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1. 发明专利

CA2770700C MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 未知
公开(公告)号：CA2770700C
公开(公告)日：2018-04-24
申请号：CA2770700
申请日：2010-08-26
申请人： UNIV MICHIGAN REGENTS , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

2. 发明专利

AU2010289769B2 Micromanipulator control arm for therapeutic and imaging ultrasound transducers 未知
公开(公告)号：AU2010289769B2
公开(公告)日：2016-06-30
申请号：AU2010289769
申请日：2010-08-26
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER JR MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

3. 发明专利

BR112015032926B1 Sistema de terapia de ultrassom 未知
公开(公告)号：BR112015032926B1
公开(公告)日：2022-04-05
申请号：BR112015032926
申请日：2014-07-03
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： MAXWELL ADAM , TEOFILOVIC DEJAN , CANNATA JONATHAN , TIMOTHY L HALL
IPC分类号： A61B8/00
摘要： sequências de excitação de histotripsia otimizadas para a formação de nuvem de bolha ao usar dispersão de choque. a presente invenção refere-se a métodos e dispositivos para a produção de cavitação em tecido. em uma modalidade, um método de dispersão de choque de terapia de histotripsia compreende a aplicação de uma forma de onda de pressão de iniciação de um transdutor de terapia de ultrassom em tecido, em que a forma de onda de pressão de iniciação é configurada para produzir pelo menos uma bolha no tecido, a aplicação de uma forma de onda de pressão de dispersão do transdutor de terapia de ultrassom em pelo menos uma bolha dentro de um ciclo de vida de pelo menos uma bolha, e a produção de núcleos da cavitação perto de pelo menos uma bolha com a forma de onda de pressão de dispersão. a forma de onda de pressão de dispersão pode ser aplicada durante o ciclo de vida de pelo menos uma bolha. em algumas modalidades, a forma de onda de pressão de dispersão é aplicado dentro 5 µs a 1 s do forma de onda de pressão de iniciação. os sistemas para executar a terapia de histotripsia de dispersão de choque também são discutidos.

4. 发明专利

CA2770452C DISPOSABLE ACOUSTIC COUPLING MEDIUM CONTAINER 未知
公开(公告)号：CA2770452C
公开(公告)日：2017-09-19
申请号：CA2770452
申请日：2010-08-17
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W
IPC分类号： A61B8/12 , A61B17/225 , A61N7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

5. 发明专利

AU2010284313B2 Disposable acoustic coupling medium container 未知
公开(公告)号：AU2010284313B2
公开(公告)日：2016-01-28
申请号：AU2010284313
申请日：2010-08-17
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： JAHNKE RUSSELL , BERTOLINA JAMES , ROBERTS WILLIAM , CAIN CHARLES , TEOFILOVIC DEJAN , DAVISON THOMAS W
IPC分类号： A61B8/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can acoustically couple an ultrasound therapy transducer to a patient. In some embodiments, the medical imaging and therapy device is configured to conform to the anatomy of a patient's perineal area to acoustically couple an ultrasound therapy transducer to the patient for treatment of BPH. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

6. 发明公开

EP3016594A4 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 有权
标题翻译： FÜRBLASENWOLKENBILDUNG MIT SCHOCKSTREUUNG OPTIMIERTE HISTOTRIPSIE-ERREGUNGSSEQUENZEN
公开(公告)号：EP3016594A4
公开(公告)日：2017-06-14
申请号：EP14819742
申请日：2014-07-03
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： CANNATA JONATHAN , HALL TIMOTHY L , MAXWELL ADAM , TEOFILOVIC DEJAN
IPC分类号： A61B8/00 , A61B17/22
CPC分类号： A61N7/00 , A61B17/22004 , A61B17/225 , A61B2017/00176 , A61B2017/22008 , A61B2017/22028 , A61N2007/0039 , A61N2007/0078

