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1. 发明申请

WO2006008503A1 PYRIMIDOTHIOPHENE COMPOUNDS 审中-公开
标题翻译：吡咯烷酮化合物
公开(公告)号：WO2006008503A1
公开(公告)日：2006-01-26
申请号：PCT/GB2005/002816
申请日：2005-07-18
申请人： VERNALIS (CAMBRIDGE) LTD , CANCER RESEARCH TECHNOLOGY LTD , THE INSTITUTE OF CANCER RESEARCH , DYMOCK, Brian, William , BARRIL-ALONSO, Xavier , BROUGH, Paul, Andrew , DRYSDALE, Martin, James , WEBB, Paul
发明人： BARRIL-ALONSO, Xavier , BROUGH, Paul, Andrew , DRYSDALE, Martin, James , WEBB, Paul
IPC分类号： C07D495/04 , A61K31/519
CPC分类号： C07D495/04
摘要： Compounds of formula (I) are inhibitors of HSP90, and useful in the treatment of, for example, cancers: Formula (I) wherein R 2 is a group of formula (IA): -(Ar 1 ) m (Alk 1 ) P (Z) r (Alk 2 ) s - Q (1A) wherein in any compatible combination Ar 1 is an optionally substituted aryl or heteroaryl radical, Alk 1 and Alk 2 are optionally substituted divalent C 1 -C 3 alkylene or C 2 -C 3 alkenylene radicals, m, p, r and s are independently 0 or 1, Z is -0-, -S-, -(C=0)-, -(C=S)-, -SO 2 -, -C(=O)O-, -C(=O)NR A - , -C(=S)NR A -, -SO 2 NRA-, -NR A C(=0)-, -NR A S0 2 - or -NR A - wherein R A is hydrogen or C 1 -C 6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R 3 is hydrogen, an optional substituent, or an optionally substituted (C 1 -C 6 )alkyl, aryl or heteroaryl radical; and R 4 is (i) hydrogen, a -CN group, a nitro group -NO 2 , or a - C(=NOH)(NH 2 ) group, or(ii) an optionally substituted C 1 -C 6 alkyl, aryl, heterocyclic, aryl(C 1 -C 6 alkyl)-, or heterocyclic(C 1 -C 6 alkyl)- group, or (iii) a group of formula - C(=0)R 5 wherein R 5 is hydroxyl, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy,aryl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkoxy)-, heteroaryl(C 1 -C 6 alkyl)-, or heteroaryl(C 1 -C 6 alkoxy)-, or (iv) a group of formula -C(=O)NHR 6 wherein R 6 is primary, secondary, tertiary or cyclic amino, or hydroxyl, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C 1 -C 6 alkyl)-, aryl(C 1 -C 6 alkoxy)-, heteroaryl(C 1 -C 6 alkyl)-, or heteroaryl(C 1 -C 6 alkoxy)-.
摘要翻译：式（I）化合物是HSP90的抑制剂，可用于例如癌症的治疗：式（I）其中R

