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1. 发明授权

US08308765B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08308765B2
公开(公告)日：2012-11-13
申请号：US10840950
申请日：2004-05-07
申请人： Vahid Saadat , Tracy D. Maahs , Richard C. Ewers , Marvin C. Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang C. Lam
发明人： Vahid Saadat , Tracy D. Maahs , Richard C. Ewers , Marvin C. Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang C. Lam
IPC分类号： A61B17/04
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This unidirectional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：用于定位和固定锚固件的装置和方法适于被输送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚固件之间的组织褶皱的收紧，并且可以在一个或多个锚固件中使用紧固组织褶皱。

2. 发明授权

US08057511B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08057511B2
公开(公告)日：2011-11-15
申请号：US10841411
申请日：2004-05-07
申请人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
发明人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/00234 , A61B17/0487 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06052 , A61B2017/06176 , Y10T24/39 , Y10T24/3969
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中使用，以收紧组织褶皱。

3. 发明申请

US20050251157A1 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US20050251157A1
公开(公告)日：2005-11-10
申请号：US10840950
申请日：2004-05-07
申请人： Vahid Saadat , Tracy Maahs , Richard Ewers , Marvin Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang Lam
发明人： Vahid Saadat , Tracy Maahs , Richard Ewers , Marvin Elmers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Cang Lam
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This unidirectional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚固件之间的组织褶皱的收紧，并且可以在一个或多个锚固件中使用紧固组织褶皱。

4. 发明申请

US20050251207A1 Apparatus and methods for positioning and securing anchors 有权
公开(公告)号：US20050251207A1
公开(公告)日：2005-11-10
申请号：US10841411
申请日：2004-05-07
申请人： Jesus Flores , Richard Ewers , Tracy Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
发明人： Jesus Flores , Richard Ewers , Tracy Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06
CPC分类号： A61B17/0469 , A61B17/00234 , A61B17/0487 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06052 , A61B2017/06176 , Y10T24/39 , Y10T24/3969
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.

5. 发明申请

US20050251206A1 Apparatus and methods for positioning and securing anchors 有权
公开(公告)号：US20050251206A1
公开(公告)日：2005-11-10
申请号：US10841245
申请日：2004-05-07
申请人： Tracy Maahs , Richard Ewers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang Lam
发明人： Tracy Maahs , Richard Ewers , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat , Cang Lam
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/08 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.

6. 发明申请

US20050251205A1 Apparatus and methods for positioning and securing anchors 审中-公开
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US20050251205A1
公开(公告)日：2005-11-10
申请号：US10840951
申请日：2004-05-07
申请人： Richard Ewers , Tracy Maahs , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
发明人： Richard Ewers , Tracy Maahs , Jesus Flores , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/28 , A61B17/34
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/10 , A61B17/29 , A61B2017/00827 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06052 , A61B2017/06176 , A61B2017/081 , A61B2017/3488 , Y10T24/39 , Y10T24/3936 , Y10T24/3969
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中使用，以收紧组织褶皱。

7. 发明授权

US08206417B2 Apparatus and methods for optimizing anchoring force 有权
标题翻译：用于优化锚固力的装置和方法
公开(公告)号：US08206417B2
公开(公告)日：2012-06-26
申请号：US10865243
申请日：2004-06-09
申请人： Tracy D. Maahs , Richard C. Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth J. Michlitsch
发明人： Tracy D. Maahs , Richard C. Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth J. Michlitsch
IPC分类号： A61B17/04
CPC分类号： A61B17/0482 , A61B17/0401 , A61B17/0469 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：本文描述了用于优化锚固力的装置和方法。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

8. 发明申请

US20050277981A1 Apparatus and methods for optimizing anchoring force 有权
标题翻译：用于优化锚固力的装置和方法
公开(公告)号：US20050277981A1
公开(公告)日：2005-12-15
申请号：US10865243
申请日：2004-06-09
申请人： Tracy Maahs , Richard Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth Michlitsch
发明人： Tracy Maahs , Richard Ewers , Vahid Saadat , Alex Khairkhahan , Kenneth Michlitsch
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B19/00
CPC分类号： A61B17/0482 , A61B17/0401 , A61B17/0469 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：本文描述了用于优化锚固力的装置和方法。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

9. 发明申请

US20050277983A1 System for optimizing anchoring force 有权
标题翻译：优化锚固力的系统
公开(公告)号：US20050277983A1
公开(公告)日：2005-12-15
申请号：US10865736
申请日：2004-06-09
申请人： Vahid Saadat , Richard Ewers , Tracy Maahs , Alex Khairkhahan , Kenneth Michlitsch
发明人： Vahid Saadat , Richard Ewers , Tracy Maahs , Alex Khairkhahan , Kenneth Michlitsch
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/08 , A61B19/00
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：这里描述了用于优化锚固力的系统。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

10. 发明授权

US08845717B2 Coaptation enhancement implant, system, and method 有权
标题翻译：接合增强植入物，系统和方法
公开(公告)号：US08845717B2
公开(公告)日：2014-09-30
申请号：US13099532
申请日：2011-05-03
申请人： Alex Khairkhahan , Michael D. Lesh
发明人： Alex Khairkhahan , Michael D. Lesh
IPC分类号： A61F2/24 , A61F2/00 , A61B17/068 , A61B17/064 , A61B17/12 , A61B17/04 , A61B17/00
CPC分类号： A61F2/246 , A61B17/0401 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12172 , A61B2017/00867 , A61B2017/0412 , A61B2017/0448 , A61B2017/0464 , A61B2017/048 , A61B2017/0649 , A61F2/2454 , A61F2/2457 , A61F2/2466 , A61F2250/0003
摘要： Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.
摘要翻译：植入物，植入物系统和治疗二尖瓣关闭不全的其它瓣膜疾病的方法通常包括接合辅助体，其保持在血流动路径内，因为瓣膜的小叶移动，瓣膜体通常相对较薄（沿着血流路径）和/或适形结构，其从合缝延伸到合缝，允许天然小叶在心脏周期阶段期间在心脏周期阶段期间接合并密封在阀体两侧的大的相对表面上，当心室收缩为空血液室，并允许血液在阀体周围通过，使得血液在心脏周期的充盈阶段期间从心房流向心室。在每个连合处附近单独部署独立的锚杆可以促进示例性三角形阀体的定位和支撑，其中第三锚定部分在心室中。阀体的外表面可以适应组织向内生长或内皮化，而吸入液体的基质可以在引入心脏后膨胀。可以在锚定器部署之后选择阀体形状，并且基于导管的部署系统可以具有期望的低轮廓。

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