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1. 发明授权

US08308765B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08308765B2
公开(公告)日：2012-11-13
申请号：US10840950
申请日：2004-05-07
申请人： Vahid Saadat , Tracy D. Maahs , Richard C. Ewers , Marvin C. Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang C. Lam
发明人： Vahid Saadat , Tracy D. Maahs , Richard C. Ewers , Marvin C. Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang C. Lam
IPC分类号： A61B17/04
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This unidirectional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：用于定位和固定锚固件的装置和方法适于被输送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚固件之间的组织褶皱的收紧，并且可以在一个或多个锚固件中使用紧固组织褶皱。

2. 发明授权

US07736378B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US07736378B2
公开(公告)日：2010-06-15
申请号：US10841245
申请日：2004-05-07
申请人： Tracy D. Maahs , Richard C. Ewers , Jesus Flores , Alexander Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang C. Lam
发明人： Tracy D. Maahs , Richard C. Ewers , Jesus Flores , Alexander Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang C. Lam
IPC分类号： A61B17/04
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中用于收紧组织折叠。

3. 发明授权

US08057511B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08057511B2
公开(公告)日：2011-11-15
申请号：US10841411
申请日：2004-05-07
申请人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
发明人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/00234 , A61B17/0487 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06052 , A61B2017/06176 , Y10T24/39 , Y10T24/3969
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中使用，以收紧组织褶皱。

4. 发明授权

US07601159B2 Interlocking tissue anchor apparatus and methods 有权
标题翻译：联锁组织锚装置和方法
公开(公告)号：US07601159B2
公开(公告)日：2009-10-13
申请号：US10955244
申请日：2004-09-30
申请人： Richard C. Ewers , Tracy D. Maahs , Cang C. Lam , Vahid Saadat , Chris Rothe
发明人： Richard C. Ewers , Tracy D. Maahs , Cang C. Lam , Vahid Saadat , Chris Rothe
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Interlocking tissue anchor apparatus and methods are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. Anchor assemblies can be delivered via the tissue manipulation assembly into or through the tissue. The anchors can incorporate various temporary interlocking features or spacing elements between one another to ensure that an anchor is not prematurely ejected from the needle assembly. This allows the anchor assembly to be advanced distally as well as withdrawn proximally within a deployment sheath while avoiding inadvertently ejecting an anchor.
摘要翻译：本文描述了联锁组织锚装置和方法。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。锚固组件可以经由组织操纵组件输送到组织或穿过组织。锚固件可以在彼此之间结合各种临时互锁特征或间隔元件，以确保锚不会从针组件过早地弹出。这允许锚固组件在部署护套内远端地向远侧推进，同时避免无意中弹出锚固件。

5. 发明授权

US08206417B2 Apparatus and methods for optimizing anchoring force 有权
标题翻译：用于优化锚固力的装置和方法
公开(公告)号：US08206417B2
公开(公告)日：2012-06-26
申请号：US10865243
申请日：2004-06-09
申请人： Tracy D. Maahs , Richard C. Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth J. Michlitsch
发明人： Tracy D. Maahs , Richard C. Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth J. Michlitsch
IPC分类号： A61B17/04
CPC分类号： A61B17/0482 , A61B17/0401 , A61B17/0469 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：本文描述了用于优化锚固力的装置和方法。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

