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1. 发明公开

EP1326605A4 METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS 审中-公开
标题翻译：抑制剂的使用白三烯B4到白三烯B4受体抑制细胞凋亡的增殖和诱导癌细胞约束力
公开(公告)号：EP1326605A4
公开(公告)日：2004-03-17
申请号：EP01935770
申请日：2001-05-08
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E
IPC分类号： A61K45/00 , A61K31/00 , A61K31/192 , A61K31/194 , A61K31/352 , A61K31/41 , A61P35/00 , A61P43/00 , A61K31/44 , A61K31/445 , A61K38/00
CPC分类号： A61K31/00 , A61K31/192 , A61K31/41

2. 发明申请

WO0170130A3 COMPOSITIONS DERIVED FROM MODIOLUS MODIOLUS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：从MODIOLUS MODIOLUS衍生的组合物及其制备和使用方法
公开(公告)号：WO0170130A3
公开(公告)日：2002-02-07
申请号：PCT/US0109192
申请日：2001-03-22
申请人： UNIV CREIGHTON , SFS INC , ADRIAN THOMAS E , COLLIN PETER D
发明人： ADRIAN THOMAS E , COLLIN PETER D
IPC分类号： A61K35/56 , A61K35/60 , A61P3/10 , A61P9/00 , A61P19/02 , A61P29/00
CPC分类号： A61K35/618
摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus ("MM") and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
摘要翻译：公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

3. 发明申请

WO2008079328A2 OMEGA-5-FATTY ACIDS USEFUL IN LIPOXYGENASE 5 INHIBITION AND IN THE TREATMENT OF CANCER 审中-公开
标题翻译：欧米茄5脂肪酸有助于LIPOXYGENASE 5抑制和治疗癌症
公开(公告)号：WO2008079328A2
公开(公告)日：2008-07-03
申请号：PCT/US2007026152
申请日：2007-12-22
申请人： UNIV CREIGHTON , ADRIAN THOMAS E , MURPHY RICHARD F
发明人： ADRIAN THOMAS E , MURPHY RICHARD F
IPC分类号： A61K31/202
CPC分类号： A61K31/202
摘要： Disclosed are omega-5 fatty acids having one of the following formulae: CH 3 - (CH 2 ) 3 -CH=CH- (CH 2 ) 9 -COOH, CH 3 - (CH 2 ) 3 -CH=CH- (CH 2 ) 11 -COOH, CH 3 - (CH 2 ) 3 -CH=CH- (CH 2 ) 13 -COOH, CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH- (CH 2 ) 6 -COOH, CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH- (CH 2 ) 8 -COOH, CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH- (CH 2 ) 10 -COOH, CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH-CH 2 -CH=CH- (CH 2 ) 5 -COOH, CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH-CH 2 -CH=CH- (CH 2 ) 7 -COOH, and CH 3 - (CH 2 ) 3 -CH=CH-CH 2 -CH=CH-CH 2 -CH=CH-CH2-CH=CH- (CH 2 ) 4 -COOH and pharmaceutically acceptable esters, salts, amides, and solvates thereof, as well as pharmaceutical compositions which include one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts/ amides, and solvates thereof. Also disclosed are methods of inhibiting 5 -lipoxygenase activity; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; and methods of treating adenocarcinoma in a subject using one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts, amides, and solvates thereof.
摘要翻译：公开了具有下式之一的ω-5脂肪酸：CH 3 - （CH 2 CH 2）3 -CH = CH-（CH 9 - （CH 2）3 - （CH 2）3 - - - - （CH 2）3 - CH = CH-（CH 2）11 - ，-COOH，CH 3 - （CH 2） 3 -CH = CH-（CH 2）13 -COOH，CH 3 - （CH 2） 3）-CH = CH-CH 2 -CH = CH-（CH 2 CH 2）6 - COOH，CH 3 - （CH 2）3 -CH = CH-CH 2 -CH = CH- （CH 2）2 -COOH，CH 3 - （CH 2 2）3 -CH = CH-CH 2 -CH = CH-（CH 2 CH 2）10 -COOH，CH 3 N / > - （CH 2）3 - - CH = CH-CH 2 -CH = CH-CH 2 - CH = CH-（CH 2 CH 2）5 -COOH，CH 3 - （CH 2 CH 2） 3 -CH = CH-CH 2 -CH = CH-CH 2 -CH = CH-（CH 2 CH 2）< （CH 2）3 -CH = CH-CH 2（CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 3）

