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1. 发明申请

WO2017044562A1 KNOWLEDGE-BASED SPATIAL DOSE METRICS AND METHODS TO GENERATE BEAM ORIENTATIONS IN RADIOTHERAPY 审中-公开
标题翻译：基于知识的空间剂量度量和放射治疗中生成光束方位的方法
公开(公告)号：WO2017044562A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050674
申请日：2016-09-08
申请人： VARIAN MEDICAL SYSTEMS, INC. , VARIAN MEDICAL SYSTEMS INTERNATIONAL AG.
发明人： ZANKOWSKI, Corey , NORD, Janne , MARCOS, Maria Isabel, Cordero , HARTMAN, Joona , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A system for estimating a dose from a radiation therapy plan includes a memory that stores machine- readable instructions and a processor communicatively coupled to the memory, the processor operable to execute the instructions to subdivide a representation of a volume of interest into voxels. The processor also determines distances between a planned radiation field origin and each respective voxel. The processor further computes geometry-based expected (GED) metrics based on the distances, a plan parameter, and a field strength parameter. The processor sums the metrics to yield an estimated dose received by the volume of interest from the planned radiation field.
摘要翻译：用于从放射治疗计划估计剂量的系统包括存储机器可读指令的存储器和通信地耦合到存储器的处理器，所述处理器可操作以执行指令以将兴趣体积的表示细分为体素。处理器还确定计划辐射场原点与每个相应体素之间的距离。处理器还基于距离，计划参数和场强参数来计算基于几何的预期（GED）度量。处理器对指标进行总和，以产生由计划辐射场感兴趣的体积所接收的估计剂量。

2. 发明申请

WO2013180969A1 APPARATUS AND METHOD PERTAINING TO OPTIMIZING A RADIATION-TREATMENT PLAN USING HISTORICAL INFORMATION 审中-公开
标题翻译：使用历史信息优化放射治疗计划的装置和方法
公开(公告)号：WO2013180969A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/041400
申请日：2013-05-16
申请人： VARIAN MEDICAL SYSTEMS, INC. , VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： ZANKOWSKI, Corey E. , NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： G06Q50/22 , A61N5/00
CPC分类号： A61N5/1031 , A61N5/1038 , A61N2005/1041 , G06F19/00
摘要： A control circuit operably couples to a memory having historical information stored therein. This historical information comprises information regarding delivered radiation doses to non-targeted patient volumes for a plurality of different volume presentations. The control circuit iteratively optimizes a radiation-treatment plan for a specific plan using that historical information. The aforementioned historical information can comprise delivered-dose metrics as correspond to different relative distances within given patients. The control circuit can employ such information to determine, for example, an estimated dosage (including, if desired, a corresponding range of estimated dosages) for at least one volume within the specific patient at a specific distance from a specific point of reference. The control circuit can compare such historical information against radiation-treatment plan optimization results to qualitatively assess the radiation-treatment plan optimization results.
摘要翻译：控制电路可操作地耦合到存储有历史信息的存储器。该历史信息包括关于针对多个不同体积呈现的非目标患者体积的递送辐射剂量的信息。控制电路使用该历史信息对特定计划的辐射处理计划进行迭代优化。上述历史信息可以包括对应于给定患者内的不同相对距离的递送剂量度量。控制电路可以使用这样的信息来确定特定患者中距离特定参考点特定距离的至少一个体积的估计剂量（包括如果需要，相应的估计剂量范围）。控制电路可以将这些历史信息与放射治疗计划优化结果进行比较，对辐射治疗计划优化结果进行定性评估。

3. 发明授权

EP3434328B1 APPARATUS TO FACILITATE THE ADMINISTRATION OF A KNOWLEDGE-BASED RADIATION TREATMENT PLAN 有权转让
公开(公告)号：EP3434328B1
公开(公告)日：2020-06-03
申请号：EP18184632.0
申请日：2018-07-20
申请人： Varian Medical Systems International AG , Varian Medical Systems Inc
发明人： NORD, Janne , HARTMAN, Joona , KUUSELA, Esa , ZANKOWSKI, Corey
IPC分类号： A61N5/10

