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1. 发明申请

WO2007005349A8 IMPROVED METHOD OF PROCESSING SEA CUCUMBERS, WITH NEW COMPOSITIONS OF MATTER 审中-公开
标题翻译：改进的海藻加工方法，新的组合物
公开(公告)号：WO2007005349A8
公开(公告)日：2007-03-15
申请号：PCT/US2006024684
申请日：2006-06-26
申请人： COASTSIDE BIO RESOURCES , COLLIN PETER D
发明人： COLLIN PETER D
IPC分类号： A61K35/12
CPC分类号： A61K36/42 , A23J1/002 , A23J1/04 , A23K10/26 , A23V2002/00 , A23V2300/34
摘要： An improved sea cucumber processing methods is disclosed that minimize water use, improve air, water and land contamination, produce marketable products, and produce distilled water as a by product.
摘要翻译：公开了一种改进的海参加工方法，其使用水量最小化，改善空气，水和土地污染，生产有价值的产品，并以副产品生产蒸馏水。

2. 发明申请

WO2006053184A3 METHODS FOR TREATING OR PREVENTING A VASCULAR DISEASE 审中-公开
公开(公告)号：WO2006053184A3
公开(公告)日：2006-05-18
申请号：PCT/US2005/040875
申请日：2005-11-09
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , COLLIN, Peter, D. , TILSON, Martin, D., III
发明人： COLLIN, Peter, D. , TILSON, Martin, D., III
IPC分类号： A61K38/05 , A61K31/7048 , A01N43/16
摘要： The present invention relates to green tea and sea cucumber extracts, compositions thereof, and methods of treating or preventing a cardiovascular disease, a peripheral vascular disease, or an aneurysm in a subject, the methods comprising administering to the subject an effective amount of a green tea extract, a sea cucumber extract, or a compound derived from a green tea extract or a sea cucumber extract.

3. 发明申请

WO2007005349A3 IMPROVED METHOD OF PROCESSING SEA CUCUMBERS, WITH NEW COMPOSITIONS OF MATTER 审中-公开
公开(公告)号：WO2007005349A3
公开(公告)日：2007-01-11
申请号：PCT/US2006/024684
申请日：2006-06-26
申请人： COASTSIDE BIO RESOURCES , COLLIN, Peter, D.
发明人： COLLIN, Peter, D.
IPC分类号： A61K35/12
摘要： An improved sea cucumber processing methods is disclosed that minimize water use, improve air, water and land contamination, produce marketable products, and produce distilled water as a by product.

4. 发明申请

WO2006053184A2 METHODS FOR TREATING OR PREVENTING A VASCULAR DISEASE 审中-公开
标题翻译：治疗或预防血管疾病的方法
公开(公告)号：WO2006053184A2
公开(公告)日：2006-05-18
申请号：PCT/US2005040875
申请日：2005-11-09
申请人： UNIV COLUMBIA , COLLIN PETER D , TILSON MARTIN D III
发明人： COLLIN PETER D , TILSON MARTIN D III
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048
摘要： The present invention relates to green tea and sea cucumber extracts, compositions thereof, and methods of treating or preventing a cardiovascular disease, a peripheral vascular disease, or an aneurysm in a subject, the methods comprising administering to the subject an effective amount of a green tea extract, a sea cucumber extract, or a compound derived from a green tea extract or a sea cucumber extract.
摘要翻译：本发明涉及绿茶和海参提取物，其组合物，以及治疗或预防受试者心血管疾病，外周血管疾病或动脉瘤的方法，所述方法包括向受试者施用有效量的绿色茶提取物，海参提取物或来自绿茶提取物或海参提取物的化合物。

