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1. 发明申请

WO2013013105A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR REPAIRING CARTILAGE DAMAGE 审中-公开
标题翻译：用于重编程细胞的组合物和方法，其无需遗传修饰以修复软骨损伤
公开(公告)号：WO2013013105A2
公开(公告)日：2013-01-24
申请号：PCT/US2012/047495
申请日：2012-07-19
申请人： VIVOSCRIPT,INC. , OREGON HEALTH AND SCIENCE UNIVERSITY , ZHU, Yong , WU, Shili , BAO, Jun , CHU, Cong-Qiu
发明人： ZHU, Yong , WU, Shili , BAO, Jun , CHU, Cong-Qiu
IPC分类号： C12N15/11 , C07K14/00 , C12N5/077 , A61K38/16 , A61L27/38 , C07K19/00
CPC分类号： C07K17/06 , A61K38/00 , A61K47/64 , A61K47/645 , A61L27/3612 , A61L27/3654 , C07K14/4702 , C07K14/4703 , C07K14/4716 , C07K2319/21 , C07K2319/60 , C12N5/0637 , C12N5/0655 , C12N5/0676 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/14 , G01N33/5073
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于其他细胞（诸如胚胎干细胞（ESC），诱导多能干细胞（iPSC），MSC，成纤维细胞，造血干细胞，内皮素的重编程的组合物和方法干细胞，脂肪细胞，软骨细胞，成骨细胞，破骨细胞和内皮细胞）向软骨细胞分化，而不向样品中引入外源基因。特别地，本发明涉及能够转导入生物样品但不是基因或导致遗传修饰的转导物质。本发明还涉及重新编程生物样品途径或使用其可转导组合物治疗疾病的方法。

2. 发明申请

WO2011163531A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰以治疗心血管疾病
公开(公告)号：WO2011163531A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041709
申请日：2011-06-23
申请人： VIVOSCRIPT, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C12N15/01 , C12N5/07 , C12N15/12 , C07K14/47 , A61K38/17 , A61P9/00
CPC分类号： A61K38/16 , A61K38/00 , B82Y5/00 , C12N5/0637 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , Y10S977/773
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如成纤维细胞）重编程成心肌细胞而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

3. 发明申请

WO2011097181A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰治疗神经病
公开(公告)号：WO2011097181A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023259
申请日：2011-02-01
申请人： VIVOSCRIPT,INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C12N15/12 , C12N15/09 , C07K14/47 , A61K38/17 , C12N15/85 , C12N5/10 , A61P25/28 , A61P25/16
CPC分类号： C12N5/0636 , A61K38/00 , C07K14/08 , C12N5/0619 , C12N5/0676 , C12N5/0696 , C12N2501/065 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/99 , C12N2506/08 , C12N2506/11 , C12N2506/1307 , C12N2506/14 , C12N2770/30041 , C12N2770/30045
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如神经胶质细胞）重编程成神经元而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

4. 发明申请

WO2010075575A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，无遗传修饰
公开(公告)号：WO2010075575A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069518
申请日：2009-12-23
申请人： BIOPIPS, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N5/0696 , A61K2035/122 , C12N5/0637 , C12N5/0676 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

5. 发明申请

WO2011050334A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF OBESITY AND RELATED DISEASES 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，无遗传修饰用于治疗肥胖和相关疾病
公开(公告)号：WO2011050334A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053865
申请日：2010-10-22
申请人： ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： A61K38/00
CPC分类号： A61K38/16 , Y02A50/414
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as white fat cells) into brown fat cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如白色脂肪细胞）重新编程成棕色脂肪细胞而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品中但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

