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1. 发明申请

WO2013009057A3 XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME 审中-公开
公开(公告)号：WO2013009057A3
公开(公告)日：2013-07-04
申请号：PCT/KR2012005423
申请日：2012-07-09
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
IPC分类号： A61F2/28 , A61L27/38 , A61L27/54 , C12N5/071
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/365 , A61L27/3687 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a bone grafting substitute and to a method for manufacturing same. The method for manufacturing the bone grafting substitute according to the present invention enables production of a bone grafting substitute which, compared with existing xenograft-derived bone grafting substitutes, has superior biocompatibility due to a lower protein content and which can fuse well in the tissues of a graft site without an inflammatory reaction, and furthermore, the method can provide increased osteoblast adhesion by treating surfaces of the bone grafting substitute with an acidic amino acid, and can provide improved conduction of newly-generated bone by introducing a bioactive factor.

2. 发明申请

WO2013009057A2 XENOGRAFT-DERIVED BONE GRAFTING SUBSTITUTE AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：异源衍生骨移植替代物及其制造方法
公开(公告)号：WO2013009057A2
公开(公告)日：2013-01-17
申请号：PCT/KR2012005423
申请日：2012-07-09
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , PARK HYUN JUNG
IPC分类号： A61F2/28 , A61L27/38 , A61L27/54 , C12N5/071
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/365 , A61L27/3687 , A61L2300/414 , A61L2400/06 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a bone grafting substitute and to a method for manufacturing same. The method for manufacturing the bone grafting substitute according to the present invention enables production of a bone grafting substitute which, compared with existing xenograft-derived bone grafting substitutes, has superior biocompatibility due to a lower protein content and which can fuse well in the tissues of a graft site without an inflammatory reaction, and furthermore, the method can provide increased osteoblast adhesion by treating surfaces of the bone grafting substitute with an acidic amino acid, and can provide improved conduction of newly-generated bone by introducing a bioactive factor.
摘要翻译：骨移植替代物及其制造方法技术领域本发明涉及一种骨移植替代物及其制造方法。根据本发明的用于制造骨移植替代物的方法能够生产骨移植替代物，与现有的异种移植物衍生的骨移植替代物相比，由于蛋白质含量较低且具有良好的生物相容性，没有炎症反应的移植部位，并且此方法通过用酸性氨基酸处理骨移植替代物的表面可以提供增加的成骨细胞粘附，并且通过引入生物活性因子可以改善新生骨的传导。

3. 发明申请

WO2012165737A9 CELL-PENETRATING FUSION PROTEIN FOR REGENERATING OR PROLIFERATING STEM CELL 审中-公开
标题翻译：细胞培养融合蛋白，用于再生或增殖干细胞
公开(公告)号：WO2012165737A9
公开(公告)日：2013-07-18
申请号：PCT/KR2011009709
申请日：2011-12-16
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
IPC分类号： C07K19/00 , A61P19/00 , C12N15/62
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/4702 , C07K14/51 , C07K2319/10 , C07K2319/21 , C07K2319/35 , C07K2319/73 , C12N9/0036 , C12N9/0089
摘要： The present invention relates to a cell-penetrating fusion protein for enhancing the regeneration of a stem cell, and more particularly, to a cell-penetrating fusion protein for enhancing the regeneration of a stem cell for accelerating stem cell differentiation, suppressing stem cell apoptosis, maintaining stem cell functionality, and recovering the functionality of the stem cell which is suppressed due to stress.
摘要翻译：本发明涉及用于增强干细胞再生的细胞穿透融合蛋白质，更具体地，涉及用于增强干细胞再生以促进干细胞分化，抑制干细胞凋亡的细胞穿透融合蛋白，维持干细胞功能，并恢复由于应激而被抑制的干细胞的功能。

