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1. 发明专利

IL288378D0 18f-radiolabeled biomolecules 未知
公开(公告)号：IL288378D0
公开(公告)日：2022-01-01
申请号：IL28837821
申请日：2021-11-24
申请人： UNIV DUKE , VAIDYANATHAN GANESAN , ZHOU ZHENGYUAN , ZALUTSKY MICHAEL ROD
发明人： VAIDYANATHAN GANESAN , ZHOU ZHENGYUAN , ZALUTSKY MICHAEL ROD
IPC分类号： C07B59/00
摘要： The application is drawn to 18F-radiolabeled residualizing agents and biomolecules and methods for radiolabeling biomolecules with radioactive fluorine atoms. The biomolecules have an affinity for particular types of cells and may specifically bind a certain cell, such as a cancer cell. Relevant biomolecules include antibodies, monoclonal antibodies, antibody fragments, peptides, other proteins, nanoparticles and aptamers. The application further provides compositions including such labeled biomolecules, as well as methods of using the labeled biomolecules and/or compositions in imaging applications.

2. 发明专利

IL276528D0 Psma targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy 未知
公开(公告)号：IL276528D0
公开(公告)日：2020-09-30
申请号：IL27652820
申请日：2020-08-05
申请人： UNIV JOHNS HOPKINS , UNIV DUKE , POMPER MARTIN G , MEASE RONNIE C , KUMAR VIVEK , RAY SANGEETA , ZALUTSKY MICHAEL , VAIDYANATHAN GANESAN
发明人： POMPER MARTIN G , MEASE RONNIE C , KUMAR VIVEK , RAY SANGEETA , ZALUTSKY MICHAEL , VAIDYANATHAN GANESAN
摘要： Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

3. 发明申请

WO2011028507A3 COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE 审中-公开
标题翻译：用于测定烷基转移酶的组合物，方法和试剂盒
公开(公告)号：WO2011028507A3
公开(公告)日：2011-07-14
申请号：PCT/US2010046432
申请日：2010-08-24
申请人： UNIV DUKE , ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
发明人： ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
IPC分类号： C07D473/18 , C07D403/12 , C07K7/06 , C12Q1/48 , G01N33/58
CPC分类号： C12Q1/48 , A61K51/088 , C07D473/18 , C07K7/06 , C07K14/485 , C07K14/68 , C07K2319/01 , G01N2333/91005
摘要： The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds provide for determining ATase levels, in particular for in vivo applications including, but not limited to, theranostic applications, in particular to cancer- related applications.
摘要翻译：本发明涉及新化合物以及包含用于测定烷基转移酶（ATase），特别是烷基鸟嘌呤-DNA烷基转移酶（AGT）的化合物的组合物，方法和试剂盒。通常，新化合物提供测定ATase水平，特别是用于体内应用，包括但不限于特异性应用，特别是癌症相关应用。

4. 发明申请

WO2009040826A3 NON-IONIC POROUS, SMALL SOLID RESIN WITH CHEMICALLY BONDED CROWN ETHER 审中-公开
标题翻译：非离子多孔，小固体树脂与化学键合的
公开(公告)号：WO2009040826A3
公开(公告)日：2009-07-02
申请号：PCT/IN2007000461
申请日：2007-09-24
申请人： SECRETARY DEPT ATOMIC ENERGY , BABU CHINTALA CHERVU ANAND , KESAVAMOORTHY RASU , DHEKANE GUNESH , VAIDYANATHAN GANESAN , BALDEVRAJ DR
发明人： BABU CHINTALA CHERVU ANAND , KESAVAMOORTHY RASU , DHEKANE GUNESH , VAIDYANATHAN GANESAN , BALDEVRAJ DR
IPC分类号： C08L23/00
CPC分类号： B01J20/3263 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/28004 , B01J20/3242 , C08F212/12 , C08F212/36 , C08F220/58 , C08F2/18
摘要： A non-ionic porous, solid spherical bead shaped resin with chemically bonded crown ether, having a particle size of 25 to 1400 µm.
摘要翻译：具有化学键合的冠醚的非离子多孔固体球形珠状树脂，其粒径为25〜1400μm。

5. 发明公开

KR20200141439A 암 방사선 치료를 위한 PSMA 표적 방사성 할로겐화 우레아-폴리아미노카복실레이트 审中-公开
公开(公告)号：KR20200141439A
公开(公告)日：2020-12-18
申请号：KR20207025695
申请日：2019-02-06
申请人： UNIV JOHNS HOPKINS , UNIV DUKE
发明人： POMPER MARTIN G , MEASE RONNIE C , KUMAR VIVEK , RAY SANGEETA , ZALUTSKY MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： C07D257/02 , A61K51/04 , C07D401/12
摘要： 소분자방사성할로겐화 PSMA 억제제및 이의금속복합체, 및전립선암을포함하여 PSMA 관련질환을치료하기위한방사선이미지화및 방사선치료에서의이의용도가개시된다. 또한, 방사성할로겐화 PSMA 억제제의표적외축적을감소시키기위한경쟁적 PSMA 리간드와소분자방사성할로겐화 PSMA 억제제의조합이개시된다.