4. 发明授权

EP3146998B1 APPARATUS TO EMPLOY A MULTI-LAYER MULTI-LEAF COLLIMATOR WHEN ADMINISTERING A RADIATION THERAPY TREATMENT 有权转让
公开(公告)号：EP3146998B1
公开(公告)日：2020-11-04
申请号：EP16187121.5
申请日：2016-09-02
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc.
发明人： NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa , PRINCE, Steven
IPC分类号： A61N5/10 , G21K1/04

5. 发明公开

EP3146998A1 METHOD AND APPARATUS TO EMPLOY A MULTI-LAYER MULTI-LEAF COLLIMATOR WHEN ADMINISTERING A RADIATION THERAPY TREATMENT 有权转让
标题翻译：方法和装置采用多涂层片更多准直器在辐射给药的治疗手段
公开(公告)号：EP3146998A1
公开(公告)日：2017-03-29
申请号：EP16187121.5
申请日：2016-09-02
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc.
发明人： NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa , PRINCE, Steven
IPC分类号： A61N5/10 , G21K1/04
摘要： A control circuit 201 administers a radiation treatment plan that specifies a planned total radiation dose for a radiation treatment session for a given patient 207 by modulating a radiation beam 203 with at least one high-resolution aperture that is formed using one of a plurality of linearly-sequential high-resolution aperture possibilities. By one approach the foregoing comprises modulating the radiation beam using at least substantially only high-resolution apertures that are formed using a plurality of the linearly-sequential high-resolution aperture possibilities. In some cases the foregoing can comprise administering the radiation treatment plan using at least two separate radiation exposures for only a single treatment field, in which case, by one approach, each of the separate radiation exposures for the single treatment field can comprise modulating the radiation beam using at least substantially only high-resolution apertures.
摘要翻译：控制电路201管理一个辐射处置计划并指定用于给定患者207辐射治疗会话通过调制的辐射束203与至少一个高分辨率孔径的计划总辐射剂量并使用的线性多个之一形成 -sequential高分辨率孔径的可能性。根据一个方案，前述的包括使用至少基本上仅高分辨率孔径并使用的线性顺序高分辨率孔径的可能性形成的多个调制的辐射束。在一些情况下，前述可包括施用使用至少两个分开的辐射照射只对单个处理场的辐射治疗计划，在这种情况下,,通过一种方法中，每一个用于所述单个处理场的单独的辐射照射的可以包括调节辐射光束使用至少基本上仅高分辨率光圈。

6. 发明公开

EP2856420A1 APPARATUS AND METHOD PERTAINING TO OPTIMIZING A RADIATION-TREATMENT PLAN USING HISTORICAL INFORMATION 有权转让
标题翻译：设备与优化的放射治疗方案方法使用历史信息
公开(公告)号：EP2856420A1
公开(公告)日：2015-04-08
申请号：EP13797463.0
申请日：2013-05-16
申请人： Varian Medical Systems, Inc. , Varian Medical Systems International AG
发明人： ZANKOWSKI, Corey E. , NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： G06Q50/22 , A61N5/00
CPC分类号： A61N5/1031 , A61N5/1038 , A61N2005/1041 , G06F19/00
摘要： A control circuit operably couples to a memory having historical information stored therein. This historical information comprises information regarding delivered radiation doses to non-targeted patient volumes for a plurality of different volume presentations. The control circuit iteratively optimizes a radiation-treatment plan for a specific plan using that historical information. The aforementioned historical information can comprise delivered-dose metrics as correspond to different relative distances within given patients. The control circuit can employ such information to determine, for example, an estimated dosage (including, if desired, a corresponding range of estimated dosages) for at least one volume within the specific patient at a specific distance from a specific point of reference. The control circuit can compare such historical information against radiation-treatment plan optimization results to qualitatively assess the radiation-treatment plan optimization results.