4. 发明申请

WO2012144778A2 SURFACE-ACTIVE COLLAGEN BARRIER MEMBRANE TO WHICH A PEPTIDE IS BOUND 审中-公开
标题翻译：表面活性胶原蛋白膜对于肽是有害的
公开(公告)号：WO2012144778A2
公开(公告)日：2012-10-26
申请号：PCT/KR2012002895
申请日：2012-04-17
申请人： NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
IPC分类号： C07K19/00 , A61K38/39 , A61L27/24 , C07K14/78
CPC分类号： C07K14/51 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/412 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/78 , C07K2319/00
摘要： The present invention relates to a barrier membrane to which a peptide, which binds to collagen and which is capable of regenerating bone tissue, is bound. More particularly, the present invention relates to a collagen barrier membrane in which a fusion peptide consisting of a collagen-bound peptide and a functional bone-tissue-regenerating peptide is fixed to the surface of collagen. According to the present invention, the surface-active collagen barrier membrane, in which a fusion peptide is coupled to the surface of collagen, can stably bind to the body due to increased local retention, and promote the transport, proliferation, and differentiation of cells, to thereby ultimately maximize bone-tissue-regenerating capacity when implanted in the body. Therefore, the barrier membrane of the present invention is useful in the development of guided bone-regeneration technology. In addition, a fusion peptide can be applied to implants made of collagen having other shapes, and a collagen-bound peptide, which constitutes the fusion peptide, can be bound to and synthesized with a peptide having effects in regenerating other tissue, and therefore can be useful in tissue-regenerating biomaterials for other purposes, e.g. for regenerating skin.
摘要翻译：本发明涉及一种与胶原结合且能够再生骨组织的肽结合的阻隔膜。更具体地说，本发明涉及胶原屏障膜，其中由胶原结合肽和功能性骨组织再生肽组成的融合肽固定在胶原蛋白表面。根据本发明，融合肽与胶原表面偶联的表面活性胶原屏障膜可以由于局部保留的增加而稳定地结合身体，促进细胞的转运，增殖和分化，从而最终使植入体内的骨组织再生能力最大化。因此，本发明的阻隔膜可用于引导骨再生技术的开发。此外，融合肽可以应用于具有其他形状的胶原的植入物，并且构成融合肽的胶原结合肽可以与具有再生其他组织的肽结合并合成，因此可以用于组织再生生物材料用于其他目的，例如用于再生皮肤。

5. 发明申请

WO2010095881A3 TARGET ACTIVATED CELL/TISSUE TRANSLOCATION PEPTIDE FOR IMPERMEABLE COMPOUND STRATEGY, AND USES THEREOF 审中-公开
标题翻译：目标活化细胞/组织转移肽用于不可复制的化合物战略及其用途
公开(公告)号：WO2010095881A3
公开(公告)日：2011-01-06
申请号：PCT/KR2010001033
申请日：2010-02-19
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG , PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C
发明人： PARK YOON-JEONG , CHUNG CHONG-PYOUNG , YANG VICTOR C
IPC分类号： C07K19/00 , A61K38/17 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K47/645 , A61K47/65 , C07K2319/10
摘要： The present invention relates to a target activated cell/tissue translocation peptide for an impermeable compound strategy (TACTICS), and to uses thereof. More particularly, the present invention relates to a target activated cell/tissue translocation peptide for an impermeable compound strategy (TACTICS), which comprises (a) a protein transport domain (PTD), (B) a masking domain, and (C) a spacer having a target cell/tissue enzyme-specific cleavage, wherein the peptide is provided with selectivity to exhibit translocation performance specifically only in the target tissue. The present invention also relates to an image of the peptide, therapeutic drugs, or a complex of drug-containing grains. The target activated cell/tissue translocation peptide for an impermeable compound strategy-drug complex according to the present invention provides the peptide with target selectivity to obtain the highest quality images and excellent curative effects, and inhibits the unspecific distribution of the complex in the body to minimize side effects and maximize diagnosis effects. Thus, the peptide of the present invention can be valuably used in treating diseases.
摘要翻译：本发明涉及用于不可渗透化合物策略（TACTICS）的靶活化细胞/组织易位肽及其应用。更具体地，本发明涉及用于不可渗透化合物策略（TACTICS）的靶活化细胞/组织易位肽，其包含（a）蛋白质转运结构域（PTD），（B）掩蔽结构域，和（C）具有靶细胞/组织酶特异性切割的间隔物，其中所述肽具有仅在靶组织中显示易位性能的选择性。本发明还涉及肽，治疗药物或含药颗粒的复合物的图像。根据本发明的用于不可渗透化合物策略 - 药物复合物的靶活化细胞/组织易位肽提供具有靶选择性的肽以获得最高质量的图像和优异的疗效，并且抑制复合体在体内的非特异性分布尽量减少副作用并最大化诊断效果。因此，本发明的肽可以有价值地用于治疗疾病。

