASED RADIATION TREATMENT PLAN 有权转让
公开(公告)号：EP3434328B1
公开(公告)日：2020-06-03
申请号：EP18184632.0
申请日：2018-07-20
申请人： Varian Medical Systems International AG , Varian Medical Systems Inc
发明人： NORD, Janne , HARTMAN, Joona , KUUSELA, Esa , ZANKOWSKI, Corey
IPC分类号： A61N5/10

3. 发明公开

EP3459595A1 VMAT TREATMENT PLANNING USING MULTICRITERIA OPTIMIZATION AND A PROGRESSIVE OPTIMIZATION SCHEME 有权转让
公开(公告)号：EP3459595A1
公开(公告)日：2019-03-27
申请号：EP18194766.4
申请日：2018-09-17
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc.
发明人： TALLINEN, Tuomas , THOMPSON, Stephen , HARTMAN, Joona , NIEMELA, Perttu
IPC分类号： A61N5/10
摘要： Computer-implemented methods and systems can be used to facilitate generation of VMAT treatment plans for providing radiation therapy to patients. Starting from a seed plan, a library of alternative plans, each with an associated outcome for a set of treatment objectives, can be generated via a set of parallel optimization operations performed on the seed plan. A graphical user interface is provided, via which the user can navigate within a treatment space defined by the alternative plans to identify a satisfactory outcome. Based on the satisfactory outcome and a candidate plan selected from the alternative plans, a deliverable VMAT treatment plan can be generated using another optimization operation.

4. 发明公开

EP3434328A1 APPARATUS TO FACILITATE THE ADMINISTRATION OF A KNOWLEDGE-BASED RADIATION TREATMENT PLAN 有权转让
公开(公告)号：EP3434328A1
公开(公告)日：2019-01-30
申请号：EP18184632.0
申请日：2018-07-20
申请人： Varian Medical Systems International AG , Varian Medical Systems Inc
发明人： NORD, Janne , HARTMAN, Joona , KUUSELA, Esa , ZANKOWSKI, Corey
IPC分类号： A61N5/10
摘要： A control circuit accesses information regarding a plurality of pre-existing vetted radiation treatment plans 202 for a variety of patients and uses that information to train at least one model 201 (such as a dose volume histogram estimation model). The control circuit then uses that model to develop estimates for a radiation treatment plan for a particular patient 209. The control circuit can then use those estimates to develop a candidate radiation treatment plan 210.

5. 发明公开

EP3347093A1 KNOWLEDGE-BASED SPATIAL DOSE METRICS AND METHODS TO GENERATE BEAM ORIENTATIONS IN RADIOTHERAPY 审中-公开
公开(公告)号：EP3347093A1
公开(公告)日：2018-07-18
申请号：EP16766783.1
申请日：2016-09-08
申请人： Varian Medical Systems, Inc. , Varian Medical Systems International AG
发明人： ZANKOWSKI, Corey , NORD, Janne , MARCOS, Maria Isabel Cordero , HARTMAN, Joona , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A system for estimating a dose from a radiation therapy plan includes a memory that stores machine-readable instructions and a processor communicatively coupled to the memory, the processor operable to execute the instructions to subdivide a representation of a volume of interest into voxels. The processor also determines distances between a planned radiation field origin and each respective voxel. The processor further computes geometry-based expected (GED) metrics based on the distances, a plan parameter, and a field strength parameter. The processor sums the metrics to yield an estimated dose received by the volume of interest from the planned radiation field.

6. 发明申请

WO2014187866A1 SYSTEMES AND METHODS FOR AUTOMATIC CREATION OF DOSE PREDICTION MODELS AND THERAPY TREATMENT PLANS AS A CLOUD SERVICE 审中-公开
标题翻译：用于自动创建剂量预测模型和治疗方案作为云服务的系统和方法
公开(公告)号：WO2014187866A1
公开(公告)日：2014-11-27
申请号：PCT/EP2014/060461
申请日：2014-05-21
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： HARTMAN, Joona , CORDERO MARCOS, Maria , KUUSELA, Esa , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/103 , A61N5/1043 , A61N2005/1041 , A61N2005/1074 , A61N2005/1087 , G06F19/00 , G06F19/3418 , G06F19/3481
摘要： The present invention proposes a method for automatically creating a dose prediction model based on existing clinical knowledge that is accumulated from multiple sources without collaborators establishing communication links between each other. According to embodiments of the claimed subject matter, clinics can collaborate in creating a dose prediction model by submitting their treatment plans into a remote computer system (such as a cloud-based system) which aggregates information from various collaborators and produces a model that captures clinical information from all submitted treatment plans. According to further embodiments, the method may contain a step where all patient data submitted by a clinic is made anonymous or the relevant parameters are extracted and condensed prior to submitting them over the communications link in order to comply with local regulations.
摘要翻译：本发明提出了一种基于从多个来源积累的现有临床知识自动创建剂量预测模型的方法，没有协作者建立彼此之间的通信链路。根据所要求保护的主题的实施例，诊所可以通过将其治疗计划提交到远程计算机系统（例如基于云的系统）中来协作来创建剂量预测模型，所述远程计算机系统聚合来自各种协作者的信息并产生捕获临床的模型所有提交的治疗计划的资料。根据另外的实施例，该方法可以包括一个步骤，其中由诊所提交的所有患者数据是匿名的，或者在通过通信链路提交相关参数之前提取和浓缩相关参数以符合当地法规。

