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1. 发明专利

CA2770700C MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 未知
公开(公告)号：CA2770700C
公开(公告)日：2018-04-24
申请号：CA2770700
申请日：2010-08-26
申请人： UNIV MICHIGAN REGENTS , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

2. 发明专利

AU2010289775B2 Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones 未知
$Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones$
公开(公告)号：AU2010289775B2
公开(公告)日：2016-02-04
申请号：AU2010289775
申请日：2010-08-26
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： CAIN CHARLES A , HALL TIMOTHY L , ROBERTS WILLIAM W , XU ZHEN , FOWLKES J BRIAN , DAVISON THOMAS W
IPC分类号： A61B17/225 , A61B6/12 , A61B8/00 , A61B18/26
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

3. 发明专利

AU2010289769B2 Micromanipulator control arm for therapeutic and imaging ultrasound transducers 未知
公开(公告)号：AU2010289769B2
公开(公告)日：2016-06-30
申请号：AU2010289769
申请日：2010-08-26
申请人： HISTOSONICS INC , UNIV MICHIGAN REGENTS
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER JR MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

4. 发明专利

CA2770706C DEVICES AND METHODS FOR USING CONTROLLED BUBBLE CLOUD CAVITATION IN FRACTIONATING URINARY STONES 未知
公开(公告)号：CA2770706C
公开(公告)日：2017-06-20
申请号：CA2770706
申请日：2010-08-26
申请人： UNIV MICHIGAN REGENTS , HISTOSONICS INC
发明人： CAIN CHARLES A , HALL TIMOTHY L , ROBERTS WILLIAM W , XU ZHEN , FOWLKES J BRIAN , DAVISON THOMAS W
IPC分类号： A61B17/225 , A61B6/12 , A61B8/00 , A61B18/26
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

5. 发明申请

WO2016210133A8 HISTOTRIPSY THERAPY SYSTEMS AND METHODS FOR THE TREATMENT OF BRAIN TISSUE 审中-公开
标题翻译：治疗脑组织的组织疗法系统及方法
公开(公告)号：WO2016210133A8
公开(公告)日：2017-02-09
申请号：PCT/US2016039020
申请日：2016-06-23
申请人： UNIV MICHIGAN REGENTS
发明人： XU ZHEN , SUKOVICH JONATHAN , PANDEY ADITYA S , CAIN CHARLES A , GURM HITINDER S
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61N2007/003 , A61N2007/0047 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.
摘要翻译：提供了构造用于治疗脑组织的组织切除治疗系统，其可以包括任何数量的特征。在一个实施例中，系统包括超声治疗换能器，排液导管和设置在排液导管中的多个压电传感器。超声治疗被配置为将超声脉冲传输到脑中以产生液化脑中的靶组织的气蚀。引流导管构造成检测超声脉冲。可以通过系统基于由排液导管测量的超声脉冲来执行像差校正算法，以自动校正由穿过患者的颅盖的超声脉冲引起的像差效应。

6. 发明专利

CA2770706A1 DEVICES AND METHODS FOR USING CONTROLLED BUBBLE CLOUD CAVITATION IN FRACTIONATING URINARY STONES 未知
公开(公告)号：CA2770706A1
公开(公告)日：2011-03-10
申请号：CA2770706
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： CAIN CHARLES A , HALL TIMOTHY L , ROBERTS WILLIAM R , XU ZHEN , FOWLKES J BRIAN , DAVISON THOMAS W
IPC分类号： A61B17/225 , A61B6/12 , A61B8/00 , A61B18/26
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

7. 发明专利

AU2010289775A1 Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones 未知
$Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones$
公开(公告)号：AU2010289775A1
公开(公告)日：2012-03-08
申请号：AU2010289775
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： CAIN CHARLES A , HALL TIMOTHY L , ROBERTS WILLIAM W , XU ZHEN , FOWLKES J BRIAN , DAVISON THOMAS W
IPC分类号： A61B17/225 , A61B6/12 , A61B8/00 , A61B18/26
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

8. 发明专利

CA2770700A1 MICROMANIPULATOR CONTROL ARM FOR THERAPEUTIC AND IMAGING ULTRASOUND TRANSDUCERS 未知
公开(公告)号：CA2770700A1
公开(公告)日：2011-03-10
申请号：CA2770700
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER MICHAEL THOMAS JR , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

9. 发明申请

WO2014043206A3 HISTOTRIPSY THERAPY SYSTEM 审中-公开
标题翻译：遗传性治疗系统
公开(公告)号：WO2014043206A3
公开(公告)日：2014-05-08
申请号：PCT/US2013059220
申请日：2013-09-11
申请人： HISTOSONICS INC , UNIV MICHIGAN
发明人： TEOFILOVIC DEJAN , HALL TIMOTHY L , CAIN CHARLES A
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/22004 , A61B2017/22008 , A61N7/02 , A61N2007/0039 , A61N2007/0078
摘要： A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes at least one signal switching amplifier electrically coupled to a high voltage power supply, a pulse generator electrically coupled to signal switching amplifier(s), at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element, each transducer element of the ultrasound transducer being coupled to the at least one matching network. In some embodiments, each transducer element has an input impedance that is higher, sometimes more than 2 times higher, than an output impedance of its corresponding signal switching amplifier. Methods of use are also described.
摘要翻译：提供了一个组织治疗系统，可以包含任何数量的功能。在一些实施例中，该系统包括电耦合到高压电源的至少一个信号开关放大器，电耦合到信号开关放大器的脉冲发生器，电耦合到信号开关放大器的至少一个匹配网络，以及具有至少一个换能器元件的超声换能器，所述超声换能器的每个换能器元件耦合到所述至少一个匹配网络。在一些实施例中，每个换能器元件具有比其对应的信号开关放大器的输出阻抗更高，有时超过2倍的输入阻抗。还描述了使用方法。

10. 发明专利

AU2010289769A1 Micromanipulator control arm for therapeutic and imaging ultrasound transducers 未知
公开(公告)号：AU2010289769A1
公开(公告)日：2012-03-15
申请号：AU2010289769
申请日：2010-08-26
申请人： UNIV MICHIGAN , HISTOSONICS INC
发明人： ROBERTS WILLIAM W , HALL TIMOTHY L , CAIN CHARLES A , FOWLKES J BRIAN , XU ZHEN , KUSNER JR MICHAEL THOMAS , TEOFILOVIC DEJAN
IPC分类号： A61N7/00 , A61B8/00 , A61B8/13 , B25J7/00
摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can image a target tissue volume and apply ultrasound energy to the target tissue volume. In some embodiments, the medical imaging and therapy device is configured controllably apply ultrasound energy into the prostate by maintaining a cavitational bubble cloud generated by an ultrasound therapy system within an image of the prostate generated by an imaging system. The medical imaging and therapy device can be used in therapeutic applications such as Histotripsy, Lithotripsy, and HIFU, for example. Methods associated with use of the medical imaging and therapy device are also covered.

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