6. 发明申请

WO2012144778A3 SURFACE-ACTIVE COLLAGEN BARRIER MEMBRANE TO WHICH A PEPTIDE IS BOUND 审中-公开
标题翻译：表面活性胶原蛋白膜对于肽是有害的
公开(公告)号：WO2012144778A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012002895
申请日：2012-04-17
申请人： NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SHIM IN KYONG , PARK HYUN JUNG
IPC分类号： C07K19/00 , A61K38/39 , A61L27/24 , C07K14/78
CPC分类号： C07K14/51 , A61K38/00 , A61L27/227 , A61L27/54 , A61L2300/25 , A61L2300/412 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/78 , C07K2319/00
摘要： The present invention relates to a barrier membrane to which a peptide, which binds to collagen and which is capable of regenerating bone tissue, is bound. More particularly, the present invention relates to a collagen barrier membrane in which a fusion peptide consisting of a collagen-bound peptide and a functional bone-tissue-regenerating peptide is fixed to the surface of collagen. According to the present invention, the surface-active collagen barrier membrane, in which a fusion peptide is coupled to the surface of collagen, can stably bind to the body due to increased local retention, and promote the transport, proliferation, and differentiation of cells, to thereby ultimately maximize bone-tissue-regenerating capacity when implanted in the body. Therefore, the barrier membrane of the present invention is useful in the development of guided bone-regeneration technology. In addition, a fusion peptide can be applied to implants made of collagen having other shapes, and a collagen-bound peptide, which constitutes the fusion peptide, can be bound to and synthesized with a peptide having effects in regenerating other tissue, and therefore can be useful in tissue-regenerating biomaterials for other purposes, e.g. for regenerating skin.
摘要翻译：本发明涉及一种与胶原结合且能够再生骨组织的肽结合的阻隔膜。更具体地说，本发明涉及胶原屏障膜，其中由胶原结合肽和功能性骨组织再生肽组成的融合肽固定在胶原蛋白表面。根据本发明，融合肽与胶原表面偶联的表面活性胶原屏障膜可以由于局部保留的增加而稳定地结合身体，促进细胞的转运，增殖和分化，从而最终使植入体内的骨组织再生能力最大化。因此，本发明的阻隔膜可用于引导骨再生技术的开发。此外，融合肽可以应用于具有其他形状的胶原的植入物，并且构成融合肽的胶原结合肽可以与具有再生其他组织的作用的肽结合并合成，因此可以用于组织再生生物材料用于其他目的，例如用于再生皮肤。

7. 发明申请

WO2011105869A3 DENTAL CLEANSER COMPOSITION FOR IMPROVING THE PROPERTIES OF ADHERING TO TEETH 审中-公开
标题翻译：牙齿清洁剂组合物，用于改善粘附于牙齿的性质
公开(公告)号：WO2011105869A3
公开(公告)日：2012-02-02
申请号：PCT/KR2011001384
申请日：2011-02-28
申请人： NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
IPC分类号： A61K6/027 , A61K6/08 , A61Q11/00
CPC分类号： A61K6/0035 , A61K8/39 , A61K8/64 , A61K8/731 , A61Q11/00 , A61Q17/005
摘要： The present invention relates to a dental cleanser for improving the properties of adhering to teeth, and more particularly, to a dental cleanser which removes a smear layer from the dentin surface of the exposed root of a tooth and oral bacteria so as to effectively improve the properties of adhering to teeth in periodontal flap surgery. The dental cleanser of the present invention removes the smear layer from the dentin surface of the root of a tooth by means of sodium ethylene diaminotetraacetate, performs antibacterial activity on periodontal pathogens, and removes lipopolysaccharide by means of octyl phenol ethoxylate, which is a surface active agent, thereby improving the properties of adhering to teeth in periodontal flap surgery.
摘要翻译：本发明涉及一种用于改善牙齿粘附性能的牙齿清洁剂，更具体地说，涉及一种牙齿清洁剂，该牙齿清洁剂从牙齿和口腔细菌的暴露根部的牙本质表面除去涂抹层，以有效地改善在牙周皮瓣手术中粘附牙齿的性质。本发明的牙齿清洁剂通过乙二胺四乙酸钠从牙根的牙本质表面除去涂抹层，对牙周病原体进行抗菌活性，并通过辛基苯酚乙氧基化物去除脂多糖，其为表面活性物质代理，从而改善牙周皮瓣手术中粘附牙齿的性质。

8. 发明申请

WO2011159071A3 PEPTIDE HAVING ANTIMICROBIAL OR ANTI-INFLAMMATORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：具有抗炎作用或抗炎活性的肽和含有作为活性成分的药物组合物
公开(公告)号：WO2011159071A3
公开(公告)日：2012-06-07
申请号：PCT/KR2011004300
申请日：2011-06-13
申请人： NANO INTELLIGENT BIOMED ENG , CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON
IPC分类号： A61K38/16 , A61K38/10 , A61K38/17 , A61K38/18 , A61P29/00 , A61P31/04
CPC分类号： C07K14/4723 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K38/1729 , A61K38/18 , A61K38/1808 , A61K38/1858
摘要： The present invention relates to a peptide having antimicrobial or anti-inflammatory activity and to a pharmaceutical composition containing the same as an active ingredient. More particularly, the present invention relates to a peptide having antimicrobial or anti-inflammatory activity against dental infection bacteria including periodontal pathogens and bacteria which cause atopic dermatitis, and to a pharmaceutical composition containing the peptide as an active ingredient. The peptide according to the present invention, which has antimicrobial or anti-inflammatory activity, can be used for treating dental infections such as periodontitis and peri-implantitis, and for treating inflammations such as atopic dermatitis, psoriasis and arthritis.
摘要翻译：本发明涉及具有抗微生物或抗炎活性的肽以及含有作为活性成分的药物组合物。更具体地，本发明涉及对牙齿感染细菌（包括牙周病原体和导致特应性皮炎的细菌）具有抗微生物或抗炎活性的肽以及含有该肽作为活性成分的药物组合物。具有抗微生物或抗炎活性的本发明的肽可用于治疗诸如牙周炎和植入周围炎之类的牙齿感染，以及用于治疗诸如特应性皮炎，牛皮癣和关节炎的炎症。