5. 发明申请

WO2005120185A3 PROCESS FOR ISOLATING SEA CUCUMBER SAPONIN FRONDOSIDE A, AND IMMUNOMODULATORY METHODS OF USE 审中-公开
标题翻译：用于分离海藻柚苷的方法A和免疫组织化学方法
公开(公告)号：WO2005120185A3
公开(公告)日：2006-03-09
申请号：PCT/RU2005000306
申请日：2005-06-03
申请人： TERN BRANCH RUSSIAN ACADEMY OF , COLLIN PETER D , WOODWARD CARL , AVILOV SERGEY ANATOLIEVICH , KALININ VLADIMIR IVANOVICH , SILCHENKO ALEXANDRA SERGEEVNA , AMININ DMITRY LVOVICH , AGAFONOVA IRINA GRIGOREVNA , STONIK VALENTIN ARONOVICH
发明人： COLLIN PETER D , WOODWARD CARL , AVILOV SERGEY ANATOLIEVICH , KALININ VLADIMIR IVANOVICH , SILCHENKO ALEXANDRA SERGEEVNA , AMININ DMITRY LVOVICH , AGAFONOVA IRINA GRIGOREVNA , STONIK VALENTIN ARONOVICH
IPC分类号： C07J71/00 , A61K35/56
CPC分类号： A61K35/616 , A61K31/70 , Y10S514/885
摘要： This invention discloses use of a chloroform/solvent mixture extraction at different solvent to-feed ratios, followed by evaporation and extraction with ethyl acetate/water; followed by chromatography of the water phase in Teflon or other non-polar resin and Silica gel column chromatography for recovering of individual triterpene glycosides (saponins) of high purity from the freeze dried or spray dried cooking water or dried powderized tissues of the industrial processed sea cucumber Cucumaria frondosa. A resulting glycoside Frondoside A stimulates lysosomal activity of peritoneal macrophages, phagocytosis and oxidative burst in the macrophages at concentrations significantly less than for acute toxicity, hemolysis and sea urchin embryo toxicity
摘要翻译：本发明公开了以不同溶剂与进料比率的氯仿/溶剂混合物萃取，然后蒸发并用乙酸乙酯/水萃取; 然后在Teflon或其他非极性树脂中进行水相色谱法和硅胶柱色谱，从冷冻干燥或喷雾干燥的蒸煮水或工业加工海的干粉末组织中回收高纯度的单一三萜糖苷（皂苷）黄瓜黄瓜（Cucumaria frondosa）。所得糖苷Frondoside A以显着低于急性毒性，溶血和海胆胚胎毒性的浓度刺激巨噬细胞中腹膜巨噬细胞，吞噬作用和氧化爆发的溶酶体活性

6. 发明申请

WO2005120185A2 PROCESS FOR ISOLATING SEA CUCUMBER SAPONIN FRONDOSIDE A, AND IMMUNOMODULATORY METHODS OF USE 审中-公开
标题翻译：用于分离海藻柚苷的方法A和免疫组织化学方法
公开(公告)号：WO2005120185A2
公开(公告)日：2005-12-22
申请号：PCT/RU2005/000306
申请日：2005-06-03
申请人： PACIFIC INSTITUTE OF BIOORGANIC CHEMISTRY, FAR-EASTERN BRANCH, RUSSIAN ACADEMY OF SCIENCES (PIBOC) , COLLIN, Peter, D. , WOODWARD, Carl , AVILOV, Sergey Anatolievich , KALININ, Vladimir Ivanovich , SILCHENKO, Alexandra Sergeevna , AMININ, Dmitry Lvovich , AGAFONOVA, Irina Grigorevna , STONIK, Valentin Aronovich
发明人： COLLIN, Peter, D. , WOODWARD, Carl , AVILOV, Sergey Anatolievich , KALININ, Vladimir Ivanovich , SILCHENKO, Alexandra Sergeevna , AMININ, Dmitry Lvovich , AGAFONOVA, Irina Grigorevna , STONIK, Valentin Aronovich
IPC分类号： A61K35/616
CPC分类号： A61K35/616 , A61K31/70 , Y10S514/885
摘要： This invention discloses use of a chloroform/solvent mixture extraction at different solvent to-feed ratios, followed by evaporation and extraction with ethyl acetate/water; followed by chromatography of the water phase in Teflon or other non-polar resin and Silica gel column chromatography for recovering of individual triterpene glycosides (saponins) of high purity from the freeze dried or spray dried cooking water or dried powderized tissues of the industrial processed sea cucumber Cucumaria frondosa . A resulting glycoside Frondoside A stimulates lysosomal activity of peritoneal macrophages, phagocytosis and oxidative burst in the macrophages at concentrations significantly less than for acute toxicity, hemolysis and sea urchin embryo toxicity
摘要翻译：本发明公开了以不同溶剂与进料比率的氯仿/溶剂混合物萃取，然后蒸发并用乙酸乙酯/水萃取; 然后在Teflon或其他非极性树脂中进行水相色谱法和硅胶柱色谱，从冷冻干燥或喷雾干燥的蒸煮水或工业加工海的干粉末组织中回收高纯度的单一三萜糖苷（皂苷）黄瓜黄瓜（Cucumaria frondosa）。所得糖苷Frondoside A以显着低于急性毒性，溶血和海胆胚胎毒性的浓度刺激巨噬细胞中腹膜巨噬细胞，吞噬作用和氧化爆发的溶酶体活性