2. 发明申请

WO2004072051A1 ISOXAZOLE COMPOUNDS AS INHIBITORS OF HEAT SHOCK PROTEINS 审中-公开
标题翻译：作为热休克蛋白的抑制剂的异噻唑化合物
公开(公告)号：WO2004072051A1
公开(公告)日：2004-08-26
申请号：PCT/GB2004/000506
申请日：2004-02-09
申请人： VERNALIS (CAMBRIDGE) LIMITED , CANCER RESEARCH TECHNOLOGY LTD , THE INSTITUTE OF CANCER RESEARCH , DRYSDALE, Martin, James , DYMOCK, Brian, William , FINCH, Harry , WEBB, Paul , MCDONALD, Edward , JAMES, Karen, Elizabeth , CHEUNG, Kwai, Ming , MATHEWS, Thomas, Peter
发明人： DRYSDALE, Martin, James , DYMOCK, Brian, William , FINCH, Harry , WEBB, Paul , MCDONALD, Edward , JAMES, Karen, Elizabeth , CHEUNG, Kwai, Ming , MATHEWS, Thomas, Peter
IPC分类号： C07D261/08
CPC分类号： A61K31/541 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , C07D261/08 , C07D261/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D495/04
摘要： Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: (A), (B) wherein R 1 , is a group of formula (IA): -Ar 1 -(Alk 1 )p-(Z) r -(Alk 2 ) S -Q, wherein in any compatible combination Ar 1 is an optionally substituted aryl or heteroaryl radical, Alk 1 and Alk 2 are optionally substituted divalent C l -C 6 alkylene or C 2 -C 6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, -S-, -(C=O)-, -(C=S)-, -SO 2 -, -C(=O)O-, -C(=O)NR A -, -C(=S)NR A -, - SO 2 NR A -, -NR A C(=O)-, -NR A SO 2 - or -NR A - wherein R A is hydrogen or C l -C 6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R 2 is (i) a group of formula (IA) above or (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula -(Alk 1 )p-(Z) r -(Alk 2 ) s -Q wherein Q, Alk 1 , Alk 2 , Z, p, r and s are as defined above in relation to group (IA); and R 3 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, or C 1 -C 6 alkynyl; or a carboxyl, carboxamide, or carboxyl ester group.
摘要翻译：式（A）或（B）的异恶唑是HSP90活性的抑制剂，可用于治疗例如癌症：（A），（B）其中R1是式（IA）的基团：-Ar 1 - （Alk 1）对 - （Z）r-（Alk 2）SQ，其中在任何相容的组合中，Ar 1是任选取代的芳基或杂芳基，Alk 1和Alk 2是任选取代的二价C 1 -C 6亚烷基或C 2 -C 6亚烯基，p，r和s独立地为0或1，Z为-O-，-S-， - （C = O） - ， - （C = S），-SO 2 - ， - C（= O）O-，-C（= O）NR A - ， - C（= S）NR A A - ， - SO 2 NR C（= O） - ， - NR A 2 - 或-NR A A - 其中R A A是氢或C 1 -C 6烷基，Q是氢或任选取代的碳环或杂环基; R2是（i）上述式（IA）的基团或（ii）甲酰胺基团; 或（iii）非芳族碳环或杂环，其中环碳任选被取代，和/或环氮任选地被式 - （Alk 1）对 - （Z）r - （Alk < 其中Q，Alk 1，Alk 2，Z，p，r和s如上文关于组（IA）所定义; 并且R 3是氢，任选取代的环烷基，环烯基，C 1 -C 6烷基，C 1 -C 6烯基或C 1 -C 6炔基; 或羧基，羧酰胺或羧基酯基团。

3. 发明申请

WO2006013370A1 PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM NEUROTOXIN A2 审中-公开
标题翻译：含有神经毒素A2的药物组合物
公开(公告)号：WO2006013370A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003057
申请日：2005-08-03
申请人： IPSEN LIMITED , PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
发明人： PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
IPC分类号： A61K38/48
CPC分类号： A61K9/0019 , A61K38/4893 , A61K47/183 , A61K47/26 , Y02A50/469
摘要： A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics selected from the group consisting of; (a) a much longer duration of action; (b) a much faster rate of onset of muscular paralysis; (c) a significantly greater intramuscular safety margin; (d) a selective action on inhibition of smooth muscle contraction; (e) a selective action on inhibition of pain-related (nociceptive) nerve cell function: Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.
摘要翻译：包含或由其组成的组合物，药物或用途，由具有一种或多种或全部特征的组合物，A2型和表面活性剂组成，（a）更长的行动期; （b）肌肉瘫痪发作速度要快得多; （c）明显更大的肌内安全余地; （d）抑制平滑肌收缩的选择性作用; （e）对疼痛相关（伤害感受）神经细胞功能的抑制的选择性作用：其中每种特征被确定为与A1型肉毒杆菌毒素相同的特征效应。

4. 发明申请

WO2009030947A1 METHOD AND COMPOSITION 审中-公开
标题翻译：方法与组合
公开(公告)号：WO2009030947A1
公开(公告)日：2009-03-12
申请号：PCT/GB2008/050776
申请日：2008-09-03
申请人： PERACHEM LIMITED , HAWKES, Jamie Anthony , WEBB, Paul , LEWIS, David Malcolm , BAYLIFF, Andrew
发明人： HAWKES, Jamie Anthony , WEBB, Paul , LEWIS, David Malcolm , BAYLIFF, Andrew
IPC分类号： C09K21/04 , C09K21/10 , D06M11/70
CPC分类号： C09K21/10 , D06M11/70 , D06M13/432 , D06M2200/30
摘要： A method of treating a material to improve flame retardancy, the method comprising applying to the material urea, phosphorous acid or a salt thereof, and a base5 comprising a monovalent metallic cation.
摘要翻译：一种处理材料以改善阻燃性的方法，所述方法包括将材料应用于尿素，亚磷酸或其盐，以及包含一价金属阳离子的碱5。

5. 发明申请

WO2008093072A3 TOPICAL COMPOSITION AGAINST CONTACT DERMATITIS DUE TO WATER 审中-公开
公开(公告)号：WO2008093072A3
公开(公告)日：2008-08-07
申请号：PCT/GB2008/000299
申请日：2008-01-29
申请人： WEBB, Paul
发明人： WEBB, Paul
IPC分类号： A61K8/26 , A61Q17/00 , A61Q19/10
摘要： This invention relates to a topical composition and particularly to a topical composition for the prophylactic and/or therapeutic treatment of contact dermatitis. The first aspect of the present invention provides a composition comprising water, kaolin, cetearyl alcohol, dicaprylyl carbonate, glycerin, xanthan gum and sodium lauryl sulfate for topical application for the prophylactic and/or therapeutic treatment of contact dermatitis due to immersion in disinfected or salinated water. The second aspect of the present invention provides a composition comprising water, kaolin, cetearyl alcohol, paraffinum liquidum, petrolatum and sodium lauryl sulfate for topical application for the prophylactic and/or therapeutic treatment of contact dermatitis due to immersion in disinfected or salinated water.

