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1. 发明申请

US20050019849A1 Nanoparticles for optical sensors 失效
标题翻译：用于光学传感器的纳米颗粒
公开(公告)号：US20050019849A1
公开(公告)日：2005-01-27
申请号：US10888392
申请日：2004-07-09
申请人： Valerie Desprez , Norbert Oranth , Jurgen Spinke , James Tusa
发明人： Valerie Desprez , Norbert Oranth , Jurgen Spinke , James Tusa
IPC分类号： G01N21/78 , C12M1/34 , C12Q1/00 , C12Q1/26 , C12Q1/54 , G01N33/52
CPC分类号： G01N33/521 , C12Q1/001
摘要： The present invention concerns a polymer layer for a sensor, wherein the polymer layer has nanoparticles embedded therein which impart to the polymer layer recognizing properties as well as transducer properties, a sensor comprising such layer and the use of the sensor for detecting and/or quantifying a target analyte.
摘要翻译：本发明涉及一种用于传感器的聚合物层，其中聚合物层具有嵌入其中的纳米颗粒，其赋予聚合物层识别特性以及换能器性质，包含该层的传感器以及用于检测和/或定量的传感器目标分析物。

2. 发明授权

US07427491B2 Nanoparticles for optical sensors 失效
标题翻译：用于光学传感器的纳米颗粒
公开(公告)号：US07427491B2
公开(公告)日：2008-09-23
申请号：US10888392
申请日：2004-07-09
申请人： Valerie Desprez , Norbert Oranth , Jurgen Spinke , James Kenneth Tusa
发明人： Valerie Desprez , Norbert Oranth , Jurgen Spinke , James Kenneth Tusa
IPC分类号： C12Q1/54
CPC分类号： G01N33/521 , C12Q1/001
摘要： The present invention concerns a polymer layer for a sensor, wherein the polymer layer has nanoparticles embedded therein which impart to the polymer layer recognizing properties as well as transducer properties, a sensor comprising such layer and the use of the sensor for detecting and/or quantifying a target analyte.
摘要翻译：本发明涉及一种用于传感器的聚合物层，其中聚合物层具有嵌入其中的纳米颗粒，其赋予聚合物层识别特性以及换能器性质，包含该层的传感器以及用于检测和/或定量的传感器目标分析物。

3. 发明授权

US10213742B2 Micro flow filtration system and flow filtration method 有权
公开(公告)号：US10213742B2
公开(公告)日：2019-02-26
申请号：US14386097
申请日：2013-03-25
申请人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
发明人： Norbert Oranth , Nadine Losleben , Sascha Lutz , Adelbert Grossmann
IPC分类号： B01D61/14 , B01D61/18 , B01D61/20 , B01D61/22
摘要： A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present). The volume of the first reservoir (1) outside the circuitry (3) is significantly larger than the volume of the second reservoir (2). The first reservoir (1) outside the fluid circuitry (3) is connected to the circuitry (3) via a connection conduit (31) such that the fluid flows unidirectionally into the circuitry (3) until the first reservoir (1) is empty so that a continuous fluid flow from the first reservoir (1) to the circuitry (3) is established.

