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1. 发明申请

WO2003015698A3 APPLICATION OF LIPID VEHICLES AND USE FOR DRUG DELIVERY 审中-公开
公开(公告)号：WO2003015698A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/025860
申请日：2002-08-13
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , FRASER, Matthew, O. , CHUANG, Yao-Chi , DE GROAT, William, C. , HUANG, Leaf , YOSHIMURA, Naoki
发明人： CHANCELLOR, Michael, B. , FRASER, Matthew, O. , CHUANG, Yao-Chi , DE GROAT, William, C. , HUANG, Leaf , YOSHIMURA, Naoki
IPC分类号： A61K9/127
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g. , antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g. , uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

2. 发明申请

WO03015698A2 APPLICATION OF LIPID VEHICLES AND USE FOR DRUG DELIVERY 审中-公开
标题翻译：脂质车辆的应用和用途在药物交付
公开(公告)号：WO03015698A2
公开(公告)日：2003-02-27
申请号：PCT/US0225860
申请日：2002-08-13
申请人： UNIV PITTSBURGH , CHANCELLOR MICHAEL B , FRASER MATTHEW O , CHUANG YAO-CHI , DE GROAT WILLIAM C , HUANG LEAF , YOSHIMURA NAOKI
发明人： CHANCELLOR MICHAEL B , FRASER MATTHEW O , CHUANG YAO-CHI , DE GROAT WILLIAM C , HUANG LEAF , YOSHIMURA NAOKI
IPC分类号： A61K9/00 , A61K9/127 , A61K36/81 , A61P29/00 , A61P31/00 , A61P35/00 , A61K
CPC分类号： A61K9/127 , A61K9/0034
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.
摘要翻译：本发明涉及用于施用基于脂质的载体以治疗各种病症（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。在各个方面，本发明的组合物和方法可用于将药物例如抗生素，疼痛治疗和抗癌剂延长递送至膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统。具体而言，本发明涉及类脂样化合物如树脂毒素，辣椒素或细菌毒素以及毒素如肉毒杆菌毒素的基于脂质体的递送，用于治疗膀胱疾病，包括疼痛，炎症，失禁和排泄障碍。进一步相关的是单独使用这些载体或与抗体（例如尿激酶原抗体）结合使用这些载体以提高脂质体附着的持续时间并提供长期膀胱内药物递送平台的方法。本发明特别涉及用于靶向药物，肽，多肽或核酸递送的特定受体的抗体包被的脂质体。在一个特定的方面，本发明涉及用针对神经生长因子（NGF）受体的抗体包被并且含有NGF反义核酸的脂质体，其用作神经原性膀胱功能障碍的治疗。

3. 发明申请

WO2006065234A1 USE OF LIPID AND HYDROGEL VEHICLES FOR TREATMENT AND DRUG DELIVERY 审中-公开
标题翻译：用于治疗和药物输送的脂质和水凝胶车辆的使用
公开(公告)号：WO2006065234A1
公开(公告)日：2006-06-22
申请号：PCT/US2004/041473
申请日：2004-12-10
申请人： UNIVERSITY OF PITTSBURGH , TYAGI, Pradeep , CHANCELLOR, Michael, B. , LI, Zhenhua , CHUANG, Yao-Chi , DE GROAT, William, C. , YOSHIMURA, Naoki , FRASER, Matthew, O. , HUANG, Leaf
发明人： TYAGI, Pradeep , CHANCELLOR, Michael, B. , LI, Zhenhua , CHUANG, Yao-Chi , DE GROAT, William, C. , YOSHIMURA, Naoki , FRASER, Matthew, O. , HUANG, Leaf
IPC分类号： A61F13/00
CPC分类号： A61K9/0024 , A61K9/127
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-or hydrogel-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction.
摘要翻译：本发明涉及用于施用基于脂质的载体以治疗各种疾病（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。在各个方面，本发明的组合物和方法可用于向膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统延长递送药物，例如抗生素，疼痛治疗和抗癌剂。特别地，本发明涉及用于治疗膀胱状况（包括疼痛，炎症，失禁等）的香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体或水凝胶的递送，和排尿功能障碍。

4. 发明申请

WO2004089288A2 METHOD OF TREATING LOWER URINARY TRACT DISORDERS 审中-公开
标题翻译：治疗下尿路疾病的方法
公开(公告)号：WO2004089288A2
公开(公告)日：2004-10-21
申请号：PCT/US2004/010088
申请日：2004-04-02
申请人： DYNOGEN PHARMACEUTICALS, INC. , LANDAU, Steven, B. , MILLER, Cheryl, L. , FRASER, Matthew, O.
发明人： LANDAU, Steven, B. , MILLER, Cheryl, L. , FRASER, Matthew, O.
IPC分类号： A61K
CPC分类号： A61K31/519 , A61K31/00 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT 3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5HT 3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.
摘要翻译：本发明涉及一种治疗需要治疗的受试者的下尿路疾病的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿。该方法包括向需要治疗的受试者施用治疗有效量的具有5-HT 3受体拮抗剂活性的化合物和NorAdrenaline再摄取抑制剂（NARI）活性。本发明还涉及在需要治疗的受试者中治疗下尿路障碍的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿，包括向所述受试者共同施用第一量的5HT3拮抗剂和第二量的NARI，其中第一和第二量一起包含治疗有效量或各自以治疗有效量存在。

5. 发明申请

WO2004089288A3 METHOD OF TREATING LOWER URINARY TRACT DISORDERS 审中-公开
标题翻译：治疗下尿路疾病的方法
公开(公告)号：WO2004089288A3
公开(公告)日：2005-04-21
申请号：PCT/US2004010088
申请日：2004-04-02
申请人： DYNOGEN PHARMACEUTICALS INC , LANDAU STEVEN B , MILLER CHERYL L , FRASER MATTHEW O
发明人： LANDAU STEVEN B , MILLER CHERYL L , FRASER MATTHEW O
IPC分类号： A01N43/54 , A61K31/00 , A61K31/135 , A61K31/519 , A61K31/535 , A61K31/551 , A61K31/5513 , A61K45/06
CPC分类号： A61K31/519 , A61K31/00 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.
摘要翻译：本发明涉及一种治疗需要治疗的受试者的下尿路疾病的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿。该方法包括向需要治疗的受试者施用治疗有效量的具有5-HT 3受体拮抗剂活性的化合物和NorAdrenaline再摄取抑制剂（NARI）活性。本发明还涉及在需要治疗的受试者中治疗下尿路障碍的至少一种症状的方法，其中所述症状选自尿频，尿急，尿急迫性尿失禁，夜尿和遗尿，包括向所述受试者共同施用第一量的5HT3拮抗剂和第二量的NARI，其中第一和第二量一起包含治疗有效量或各自以治疗有效量存在。

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