7. 发明公开

EP3434328A1 APPARATUS TO FACILITATE THE ADMINISTRATION OF A KNOWLEDGE-BASED RADIATION TREATMENT PLAN 有权转让
公开(公告)号：EP3434328A1
公开(公告)日：2019-01-30
申请号：EP18184632.0
申请日：2018-07-20
申请人： Varian Medical Systems International AG , Varian Medical Systems Inc
发明人： NORD, Janne , HARTMAN, Joona , KUUSELA, Esa , ZANKOWSKI, Corey
IPC分类号： A61N5/10
摘要： A control circuit accesses information regarding a plurality of pre-existing vetted radiation treatment plans 202 for a variety of patients and uses that information to train at least one model 201 (such as a dose volume histogram estimation model). The control circuit then uses that model to develop estimates for a radiation treatment plan for a particular patient 209. The control circuit can then use those estimates to develop a candidate radiation treatment plan 210.

8. 发明公开

EP3347093A1 KNOWLEDGE-BASED SPATIAL DOSE METRICS AND METHODS TO GENERATE BEAM ORIENTATIONS IN RADIOTHERAPY 审中-公开
公开(公告)号：EP3347093A1
公开(公告)日：2018-07-18
申请号：EP16766783.1
申请日：2016-09-08
申请人： Varian Medical Systems, Inc. , Varian Medical Systems International AG
发明人： ZANKOWSKI, Corey , NORD, Janne , MARCOS, Maria Isabel Cordero , HARTMAN, Joona , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A system for estimating a dose from a radiation therapy plan includes a memory that stores machine-readable instructions and a processor communicatively coupled to the memory, the processor operable to execute the instructions to subdivide a representation of a volume of interest into voxels. The processor also determines distances between a planned radiation field origin and each respective voxel. The processor further computes geometry-based expected (GED) metrics based on the distances, a plan parameter, and a field strength parameter. The processor sums the metrics to yield an estimated dose received by the volume of interest from the planned radiation field.

9. 发明申请

WO2022129144A1 TRAINING ARTIFICIAL INTELLIGENCE MODELS FOR RADIATION THERAPY 审中-公开
公开(公告)号：WO2022129144A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085848
申请日：2021-12-15
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： BASIRI, Shahab , HAKALA, Mikko , KUUSELA, Esa , CZEIZLER, Elena
IPC分类号： G16H20/40
摘要： Disclosed herein are systems and methods for iteratively training artificial intelligence models using reinforcement learning techniques. With each iteration, a training agent applies a random radiation therapy treatment attribute corresponding to the radiation therapy treatment attribute associated with previously performed radiation therapy treatments when an epsilon value indicative of a likelihood of exploration and exploitation training of the artificial intelligence model satisfies a threshold. When the epsilon value does not satisfy the threshold, the agent generates (242), using an existing policy, a first predicted radiation therapy treatment attribute, and generates (244), using a predefined model, a second predicted radiation therapy treatment attribute. The agent applies (246) one of the first predicted radiation therapy treatment attribute or the second predicted radiation therapy treatment attribute that is associated with a higher reward. The agent iteratively repeats (248) training the artificial intelligence model until the existing policy satisfies an accuracy threshold.

10. 发明申请

WO2020200849A1 USING ISODOSE SURFACES FOR OPTIMIZING DOSE DISTRIBUTION IN RADIATION TREATMENT PLANNING 审中-公开
公开(公告)号：WO2020200849A1
公开(公告)日：2020-10-08
申请号：PCT/EP2020/057847
申请日：2020-03-20
申请人： VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
发明人： KUUSELA, Esa , LAAKSONEN, Hannu , HALKO, Lauri
IPC分类号： A61N5/10
摘要： Cost functions and cost function gradients for use in radiation treatment planning can be computed based on an approximation of an "isodose" surface. Where a clinical goal is expressed by reference to a threshold isodose surface, a corresponding cost function component can be defined directly by reference to that isodose surface 1004, and a corresponding contribution to the cost function gradient can be approximated by identifying voxels that are intersected by the threshold isodose surface and approximating the gradient of the dose distribution within each such voxel.

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