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1. 发明申请

WO2008106662A2 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： NITRILASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：WO2008106662A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/055569
申请日：2008-02-29
申请人： VERENIUM CORPORATION , DESANTIS, Grace
发明人： DESANTIS, Grace
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , C12N9/78 , C12P13/002 , C12P13/004 , C12P13/005 , C12P13/04 , C12P41/007
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

2. 发明申请

WO2008027501A3 LACCASES FOR PULP BIO-BLEACHING 审中-公开
公开(公告)号：WO2008027501A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/019124
申请日：2007-08-31
申请人： VERENIUM CORPORATION , KEROVUO, Janne, Samuli , HAREMZA, Sylke , KOCH, Oliver , HABICHER, Tilo , ROBERTSON, Dan , DESANTIS, Grace , MCCANN, Ryan , LUGINBUHL, Peter
发明人： KEROVUO, Janne, Samuli , HAREMZA, Sylke , KOCH, Oliver , HABICHER, Tilo , ROBERTSON, Dan , DESANTIS, Grace , MCCANN, Ryan , LUGINBUHL, Peter
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00 , C07K16/00
摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

3. 发明申请

WO2003000840A2 NITRILASES 审中-公开
标题翻译：腈
公开(公告)号：WO2003000840A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/015983
申请日：2002-05-15
申请人： DIVERSA CORPORATION , MADDEN, Darcy , DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
发明人： DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
IPC分类号： C12N
CPC分类号： C12P13/004 , C12N9/78 , C12P7/42 , C12P13/04 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

4. 发明申请

WO2003000909A3 METHODS FOR THE MANUFACTURE OF PURE SINGLE ENANTIOMER COMPOUNDS AND FOR SELECTING ENANTIOSELECTIVE ENZYMES 审中-公开
公开(公告)号：WO2003000909A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/019706
申请日：2002-06-21
申请人： DIVERSA CORPORATION , WEINER, David , HITCHMAN, Tim , ZHAO, Lishan , BURK, Mark , DESANTIS, Grace , HANSON, Sarah, Richardson , MILAN, Aileen , RICHARDSON, Toby , KRETZ, Patti , GREENBURG, William
发明人： WEINER, David , HITCHMAN, Tim , ZHAO, Lishan , BURK, Mark , DESANTIS, Grace , HANSON, Sarah, Richardson , MILAN, Aileen , RICHARDSON, Toby , KRETZ, Patti , GREENBURG, William
IPC分类号： C12Q1/68
摘要： The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. The invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated form nucleic acids isolated from more than one organism for enzyme, e.g., transaminase, activities are also provided.

5. 发明申请

WO2006128590A1 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：水解物，核酸编码方法及其使用方法
公开(公告)号：WO2006128590A1
公开(公告)日：2006-12-07
申请号：PCT/EP2006/004736
申请日：2006-05-18
申请人： DSM IP ASSETS B.V. , MINK, Daniel , KIERKELS, Joannes, Gerardus, Theodorus , DESANTIS, Grace , FARWELL, Robert , WHIPPLE, Lawrence , BURK, Mark
发明人： MINK, Daniel , KIERKELS, Joannes, Gerardus, Theodorus , DESANTIS, Grace , FARWELL, Robert , WHIPPLE, Lawrence , BURK, Mark
IPC分类号： C12P41/00
CPC分类号： C12P7/62 , C12N9/16 , C12P17/06 , C12P41/005
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and/or D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和/或D活性，patatin活性，脂质酰基水解酶（LAH）活性）或蛋白酶活性，包括热稳定和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。另一方面，本发明的多肽用于合成对映体纯的手性产物。

6. 发明申请

WO2003097810A3 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2003097810A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015712
申请日：2003-05-15
申请人： DIVERSA CORPORATION , DESANTIS, Grace , SHORT, Jay, M. , BURK, Mark , WONG, Kevin , FARWELL, Robert , CHATMAN, Kelly
发明人： DESANTIS, Grace , SHORT, Jay, M. , BURK, Mark , WONG, Kevin , FARWELL, Robert , CHATMAN, Kelly
IPC分类号： C12N9/00
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

7. 发明申请

WO2003000840A3 NITRILASES 审中-公开
公开(公告)号：WO2003000840A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/015983
申请日：2002-05-15
申请人： DIVERSA CORPORATION , MADDEN, Darcy , DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
发明人： DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
IPC分类号： C12N9/00 , C12N9/78 , C12N1/20 , C12N15/00 , C07H21/02 , C12P1/00 , C12P7/00 , C12P7/62 , C07K1/00
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

8. 发明公开

EP2059587A2 LACCASES FOR PULP BIO-BLEACHING 有权
标题翻译：漆酶对生物漂白纸浆
公开(公告)号：EP2059587A2
公开(公告)日：2009-05-20
申请号：EP07837576.3
申请日：2007-08-31
申请人： Verenium Corporation , BASF SE
发明人： KEROVUO, Janne Samuli , HAREMZA, Sylke , KOCH, Oliver , HABICHER, Tilo , ROBERTSON, Dan , DESANTIS, Grace , MCCANN, Ryan , LUGINBUHL, Peter
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00 , C07K16/00
CPC分类号： C12N9/0061 , C12N15/09 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y110/03002 , D21C5/005 , D21C9/005 , D21C9/1063
摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

9. 发明授权

EP2059587B1 LACCASES FOR PULP BIO-BLEACHING 有权
标题翻译：漆酶对生物漂白纸浆
公开(公告)号：EP2059587B1
公开(公告)日：2012-01-04
申请号：EP07837576.3
申请日：2007-08-31
申请人： Verenium Corporation , BASF SE
发明人： KEROVUO, Janne Samuli , HAREMZA, Sylke , KOCH, Oliver , HABICHER, Tilo , ROBERTSON, Dan , DESANTIS, Grace , MCCANN, Ryan , LUGINBUHL, Peter
IPC分类号： C12N9/02 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00
CPC分类号： C12N9/0061 , C12N15/09 , C12P5/00 , C12P7/00 , C12P19/00 , C12Y110/03002 , D21C5/005 , D21C9/005 , D21C9/1063
摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

10. 发明公开

EP2115153A2 NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：腈水解酶，为生产和使用的核酸编码AND METHOD
公开(公告)号：EP2115153A2
公开(公告)日：2009-11-11
申请号：EP08731180.9
申请日：2008-02-29
申请人： Verenium Corporation
发明人： DESANTIS, Grace , CHAPLIN, Jennifer Ann , CHI, Ellen , ROBERTSON, Dan Eric , WEINER, David P , SHORT, Jay M. , MILAN, Aileen
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , C12N9/78 , C12P13/002 , C12P13/004 , C12P13/005 , C12P13/04 , C12P41/007
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

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