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    • 3. 发明授权
    • Micro flow filtration system and flow filtration method
    • US10213742B2
    • 2019-02-26
    • US14386097
    • 2013-03-25
    • Norbert OranthNadine LoslebenSascha LutzAdelbert Grossmann
    • Norbert OranthNadine LoslebenSascha LutzAdelbert Grossmann
    • B01D61/14B01D61/18B01D61/20B01D61/22
    • A micro flow filtration system comprises a fluid circuitry (3) and a first reservoir (1) outside the circuitry (3) suitable for containing a fluid. The fluid circuitry (3) comprises a tangential flow filtration module (10) capable of separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid sample into the tangential flow filtration module (10) through an inlet feed (18). The fluid circuitry (3) further comprises a second reservoir (2) integrated in the fluid circuitry (3), a pump (5) for creating and driving a fluid flow, optionally at least one pressure sensor (6, 7 or 8) for acquiring and detecting data about the fluid sample, optionally a pressure regulator (9) for regulating the flow in the fluid circuitry (3) and a plurality of conduits (22) forming the fluid circuitry (3) together with the second reservoir (2), the TFF-module (10), the pump (5), the pressure sensor (6, 7 or 8) (if present) and the pressure regulator (9) (if present). The volume of the first reservoir (1) outside the circuitry (3) is significantly larger than the volume of the second reservoir (2). The first reservoir (1) outside the fluid circuitry (3) is connected to the circuitry (3) via a connection conduit (31) such that the fluid flows unidirectionally into the circuitry (3) until the first reservoir (1) is empty so that a continuous fluid flow from the first reservoir (1) to the circuitry (3) is established.
    • 4. 发明申请
    • Method and Apparatus for Determining an Analyte in a Liquid Sample
    • 用于测定液体样品中分析物的方法和装置
    • US20090305332A1
    • 2009-12-10
    • US12478878
    • 2009-06-05
    • Erich HaendlerNorbert Oranth
    • Erich HaendlerNorbert Oranth
    • C12Q1/02G01N21/00C12M1/34G01N30/96
    • G01N33/557G01N21/8483G01N33/558
    • A method for the determination of an analyte in a liquid sample, especially a body liquid sample, with the aid of an analytical apparatus. The apparatus receives a first measuring signal si (i=0, 1, . . . ) and a second measuring signal sj (j=1, 2, . . . ; j>i) for a test system with several successively arranged measuring areas through which a liquid sample with an analyte can flow after being applied on the test system are received by an evaluation apparatus comprised by the analytical apparatus, wherein the first measuring signal si indicates a part of the analyte bound in a first measuring area and the second measuring signal sj indicates a part of the analyte bound in a second measuring area that is arranged downstream the first measuring area on the test system after the application of the liquid sample on the test system, a concentration measure N correlating with the concentration of the analyte in the liquid sample is determined by the evaluation apparatus in accordance with the following linkage of measuring signals: N = ( s j ) i + 2 [ s i - ( ( s i ) j - i - 1 · s j ) 1 j - i ] · ( ( s i ) j - i - 1 · s j ) i j - 1 , and the concentration measurement is outputted by the evaluation apparatus after a selective further processing. Furthermore, the invention relates to an analytical apparatus for the determination of an analyte in a liquid sample as well as to a computer readable medium for performing function to determine an analyte in a liquid sample.
    • 借助于分析装置测定液体样品,特别是体液样品中的分析物的方法。 该装置接收具有多个连续布置的测量区域的测试系统的第一测量信号si(i = 0,1等)和第二测量信号sj(j = 1,2,...,j> i) 通过分析装置包含的评估装置接收具有分析物的液体样品在被施加在测试系统上之后流动,其中第一测量信号si表示在第一测量区域中被结合的分析物的一部分,第二测量信号 测量信号sj表示在将液体样品施加到测试系统上之后,在测试系统上的第一测量区域下游布置的第二测量区域中结合的分析物的一部分,与分析物浓度相关的浓度测量N 在液体样品中,根据测量信号的以下连接,由评估装置确定:N =(sj)i + 2 [si - ((si)j - i - 1。sj)1 j - i]。 ((s i)j-i-1,s j)i j-1,并且在选择性进一步处理之后,由评估装置输出浓度测量值。 此外,本发明涉及一种用于确定液体样品中的分析物以及用于执行功能以确定液体样品中的分析物的计算机可读介质的分析装置。
    • 5. 发明授权
    • Method and apparatus for determining an analyte in a liquid sample
    • 用于测定液体样品中分析物的方法和装置
    • US08129138B2
    • 2012-03-06
    • US12478878
    • 2009-06-05
    • Erich HaendlerNorbert Oranth
    • Erich HaendlerNorbert Oranth
    • C12M1/34C12Q1/02G01N21/00G01N30/96
    • G01N33/557G01N21/8483G01N33/558
    • A method for the determination of an analyte in a liquid sample, especially a body liquid sample, with the aid of an analytical apparatus. The apparatus receives a first measuring signal si (i=0, 1, . . . ) and a second measuring signal sj (j=1, 2, . . . ; j>i) for a test system with several successively arranged measuring areas through which a liquid sample with an analyte can flow after being applied on the test system are received by an evaluation apparatus comprised by the analytical apparatus, wherein the first measuring signal si indicates a part of the analyte bound in a first measuring area and the second measuring signal sj indicates a part of the analyte bound in a second measuring area that is arranged downstream the first measuring area on the test system after the application of the liquid sample on the test system, a concentration measure N correlating with the concentration of the analyte in the liquid sample is determined by the evaluation apparatus in accordance with the following linkage of measuring signals: N = ( s j ) i + 2 [ s i - ( ( s i ) j - i - 1 · s j ) 1 j - i ] · ( ( s i ) j - i - 1 · s j ) i j - 1 , and the concentration measurement is outputted by the evaluation apparatus after a selective further processing. Furthermore, the invention relates to an analytical apparatus for the determination of an analyte in a liquid sample as well as to a computer readable medium for performing function to determine an analyte in a liquid sample.