4. 发明申请

US20090305332A1 Method and Apparatus for Determining an Analyte in a Liquid Sample 有权
标题翻译：用于测定液体样品中分析物的方法和装置
公开(公告)号：US20090305332A1
公开(公告)日：2009-12-10
申请号：US12478878
申请日：2009-06-05
申请人： Erich Haendler , Norbert Oranth
发明人： Erich Haendler , Norbert Oranth
IPC分类号： C12Q1/02 , G01N21/00 , C12M1/34 , G01N30/96
CPC分类号： G01N33/557 , G01N21/8483 , G01N33/558
摘要： A method for the determination of an analyte in a liquid sample, especially a body liquid sample, with the aid of an analytical apparatus. The apparatus receives a first measuring signal si (i=0, 1, . . . ) and a second measuring signal sj (j=1, 2, . . . ; j>i) for a test system with several successively arranged measuring areas through which a liquid sample with an analyte can flow after being applied on the test system are received by an evaluation apparatus comprised by the analytical apparatus, wherein the first measuring signal si indicates a part of the analyte bound in a first measuring area and the second measuring signal sj indicates a part of the analyte bound in a second measuring area that is arranged downstream the first measuring area on the test system after the application of the liquid sample on the test system, a concentration measure N correlating with the concentration of the analyte in the liquid sample is determined by the evaluation apparatus in accordance with the following linkage of measuring signals: N = ( s j ) i + 2 [ s i - ( ( s i ) j - i - 1 · s j ) 1 j - i ] · ( ( s i ) j - i - 1 · s j ) i j - 1 , and the concentration measurement is outputted by the evaluation apparatus after a selective further processing. Furthermore, the invention relates to an analytical apparatus for the determination of an analyte in a liquid sample as well as to a computer readable medium for performing function to determine an analyte in a liquid sample.
摘要翻译：借助于分析装置测定液体样品，特别是体液样品中的分析物的方法。该装置接收具有多个连续布置的测量区域的测试系统的第一测量信号si（i = 0,1等）和第二测量信号sj（j = 1,2，...，j> i）通过分析装置包含的评估装置接收具有分析物的液体样品在被施加在测试系统上之后流动，其中第一测量信号si表示在第一测量区域中被结合的分析物的一部分，第二测量信号测量信号sj表示在将液体样品施加到测试系统上之后，在测试系统上的第一测量区域下游布置的第二测量区域中结合的分析物的一部分，与分析物浓度相关的浓度测量N 在液体样品中，根据测量信号的以下连接，由评估装置确定：N =（sj）i + 2 [si - （（si）j - i - 1。sj）1 j - i]。（（s i）j-i-1，s j）i j-1，并且在选择性进一步处理之后，由评估装置输出浓度测量值。此外，本发明涉及一种用于确定液体样品中的分析物以及用于执行功能以确定液体样品中的分析物的计算机可读介质的分析装置。

5. 发明授权

US08129138B2 Method and apparatus for determining an analyte in a liquid sample 有权
标题翻译：用于测定液体样品中分析物的方法和装置
公开(公告)号：US08129138B2
公开(公告)日：2012-03-06
申请号：US12478878
申请日：2009-06-05
申请人： Erich Haendler , Norbert Oranth
发明人： Erich Haendler , Norbert Oranth
IPC分类号： C12M1/34 , C12Q1/02 , G01N21/00 , G01N30/96
CPC分类号： G01N33/557 , G01N21/8483 , G01N33/558
摘要： A method for the determination of an analyte in a liquid sample, especially a body liquid sample, with the aid of an analytical apparatus. The apparatus receives a first measuring signal si (i=0, 1, . . . ) and a second measuring signal sj (j=1, 2, . . . ; j>i) for a test system with several successively arranged measuring areas through which a liquid sample with an analyte can flow after being applied on the test system are received by an evaluation apparatus comprised by the analytical apparatus, wherein the first measuring signal si indicates a part of the analyte bound in a first measuring area and the second measuring signal sj indicates a part of the analyte bound in a second measuring area that is arranged downstream the first measuring area on the test system after the application of the liquid sample on the test system, a concentration measure N correlating with the concentration of the analyte in the liquid sample is determined by the evaluation apparatus in accordance with the following linkage of measuring signals: N = ( s j ) i + 2 [ s i - ( ( s i ) j - i - 1 · s j ) 1 j - i ] · ( ( s i ) j - i - 1 · s j ) i j - 1 , and the concentration measurement is outputted by the evaluation apparatus after a selective further processing. Furthermore, the invention relates to an analytical apparatus for the determination of an analyte in a liquid sample as well as to a computer readable medium for performing function to determine an analyte in a liquid sample.
摘要翻译：借助于分析装置测定液体样品，特别是体液样品中的分析物的方法。该装置接收具有多个连续布置的测量区域的测试系统的第一测量信号si（i = 0,1等）和第二测量信号sj（j = 1,2，...，j> i）通过分析装置包含的评估装置接收具有分析物的液体样品在被施加在测试系统上之后流动，其中第一测量信号si表示在第一测量区域中被结合的分析物的一部分，第二测量信号测量信号sj表示在将液体样品施加到测试系统上之后，在测试系统上的第一测量区域下游布置的第二测量区域中结合的分析物的一部分，与分析物浓度相关的浓度测量N 在液体样品中，根据测量信号的以下连接，由评估装置确定：N =（sj）i + 2 [si - （（si）j-i-1·sj）1 j -i]·（（si）j - i - 1·sj） i j-1，并且在选择性进一步处理之后，由评估装置输出浓度测量值。此外，本发明涉及一种用于确定液体样品中的分析物以及用于执行功能以确定液体样品中的分析物的计算机可读介质的分析装置。

