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1. 发明申请

WO2006046065A1 BOTULINUM TOXIN THERAPY OF HEART RHYTHM DISORDERS 审中-公开
标题翻译：心脏恶臭病人的丁香毒素治疗
公开(公告)号：WO2006046065A1
公开(公告)日：2006-05-04
申请号：PCT/GB2005/004182
申请日：2005-10-28
申请人： IPSEN LIMITED , BATCHELOR, John
发明人： BATCHELOR, John
IPC分类号： A61K38/16 , A61K38/48 , A61P9/10 , A61P9/04
CPC分类号： A61K38/4893 , C12Y304/24069
摘要： The instant invention relates to the use of a pre-synaptic neuromuscular blocking substance for preparing a medicament intended to treat or prevent heart fibrillation disorders. Preferably, the pre-synaptic neuromuscular blocking substance will be a botulinum toxin. Preferably also, the heart fibrillation disorder to be treated of prevented will be atrial fibrillation.
摘要翻译：本发明涉及突触前神经肌肉阻滞物质用于制备旨在治疗或预防心脏颤动障碍的药物的用途。优选地，突触前神经肌肉阻滞物质将是肉毒杆菌毒素。优选地，待治疗的心脏颤动障碍也将是心房颤动。

2. 发明申请

US20150328293A1 PHARMACEUTICAL COMPOSITION COMPRISING BOTULINUM, A NON IONIC SURFACTANT, SODIUM CHLORIDE AND SUCROSE 有权
标题翻译：包含BOTULINUM的药物组合物，非离子表面活性剂，氯化钠和蔗糖
公开(公告)号：US20150328293A1
公开(公告)日：2015-11-19
申请号：US14810975
申请日：2015-07-28
申请人： Ipsen Limited
发明人： Paul WEBB , Mary WHITE , Julie PARTINGTON
IPC分类号： A61K38/48
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/4886 , A61K38/4893 , A61K47/26 , C12Y304/24069 , Y02A50/469 , A61K2300/00
摘要： The invention relates to a solid or liquid pharmaceutical composition comprising botulinum neurotoxin complex (type A, B, C, D, E, F or G) or high purity botulinum neurotoxin (type A, B, C, D, E, F or G), and a surfactant. In particular the invention relates to a solid or liquid pharmaceutical composition comprising a crystalline agent.
摘要翻译：本发明涉及包含肉毒杆菌神经毒素复合物（A，B，C，D，E，F或G型）或高纯度肉毒杆菌神经毒素（A，B，C，D，E，F或G型）的固体或液体药物组合物）和表面活性剂。特别地，本发明涉及包含结晶剂的固体或液体药物组合物。

3. 发明申请

WO2006005912A2 BOTULINUM TOXIN THERAPEUTIC USE 审中-公开
标题翻译： BOTULINUM TOXIN THERAPEUTIC使用
公开(公告)号：WO2006005912A2
公开(公告)日：2006-01-19
申请号：PCT/GB2005/002659
申请日：2005-07-06
申请人： IPSEN LIMITED , D'ARBIGNY, Pierre, Bernard , CHABRIER DE LASSAUNIERE, Piere-Etienne , BARCOCK, Alan
发明人： D'ARBIGNY, Pierre, Bernard , CHABRIER DE LASSAUNIERE, Piere-Etienne , BARCOCK, Alan
IPC分类号： A61K38/48
CPC分类号： A61K38/4893
摘要： The invention relates to the use of a pre-synaptic neuromuscular blocking substance for preparing a medicament intended to treat a gland, organ or duct obstructed by a naturally formed stone. This method can be applied notably for salivary gland, gall bladder, kidney or pancreas stones.
摘要翻译：本发明涉及突触前神经肌肉阻滞物质用于制备旨在治疗被天然形成的石块阻塞的腺体，器官或管道的药物的用途。该方法特别适用于唾液腺，胆囊，肾或胰腺结石。

4. 发明申请

WO2006005910A3 PHARMACEUTICAL COMPOSITION COMPRISING BOTULINUM, A NON IONIC SURFACTANT, SODIUM CHLORIDE AND SUCROSE 审中-公开
公开(公告)号：WO2006005910A3
公开(公告)日：2006-01-19
申请号：PCT/GB2005/002653
申请日：2005-07-06
申请人： IPSEN LIMITED , WEBB, Paul , WHITE, Mary , PARTINGTON, Julie
发明人： WEBB, Paul , WHITE, Mary , PARTINGTON, Julie
IPC分类号： A61K38/48 , A61K47/30
摘要： The invention relates to a solid or liquid pharmaceutical composition comprising botulinum neurotoxin complex (type A, B, C, D, E, F or G) or high purity botulinum neurotoxin (type A, B, C, D, E, F or G), and a surfactant. In particular the invention relates to a solid or liquid pharmaceutical composition comprising a crystalline agent.

