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1. 发明申请

WO2008086040A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF URINARY TRACT PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗尿道病变的肌肉衍生细胞及其制备和使用方法
公开(公告)号：WO2008086040A1
公开(公告)日：2008-07-17
申请号：PCT/US2008/000443
申请日：2008-01-11
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , JANKOWSKI, Ronald , PRUCHNIC, Ryan , HUARD, Johnny
发明人： CHANCELLOR, Michael, B. , JANKOWSKI, Ronald , PRUCHNIC, Ryan , HUARD, Johnny
IPC分类号： C12N5/06 , A61K35/34 , A61P13/10
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

2. 发明申请

WO2008066886A2 MUSCLE DERIVED CELLS FOR THE TREATMENT OF CARDIAC PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗心脏病变的肌肉衍生细胞及其制备和使用方法
公开(公告)号：WO2008066886A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/024566
申请日：2007-11-28
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , PAYNE, Thomas , JANKOWSKI, Ronald , PRUCHNIC, Ryan
发明人： CHANCELLOR, Michael, B. , PAYNE, Thomas , JANKOWSKI, Ronald , PRUCHNIC, Ryan
IPC分类号： A61K35/34 , A61P9/00
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植入身体组织后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增强软组织，从而增强软组织软组织。还提供了分离肌肉衍生祖细胞的方法，以及基因修饰细胞用于基因转移疗法的方法。本发明进一步提供了使用包含肌肉衍生祖细胞的组合物在包括畸形，损伤，虚弱，疾病或功能障碍在内的各种美容或功能性病症的治疗中用于增强和增大哺乳动物（包括人类）软组织的方法。具体而言，本发明提供了治疗和改善皮肤病，胃食管反流，膀胱 - 输尿管返流，尿失禁，大便失禁，心力衰竭和心肌梗塞。

3. 发明申请

WO2004096245A2 MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATION 审中-公开
标题翻译：肌肉衍生细胞（MDCS）用于促进和增强神经修复和再生
公开(公告)号：WO2004096245A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/013115
申请日：2004-04-26
申请人： THE UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , HUARD, Johnny , MINNERY, Brandon
发明人： CHANCELLOR, Michael, B. , HUARD, Johnny , MINNERY, Brandon
IPC分类号： A61K35/34
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34
摘要： The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs, particularly associated with nerve damage or neuropathy. The invention relates to MDCs for use in methods for promoting or enhancing innervation of nerve cells, particularly in the peripheral nervous system, and their ability to contribute to the development of neuronal tissue when MDCs are introduced at or near a tissue or organ site in need of repair due to injury, damage, disease, or dysfunction. Such methods are useful for the treatment of central and peripheral nervous system disorders and to alleviate, abate, or eliminate the symptoms of neurologic or neurodegenerative diseases in animals, particularly mammals, including humans. The methods are also useful for treating both nerve and muscle tissue following injury, damage, or dysfunction to these tissue types.
摘要翻译：本发明描述了使用优选从骨骼肌获得的肌肉衍生细胞（MDC）来支持损伤的组织和器官的神经支配和修复，特别是与神经损伤或神经病有关的方法。本发明涉及用于促进或增强神经细胞神经细胞，特别是周围神经系统神经支配的方法中使用的MDC，以及当将MDCs引入到需要的组织或器官部位处或附近时有助于神经元组织发育的能力由于受伤，损伤，疾病或功能障碍引起的修复。这样的方法可用于治疗中枢和周围神经系统疾病并减轻，减轻或消除动物，特别是包括人在内的哺乳动物的神经退行性疾病或神经变性疾病的症状。这些方法对于在损伤，损伤或这些组织类型的功能障碍之后治疗神经和肌肉组织也是有用的。

4. 发明申请

WO2008076435A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗胃肠道病理学的肌肉衍生细胞及其制备和使用方法
公开(公告)号：WO2008076435A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/025863
申请日：2007-12-18
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , PASTRICHA, Jay , JANKOWSKI, Ron , PRUCHNIC, Ryan
发明人： CHANCELLOR, Michael, B. , PASTRICHA, Jay , JANKOWSKI, Ron , PRUCHNIC, Ryan
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2509/00 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物（包括人）软组织的增加和膨胀中。特别地，本发明提供了治疗和改善诸如胃食管反流的胃食管病理学症状。