7. 发明申请

WO2015044924A1 DECISION SUPPORT TOOL FOR CHOOSING TREATMENT PLANS 审中-公开
标题翻译：决定支持工具选择治疗计划
公开(公告)号：WO2015044924A1
公开(公告)日：2015-04-02
申请号：PCT/IB2014/064936
申请日：2014-09-29
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： HARTMAN, Joona , MARCOS, Maria, Isabel, Cordero , KUUSELA, Esa , PELTOLA, Jarkko, Yrjana , NORD, Janne, Ilmari
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , A61N5/103 , A61N2005/1041 , G06F19/00 , G16H50/20
摘要： Patient data can be used to determine input values to different estimation functions for different treatment types. The estimation functions can each be used to estimate one or more outcome values for the respective treatment. A quality score can be be determined using the outcome value(s). A first treatment plan having an optimal quality score can be identified, e.g., by displaying the treatment plans with the quality scores, which may correspond to the outcome values.
摘要翻译：患者数据可用于确定不同治疗类型的不同估计功能的输入值。估计函数可以分别用于估计相应治疗的一个或多个结果值。可以使用结果值确定质量得分。可以例如通过显示具有与结果值对应的质量得分的治疗计划来确定具有最佳质量得分的第一治疗计划。

8. 发明申请

WO2015042727A1 PREDICTING ACHIEVABLE DOSE DISTRIBUTION USING 3D INFORMATION AS AN INPUT 审中-公开
标题翻译：使用3D信息作为输入预测可实现的剂量分配
公开(公告)号：WO2015042727A1
公开(公告)日：2015-04-02
申请号：PCT/CH2014/000139
申请日：2014-09-30
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , HARTMAN, Joona , NORD, Janne , BAGHAIE, Ramin
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1045 , A61N5/1065 , A61N5/1071 , A61N2005/1041 , G06T7/344 , G06T2207/10104 , G06T2207/30096
摘要： Knowledge-based radiotherapy treatment planning is expanded to include spatial information from, for example, positron emission tomography (PET). Information that is specific to a patient is accessed. A prediction of a spatial dose distribution inside a target volume in the patient is determined using the patient-specific information as an input to a prediction model. The prediction model is established using training data that includes data resulting from applying other radiation treatment plans to other patients. The training data includes spatially distributed information indicating a level of activity in target volumes in the other patients (e.g., PET image data). A dose-volume histogram and associated three-dimensional dose distribution information based on the prediction are produced. The dose-volume histogram and the three-dimensional dose distribution information can be used to develop a radiation treatment plan for the patient.
摘要翻译：基于知识的放射治疗计划扩大到包括例如正电子发射断层扫描（PET）的空间信息。访问特定于患者的信息。使用患者特定信息作为预测模型的输入来确定患者中目标体积内的空间剂量分布的预测。使用训练数据建立预测模型，训练数据包括将其他辐射治疗计划应用于其他患者所产生的数据。训练数据包括指示其他患者的目标体积的活动水平的空间分布信息（例如，PET图像数据）。产生了基于预测的剂量体积直方图和相关联的三维剂量分布信息。剂量体积直方图和三维剂量分布信息可用于为患者制定放射治疗计划。

9. 发明申请

WO2014139040A2 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 审中-公开
标题翻译：辐射治疗计划的集成模型
公开(公告)号：WO2014139040A2
公开(公告)日：2014-09-18
申请号：PCT/CH2014/000029
申请日：2014-03-14
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , MARIA, Cordero Marcos , HARTMAN, Joona , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： G06F19/3437 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06N5/00 , G06N5/022 , G16H50/50
摘要： System and method for automatically generate therapy plan parameters by use of an integrate model with extended applicable regions. The integrated model integrates multiple predictive models from which a suitable predictive model can be selected automatically to perform prediction for a new patient case. The integrated model may operate to evaluate prediction results generated by each predictive model and the associated prediction reliabilities and selectively output a satisfactory prediction. Alternatively, the integrated model may select a suitable predictive model by a decision hierarchy in which each level corresponds to divisions of a patient data feature set and divisions on a subordinate level are nested with divisions on a superordinate level.
摘要翻译：
通过使用扩展适用区域的集成模型自动生成治疗计划参数的系统和方法。该集成模型集成了多个预测模型，从中可以自动选择合适的预测模型来执行新病例的预测。综合模型可用于评估由每个预测模型产生的预测结果和相关联的预测可靠性并选择性地输出令人满意的预测。或者，集成模型可以通过决策层次来选择合适的预测模型，其中每个层次对应于患者数据特征集合的划分，并且下级层级上的划分与上级层级上的划分嵌套。

10. 发明公开

EP3403694A1 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 有权转让
公开(公告)号：EP3403694A1
公开(公告)日：2018-11-21
申请号：EP18179560.0
申请日：2014-03-14
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , MARIA, Cordero Marcos , HARTMAN, Joona , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： G16H50/50 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06N5/00 , G06N5/022
摘要： A method of automatically generating an integrated model for planning a therapy comprises: configuring an input interface 503 operable to receive patient data 501 of a plurality of features; accessing a plurality of predictive models 520, wherein each predictive model is operable to generate a therapy prediction based on said patient data; associating an applicable category with respect to each of said plurality of features for each predictive model; integrating 530 said plurality of predictive models into a hierarchy comprising a bottom level and one or more decision levels, wherein said bottom level comprises said plurality of predictive models, and wherein said one or more decision levels are operable to automatically select one or more predictive models from said bottom level based on applicable categories associated therewith; and configuring an output interface 504 operable to output a therapy prediction generated by a predictive models in response to said patient data.

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