5. 发明申请

WO2006001676A1 PHARMACEUTICAL COMPOSITION COMPRISING BOTULINUM TOXIN FOR TREATING KNEE JOINT PAIN BY SAPHENOUS NERVE ENTRAPMENT 审中-公开
标题翻译：药物组合物包含用于治疗膝关节疼痛的神经营养因子
公开(公告)号：WO2006001676A1
公开(公告)日：2006-01-05
申请号：PCT/KR2005/002002
申请日：2005-06-27
申请人： IPSEN LIMITED , AHN, Kang
发明人： AHN, Kang
IPC分类号： A61K38/16
CPC分类号： A61K38/4893
摘要： There is provided a pharmaceutical composition comprising botulinum toxin and a pharmacologically acceptable carrier for treating pain in the knee joint caused by saphenous nerve entrapment. The composition of the present invention is for subcutaneous injection above the medial side of the knee.
摘要翻译：提供了包含肉毒杆菌毒素和用于治疗由隐神经夹带引起的膝关节疼痛的药理学上可接受的载体的药物组合物。本发明的组合物用于在膝盖的内侧上方皮下注射。

6. 发明申请

WO2006013370A1 PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM NEUROTOXIN A2 审中-公开
标题翻译：含有神经毒素A2的药物组合物
公开(公告)号：WO2006013370A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003057
申请日：2005-08-03
申请人： IPSEN LIMITED , PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
发明人： PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
IPC分类号： A61K38/48
CPC分类号： A61K9/0019 , A61K38/4893 , A61K47/183 , A61K47/26 , Y02A50/469
摘要： A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics selected from the group consisting of; (a) a much longer duration of action; (b) a much faster rate of onset of muscular paralysis; (c) a significantly greater intramuscular safety margin; (d) a selective action on inhibition of smooth muscle contraction; (e) a selective action on inhibition of pain-related (nociceptive) nerve cell function: Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.
摘要翻译：包含或由其组成的组合物，药物或用途，由具有一种或多种或全部特征的组合物，A2型和表面活性剂组成，（a）更长的行动期; （b）肌肉瘫痪发作速度要快得多; （c）明显更大的肌内安全余地; （d）抑制平滑肌收缩的选择性作用; （e）对疼痛相关（伤害感受）神经细胞功能的抑制的选择性作用：其中每种特征被确定为与A1型肉毒杆菌毒素相同的特征效应。

7. 发明申请

WO2006013354A1 METHOD FOR DETERMINING THE SELECTIVITY OF A PRE-SYNAPTIC NEUROMUSCULAR BLOCKING SUBSTANCE 审中-公开
标题翻译：确定预应激性神经阻滞物质选择性的方法
公开(公告)号：WO2006013354A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003032
申请日：2005-08-02
申请人： IPSEN LIMITED , FRANCE, Richard , QUIRK, Robin , RICCALTON-BANKS, Lisa , PICKETT, Andrew, Martin
发明人： FRANCE, Richard , QUIRK, Robin , RICCALTON-BANKS, Lisa , PICKETT, Andrew, Martin
IPC分类号： G01N33/68
CPC分类号： C12N5/0661 , G01N33/5082
摘要： The invention relates to a method for determining the quantity of pre-synaptic neuromuscular blocking substance (notably botulinum toxin) contained in a sample. In one aspects, the method comprises the following steps: (i) determining the minimum voltage V msm needed to induce the contraction of a smooth muscle tissue, said smooth muscle tissue being linked to an electrical stimulator through an electrically conducting liquid and preferably immersed in an oxygenated physiological buffer containing glucose; (ii) adding the sample containing the pre-synaptic neuromuscular mocking substance; (iii) electrically stimulating, at a voltage at least equal to V msm , the smooth muscle tissue at certain time intervals; (iv) comparing the effect induced by the sample to the effect induced by a reference substance and thereby determining the quantity of the pre-synaptic neuromuscular blocking substance in the sample. The invention also relates to a method for determining the selectivity of a pre-synaptic neuromuscular blocking substance.
摘要翻译：本发明涉及一种测定样品中包含的突触后神经肌肉阻滞物质（特别是肉毒杆菌毒素）的量的方法。在一个方面，该方法包括以下步骤：（i）确定诱导平滑肌组织收缩所需的最小电压V max，所述平滑肌组织通过电刺激器与导电液体，优选浸入含有葡萄糖的含氧生理缓冲液中; （ii）加入含有突触后神经肌肉嘲笑物质的样品; （iii）以一定时间间隔电平刺激平滑肌组织在至少等于V max的电压下; （iv）将样品诱导的效应与参考物质诱导的效果进行比较，从而确定样品中突触前神经肌肉阻滞物质的量。本发明还涉及确定突触前神经肌肉阻滞物质的选择性的方法。