5. 发明申请

WO2006065234A1 USE OF LIPID AND HYDROGEL VEHICLES FOR TREATMENT AND DRUG DELIVERY 审中-公开
标题翻译：用于治疗和药物输送的脂质和水凝胶车辆的使用
公开(公告)号：WO2006065234A1
公开(公告)日：2006-06-22
申请号：PCT/US2004/041473
申请日：2004-12-10
申请人： UNIVERSITY OF PITTSBURGH , TYAGI, Pradeep , CHANCELLOR, Michael, B. , LI, Zhenhua , CHUANG, Yao-Chi , DE GROAT, William, C. , YOSHIMURA, Naoki , FRASER, Matthew, O. , HUANG, Leaf
发明人： TYAGI, Pradeep , CHANCELLOR, Michael, B. , LI, Zhenhua , CHUANG, Yao-Chi , DE GROAT, William, C. , YOSHIMURA, Naoki , FRASER, Matthew, O. , HUANG, Leaf
IPC分类号： A61F13/00
CPC分类号： A61K9/0024 , A61K9/127
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-or hydrogel-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction.
摘要翻译：本发明涉及用于施用基于脂质的载体以治疗各种疾病（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。在各个方面，本发明的组合物和方法可用于向膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统延长递送药物，例如抗生素，疼痛治疗和抗癌剂。特别地，本发明涉及用于治疗膀胱状况（包括疼痛，炎症，失禁等）的香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体或水凝胶的递送，和排尿功能障碍。

6. 发明申请

WO2007044748A2 SPHINGOMYELIN LIPOSOMES FOR THE TREATMENT OF HYPERACTIVE BLADDER DISORDERS 审中-公开
标题翻译：用于治疗高血压性疾病的SPHINGOMYELIN脂质体
公开(公告)号：WO2007044748A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039614
申请日：2006-10-11
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , TYAGI, Pradeep , HUANG, Leaf
发明人： CHANCELLOR, Michael, B. , TYAGI, Pradeep , HUANG, Leaf
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/1272
摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.
摘要翻译：本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍作为有需要的动物或人类的间质性膀胱炎（IC）。还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

7. 发明申请

WO2003015698A3 APPLICATION OF LIPID VEHICLES AND USE FOR DRUG DELIVERY 审中-公开
公开(公告)号：WO2003015698A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/025860
申请日：2002-08-13
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , FRASER, Matthew, O. , CHUANG, Yao-Chi , DE GROAT, William, C. , HUANG, Leaf , YOSHIMURA, Naoki
发明人： CHANCELLOR, Michael, B. , FRASER, Matthew, O. , CHUANG, Yao-Chi , DE GROAT, William, C. , HUANG, Leaf , YOSHIMURA, Naoki
IPC分类号： A61K9/127
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g. , antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g. , uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

8. 发明申请

WO2010078403A2 METHODS AND COMPOSITIONS FOR DIAGNOSING UROLOGICAL DISORDERS 审中-公开
标题翻译：用于诊断尿路疾病的方法和组合
公开(公告)号：WO2010078403A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069784
申请日：2009-12-30
申请人： LIPELLA PHARMACEUTICALS INC. , CHANCELLOR, Michael, B. , KUO, Hann-Chorng
发明人： CHANCELLOR, Michael, B. , KUO, Hann-Chorng
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2800/348
摘要： It has been discovered that cytokines, chemokines, and growth factors in urine are biomarkers indicative of urological disorders including interstitial cystitis/painful bladder syndrome and overactive bladder syndrome. Preferred chemokine biomarkers are CCL2, CCL4 (MIP-1β), CCL11, CXCL1 (GRO-α), sCD40L, IL-12p70/p40, IL-5. sIL-2Rα, IL-6, IL- 10, IL-8, and EGF. The concentration of one or more of these chemokines in an urine sample can be used to assist in the diagnosis of urological disorders. Methods for evaluating the effectiveness of treatments for urological disorders and for assessing the severity of urological disorders are also provided.
摘要翻译：已经发现尿中的细胞因子，趋化因子和生长因子是指示泌尿系统疾病的生物标志物，包括间质性膀胱炎/膀胱膀胱综合征和膀胱过度活动症。优选的趋化因子生物标志物是CCL2，CCL4（MIP-1β），CCL11，CXCL1（GRO-a），sCD40L，IL-12p70 / p40，IL-5。 sIL-2Ra，IL-6，IL-10，IL-8和EGF。尿液样本中一种或多种这些趋化因子的浓度可用于协助诊断泌尿系统疾病。还提供了评估泌尿系统疾病治疗有效性和评估泌尿系统疾病严重程度的方法。