9. 发明申请

WO2010041884A3 COMPOSITION FOR TOOTH DESENSITIZER 审中-公开
标题翻译：用于牙科去渗剂的组合物
公开(公告)号：WO2010041884A3
公开(公告)日：2010-07-08
申请号：PCT/KR2009005760
申请日：2009-10-08
申请人： SEOUL NAT UNIVERSITY R & DB FO , PARK YOON-JEONG , CHUNG CHONG-PYOUNG , LEE JUE-YEON , PARK HYUN JUNG
发明人： PARK YOON-JEONG , CHUNG CHONG-PYOUNG , LEE JUE-YEON , PARK HYUN JUNG
IPC分类号： A61K6/08
CPC分类号： A61K6/08 , A61K6/0017 , C08L71/02 , C08L1/08 , C08L29/04 , C08L35/08 , C08L39/06
摘要： The present invention relates to a composition for a tooth desensitizer, and more specifically to a composition for a tooth desensitizer comprising an adhesive polymer for tooth coating, an active substance for desensitization, a substance for promoting penetration of said active substance for desensitization, an active substance for alleviating sensitive nerves, and a pH regulator. The sensation during usage of the tooth composition for desensitizer of the present invention can be the same as the sensation during usage of existing tooth desensitizers and desensitizing effects thereof can rapidly be exhibited. Further, the tooth composition for desensitizer may have the long-term preservation of the desensitizing condition.
摘要翻译：本发明涉及一种用于牙齿脱敏剂的组合物，更具体地说，涉及一种用于牙齿脱敏剂的组合物，其包括用于牙齿涂覆的粘合剂聚合物，用于脱敏的活性物质，用于促进所述活性物质渗透以脱敏的物质，活性物质减轻敏感神经的物质和pH调节剂。在本发明的脱敏剂用牙齿组合物使用中的感觉可以与使用现有的牙齿脱敏剂时的感觉相同，并且可以快速显示其脱敏作用。此外，用于脱敏剂的牙齿组合物可以长期保持脱敏状态。

10. 发明公开

EP2615105A4 HUMAN-DERIVED CELL-PERMEABLE PEPTIDE BIOACTIVE PEPTIDE CONJUGATE, AND USE THEREOF 有权
标题翻译： AUS MENSCHLICHEN ZELLEN GEWONNENES ZELLPERMEABLES PEPTID，BIOAKTIVES PEPTIDKONJUGAT UND VERWENDUNG DAVON
公开(公告)号：EP2615105A4
公开(公告)日：2013-11-13
申请号：EP11823705
申请日：2011-04-25
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SUH JIN SOOK
IPC分类号： C07K7/06 , A61K38/08 , A61P19/00 , C07K7/08
CPC分类号： C07K14/435 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/51
摘要： The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof, and more particularly, to human-derived cell permeable peptide-bioactive peptide conjugate capable of directly permeate into a target cell to function as a peptide therapeutics by chemically binding cell permeable peptide to a bioactivity inducing sequences selected from a group consisting of a bone differentiation inducing sequence, a bone regeneration inducting sequence, and an anti-inflammation functional sequence to thereby directly introduce an important domain of an impermeable intracellular protein having a bioactivity into cells, and to a pharmaceutical composition for treatment containing the same. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immuno-genicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development pf a drug delivery system and treatment technologies using said peptide.
摘要翻译：本发明涉及新的源于人的细胞可渗透性肽 - 生物活性肽缀合物及其用途，并且更具体地涉及能够直接渗透到靶细胞中以起到肽的作用的源自人的可透过细胞的肽 - 生物活性肽缀合物通过化学结合细胞可渗透肽至选自骨分化诱导序列，骨再生诱导序列和抗炎功能序列的生物活性诱导序列，从而直接引入不可渗透细胞内蛋白质的重要结构域生物活性进入细胞，并且涉及包含其的治疗用药物组合物。根据本发明，源自人骨形态发生蛋白-4的阳离子细胞可渗透肽没有毒性和免疫原性，因此与病毒肽递送载体相比表现出高稳定性，并且可以将细胞不可渗透的物质转运入细胞并进入生物体而不会对细胞或物质造成任何损害，从而显着增加靶基因表达。另外，所述肽可以应用于临床使用而不需要经历大量工艺并且大量生产，使得本发明可以用于药物递送系统的开发以及使用所述肽的治疗技术。

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