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1. 发明申请

WO2011163531A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰以治疗心血管疾病
公开(公告)号：WO2011163531A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041709
申请日：2011-06-23
申请人： VIVOSCRIPT, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C12N15/01 , C12N5/07 , C12N15/12 , C07K14/47 , A61K38/17 , A61P9/00
CPC分类号： A61K38/16 , A61K38/00 , B82Y5/00 , C12N5/0637 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , Y10S977/773
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如成纤维细胞）重编程成心肌细胞而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

2. 发明申请

WO2011097181A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰治疗神经病
公开(公告)号：WO2011097181A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023259
申请日：2011-02-01
申请人： VIVOSCRIPT,INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C12N15/12 , C12N15/09 , C07K14/47 , A61K38/17 , C12N15/85 , C12N5/10 , A61P25/28 , A61P25/16
CPC分类号： C12N5/0636 , A61K38/00 , C07K14/08 , C12N5/0619 , C12N5/0676 , C12N5/0696 , C12N2501/065 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/99 , C12N2506/08 , C12N2506/11 , C12N2506/1307 , C12N2506/14 , C12N2770/30041 , C12N2770/30045
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as glial cells) into neurons without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如神经胶质细胞）重编程成神经元而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

3. 发明申请

WO2013013105A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR REPAIRING CARTILAGE DAMAGE 审中-公开
标题翻译：用于重编程细胞的组合物和方法，其无需遗传修饰以修复软骨损伤
公开(公告)号：WO2013013105A2
公开(公告)日：2013-01-24
申请号：PCT/US2012/047495
申请日：2012-07-19
申请人： VIVOSCRIPT,INC. , OREGON HEALTH AND SCIENCE UNIVERSITY , ZHU, Yong , WU, Shili , BAO, Jun , CHU, Cong-Qiu
发明人： ZHU, Yong , WU, Shili , BAO, Jun , CHU, Cong-Qiu
IPC分类号： C12N15/11 , C07K14/00 , C12N5/077 , A61K38/16 , A61L27/38 , C07K19/00
CPC分类号： C07K17/06 , A61K38/00 , A61K47/64 , A61K47/645 , A61L27/3612 , A61L27/3654 , C07K14/4702 , C07K14/4703 , C07K14/4716 , C07K2319/21 , C07K2319/60 , C12N5/0637 , C12N5/0655 , C12N5/0676 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/14 , G01N33/5073
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于其他细胞（诸如胚胎干细胞（ESC），诱导多能干细胞（iPSC），MSC，成纤维细胞，造血干细胞，内皮素的重编程的组合物和方法干细胞，脂肪细胞，软骨细胞，成骨细胞，破骨细胞和内皮细胞）向软骨细胞分化，而不向样品中引入外源基因。特别地，本发明涉及能够转导入生物样品但不是基因或导致遗传修饰的转导物质。本发明还涉及重新编程生物样品途径或使用其可转导组合物治疗疾病的方法。

4. 发明申请

WO2010075575A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，无遗传修饰
公开(公告)号：WO2010075575A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069518
申请日：2009-12-23
申请人： BIOPIPS, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N5/0696 , A61K2035/122 , C12N5/0637 , C12N5/0676 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

5. 发明申请

WO2011050334A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF OBESITY AND RELATED DISEASES 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，无遗传修饰用于治疗肥胖和相关疾病
公开(公告)号：WO2011050334A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053865
申请日：2010-10-22
申请人： ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： A61K38/00
CPC分类号： A61K38/16 , Y02A50/414
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as white fat cells) into brown fat cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如白色脂肪细胞）重新编程成棕色脂肪细胞而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品中但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

6. 发明申请

WO2015017424A1 TRANSDUCIBLE MATERIALS FOR CELL REPROGRAMMING 审中-公开
标题翻译：用于细胞转录的可转移材料
公开(公告)号：WO2015017424A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/048646
申请日：2014-07-29
申请人： VIVOSCRIPT, INC.
发明人： ZHU, Yong , CHEN, Huei-Sheng Vincent , WU, Shili , BAO, Jun
IPC分类号： C07K14/435 , C12N5/02 , A61K38/17
CPC分类号： C12N5/0662 , A61K38/17 , C07K14/43595 , C07K14/47 , C07K2319/09 , C07K2319/095 , C07K2319/10 , C07K2319/60 , C12N2501/60 , C12N2501/999 , C12N2506/13
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the sample. In particular, the present inventions are directed to transducible materials that are capable of transducing into the nuclei and have enhanced retention in the nuclei of the biological sample. The present inventions also are directed to methods of reprogramming a biological sample or treating diseases using the transducible compositions thereof.
摘要翻译：本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导入细胞核并且具有增强的生物样品核的保留性的可导出材料。本发明还涉及使用其可转导组合物重新编程生物样品或治疗疾病的方法。

