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1. 发明申请

WO02051406A9 METHODS FOR INDUCING APOPTOSIS AND INHIBITING PROLIFERATION IN CANCER CELLS 审中-公开
标题翻译：诱导癌症和抑制癌细胞增殖的方法
公开(公告)号：WO02051406A9
公开(公告)日：2003-05-01
申请号：PCT/US0149689
申请日：2001-12-24
申请人： UNIV CREIGHTON , SFS INC , ADRIAN THOMAS E , COLLIN PETER
发明人： ADRIAN THOMAS E , COLLIN PETER
IPC分类号： A61K31/201 , A61P35/00 , A61K31/22 , A61K31/20
CPC分类号： A61K31/201
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having the formula ("Formula I"): CH3-(CH2)n-CH=CH-(CH2)m-COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subject an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.
摘要翻译：公开了减少腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化成非癌细胞的方法。所述方法包括使包含腺癌细胞的样品与具有式（“式I”）的化合物接触：CH 3 - （CH 2）n -CH = CH-（CH 2）m -COOH）其中n为0至15的整数， m为约1至16的整数，m和n的和为6至16的整数，或其药学上可接受的酯，盐，酰胺，溶剂合物或代谢物。还公开了治疗受试者中腺癌的方法。所述方法包括向受试者施用有效量的具有式I的化合物或其药学上可接受的酯，盐，酰胺，溶剂合物或代谢物。

2. 发明专利

CA2436536C METHODS FOR INDUCING APOPTOSIS AND INHIBITING PROLIFERATION IN CANCER CELLS 未知
公开(公告)号：CA2436536C
公开(公告)日：2008-07-08
申请号：CA2436536
申请日：2001-12-24
申请人： UNIV CREIGHTON
发明人： ADRIAN THOMAS E , COLLIN PETER
IPC分类号： A61K31/231 , A61K31/16 , A61K31/201 , A61P35/00
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having the formula ("Formula I"): CH3-(CH2)n-CH=CH-(CH2)m-COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subject an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.

3. 发明专利

CA2436536A1 METHODS FOR INDUCING APOPTOSIS AND INHIBITING PROLIFERATION IN CANCER CELLS 未知
公开(公告)号：CA2436536A1
公开(公告)日：2002-07-04
申请号：CA2436536
申请日：2001-12-24
申请人： UNIV CREIGHTON
发明人： COLLIN PETER , ADRIAN THOMAS E
IPC分类号： A61K31/201 , A61P35/00 , A61K31/22 , A61K31/20
摘要： Disclosed are methods of decreasing proliferation of adenocarcinoma cells, o r of inducing apoptosis of adenocarcinoma cells, or of inducing differentiatio n of adenocarcinoma cells into non-cancerous cells. The methods include contacting a sample comprising adenocarcinoma cells with a compound having t he formula ("Formula I"): CH3-(CH2)n-CH=CH-(CH2)m-COOH) wherein n is an integer from 0 to 15, m is an integer from about 1 to 16, and the sum of m and n is an integer from 6 to 16, or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof. Also disclosed are methods for treating adenocarcinoma in a subject. The methods include administering to the subjec t an effective amount of a compound having Formula I or a pharmaceutically acceptable ester, salt, amide, solvate, or metabolite thereof.

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