6. 发明公开

EP2470535A4 COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE 审中-公开
标题翻译：组合物，方法和试剂盒用于确定alkyltransferase
公开(公告)号：EP2470535A4
公开(公告)日：2014-01-01
申请号：EP10814228
申请日：2010-08-24
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , VAIDYANATHAN GANESAN
IPC分类号： C07D473/18 , C07D403/12 , C07K7/06 , C07K14/485 , C07K14/68 , C12Q1/48 , G01N33/58
CPC分类号： C12Q1/48 , A61K51/088 , C07D473/18 , C07K7/06 , C07K14/485 , C07K14/68 , C07K2319/01 , G01N2333/91005

7. 发明公开

EP2991687A4 PROSTHETIC COMPOUNDS FOR LABELING INTERNALIZING BIOMOLECULES 审中-公开
标题翻译：假体连接方案内在生物分子标记
公开(公告)号：EP2991687A4
公开(公告)日：2016-11-09
申请号：EP14792079
申请日：2014-05-02
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： A61K51/04 , A61K49/04 , A61K49/10 , A61K51/02
CPC分类号： A61K51/1093 , A61K51/088 , A61K51/1051 , C07B59/002 , C07D207/416 , C07D207/46 , C07D403/12 , C07D487/04
摘要： Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18F. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mAbs) and nanobodies (sdAbs)), antibody fragments, and peptides that may have an affinity for particular types of cells, such as cancer cells. The prosthetic compounds effectively address the art-recognized difficulties associated with the retention of radioactivity within the targeted cells, due to internalization of the biomolecule, followed by proteolytic degradation. Representative prosthetic compounds include (i) a succinimidyloxycarbonyl moiety, (ii) a radioactive moiety bearing 18F, and (iii) a charged moiety, i.e., a moiety that is charged under the physiological conditions of the internal cell environment.

8. 发明申请

WO0185221A3 ASSESSING LEVELS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE IN VIVO 审中-公开
标题翻译：评估VIVO中O6-氨基嘌呤-DNA烷基转移酶的水平
公开(公告)号：WO0185221A3
公开(公告)日：2002-08-15
申请号：PCT/US0115370
申请日：2001-05-14
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , COLVIN MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： A61K51/04
CPC分类号： A61K51/0491 , A61K51/04
摘要： Radiolabeled O6-derivatized guanine molecules can be used to form radiolabeled AGT molecules which can be detected in vivo assessment of AGT levels is useful for optimizing the efficacy of chemotherapy. In addition, assessing AGT levels in tumors in vivo permits selection of patients most likely to benefit from such chemotherapy and enables clinicians to monitor the effect of known and potential chemotherapeutic agents. In particular, methods have been developed for the efficient syntheses of [18F]FBG and [131I]IBG, both of which bind specifically to purified AGT. These two radiolabeled O6 benzylguanine analogues can be used to assess levels of AGT in vivo.
摘要翻译：放射性标记的O6衍生的鸟嘌呤分子可用于形成放射性标记的AGT分子，其可以在体内检测AGT水平的评估用于优化化疗的功效。此外，在体内评估肿瘤中的AGT水平允许选择最有可能受益于这种化学疗法的患者，并使临床医生能够监测已知和潜在的化学治疗剂的作用。特别地，已经开发了用于[18F] FBG和[131I] IBG的有效合成的方法，两者都特异性结合纯化的AGT。这两种放射性标记的O6苄基鸟嘌呤类似物可用于评估体内AGT的水平。

9. 发明专利

AU2019217838A1 PSMA targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy 未知
公开(公告)号：AU2019217838A1
公开(公告)日：2020-09-24
申请号：AU2019217838
申请日：2019-02-06
申请人： UNIV DUKE , UNIV JOHNS HOPKINS
发明人： POMPER MARTIN G , MEASE RONNIE C , KUMAR VIVEK , RAY SANGEETA , ZALUTSKY MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： C07D257/02 , A61K51/04 , C07D401/12
摘要： Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing offtarget accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

10. 发明专利

AU7290901A Reagents and methods for assessing levels of O⁶-alkylguanine-DNA alkyltransferase in vivo 未知
公开(公告)号：AU7290901A
公开(公告)日：2001-11-20
申请号：AU7290901
申请日：2001-05-14
申请人： UNIV DUKE
发明人： ZALUTSKY MICHAEL R , COLVIN MICHAEL , VAIDYANATHAN GANESAN
IPC分类号： A61K51/04

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