7. 发明申请

WO2015188020A1 METHODS FOR REPAIRING CARTILAGE DAMAGE 审中-公开
标题翻译：修复损伤的方法
公开(公告)号：WO2015188020A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034309
申请日：2015-06-05
申请人： VIVOSCRIPT, INC.
发明人： CHU, Cong-Qiu , ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： A61K38/00
CPC分类号： A61L27/3852 , A61K9/0024 , A61K9/06 , A61K38/1709 , A61K47/42 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3834 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/412 , A61L2430/06 , C07K14/47 , C07K2319/00 , C07K2319/095 , C07K2319/10 , C07K2319/60
摘要： A method for repairing cartilage damage comprising (a) creating a microfracture or performing other bone marrow stimulation techniques on a patient inflicted with cartilage damage; and (b) administering a composition to the microfracture, wherein the composition comprises an agent capable of regenerating organized hyaline cartilage.
摘要翻译：一种修复软骨损伤的方法，包括（a）在患有软骨损伤的患者身上产生微裂缝或执行其他骨髓刺激技术; 和（b）向所述微裂缝施用组合物，其中所述组合物包含能够再生有组织的透明软骨的药剂。

8. 发明申请

WO2018053188A1 COSMETIC TENSIONING COMPOSITION 审中-公开
标题翻译：化妆品张力组合物
公开(公告)号：WO2018053188A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051647
申请日：2017-09-14
申请人： ZHU, Yong , GUAY, Gordon Gerald
发明人： ZHU, Yong , GUAY, Gordon Gerald
IPC分类号： A61K8/25 , A61Q1/00 , A61Q1/04 , A61Q1/10 , A61Q5/06 , A61Q19/00 , A61K8/81
摘要： A cosmetic composition having a film-forming tensioning polymer system and at least one hydrophilic non-colloidal particulate agent comprising precipitated silica particles is disclosed. The film forming composition comprises a first non-crosslinking polyamide/polyacrylate copolymer comprising at least one amide monomer; (meth)acrylate monomers; monomers having at least one carboxylic functional group; and monomers having at least one amine functional group. The film forming composition also comprises a second non-crosslinking polyamide copolymer comprising at least one amide; at least one quaternary ammonium containing monomer; and monomers having at least one amine functional group.
摘要翻译：公开了具有成膜张力聚合物体系和至少一种包含沉淀二氧化硅颗粒的亲水性非胶体颗粒剂的化妆品组合物。成膜组合物包含第一非交联聚酰胺/聚丙烯酸酯共聚物，其包含至少一种酰胺单体; （甲基）丙烯酸酯单体; 具有至少一个羧基官能团的单体; 和具有至少一个胺官能团的单体。成膜组合物还包含第二种非交联聚酰胺共聚物，其包含至少一种酰胺; 至少一种含季铵的单体; 和具有至少一个胺官能团的单体。

9. 发明申请

WO2010015702A1 CASING FOR SHELTERING ELECTRONIC COMPONENTS, NETWORK ELEMENT AND AIR PASSAGE 审中-公开
标题翻译：电子元件，网络元件和空气通风
公开(公告)号：WO2010015702A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060272
申请日：2009-08-07
申请人： NOKIA SIEMENS NETWORKS OY , HUANG, Zi Liang , ZHU, Yong
发明人： HUANG, Zi Liang , ZHU, Yong
IPC分类号： H05K7/20
CPC分类号： H05K7/20009 , H05K5/0213 , H05K7/20536
摘要： A casing for sheltering electronic components (52, 83) is disclosed, comprising: - an air inlet (110) at a first position of the casing (11) and, - an air outlet at a second position of the casing (11). The air inlet (110) comprises a first plate (112) with at least one first aperture (190) therein. The inlet (110) also comprises a second plate (114) that is arranged between the first plate (112) and an inner part of the casing (11). The second plate comprises at least one second aperture (192).
摘要翻译：公开了一种用于防护电子部件（52,83）的壳体，包括： - 在所述壳体（11）的第一位置处的空气入口（110）和 - 所述壳体（11）的第二位置处的空气出口。空气入口（110）包括其中具有至少一个第一孔（190）的第一板（112）。入口（110）还包括布置在第一板（112）和壳体（11）的内部之间的第二板（114）。第二板包括至少一个第二孔（192）。

10. 发明申请

WO2019006334A1 FILM FORMING COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2019006334A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040341
申请日：2018-06-29
申请人： ZHU, Yong
发明人： ZHU, Yong
IPC分类号： A45D34/04 , A45D40/26 , C09D133/06 , C09D139/00
CPC分类号： A45D34/042 , A45D40/262 , C09D133/06 , C09D133/064 , C09D139/00 , C08L39/00 , C08L33/06 , C08L33/26 , C08L33/14
摘要： The present disclosure is directed to film forming compositions comprising a first anionic or non-ionic non-crosslinking polyacrylate random copolymer and a second cationic non-crosslinking polyamide random copolymer. The present disclosure is also directed to methods of using the film forming compositions.

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