4. 发明申请

WO02051406A9 METHODS FOR INDUCING APOPTOSIS AND INHIBITING PROLIFERATION IN CANCER CELLS 审中-公开
标题翻译：诱导癌症和抑制癌细胞增殖的方法
公开(公告)号：WO02051406A9
公开(公告)日：2003-05-01
申请号：PCT/US0149689
申请日：2001-12-24
申请人： UNIV CREIGHTON , SFS INC , ADRIAN THOMAS E , COLLIN PETER
发明人： ADRIAN THOMAS E , COLLIN PETER
IPC分类号： A61K31/201 , A61P35/00 , A61K31/22 , A61K31/20
CPC分类号： A61K31/201
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having the formula ("Formula I"): CH3-(CH2)n-CH=CH-(CH2)m-COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subject an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.
摘要翻译：公开了减少腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化成非癌细胞的方法。所述方法包括使包含腺癌细胞的样品与具有式（“式I”）的化合物接触：CH 3 - （CH 2）n -CH = CH-（CH 2）m -COOH）其中n为0至15的整数， m为约1至16的整数，m和n的和为6至16的整数，或其药学上可接受的酯，盐，酰胺，溶剂合物或代谢物。还公开了治疗受试者中腺癌的方法。所述方法包括向受试者施用有效量的具有式I的化合物或其药学上可接受的酯，盐，酰胺，溶剂合物或代谢物。

5. 发明专利

NO20025343A 未知
公开(公告)号：NO20025343A
公开(公告)日：2003-01-09
申请号：NO20025343
申请日：2002-11-07
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E
IPC分类号： A61K45/00 , A61K31/00 , A61K31/192 , A61K31/194 , A61K31/352 , A61K31/41 , A61P35/00 , A61P43/00 , A61K31/05
CPC分类号： A61K31/00 , A61K31/192 , A61K31/41

6. 发明专利

NO20025343D0 未知
公开(公告)号：NO20025343D0
公开(公告)日：2002-11-07
申请号：NO20025343
申请日：2002-11-07
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E
IPC分类号： A61K45/00 , A61K31/00 , A61K31/192 , A61K31/194 , A61K31/352 , A61K31/41 , A61P35/00 , A61P43/00 , A61K
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cancer cells, or of inducing apoptosis of adenocarcinoma cancer cells, or of inducing differentiation of adenocarcinoma cancer cells into non-cancerous cells. One such method includes contacting the adenocarcinoma cancer cells with a compound under conditions effective for the compound to inhibit binding of leukotriene B4 to leukotriene B4 receptor. In another such method, the method includes contacting the adenocarcinoma cancer cells with 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof. Also disclosed are methods of treating adenocarcinomas in a subject. One method includes administering to the subject an amount of a compound effective to inhibit binding of leukotriene B4 to leukotriene B4 receptor. Another method includes administering 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluoropheyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof, to the subject.

