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1. 发明公开

EP2615105A4 HUMAN-DERIVED CELL-PERMEABLE PEPTIDE BIOACTIVE PEPTIDE CONJUGATE, AND USE THEREOF 有权
标题翻译： AUS MENSCHLICHEN ZELLEN GEWONNENES ZELLPERMEABLES PEPTID，BIOAKTIVES PEPTIDKONJUGAT UND VERWENDUNG DAVON
公开(公告)号：EP2615105A4
公开(公告)日：2013-11-13
申请号：EP11823705
申请日：2011-04-25
申请人： UNIV SEOUL NAT R & DB FOUND , NANO INTELLIGENT BIOMED ENG
发明人： CHUNG CHONG-PYOUNG , PARK YOON-JEONG , LEE JUE-YEON , SUH JIN SOOK
IPC分类号： C07K7/06 , A61K38/08 , A61P19/00 , C07K7/08
CPC分类号： C07K14/435 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/51
摘要： The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof, and more particularly, to human-derived cell permeable peptide-bioactive peptide conjugate capable of directly permeate into a target cell to function as a peptide therapeutics by chemically binding cell permeable peptide to a bioactivity inducing sequences selected from a group consisting of a bone differentiation inducing sequence, a bone regeneration inducting sequence, and an anti-inflammation functional sequence to thereby directly introduce an important domain of an impermeable intracellular protein having a bioactivity into cells, and to a pharmaceutical composition for treatment containing the same. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immuno-genicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development pf a drug delivery system and treatment technologies using said peptide.
摘要翻译：本发明涉及新的源于人的细胞可渗透性肽 - 生物活性肽缀合物及其用途，并且更具体地涉及能够直接渗透到靶细胞中以起到肽的作用的源自人的可透过细胞的肽 - 生物活性肽缀合物通过化学结合细胞可渗透肽至选自骨分化诱导序列，骨再生诱导序列和抗炎功能序列的生物活性诱导序列，从而直接引入不可渗透细胞内蛋白质的重要结构域生物活性进入细胞，并且涉及包含其的治疗用药物组合物。根据本发明，源自人骨形态发生蛋白-4的阳离子细胞可渗透肽没有毒性和免疫原性，因此与病毒肽递送载体相比表现出高稳定性，并且可以将细胞不可渗透的物质转运入细胞并进入生物体而不会对细胞或物质造成任何损害，从而显着增加靶基因表达。另外，所述肽可以应用于临床使用而不需要经历大量工艺并且大量生产，使得本发明可以用于药物递送系统的开发以及使用所述肽的治疗技术。

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