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1. 发明申请

WO2012045273A1 MOESIN FRAGMENTS AND USES THEREOF 审中-公开
标题翻译： MOESIN片段及其用途
公开(公告)号：WO2012045273A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080519
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZENG, Xiaofeng , ZHANG, Yue , SHOU, Zhinan , MAO, Hua , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
发明人： ZENG, Xiaofeng , ZHANG, Yue , SHOU, Zhinan , MAO, Hua , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
IPC分类号： A61K38/02 , G01N33/564
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , C07K14/705 , C07K16/18 , G01N33/564 , G01N33/6854 , G01N2800/52
摘要： The present invention provides compositions and methods useful for detecting and monitoring autoimmune diseases.
摘要翻译：本发明提供了用于检测和监测自身免疫疾病的组合物和方法。

2. 发明申请

WO2012045275A1 MOESIN FRAGMENTS ASSOCIATED WITH APLASTIC ANEMIA 审中-公开
标题翻译：与APLASTIC ANEMIA相关的MOESIN片段
公开(公告)号：WO2012045275A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080523
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
发明人： ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
IPC分类号： A61K38/16 , C07K2/00
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , G01N33/564 , G01N2800/22
摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.
摘要翻译：本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

3. 发明申请

WO2010129537A1 PHOSPHOPEPTIDES AS MELANOMA VACCINES 审中-公开
标题翻译：磷酸盐作为微生物疫苗
公开(公告)号：WO2010129537A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033530
申请日：2010-05-04
申请人： THE JOHNS HOPKINS UNIVERSITY , UNIVERSITY OF VIRGINIA PATENT FOUNDATION , TOPALIAN, Suzanne L. , DEPONTIEU, Florence A. , HUNT, Donald F. , SHABANOWITZ, Jeffrey , QIAN, Jie , ENGELHARD, Victor H. , ZARLING, Angela Lee
发明人： TOPALIAN, Suzanne L. , DEPONTIEU, Florence A. , HUNT, Donald F. , SHABANOWITZ, Jeffrey , QIAN, Jie , ENGELHARD, Victor H. , ZARLING, Angela Lee
IPC分类号： C07K2/00 , A61K39/385 , A61K39/00
CPC分类号： C07K14/4748 , A61K39/0011 , A61K39/39 , A61K2039/5154 , A61K2039/5158 , G01N33/5743
摘要： We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived from source proteins which may have roles in cancer development, growth and metastasis. Most were expressed exclusively by either melanomas or transformed B cells, suggesting the potential to define cell type-specific phosphatome "fingerprints". We generated HLA-DRβ1*0101-restricted CD4 + T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells showed specificity for phosphopeptide-pulsed antigen presenting cells as well as for intact melanoma cells. MHC II-restricted phosphopeptides recognizable by human CD4 + T cells are potential targets for cancer immunotherapy.
摘要翻译：我们使用顺序亲和分离，生物化学富集，质谱测序和比较分析鉴定了总共175个HLA-DR相关磷酸肽。许多来源于可能在癌症发展，生长和转移中起作用的源蛋白质。大多数仅由黑素瘤或转化的B细胞表达，表明可能定义细胞类型特异性磷酸酯“指纹”。我们产生HLA-DRß1* 0101限制性CD4 + T细胞，特异于两种黑素瘤细胞系中鉴定的磷酸化MART-1肽。这些T细胞对磷酸肽脉冲的抗原呈递细胞以及完整的黑素瘤细胞显示出特异性。人CD4 + T细胞可识别的MHC II限制性磷酸肽是癌症免疫治疗的潜在靶标。

4. 发明申请

US20090024184A1 COCHLEAR IMPLANT UTILIZING MULTIPLE-RESOLUTION CURRENT SOURCES AND FLEXIBLE DATA ENCODING 审中-公开
标题翻译：使用多分辨率电流源和灵活数据编码的COCHLEAR IMPLAN
公开(公告)号：US20090024184A1
公开(公告)日：2009-01-22
申请号：US11779216
申请日：2007-07-17
申请人： Xiaoan Sun , Hongbin Chen , Qian-Jie Fu , Fan-Gang Zeng
发明人： Xiaoan Sun , Hongbin Chen , Qian-Jie Fu , Fan-Gang Zeng
IPC分类号： A61N1/36
CPC分类号： A61N1/36038
摘要： A programmable cochlear implant system utilizes multiple-resolution current sources and flexible data-encoding scheme for transcutaneous transmission. In certain embodiments, the number of current sources may be equal to or greater than 2, but equal or less than N−1, where N is the number of electrodes. The multi-resolution current source may introduce offset currents to achieve perceptually-based multiple resolutions with high resolution at low amplitudes and low resolution at high amplitudes. The flexible data-encoding scheme may allow arbitrary waveforms in terms of phase polarity, phase duration, pseudo-analog-waveform, while producing high-rate and high-temporal-precision stimulation. In one embodiment, a 2-current-source system may support simultaneous and non-simultaneous stimulation as well as monopolar, bipolar, pseudo-tripolar, and tripolar electrode configurations.
摘要翻译：可编程耳蜗植入系统利用多分辨率电流源和灵活的数据编码方案进行经皮传输。在某些实施例中，电流源的数量可以等于或大于2，但等于或小于N-1，其中N是电极的数量。多分辨率电流源可以引入偏移电流，以在低幅度下以高分辨率实现基于感知的多分辨率，并且在高幅度下实现低分辨率。柔性数据编码方案可以在产生高速率和高时间精度刺激的同时允许在相位极性，相位持续时间，伪模拟波形方面的任意波形。在一个实施例中，2-电流源系统可以支持同时和非同时刺激以及单极，双极，伪三极和三极电极配置。

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