8. 发明申请

WO2004074838A1 QUANTIFICATION OF BOTULINUM TOXIN 审中-公开
标题翻译：丁香毒素的定量
公开(公告)号：WO2004074838A1
公开(公告)日：2004-09-02
申请号：PCT/GB2004/000697
申请日：2004-02-20
申请人： IPSEN LIMITED , PICKETT, Andrew, Martin , QUIRK, Robert, Andrew , FRANCE, Richard, Melville , RICCALTON-BANKS, Lisa, Anne
发明人： PICKETT, Andrew, Martin , QUIRK, Robert, Andrew , FRANCE, Richard, Melville , RICCALTON-BANKS, Lisa, Anne
IPC分类号： G01N33/68
CPC分类号： G01N33/944 , G01N33/5088
摘要： The invention relates to a method for determining the quantity of pre-synaptic neuromuscular blocking substance (notably botulinum toxin) contained in a sample. In one aspects, the method comprises the following steps: (i) determining the minimum voltage V m needed to induce the contraction of muscle tissue, said muscle tissue being connected to an electrical stimulator through a motor nerve and preferably immersed in an oxygenated physiological buffer containing glucose; (ii) adding the sample containing the pre-synaptic neuromuscular blocking substance; (iii) electrically stimulating, at a voltage at least equal to V m , the muscle tissue at certain time intervals; (iv) comparing the effect induced by the sample to the effect induced by a reference substance and thereby determining the quantity of the pre-synaptic neuromuscular blocking substance in the sample.
摘要翻译：本发明涉及一种测定样品中包含的突触后神经肌肉阻滞物质（特别是肉毒杆菌毒素）的量的方法。在一个方面，该方法包括以下步骤：（i）确定诱导肌肉组织收缩所需的最小电压Vm，所述肌肉组织通过运动神经连接到电刺激器，并优选浸入含氧的生理缓冲液中葡萄糖; （ii）加入含有突触后神经肌肉阻滞物质的样品; （iii）在至少等于Vm的电压下以一定的时间间隔电刺激肌肉组织; （iv）将样品诱导的效应与参考物质诱导的效果进行比较，从而确定样品中突触前神经肌肉阻滞物质的量。

9. 发明申请

WO2006013357A1 PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM NEUROTOXIN A2 审中-公开
标题翻译：含有神经毒素A2的药物组合物
公开(公告)号：WO2006013357A1
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003036
申请日：2005-08-03
申请人： IPSEN LIMITED , PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
发明人： PANJWANI, Naveed , WEBB, Paul , PICKETT, Andy
IPC分类号： A61K38/48
CPC分类号： A61K9/0019 , A61K8/99 , A61K38/4893 , A61K47/26 , A61Q7/00 , A61Q19/08
摘要： A composition, medicament or use, comprising or consisting of botulinum toxin type A2 and a surfactant, having one or more or all of the characteristics selected from the group consisting of; (a) a much longer duration of action; (b) a much faster rate of onset of muscular paralysis; (c) a significantly greater intramuscular safety margin; (d) a selective action on inhibition of skeletal muscle contraction; (e) a selective action on inhibition of pain-related (nociceptive) nerve cell function. Wherein each characteristic is determined comparative to the same characteristic effect of botulinum toxin type A1.
摘要翻译：包含或由其组成的组合物，药物或用途，由具有一种或多种或全部特征的组合物，A2型和表面活性剂组成，（a）更长的行动期; （b）肌肉瘫痪发作速度要快得多; （c）明显更大的肌内安全余地; （d）抑制骨骼肌收缩的选择性作用; （e）对疼痛相关（伤害感受）神经细胞功能的抑制的选择性作用。其中每个特征的确定与A1型肉毒毒素相同的特征效应相比较。

10. 发明授权

EP1773378B1 USE OF BOTULINUM TOXIN FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF LITHIASIS OF SALIVARY GLAND, GALL BLADDER, KIDNEY, OR PANCREAS 有权
标题翻译：用肉毒杆菌毒素制备治疗唾液腺，膀胱炎，肾病或胰腺炎的药物
公开(公告)号：EP1773378B1
公开(公告)日：2007-12-12
申请号：EP05757840.3
申请日：2005-07-06
申请人： Ipsen Limited , Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.)
发明人： D'ARBIGNY, Pierre, Bernard , CHABRIER DE LASSAUNIERE, Piere-Etienne , BARCOCK, Alan 190 Bath Road
IPC分类号： A61K38/48
CPC分类号： A61K38/4893
摘要： The invention relates to the use of a pre-synaptic neuromuscular blocking substance for preparing a medicament intended to treat a gland, organ or duct obstructed by a naturally formed stone. This method can be applied notably for salivary gland, gall bladder, kidney or pancreas stones.
摘要翻译：本发明涉及突触前神经肌肉阻断物质用于制备旨在治疗被自然形成的石头阻塞的腺体，器官或管道的药物的用途。该方法可以特别用于唾液腺，胆囊，肾脏或胰腺结石。

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