6. 发明申请

WO2006013357A1 PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM NEUROTOXIN A2 审中-公开
标题翻译：含有神经毒素A2的药物组合物
公开(公告)号：WO2006013357A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003036
申请日：2005-08-03
申请人： IPSEN LIMITED , PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
发明人： PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
IPC分类号： A61K38/48
CPC分类号： A61K9/0019 , A61K8/99 , A61K38/4893 , A61K47/26 , A61Q7/00 , A61Q19/08
摘要： A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics selected from the group consisting of; (a) a much longer duration of action; (b) a much faster rate of onset of muscular paralysis; (c) a significantly greater intramuscular safety margin; (d) a selective action on inhibition of skeletal muscle contraction; (e) a selective action on inhibition of pain-related (nociceptive) nerve cell function. Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.
摘要翻译：包含或由其组成的组合物，药物或用途，由具有一种或多种或全部特征的组合物，A2型和表面活性剂组成，（a）更长的行动期; （b）肌肉瘫痪发作速度要快得多; （c）明显更大的肌内安全余地; （d）抑制骨骼肌收缩的选择性作用; （e）对疼痛相关（伤害感受）神经细胞功能的抑制的选择性作用。其中每个特征的确定与A1型肉毒毒素相同的特征效应相比较。

7. 发明申请

WO2010082063A1 METHOD OF TREATING WOOL 审中-公开
标题翻译：处理羊毛的方法
公开(公告)号：WO2010082063A1
公开(公告)日：2010-07-22
申请号：PCT/GB2010/050060
申请日：2010-01-15
申请人： PERACHEM LIMITED , HAWKES, Jamie Anthony , LEWIS, David Malcolm , WEBB, Paul , LU, Yong
发明人： HAWKES, Jamie Anthony , LEWIS, David Malcolm , WEBB, Paul , LU, Yong
IPC分类号： D06M11/66 , D06M11/70 , D06M13/432 , C09K21/04 , C09K21/12 , D06M101/12
CPC分类号： D06M13/432 , C09K21/12 , D06M11/66 , D06M11/70 , D06M2101/12 , D06M2200/30
摘要： A method of treating a material to improve its flame retardancy, the method comprising applying to the material a composition having a pH of less than 4 and which comprises urea and an acid selected from phosphorous acid, phosphoric acid, sulfamic acid and mixtures thereof.
摘要翻译：一种处理材料以改善其阻燃性的方法，所述方法包括向该材料施加pH小于4的组合物，其包含尿素和选自亚磷酸，磷酸，氨基磺酸及其混合物的酸。