6. 发明申请

US20090191643A1 Rotatable Test Element 有权
标题翻译：可旋转测试元件
公开(公告)号：US20090191643A1
公开(公告)日：2009-07-30
申请号：US12407419
申请日：2009-03-19
申请人： Christoph Boehm , Norbert Oranth , Juergen Spinke
发明人： Christoph Boehm , Norbert Oranth , Juergen Spinke
IPC分类号： G01N21/00 , G01N9/30
CPC分类号： B01L3/502753 , B01L3/5023 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2300/0663 , B01L2300/0681 , B01L2300/069 , B01L2300/0806 , B01L2300/0861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/082 , Y10T436/110833 , Y10T436/111666
摘要： A test element and method for detecting an analyte with the aid thereof is provided. The test element is essentially disk-shaped and flat, and can be rotated about a preferably central axis which is perpendicular to the plane of the disk-shaped test element. The test element has a sample application opening for applying a liquid sample, a capillary-active zone, in particular a porous, absorbent matrix, having a first end that is remote from the axis and a second end that is near to the axis, and a sample channel which extends from an area near to the axis to the first end of the capillary-active zone that is remote from the axis.
摘要翻译：提供了一种借助于它来检测分析物的测试元件和方法。测试元件基本上是圆盘形且平坦的，并且可以围绕垂直于盘形测试元件的平面的优选中心轴线旋转。测试元件具有用于施加液体样品，毛细管 - 活性区域，特别是多孔吸收性基质的样品施加开口，其具有远离轴线的第一端和靠近轴线的第二端，以及样品通道，其从靠近轴线的区域延伸到远离轴线的毛细管 - 活动区域的第一端。

7. 发明授权

US08137905B2 Apparatus and method for determining an analyte in a fluid 失效
标题翻译：用于确定流体中分析物的装置和方法
公开(公告)号：US08137905B2
公开(公告)日：2012-03-20
申请号：US11969278
申请日：2008-01-04
申请人： Michael Brauner , Thomas Kotnig , Dieter Mangold , Norbert Oranth , Christoph Ritter , Gerd Schweiger , Valerie Winckler-Desprez
发明人： Michael Brauner , Thomas Kotnig , Dieter Mangold , Norbert Oranth , Christoph Ritter , Gerd Schweiger , Valerie Winckler-Desprez
IPC分类号： C12Q1/00
CPC分类号： B01F13/0059 , B01F13/0818 , B01L3/50273 , B01L2200/16 , B01L2300/0636 , B01L2300/069 , B01L2300/0825 , B01L2400/0475 , G01N2035/00534
摘要： The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being configured so as to stir the sample of fluid introduced into the stirring zone and being loaded with at least one reagent which reacts with the analyte. The invention also provides a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being loaded with the at least one reagent which reacts with the analyte.
摘要翻译：本发明涉及一种用于确定流体中分析物的装置和方法。在装置中设置的是以任选的微流体三维结构形成的搅拌区，搅拌区可以引入流体的样品，并且其中存在能够以非接触方式操作并且可选地设计的搅拌装置作为微型搅拌器，搅拌装置被配置为搅拌引入搅拌区的流体样品，并加载至少一种与分析物反应的试剂。本发明还提供一种可以非接触式操作并且可选地设计为微型搅拌器的搅拌装置，该搅拌装置装有至少一种与分析物反应的试剂。

