专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010022083A3 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用生物化学基质中的肌肉衍生的原料组合物的骨质保护及其治疗
公开(公告)号：WO2010022083A3
公开(公告)日：2010-06-24
申请号：PCT/US2009054200
申请日：2009-08-18
申请人： UNIV PITTSBURGH , PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
发明人： PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加非软组织进入非软组织部位（例如，骨）与生物相容性基质（优选SIS）组合时。本发明还提供使用包含肌源性祖细胞的组合物与生物相容性基质的方法，用于在治疗各种功能状况（包括骨质疏松症，佩吉特氏病，成骨不全，骨折）的哺乳动物，包括人类骨组织的增大和膨胀中，骨软化，骨小梁强度降低，骨皮质强度下降，老年骨密度降低。

2. 发明申请

WO2010022083A9 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 审中-公开
标题翻译：利用生物相容性基质中的肌肉衍生的前列腺组合物进行骨增强及其治疗
公开(公告)号：WO2010022083A9
公开(公告)日：2010-04-22
申请号：PCT/US2009054200
申请日：2009-08-18
申请人： UNIV PITTSBURGH , PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
发明人： PAYNE THOMAS , JANKOWSKI RONALD , USAS ARVYDAS , PAYNE KARIN A , HUARD JOHNNY
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植入身体组织后显示出长期存活并且可以在引入（例如经由注射，移植或植入）之后增强非软组织（例如通过注射，移植或植入）到非软组织部位骨）当与生物相容性基质（优选SIS）组合时。本发明进一步提供了使用包含肌肉衍生的祖细胞和生物相容性基质的组合物在包括骨质疏松症，佩吉特氏病，成骨不全，骨折在内的各种功能性病症的治疗中用于增强和增大哺乳动物包括人骨组织的方法，骨软化，骨小梁强度降低，骨皮质强度降低以及随年龄增长骨密度降低。

3. 发明申请

WO2010022083A2 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 审中-公开
标题翻译：利用生物相容性基质中的肌肉衍生的前列腺组合物进行骨增强及其治疗
公开(公告)号：WO2010022083A2
公开(公告)日：2010-02-25
申请号：PCT/US2009/054200
申请日：2009-08-18
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , PAYNE, Thomas , JANKOWSKI, Ronald , USAS, Arvydas , PAYNE, Karin, A. , HUARD, Johnny
发明人： PAYNE, Thomas , JANKOWSKI, Ronald , USAS, Arvydas , PAYNE, Karin, A. , HUARD, Johnny
IPC分类号： A61K35/32 , A61K35/38 , A61P19/00 , A61P19/10
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植入身体组织后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增强非软组织当与生物相容性基质（优选SIS）组合时，非软组织部位（例如骨）。本发明进一步提供了使用包含肌肉衍生的祖细胞和生物相容性基质的组合物在包括骨质疏松症，佩吉特氏病，成骨不全，骨折在内的各种功能性病症的治疗中用于增强和增大哺乳动物包括人骨组织的方法，骨软化，骨小梁强度下降，骨皮质强度下降和老年人骨密度下降。

4. 发明申请

WO0178754A3 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells compositionsand treatments thereof 审中-公开
标题翻译：使用肌肉来源的祖细胞组合物及其处理软组织和骨增大和膨胀
公开(公告)号：WO0178754A3
公开(公告)日：2002-04-25
申请号：PCT/US0112084
申请日：2001-04-12
申请人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER C , QU ZHUQING , UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , CAPELLI CHRISTOPHER C , QU ZHUQING
IPC分类号： A61P1/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P15/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P43/00 , C12N5/077 , A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the use of MDCs for the increase of skeletal muscle.

5. 发明申请

WO2004096245A3 MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATION 审中-公开
标题翻译：肌肉衍生细胞（MDCS）用于促进和增强神经修复和再生
公开(公告)号：WO2004096245A3
公开(公告)日：2005-02-10
申请号：PCT/US2004013115
申请日：2004-04-26
申请人： UNIV PITTSBURGH , CHANCELLOR MICHAEL B , HUARD JOHNNY , MINNERY BRANDON
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY , MINNERY BRANDON
IPC分类号： A61P25/00 , C12N5/077 , A61K35/34
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34
摘要： The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs, particularly associated with nerve damage or neuropathy. The invention relates to MDCs for use in methods for promoting or enhancing innervation of nerve cells, particularly in the peripheral nervous system, and their ability to contribute to the development of neuronal tissue when MDCs are introduced at or near a tissue or organ site in need of repair due to injury, damage, disease, or dysfunction. Such methods are useful for the treatment of central and peripheral nervous system disorders and to alleviate, abate, or eliminate the symptoms of neurologic or neurodegenerative diseases in animals, particularly mammals, including humans. The methods are also useful for treating both nerve and muscle tissue following injury, damage, or dysfunction to these tissue types.
摘要翻译：本发明描述了使用优选从骨骼肌获得的肌肉衍生细胞（MDC）来支持损伤的组织和器官的神经支配和修复，特别是与神经损伤或神经病有关的方法。本发明涉及用于促进或增强神经细胞神经细胞，特别是周围神经系统神经支配的方法中使用的MDC，以及当将MDCs引入到需要的组织或器官部位处或附近时有助于神经元组织发育的能力由于受伤，损伤，疾病或功能障碍引起的修复。这样的方法可用于治疗中枢和周围神经系统疾病并减轻，减轻或消除动物，特别是包括人在内的哺乳动物的神经退行性疾病或神经变性疾病的症状。这些方法对于在损伤，损伤或这些组织类型的功能障碍之后治疗神经和肌肉组织也是有用的。