6. 发明授权

US08906038B2 Devices and methods for laparoscopic gastric tissue reconfiguration 有权
标题翻译：腹腔镜胃组织重构的装置和方法
公开(公告)号：US08906038B2
公开(公告)日：2014-12-09
申请号：US13033485
申请日：2011-02-23
申请人： Richard C. Ewers , Eugene G. Chen , Tracy D. Maahs , Stuart Moran , Cang C. Lam
发明人： Richard C. Ewers , Eugene G. Chen , Tracy D. Maahs , Stuart Moran , Cang C. Lam
IPC分类号： A61B17/10 , A61B17/08 , A61B17/04 , A61B17/42 , A61F5/00 , A61B17/00 , A61B17/06 , A61B17/29
CPC分类号： A61B17/04 , A61B17/0487 , A61B17/42 , A61B2017/00349 , A61B2017/00818 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/2926 , A61F5/0083
摘要： Devices and methods for forming and securing tissue folds and elongated invaginations in gastric tissue are used as a treatment for obesity. In several embodiments, a plurality of tissue folds is formed along the greater curvature of the stomach using laparoscopic tissue anchor deployment devices. Additional embodiments include various combinations of tissue folds, elongated invaginations, and other reconfigurations of stomach tissue using laparoscopic devices or laparoscopic devices in combination with endoscopic devices.
摘要翻译：用于在胃组织中形成和固定组织褶皱和细长凹陷的装置和方法用作肥胖症的治疗。在几个实施例中，使用腹腔镜组织锚定部署装置沿着胃的较大曲率形成多个组织褶皱。另外的实施例包括使用腹腔镜装置或腹腔镜装置与内窥镜装置组合的组织折叠，细长凹陷和胃组织的其它重新配置的各种组合。

7. 发明授权

US07695493B2 System for optimizing anchoring force 有权
标题翻译：优化锚固力的系统
公开(公告)号：US07695493B2
公开(公告)日：2010-04-13
申请号：US10865736
申请日：2004-06-09
申请人： Vahid Saadat , Richard C. Ewers , Tracy D. Maahs , Alexander Khairkhahan , Kenneth J. Michlitsch
发明人： Vahid Saadat , Richard C. Ewers , Tracy D. Maahs , Alexander Khairkhahan , Kenneth J. Michlitsch
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：这里描述了用于优化锚固力的系统。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

8. 发明授权

US07520884B2 Methods for performing gastroplasty 有权
标题翻译：进行胃成形术的方法
公开(公告)号：US07520884B2
公开(公告)日：2009-04-21
申请号：US10841233
申请日：2004-05-07
申请人： Lee L. Swanstrom , Richard C. Ewers , Tracy D. Maahs , Eugene G. Chen , Vahid Saadat
发明人： Lee L. Swanstrom , Richard C. Ewers , Tracy D. Maahs , Eugene G. Chen , Vahid Saadat
IPC分类号： A61B17/08
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/085 , A61B17/1114 , A61B2017/0496 , A61B2017/081 , A61F5/0086
摘要： Methods for performing gastroplasty include reducing the effective volume or cross-sectional area of the stomach via approximation of gastric tissue. Such reduction preferably is achieved endoluminally, either with or without laparoscopic ports. In one variation, a sleeve, pouch, Magenstrasse and Mill, Vertical Banded Gastroplasty (“VBG”), etc.,is formed within the stomach by approximating opposing anterior and posterior segments or ridges of the stomach wall at locations inferior to the gastroesophageal junction. In another variation, opposing walls of the stomach are approximated at a plurality of substantially random locations to reduce an effective volume of the stomach. In yet another variation, both a sleeve and random approximations are formed, the random approximations preferably disposed in a portion of the stomach excluded by the sleeve. In still another variation, opposing walls of the stomach are approximated over significant lengths at random or specified locations.
摘要翻译：进行胃成形术的方法包括通过胃组织的近似来减小胃的有效体积或横截面积。这种减少优选是在腹腔镜下或腹腔镜下进行的。在一个变型中，通过在胃壁下方的胃壁的相邻的前部和后部区段或脊部近似形成在胃内形成套筒，袋，Magenstrasse和Mill，垂直带状胃成形术（“VBG”）等。在另一个变型中，胃的相对壁在多个基本上随机的位置近似，以减少胃的有效体积。在另一个变型中，形成套筒和随机近似，随机近似优选地设置在由套筒排除的胃的一部分中。在另一个变体中，胃的相对的壁在随机或指定的位置处以相当长的长度近似。

