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1. 发明申请

WO2011028603A2 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 审中-公开
标题翻译：用于治疗和成像超声波传感器的微机控制器
公开(公告)号：WO2011028603A2
公开(公告)日：2011-03-10
申请号：PCT/US2010046794
申请日：2010-08-26
申请人： UNIV MICHIGAN , ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS JR , TEOFILOVIC DEJAN
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS JR , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是可以对目标组织体积进行成像，并将超声能量应用于目标组织体积。在一些实施例中，医疗成像和治疗装置被配置为可控制地将超声能量施加到前列腺中，通过维持由成像系统产生的前列腺图像内的超声治疗系统产生的空泡气泡云。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

2. 发明申请

WO2011022411A3 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 审中-公开
标题翻译：可配置的声学耦合中间容器
公开(公告)号：WO2011022411A3
公开(公告)日：2012-04-19
申请号：PCT/US2010045775
申请日：2010-08-17
申请人： HISTOSONICS INC , JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W , UNIV MICHIGAN
发明人： JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W
IPC分类号： A61B8/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的医学成像和治疗装置。该装置的一个特点是它可以将超声治疗换能器声学耦合到患者。在一些实施例中，医学成像和治疗装置被配置为符合患者的会阴区域的解剖结构，以便将超声治疗换能器声学耦合到患者以治疗BPH。医学成像和治疗装置可用于治疗应用，例如组织切除术，碎石术和HIFU。还涉及与使用医学成像和治疗装置相关的方法。

3. 发明公开

EP3016594A4 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 有权
标题翻译： FÜRBLASENWOLKENBILDUNG MIT SCHOCKSTREUUNG OPTIMIERTE HISTOTRIPSIE-ERREGUNGSSEQUENZEN
公开(公告)号：EP3016594A4
公开(公告)日：2017-06-14
申请号：EP14819742
申请日：2014-07-03
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： CANNATA JONATHAN , HALL TIMOTHY L , MAXWELL ADAM , TEOFILOVIC DEJAN
IPC分类号： A61B8/00 , A61B17/22
CPC分类号： A61N7/00 , A61B17/22004 , A61B17/225 , A61B2017/00176 , A61B2017/22008 , A61B2017/22028 , A61N2007/0039 , A61N2007/0078

4. 发明申请

WO2014043206A3 HISTOTRIPSY THERAPY SYSTEM 审中-公开
标题翻译：遗传性治疗系统
公开(公告)号：WO2014043206A3
公开(公告)日：2014-05-08
申请号：PCT/US2013059220
申请日：2013-09-11
申请人： HISTOSONICS INC , UNIV MICHIGAN
发明人： TEOFILOVIC DEJAN , HALL TIMOTHY L , CAIN CHARLES A
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/22004 , A61B2017/22008 , A61N7/02 , A61N2007/0039 , A61N2007/0078
摘要： A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes at least one signal switching amplifier electrically coupled to a high voltage power supply, a pulse generator electrically coupled to signal switching amplifier(s), at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element, each transducer element of the ultrasound transducer being coupled to the at least one matching network. In some embodiments, each transducer element has an input impedance that is higher, sometimes more than 2 times higher, than an output impedance of its corresponding signal switching amplifier. Methods of use are also described.
摘要翻译：提供了一个组织治疗系统，可以包含任何数量的功能。在一些实施例中，该系统包括电耦合到高压电源的至少一个信号开关放大器，电耦合到信号开关放大器的脉冲发生器，电耦合到信号开关放大器的至少一个匹配网络，以及具有至少一个换能器元件的超声换能器，所述超声换能器的每个换能器元件耦合到所述至少一个匹配网络。在一些实施例中，每个换能器元件具有比其对应的信号开关放大器的输出阻抗更高，有时超过2倍的输入阻抗。还描述了使用方法。

5. 发明专利

CA2770700C MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 未知
公开(公告)号：CA2770700C
公开(公告)日：2018-04-24
申请号：CA2770700
申请日：2010-08-26
申请人： UNIV MICHIGAN REGENTS , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

6. 发明专利

CA2770452A1 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 未知
公开(公告)号：CA2770452A1
公开(公告)日：2011-02-24
申请号：CA2770452
申请日：2010-08-17
申请人： HISTOSONICS INC , UNIV MICHIGAN
发明人： JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W
IPC分类号： A61B8/14 , A61N7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

7. 发明公开

EP2470267A4 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 有权
标题翻译：微机器人控制臂的治疗和成像的超声波转换器
公开(公告)号：EP2470267A4
公开(公告)日：2013-09-18
申请号：EP10814299
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS JR , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
CPC分类号： A61N7/02 , A61B8/12 , A61B8/4218 , A61B34/72 , A61B90/50 , A61B2017/22008 , A61B2090/378
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

8. 发明公开

EP2467062A4 DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 有权
标题翻译： EINWEG-MEDIENGERÄÄMIT AKUSTISCHER KOPPLUNG
公开(公告)号：EP2467062A4
公开(公告)日：2013-04-24
申请号：EP10810498
申请日：2010-08-17
申请人： HISTOSONICS INC , UNIV MICHIGAN
发明人： JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2251 , A61B17/2256 , A61B2017/00274 , A61B2017/2253 , A61B2018/00547 , A61B2090/378 , A61N2007/0039 , A61N2007/0043

9. 发明专利

AU2010289769B2 Micromanipulator control arm for therapeutic and imaging ultrasound transducers 未知
公开(公告)号：AU2010289769B2
公开(公告)日：2016-06-30
申请号：AU2010289769
申请日：2010-08-26
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER JR MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

10. 发明专利

CA2770700A1 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 未知
公开(公告)号：CA2770700A1
公开(公告)日：2011-03-10
申请号：CA2770700
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS JR , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

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