7. 发明申请

WO2007005349A2 IMPROVED METHOD OF PROCESSING SEA CUCUMBERS, WITH NEW COMPOSITION OF MATTER 审中-公开
标题翻译：改进海藻加工方法，具有新的成分组成
公开(公告)号：WO2007005349A2
公开(公告)日：2007-01-11
申请号：PCT/US2006024684
申请日：2006-06-26
申请人： COASTSIDE BIO RESOURCES , COLLIN PETER D
发明人： COLLIN PETER D
IPC分类号： A61K35/12
CPC分类号： A61K36/42 , A23J1/002 , A23J1/04 , A23K10/26 , A23V2002/00 , A23V2300/34
摘要： An improved sea cucumber processing methods is disclosed that minimize water use, improve air, water and land contamination, produce marketable products, and produce distilled water as a by product.
摘要翻译：公开了一种改进的海参加工方法，其使用水量最小化，改善空气，水和土地污染，生产有价值的产品，并以副产品生产蒸馏水。

8. 发明申请

WO2003092672A1 METHOD OF INHIBITING REJECTION OF TRANSPLANTED MATERIAL 审中-公开
标题翻译：阻止迁移材料的抑制方法
公开(公告)号：WO2003092672A1
公开(公告)日：2003-11-13
申请号：PCT/AU2003/000523
申请日：2003-05-02
申请人： THE QUEEN ELIZABETH HOSPITAL RESEARCH FOUNDATION INC. , KRISHNAN, Ravi , COLLIN, Peter, D.
发明人： KRISHNAN, Ravi , COLLIN, Peter, D.
IPC分类号： A61K31/19
CPC分类号： A61K45/06 , A61K31/19 , A61K31/20 , A61K2300/00
摘要： The present invention relates to a method of inhibiting leukocyte proliferation in a biological system, the method including the step of administering to the biological system an effective amount of an alkyl-substituted fatty acid, wherein the alkyl-substituted fatty acid is capable of inhibiting leukocyte proliferation.
摘要翻译：本发明涉及一种抑制生物系统白细胞增殖的方法，所述方法包括向生物系统施用有效量的烷基取代的脂肪酸的步骤，其中烷基取代的脂肪酸能够抑制白细胞增殖。

9. 发明申请

WO0170130A3 COMPOSITIONS DERIVED FROM MODIOLUS MODIOLUS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：从MODIOLUS MODIOLUS衍生的组合物及其制备和使用方法
公开(公告)号：WO0170130A3
公开(公告)日：2002-02-07
申请号：PCT/US0109192
申请日：2001-03-22
申请人： UNIV CREIGHTON , SFS INC , ADRIAN THOMAS E , COLLIN PETER D
发明人： ADRIAN THOMAS E , COLLIN PETER D
IPC分类号： A61K35/56 , A61K35/60 , A61P3/10 , A61P9/00 , A61P19/02 , A61P29/00
CPC分类号： A61K35/618
摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus ("MM") and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
摘要翻译：公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

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