7. 发明专利

CA2869400C SYSTEMS AND METHODS FOR OBTAINING LARGE CREEPAGE ISOLATION ON PRINTED CIRCUIT BOARDS 未知
公开(公告)号：CA2869400C
公开(公告)日：2020-09-15
申请号：CA2869400
申请日：2013-04-11
申请人： HISTOSONICS INC
发明人： TEOFILOVIC DEJAN
IPC分类号： G02B6/43 , A61B17/00 , A61B18/00 , H03K17/78 , H04B10/80
摘要： An electrical circuit with large creepage isolation distances is provided. In some embodiments, the electrical circuit is capable of increasing creepage isolation distances by many multiples over traditional electrical circuits. In one embodiment, an electrical circuit comprises a ground circuit optically coupled to a floating circuit, and an isolated circuit optically coupled to the floating circuit. The circuits can be optically coupled with opto-isolators, for example. The isolated circuit can have a creepage isolation distance at least twice as large as a traditional circuit. In some embodiments, "n" number of floating circuits can be optically coupled between the ground circuit and the isolated circuit to increase the total creepage isolation distance by a factor of "n". Methods of use are also described.

8. 发明申请

WO2014043206A3 HISTOTRIPSY THERAPY SYSTEM 审中-公开
标题翻译：遗传性治疗系统
公开(公告)号：WO2014043206A3
公开(公告)日：2014-05-08
申请号：PCT/US2013059220
申请日：2013-09-11
申请人： HISTOSONICS INC , UNIV MICHIGAN
发明人： TEOFILOVIC DEJAN , HALL TIMOTHY L , CAIN CHARLES A
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/22004 , A61B2017/22008 , A61N7/02 , A61N2007/0039 , A61N2007/0078
摘要： A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes at least one signal switching amplifier electrically coupled to a high voltage power supply, a pulse generator electrically coupled to signal switching amplifier(s), at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element, each transducer element of the ultrasound transducer being coupled to the at least one matching network. In some embodiments, each transducer element has an input impedance that is higher, sometimes more than 2 times higher, than an output impedance of its corresponding signal switching amplifier. Methods of use are also described.
摘要翻译：提供了一个组织治疗系统，可以包含任何数量的功能。在一些实施例中，该系统包括电耦合到高压电源的至少一个信号开关放大器，电耦合到信号开关放大器的脉冲发生器，电耦合到信号开关放大器的至少一个匹配网络，以及具有至少一个换能器元件的超声换能器，所述超声换能器的每个换能器元件耦合到所述至少一个匹配网络。在一些实施例中，每个换能器元件具有比其对应的信号开关放大器的输出阻抗更高，有时超过2倍的输入阻抗。还描述了使用方法。

9. 发明专利

CA3120586A1 HISTOTRIPSY SYSTEMS AND METHODS 未知
公开(公告)号：CA3120586A1
公开(公告)日：2020-06-04
申请号：CA3120586
申请日：2019-11-27
申请人： HISTOSONICS INC
发明人： CANNATA JONATHAN M , MILLER RYAN , DURYEA ALEXANDER P , TEOFILOVIC DEJAN , MLADENOVIC ZELJKO , RAKIC ALEKSANDRA , STOPEK JOSHUA
IPC分类号： A61B17/22 , A61B8/00 , A61B17/225 , A61B90/00 , A61N7/00
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

10. 发明专利

AU2013245840B2 Systems and methods for obtaining large creepage isolation on printed circuit boards 未知
公开(公告)号：AU2013245840B2
公开(公告)日：2017-01-05
申请号：AU2013245840
申请日：2013-04-11
申请人： HISTOSONICS INC
发明人： TEOFILOVIC DEJAN
IPC分类号： G02B26/00
摘要： An electrical circuit with large creepage isolation distances is provided. In some embodiments, the electrical circuit is capable of increasing creepage isolation distances by many multiples over traditional electrical circuits. In one embodiment, an electrical circuit comprises a ground circuit optically coupled to a floating circuit, and an isolated circuit optically coupled to the floating circuit. The circuits can be optically coupled with opto-isolators, for example. The isolated circuit can have a creepage isolation distance at least twice as large as a traditional circuit. In some embodiments, "n" number of floating circuits can be optically coupled between the ground circuit and the isolated circuit to increase the total creepage isolation distance by a factor of "n". Methods of use are also described.

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