9. 发明授权

US08439898B2 Endoscopic tissue anchor deployment 有权
标题翻译：内窥镜组织锚部署
公开(公告)号：US08439898B2
公开(公告)日：2013-05-14
申请号：US12486578
申请日：2009-06-17
申请人： Cang C. Lam , Stuart Moran , Tracy D. Maahs , John Fernando Rodriguez , Seferino Enrique Torres , Wesley Lummis
发明人： Cang C. Lam , Stuart Moran , Tracy D. Maahs , John Fernando Rodriguez , Seferino Enrique Torres , Wesley Lummis
IPC分类号： A61B17/00
CPC分类号： A61B1/018 , A61B17/0401 , A61B17/0487 , A61B17/29 , A61B2017/00353 , A61B2017/0409 , A61B2017/0417 , A61B2017/0464 , A61B2017/06052 , A61B2017/2905 , A61B2017/2916
摘要： An endoscopic tissue anchor deployment device includes a handle, an elongated shaft defining an internal lumen, and an end effector attached to the distal end of the elongated shaft. A tissue anchor catheter is removably inserted through the lumen of the elongated shaft, the catheter having a tissue anchor assembly that is deployable from its distal end. In some embodiments, the handle includes a pin and track assembly that define a series of handle actuation steps corresponding to deployment steps for the deployment device end effector and the tissue anchor catheter. In some embodiments, the handle includes a catheter stop member that prevents movement of the tissue anchor catheter under certain circumstances, and a handle stop member that prevents actuation of the handle under certain circumstances.
摘要翻译：内窥镜组织锚定部署装置包括手柄，限定内腔的细长轴和附接到细长轴的远端的端部执行器。组织锚导管可移除地插入穿过细长轴的内腔，该导管具有可从其远端展开的组织锚组件。在一些实施例中，手柄包括销和轨道组件，其限定对应于展开装置端部执行器和组织锚固导管的展开步骤的一系列手柄致动步骤。在一些实施例中，手柄包括防止组织锚固导管在某些情况下移动的导管止动构件以及在某些情况下阻止手柄致动的手柄止动构件。

10. 发明申请

US20090312603A1 ENDOSCOPIC TISSUE ANCHOR DEPLOYMENT 有权
标题翻译：内窥镜组织锚固部分
公开(公告)号：US20090312603A1
公开(公告)日：2009-12-17
申请号：US12486578
申请日：2009-06-17
申请人： Cang C. LAM , Stuart Moran , Tracy D. Maahs , John Fernando Rodriguez , Seferino Enrique Torres , Wesley Lummis
发明人： Cang C. LAM , Stuart Moran , Tracy D. Maahs , John Fernando Rodriguez , Seferino Enrique Torres , Wesley Lummis
IPC分类号： A61B1/018
CPC分类号： A61B1/018 , A61B17/0401 , A61B17/0487 , A61B17/29 , A61B2017/00353 , A61B2017/0409 , A61B2017/0417 , A61B2017/0464 , A61B2017/06052 , A61B2017/2905 , A61B2017/2916
摘要： An endoscopic tissue anchor deployment device includes a handle, an elongated shaft defining an internal lumen, and an end effector attached to the distal end of the elongated shaft. A tissue anchor catheter is removably inserted through the lumen of the elongated shaft, the catheter having a tissue anchor assembly that is deployable from its distal end. In some embodiments, the handle includes a pin and track assembly that define a series of handle actuation steps corresponding to deployment steps for the deployment device end effector and the tissue anchor catheter. In some embodiments, the handle includes a catheter stop member that prevents movement of the tissue anchor catheter under certain circumstances, and a handle stop member that prevents actuation of the handle under certain circumstances.
摘要翻译：内窥镜组织锚定部署装置包括手柄，限定内腔的细长轴和附接到细长轴的远端的端部执行器。组织锚导管可移除地插入穿过细长轴的内腔，该导管具有可从其远端展开的组织锚组件。在一些实施例中，手柄包括销和轨道组件，其限定对应于展开装置端部执行器和组织锚固导管的展开步骤的一系列手柄致动步骤。在一些实施例中，手柄包括防止组织锚固导管在某些情况下移动的导管止动构件以及在某些情况下阻止手柄致动的手柄止动构件。

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