6. 发明申请

WO2021030730A1 METHODS FOR TREATING DISEASE ASSOCIATED WITH SENESCENCE 审中-公开
公开(公告)号：WO2021030730A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/046461
申请日：2020-08-14
申请人： STEADMAN PHILIPPON RESEARCH INSTITUTE , HUARD, Johnny , PHILIPPON, Marc Joseph , RAVURI, Sudheer Kumar , HAMBRIGHT, William Sealy , HUARD, Charles , MULLEN II, Michael Terrance , MITCHELL, John Weston , WHITNEY, Kaitlyn Elizabeth
发明人： HUARD, Johnny , PHILIPPON, Marc Joseph , RAVURI, Sudheer Kumar , HAMBRIGHT, William Sealy , HUARD, Charles , MULLEN II, Michael Terrance , MITCHELL, John Weston , WHITNEY, Kaitlyn Elizabeth
IPC分类号： A61K31/47 , A61K31/4709
摘要： The present disclosure provides method of detecting senescent cells in a cell sample and methods of treating a disease, disorder, or condition associated with senescence in a subject by administering at least one senolytic agent to the subject.

7. 发明申请

WO2008086040A1 MUSCLE DERIVED CELLS FOR THE TREATMENT OF URINARY TRACT PATHOLOGIES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用于治疗尿道病变的肌肉衍生细胞及其制备和使用方法
公开(公告)号：WO2008086040A1
公开(公告)日：2008-07-17
申请号：PCT/US2008/000443
申请日：2008-01-11
申请人： UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , JANKOWSKI, Ronald , PRUCHNIC, Ryan , HUARD, Johnny
发明人： CHANCELLOR, Michael, B. , JANKOWSKI, Ronald , PRUCHNIC, Ryan , HUARD, Johnny
IPC分类号： C12N5/06 , A61K35/34 , A61P13/10
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for urinary incontinence and other urinary tract pathologies.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗包括畸形，损伤，无力，疾病或功能障碍的各种功能状况的哺乳动物包括人类软组织的增加和膨胀中。特别地，本发明提供了治疗和改善尿失禁和其他尿路病变。

8. 发明申请

WO2004096245A2 MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATION 审中-公开
标题翻译：肌肉衍生细胞（MDCS）用于促进和增强神经修复和再生
公开(公告)号：WO2004096245A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/013115
申请日：2004-04-26
申请人： THE UNIVERSITY OF PITTSBURGH , CHANCELLOR, Michael, B. , HUARD, Johnny , MINNERY, Brandon
发明人： CHANCELLOR, Michael, B. , HUARD, Johnny , MINNERY, Brandon
IPC分类号： A61K35/34
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34
摘要： The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs, particularly associated with nerve damage or neuropathy. The invention relates to MDCs for use in methods for promoting or enhancing innervation of nerve cells, particularly in the peripheral nervous system, and their ability to contribute to the development of neuronal tissue when MDCs are introduced at or near a tissue or organ site in need of repair due to injury, damage, disease, or dysfunction. Such methods are useful for the treatment of central and peripheral nervous system disorders and to alleviate, abate, or eliminate the symptoms of neurologic or neurodegenerative diseases in animals, particularly mammals, including humans. The methods are also useful for treating both nerve and muscle tissue following injury, damage, or dysfunction to these tissue types.
摘要翻译：本发明描述了使用优选从骨骼肌获得的肌肉衍生细胞（MDC）来支持损伤的组织和器官的神经支配和修复，特别是与神经损伤或神经病有关的方法。本发明涉及用于促进或增强神经细胞神经细胞，特别是周围神经系统神经支配的方法中使用的MDC，以及当将MDCs引入到需要的组织或器官部位处或附近时有助于神经元组织发育的能力由于受伤，损伤，疾病或功能障碍引起的修复。这样的方法可用于治疗中枢和周围神经系统疾病并减轻，减轻或消除动物，特别是包括人在内的哺乳动物的神经退行性疾病或神经变性疾病的症状。这些方法对于在损伤，损伤或这些组织类型的功能障碍之后治疗神经和肌肉组织也是有用的。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式