    • 借助于分析装置测定液体样品,特别是体液样品中的分析物的方法。 该装置接收具有多个连续布置的测量区域的测试系统的第一测量信号si(i = 0,1等)和第二测量信号sj(j = 1,2,...,j> i) 通过分析装置包含的评估装置接收具有分析物的液体样品在被施加在测试系统上之后流动,其中第一测量信号si表示在第一测量区域中被结合的分析物的一部分,第二测量信号 测量信号sj表示在将液体样品施加到测试系统上之后,在测试系统上的第一测量区域下游布置的第二测量区域中结合的分析物的一部分,与分析物浓度相关的浓度测量N 在液体样品中,根据测量信号的以下连接,由评估装置确定:N =(sj)i + 2 [si - ((si)j-i-1·sj)1 j -i]·( (si)j - i - 1·sj) i j-1,并且在选择性进一步处理之后,由评估装置输出浓度测量值。 此外,本发明涉及一种用于确定液体样品中的分析物以及用于执行功能以确定液体样品中的分析物的计算机可读介质的分析装置。
    • 8. 发明申请
    • Method and Apparatus for Analyzing a Dry-Chemical Test Element
    • 用于分析干化学试验元件的方法和装置
    • US20090086195A1
    • 2009-04-02
    • US12206803
    • 2008-09-09
    • Carlo EffenhauserErich HaendlerNorbert Oranth
    • Carlo EffenhauserErich HaendlerNorbert Oranth
    • G01J1/00
    • G01N21/253G01N21/8483
    • The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.
    • 本发明涉及一种用于分析干化学测试元件,特别是免疫测试元件的方法和设备,其中在该方法中,通过光学扫描分析干化学测试元件,由此测量光束离开测定区域 通过检测器装置检测装载有一个或多个固定的光学活性物质的各个测量光强度的测试元件。 该方法包括以下步骤:在第一测定区域的光学扫描期间,测量光束以第一测量光强度离开,来自测量光束的第一数量的光照射在检测器装置上,工作范围 通过根据第一组扫描参数选择扫描参数,并且在第二测定区域的光学扫描期间,通过与第二测量光束不同的第二测量光强度离开测量光束而使检测器设备彼此适配 通过根据与第一测量光强度不同的第二组扫描参数选择扫描参数,第一测量光强度,撞击检测器装置的测量光束的第二数量的光和检测器装置的工作范围彼此适配 扫描参数集。
    • 9. 发明授权
    • Method and device for optically scanning an object and device
    • 用于光学扫描物体和装置的方法和装置
    • US08451511B2
    • 2013-05-28
    • US12766482
    • 2010-04-23
    • Erich HaendlerNorbert Oranth
    • Erich HaendlerNorbert Oranth
    • H04N1/04H04N1/00H04N7/18B41J29/38G11C11/34H01J3/14G06K7/10
    • G06T3/4038
    • A method and device for optically scanning an object is provided. A detection device optically scans a scanning region of the object by displacing the detection device and the object relative to one another into successive scanning positions spaced apart by a scanning step size along a scanning direction in an object plane. An optical imaging device generates a plurality of scanned images by imaging a partial scanning region from the object plane onto a detection surface in an image plane in the scanning positions. The plurality of scanned images are broken down into scanned part images and are combined to generate combined result images. At least one object measurement image is selected from the combined result images in accordance with one or more predetermined selection criteria.
    • 提供了一种用于光学扫描物体的方法和装置。 检测装置通过将检测装置和物体相对于彼此移动到沿对象平面中的扫描方向上的扫描步长尺寸间隔开的连续扫描位置来光学扫描物体的扫描区域。 光学成像装置通过将部分扫描区域从物体平面成像到扫描位置上的图像平面中的检测表面上来生成多个扫描图像。 多个扫描图像被分解成扫描的部分图像并被组合以产生组合的结果图像。 根据一个或多个预定的选择标准,从组合的结果图像中选择至少一个对象测量图像。
    • 10. 发明授权
    • Method and apparatus for analyzing a dry-chemical test element
    • 用于分析干化学试验元件的方法和装置
    • US07760346B2
    • 2010-07-20
    • US12206803
    • 2008-09-09
    • Carlo EffenhauserErich HaendlerNorbert Oranth
    • Carlo EffenhauserErich HaendlerNorbert Oranth
    • G01J1/00
    • G01N21/253G01N21/8483
    • The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.
    • 本发明涉及一种用于分析干化学测试元件,特别是免疫测试元件的方法和设备,其中在该方法中,通过光学扫描分析干化学测试元件,由此测量光束离开测定区域 通过检测器装置检测装载有一个或多个固定的光学活性物质的各个测量光强度的测试元件。 该方法包括以下步骤:在第一测定区域的光学扫描期间,测量光束以第一测量光强度离开,来自测量光束的第一数量的光照射在检测器装置上,工作范围 通过根据第一组扫描参数选择扫描参数,并且在第二测定区域的光学扫描期间,通过与第二测量光束不同的第二测量光强度离开测量光束而使检测器设备彼此适配 通过根据与第一测量光强度不同的第二组扫描参数选择扫描参数,第一测量光强度,撞击检测器装置的测量光束的第二数量的光和检测器装置的工作范围彼此适配 扫描参数集。