9. 发明申请

WO2009139984A2 METHOD OF TREATMENT FOR BLADDER DYSFUNCTION 审中-公开
标题翻译：刀片功能障碍治疗方法
公开(公告)号：WO2009139984A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/039489
申请日：2009-04-03
申请人： LIPELLA PHARMACEUTICALS, INC. , CHANCELLOR, Michael, B. , KAUFMAN, Jonathan, H.
发明人： CHANCELLOR, Michael, B. , KAUFMAN, Jonathan, H.
IPC分类号： A61K9/127
CPC分类号： A61K9/0034 , A61K9/127 , A61K38/4893
摘要： Liposomes are used for intravesical drug delivery, especially delivery of botulinuni toxin (BoNT) to help improve lower urinary tract symptoms by decreasing bladder irritation and frequency. The system uses a lower and safer dose of BoNT with lower risk of urinary retention. A simple instillation of liposome-BoNT as a liquid formulation into the bladder, in a typical volume of 30-60 ml, will achieve efficacy similar to that currently achieved with cystscopic needle injection of BoNT. The dose may be lower than that done by injection, thereby causing significantly less risk of urinary retention, Liposome-BoNT can protect the BoNT from bladder and urine breakdown. Liposome-BoNT instillation is more comfortable for the patients and allows many more doctors' offices to offer this form of treatment that would otherwise be restricted to doctors skilled and certified in cystoscopic BoNT injection.
摘要翻译：脂质体用于膀胱内药物递送，特别是输送肉毒杆菌毒素（BoNT），以帮助通过降低膀胱刺激和频率来改善下尿路症状。该系统使用较低和更安全的BoNT剂量，具有较低的尿潴留风险。在30-60ml的典型体积中，将作为液体制剂的脂质体-BoNT作为液体制剂的简单滴注将达到与目前通过膀胱镜针注射BoNT实现的功效相似。剂量可能低于通过注射进行的剂量，从而导致尿潴留的风险显着降低，脂质体-TBNT可以保护BoNT免于膀胱和尿液分解。脂质体 - BoNT滴注对患者来说更为舒适，并允许更多的医生办公室提供这种形式的治疗，否则这些治疗方式将被限制在医师熟练并且在膀胱镜下注射BoNT中。

10. 发明申请

WO2011060065A2 INSTILLATION OF LIPOSOMAL FORMULATION OF SIRNA AND ANTISENSE OLIGONUCLEOTIDES 审中-公开
标题翻译： SIRNA和抗原寡核苷酸的脂质体制剂的研究
公开(公告)号：WO2011060065A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/056224
申请日：2010-11-10
申请人： LIPELLA PHARMACEUTICALS INC. , CHANCELLOR, Michael, B. , KAUFMAN, Jonathan, Howard
发明人： CHANCELLOR, Michael, B. , KAUFMAN, Jonathan, Howard
IPC分类号： C12N15/113 , A61K31/7088 , A61K9/127 , A61P13/10
CPC分类号： C12N15/1136 , C12N2310/11 , C12N2320/32
摘要： A pharmaceutically acceptable deliverable composition and methods for administration of macromolecules for sequence-specific gene-silencing in bladder to treat overactive bladder (OAB), interstitial cystitis/painful bladder syndrome (IC/PBS), lower urinary tract symptoms (LUTS) locally in the bladder, or other diseases or disorders of the bladder or LUTS, has been discovered, In the preferred embodiment, a liposome based delivery system is used to deliver an effective amount of antisense oligonucleotides (ODN) or siRNA that interact with or bind to messenger RNA (mRNA) coding for human nerve growth factor (NGF) to stop the synthesis of NGF.
摘要翻译：药物可接受的递送组合物和用于在膀胱中用于顺序特异性基因沉默的大分子的施用方法，用于治疗膀胱膀胱过度活动症（OAB），间质性膀胱炎/疼痛膀胱综合征（IC / PBS），下尿路症状（LUTS）膀胱或膀胱或LUTS的其它疾病或病症已被发现。在优选实施方案中，使用基于脂质体的递送系统递送有效量的与信使RNA相互作用或结合信使RNA的反义寡核苷酸（ODN）或siRNA （mRNA）编码人神经生长因子（NGF）以停止NGF的合成。

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