8. 发明申请

WO2009093012A1 INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY 审中-公开
标题翻译：具有检测点激酶1的吲哚基 - 吡啶酮衍生物1抑制活性
公开(公告)号：WO2009093012A1
公开(公告)日：2009-07-30
申请号：PCT/GB2009/000149
申请日：2009-01-20
申请人： VERNALIS (R & D) LTD , STOKES, Stephen , FOLOPPE, Nicolas , FIUMANA, Andrea , DRYSDALE, Martin , BEDFORD, Simon , WEBB, Paul
发明人： STOKES, Stephen , FOLOPPE, Nicolas , FIUMANA, Andrea , DRYSDALE, Martin , BEDFORD, Simon , WEBB, Paul
IPC分类号： C07D401/14 , A61K31/4412 , A61P35/00
CPC分类号： C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , C07D413/14
摘要： Compounds of formula (I) have checkpoint kinase 1 (CHK1 ) inhibitory activity: wherein R 1 , R 2 , R 5 and R 6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, trifluoromethoxy, methylamino and dimethylamino; R 3 , and R 4 are independently selected from hydrogen, hydroxy, C 1 -C 3 alkyl, fluoro-(C 1 -C 3 )-alkyl, hydroxy-(C 1 C 3 )-alkyl, C 1 -C 3 alkoxy, fluoro-(C 1 -C 3 )-alkoxy, hydroxy-(C 1 -C 3 )-alkoxy, -N(R 11 )-R 12 , -AIk-N(R 11 )-R 12 , -0-AIk-N(R 11 )-R 12 , -C(=O)OH, carboxy-(C 1 -C 3 )-alkyl, or -C(=O)-NH-R 13 ; AIk is a straight or branched chain divalent C 1 -C 6 alkylene radical; R 7 and R 8 are independently selected from hydrogen, hydroxy, or C 1 -C 3 alkoxy; X is a straight chain divalent C 1 -C 3 alkylene radical, optionally substituted on one or more carbons by R 9 and/or R 10 ; W is selected from -C(=O)-N(-R 16 )- or -N(-R 17 )-C(=O)-; Y is hydrogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, or halo; and Q is selected from optionally substituted phenyl, optionally substituted cyclohexyl, or an optionally substituted 6-membered monocyclic heteroaryl ring.
摘要翻译：式（I）化合物具有检测点激酶1（CHK1）抑制活性：其中R1，R2，R5和R6独立地选自氢，羟基，甲基，三氟甲基，羟甲基，甲氧基，三氟甲氧基，甲基氨基和二甲基氨基; R 3和R 4独立地选自氢，羟基，C 1 -C 3烷基，氟 - （C 1 -C 3） - 烷基，羟基 - （C 1 -C 3） - 烷基，C 1 -C 3烷氧基，氟 - （C 1 -C 3） - 烷氧基，羟基 - （C 1 -C 3） - 烷氧基，-N（R 11）-R 12，-A 1 k-N（R 11）-R 12，-O-Alk-N（R 11）-R 12，-C（= O）OH，（C 1 -C 3） - 烷基或-C（= O）-NH-R 13; Alk是直链或支链二价C1-C6亚烷基; R 7和R 8独立地选自氢，羟基或C 1 -C 3烷氧基; X是直链的二价C1-C3亚烷基，任选地被一个或多个碳上被R9和/或R10取代; W选自-C（= O）-N（-R 16） - 或-N（-R 17）-C（= O） - ; Y是氢，C 1 -C 3烷基，C 1 -C 3烷氧基或卤素; 并且Q选自任选取代的苯基，任选取代的环己基或任选取代的6元单环杂芳基环。

9. 发明申请

WO2004052302A2 A METHOD FOR CREATING SPECIFIC, HIGH AFFINITY NUCLEAR RECEPTOR PHARMACEUTICALS 审中-公开
标题翻译：一种创造特定的高亲和核受体药物的方法
公开(公告)号：WO2004052302A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039257
申请日：2003-12-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BAXTER, John, D. , SCANLAN, Thomas, S. , FETTERICK, Robert, J. , BORNGRAEBER, Sabine , WEBB, Paul , CHIELLINI, Grazia
发明人： BAXTER, John, D. , SCANLAN, Thomas, S. , FETTERICK, Robert, J. , BORNGRAEBER, Sabine , WEBB, Paul , CHIELLINI, Grazia
IPC分类号： A61K
CPC分类号： G01N33/74 , G01N33/566 , G01N2500/00
摘要： This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor: agonist complexes and libraries of agonists.
摘要翻译：本发明涉及激活核受体的激动剂。这些激动剂包括与天然配体结合口外的核受体的区域接触的延伸。用于制备，鉴定和设计这些激动剂的方法包括核受体：激动剂复合物和激动剂文库。

10. 发明申请

WO2003061586A3 HIGH AFFINITY SENSOR FOR BIOLOGICAL PATHOGENS 审中-公开
公开(公告)号：WO2003061586A3
公开(公告)日：2003-07-31
申请号：PCT/US2003/001665
申请日：2003-01-21
申请人： UAB RESEARCH FOUNDATION , BANASIEWICZ, Ken , BELOTSERKOVSKIY, Vladimir , BROUILLETTE, Christie , CHODAVARAPU, Ramarao , CORDLE, James, H. , DELUCAS, Larry , DEY, Susanta , KUDRYAVTSEV, Anatoliy , MIROV, Sergey , MORADI, Lee , RAY, Marjorie , WEBB, Paul
发明人： BANASIEWICZ, Ken , BELOTSERKOVSKIY, Vladimir , BROUILLETTE, Christie , CHODAVARAPU, Ramarao , CORDLE, James, H. , DELUCAS, Larry , DEY, Susanta , KUDRYAVTSEV, Anatoliy , MIROV, Sergey , MORADI, Lee , RAY, Marjorie , WEBB, Paul
IPC分类号： G01N21/76
摘要： Methods and devices for detecting and identifying species, particularly pathogenic species are provided. A preferred method includes forming detectable complexes of agents of the invention with the species to be detected and partitioning the detectable complexes from uncomplexed agents. Optionally, the partitioned detectable species can be detected. Optionally, methods can include collection of species to be detected from atmospheric, liquid or solid samples. Devices of the invention are adapted to performing or facilitating the methods of the invention in whole or in part.

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