7. 发明专利

MXPA02010974A METODOS PARA INHIBIR LA PROLIFERACION E INDUCIR APOPTOSIS EN CELULAS CARCEROSAS. 未知
公开(公告)号：MXPA02010974A
公开(公告)日：2004-09-06
申请号：MXPA02010974
申请日：2001-05-08
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E
IPC分类号： A61K45/00 , A61K31/00 , A61K31/192 , A61K31/194 , A61K31/352 , A61K31/41 , A61P35/00 , A61P43/00 , A61K31/44 , A61K31/445 , A61K38/00
摘要： Se describen metodos para disminuir la proliferacion de celulas cancerosas de adenocarcinoma o de inducir apoptosis de celulas cancerosas de adenocarcinoma o de inducir la diferenciacion de celulas cancerosas de adenocarcinoma en celulas no cancerosas. Uno de tales metodos incluye poner en contacto las celulas cancerosas de adenocarcinoma con un compuesto bajo condiciones efectivas para que el compuesto inhiba la union del leucotrieno B4 al receptor del leucotrieno B4. En otro metodo, el metodo incluye poner en contacto las celulas cancerosas de adenocarcinoma con el acido 2-(2-propil-3-(3-(2-etil-4-(4- fluorofenil)-5-hidroxifenoxi) propoxi) fenoxi) benzoico o una sal, solvato o congenere farmaceuticamente aceptable de este. Tambien se describen los metodos para tratar adenocarcinomas en un sujeto. Un metodo incluye administrar al sujeto una cantidad de un compuesto efectivo para inhibir la union del leucotrieno B4 al receptor del leucotrieno B4. Otro metodo incluye administrar acido 2-(2-propil-3-(3-(2-etil-4-(4- fluorofenil)-5-hidroxifenoxi)propoxi) fenoxi) benzoico o una sal, solvato o congenere farmaceuticamente aceptable de este, al sujeto.

8. 发明专利

CA2408622A1 METHODS FOR INHIBITING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS 未知
公开(公告)号：CA2408622A1
公开(公告)日：2001-11-15
申请号：CA2408622
申请日：2001-05-08
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E
IPC分类号： A61K45/00 , A61K31/00 , A61K31/192 , A61K31/194 , A61K31/352 , A61K31/41 , A61P35/00 , A61P43/00 , A61K38/00 , A61K31/44 , A61K31/445
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cancer cells, or of inducing apoptosis of adenocarcinoma cancer cells, or of inducing differentiation of adenocarcinoma cancer cells into non-cancerous cells. One such method includes contacting the adenocarcinoma cancer cells with a compound under conditions effective for the compound to inhibit binding of leukotriene B4 to leukotriene B4 receptor. In another such method, the method includes contacting the adenocarcinoma cancer cells with 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof. Also disclosed are methods of treating adenocarcinomas in a subject. One method includes administering to the subject an amount of a compound effective to inhibit binding of leukotriene B4 to leukotriene B4 receptor. Another method includes administering 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluoropheyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid or a pharmaceutically acceptable salt, solvate, or congener thereof, to the subject.

9. 发明专利

CA2403671A1 COMPOSITIONS DERIVED FROM MODIOLUS MODIOLUS AND METHODS FOR MAKING AND USING SAME 未知
公开(公告)号：CA2403671A1
公开(公告)日：2001-09-27
申请号：CA2403671
申请日：2001-03-22
申请人： UNIV CREIGHTON
发明人： COLLIN PETER D , ADRIAN THOMAS E
IPC分类号： A61K35/56 , A61K35/60 , A61K35/618 , A61P3/10 , A61P9/00 , A61P19/02 , A61P29/00
摘要： Disclosed are compositions which include an isolated soft tissue from Modiol us modiolus ("MM") and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation o f adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof wi th a solvent under conditions effective to extract one or more materials from t he MM or portion thereof is also described.

10. 发明专利

CA2436536C METHODS FOR INDUCING APOPTOSIS AND INHIBITING PROLIFERATION IN CANCER CELLS 未知
公开(公告)号：CA2436536C
公开(公告)日：2008-07-08
申请号：CA2436536
申请日：2001-12-24
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E , COLLIN PETER
IPC分类号： A61K31/231 , A61K31/16 , A61K31/201 , A61P35/00
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having the formula ("Formula I"): CH3-(CH2)n-CH=CH-(CH2)m-COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subject an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.

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