8. 发明申请

US20090086195A1 Method and Apparatus for Analyzing a Dry-Chemical Test Element 有权
标题翻译：用于分析干化学试验元件的方法和装置
公开(公告)号：US20090086195A1
公开(公告)日：2009-04-02
申请号：US12206803
申请日：2008-09-09
申请人： Carlo Effenhauser , Erich Haendler , Norbert Oranth
发明人： Carlo Effenhauser , Erich Haendler , Norbert Oranth
IPC分类号： G01J1/00
CPC分类号： G01N21/253 , G01N21/8483
摘要： The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.
摘要翻译：本发明涉及一种用于分析干化学测试元件，特别是免疫测试元件的方法和设备，其中在该方法中，通过光学扫描分析干化学测试元件，由此测量光束离开测定区域通过检测器装置检测装载有一个或多个固定的光学活性物质的各个测量光强度的测试元件。该方法包括以下步骤：在第一测定区域的光学扫描期间，测量光束以第一测量光强度离开，来自测量光束的第一数量的光照射在检测器装置上，工作范围通过根据第一组扫描参数选择扫描参数，并且在第二测定区域的光学扫描期间，通过与第二测量光束不同的第二测量光强度离开测量光束而使检测器设备彼此适配通过根据与第一测量光强度不同的第二组扫描参数选择扫描参数，第一测量光强度，撞击检测器装置的测量光束的第二数量的光和检测器装置的工作范围彼此适配扫描参数集。

9. 发明授权

US08451511B2 Method and device for optically scanning an object and device 有权
标题翻译：用于光学扫描物体和装置的方法和装置
公开(公告)号：US08451511B2
公开(公告)日：2013-05-28
申请号：US12766482
申请日：2010-04-23
申请人： Erich Haendler , Norbert Oranth
发明人： Erich Haendler , Norbert Oranth
IPC分类号： H04N1/04 , H04N1/00 , H04N7/18 , B41J29/38 , G11C11/34 , H01J3/14 , G06K7/10
CPC分类号： G06T3/4038
摘要： A method and device for optically scanning an object is provided. A detection device optically scans a scanning region of the object by displacing the detection device and the object relative to one another into successive scanning positions spaced apart by a scanning step size along a scanning direction in an object plane. An optical imaging device generates a plurality of scanned images by imaging a partial scanning region from the object plane onto a detection surface in an image plane in the scanning positions. The plurality of scanned images are broken down into scanned part images and are combined to generate combined result images. At least one object measurement image is selected from the combined result images in accordance with one or more predetermined selection criteria.
摘要翻译：提供了一种用于光学扫描物体的方法和装置。检测装置通过将检测装置和物体相对于彼此移动到沿对象平面中的扫描方向上的扫描步长尺寸间隔开的连续扫描位置来光学扫描物体的扫描区域。光学成像装置通过将部分扫描区域从物体平面成像到扫描位置上的图像平面中的检测表面上来生成多个扫描图像。多个扫描图像被分解成扫描的部分图像并被组合以产生组合的结果图像。根据一个或多个预定的选择标准，从组合的结果图像中选择至少一个对象测量图像。

10. 发明授权

US07760346B2 Method and apparatus for analyzing a dry-chemical test element 有权
标题翻译：用于分析干化学试验元件的方法和装置
公开(公告)号：US07760346B2
公开(公告)日：2010-07-20
申请号：US12206803
申请日：2008-09-09
申请人： Carlo Effenhauser , Erich Haendler , Norbert Oranth
发明人： Carlo Effenhauser , Erich Haendler , Norbert Oranth
IPC分类号： G01J1/00
CPC分类号： G01N21/253 , G01N21/8483
摘要： The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.
摘要翻译：本发明涉及一种用于分析干化学测试元件，特别是免疫测试元件的方法和设备，其中在该方法中，通过光学扫描分析干化学测试元件，由此测量光束离开测定区域通过检测器装置检测装载有一个或多个固定的光学活性物质的各个测量光强度的测试元件。该方法包括以下步骤：在第一测定区域的光学扫描期间，测量光束以第一测量光强度离开，来自测量光束的第一数量的光照射在检测器装置上，工作范围通过根据第一组扫描参数选择扫描参数，并且在第二测定区域的光学扫描期间，通过与第二测量光束不同的第二测量光强度离开测量光束而使检测器设备彼此适配通过根据与第一测量光强度不同的第二组扫描参数选择扫描参数，第一测量光强度，撞击检测器装置的测量光束的第二数量的光和检测器装置的工作范围彼此适配扫描参数集。

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