6. 发明公开

EP1731530A1 A KIND OF FUSION PROTEIN, GENE ENCODING IT, EXPRESSION METHOD AND USE THEREOF 审中-公开
标题翻译： EINE ART FUSIONSPROTEIN，GEN，DAS DIESES CODIERT，EXPRESSIONSVERFAHREN UND ANWENDUNG DAVON
公开(公告)号：EP1731530A1
公开(公告)日：2006-12-13
申请号：EP04731810.0
申请日：2004-05-08
申请人： Wu, Xianggui , Chen, Haiming , Gao, Junyu , Bao, Jun
发明人： CHEN, Haiming , GAO, Junyu , BAO, Jun
IPC分类号： C07K16/46 , C12N15/62 , A61K39/395 , A61P37/08
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2319/30 , Y10S530/862 , Y10S530/868
摘要： This invention provides a fusion protein (FP4) and the code gene, expression method, and clinical application; its goal is to provide a fusion protein, the code gene, and the expression method as well as to take this fusion protein as the active constituent anti-allergic medicine. In addition, the invention provides the sequence of fusion protein attached on SEQ ID 2 and any derivation protein of the fusion protein (FP4) which includes adding or deleting several amino acids of SEQ ID2 as well as increasing or deducing nuclear tides of SEQ ID 1. We designed to cross-link IgE active receptor and an IgG inhibitory receptor by endogens hinge without any extraneous chemical link. This invention fusion protein has function to block the IgE acceptor, moreover fragment of fusion protein has ability to specifically bind to a native IgG inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motif, thereby inhibiting the IgE-driven mediator release from mast cells and basophils. It will play important role in the allergic disease treatment.
摘要翻译：本发明提供融合蛋白（FP4）及其代码基因，表达方法和临床应用; 其目标是提供融合蛋白，代码基因和表达方法，并将该融合蛋白作为活性成分抗过敏药物。此外，本发明提供了连接在SEQ ID 2上的融合蛋白的序列和融合蛋白（FP4）的任何衍生蛋白，其包括添加或缺失SEQ ID2的几个氨基酸，以及增加或推导出SEQ ID No.1 我们设计通过内源性铰链交联IgE活性受体和IgG抑制受体，而没有任何外来化学连接。本发明融合蛋白具有阻断IgE受体的功能，此外，融合蛋白的片段具有与含有免疫受体酪氨酸的抑制基序的天然IgG抑制受体特异性结合的能力，从而抑制IgE驱动的介体从肥大细胞和嗜碱性粒细胞释放。它将在过敏性疾病治疗中发挥重要作用。

7. 发明申请

WO2015188020A1 METHODS FOR REPAIRING CARTILAGE DAMAGE 审中-公开
标题翻译：修复损伤的方法
公开(公告)号：WO2015188020A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034309
申请日：2015-06-05
申请人： VIVOSCRIPT, INC.
发明人： CHU, Cong-Qiu , ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： A61K38/00
CPC分类号： A61L27/3852 , A61K9/0024 , A61K9/06 , A61K38/1709 , A61K47/42 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3834 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/412 , A61L2430/06 , C07K14/47 , C07K2319/00 , C07K2319/095 , C07K2319/10 , C07K2319/60
摘要： A method for repairing cartilage damage comprising (a) creating a microfracture or performing other bone marrow stimulation techniques on a patient inflicted with cartilage damage; and (b) administering a composition to the microfracture, wherein the composition comprises an agent capable of regenerating organized hyaline cartilage.
摘要翻译：一种修复软骨损伤的方法，包括（a）在患有软骨损伤的患者身上产生微裂缝或执行其他骨髓刺激技术; 和（b）向所述微裂缝施用组合物，其中所述组合物包含能够再生有组织的透明软骨的药剂。

8. 发明申请

WO2012045275A1 MOESIN FRAGMENTS ASSOCIATED WITH APLASTIC ANEMIA 审中-公开
标题翻译：与APLASTIC ANEMIA相关的MOESIN片段
公开(公告)号：WO2012045275A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080523
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
发明人： ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
IPC分类号： A61K38/16 , C07K2/00
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , G01N33/564 , G01N2800/22
摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.
摘要翻译：本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

9. 发明申请

WO2012045279A1 MOESIN FRAGMENTS ASSOCIATED WITH IMMUNE THROMBOCYTOPENIA 审中-公开
标题翻译：与免疫性血栓形成相关的MOESIN片段
公开(公告)号：WO2012045279A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080532
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun
发明人： ZHANG, Yue , BAO, Jun
IPC分类号： A61K38/16 , C07K2/00
CPC分类号： G01N33/6854 , C07K14/52 , C07K2319/02 , C07K2319/50 , G01N33/564 , G01N2800/222 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring immune thrombocytopenia.
摘要翻译：本申请提供了用于检测和监测免疫血小板减少症的组合物和方法。

10. 发明申请

WO2012045281A1 DIAGNOSTIC AND THERAPEUTIC USES OF MOESIN FRAGMENTS 审中-公开
标题翻译：糖蛋白片的诊断和治疗用途
公开(公告)号：WO2012045281A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080538
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun
发明人： ZHANG, Yue , BAO, Jun
IPC分类号： A61K38/02 , A61K39/395 , G01N33/564 , A61P7/00
CPC分类号： A61K39/3955 , A61K38/1703 , A61K38/1709 , C07K16/18 , C07K2317/76 , G01N33/564 , G01N33/6854 , G01N2800/10 , G01N2800/52
摘要： The present application provides compositions and methods for modulating the activity and quantity of platelets and preventing and treating disorders or diseases associated with abnormal activity and quantity of platelets.
摘要翻译：本申请提供调节血小板的活性和量的组合物和方法，并预防和治疗与血小板的异常活性和数量相关的疾病或疾病。

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