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1. 发明申请

US20080040049A1 Optical System for Measuring Metabolism in a Body, Method and Program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US20080040049A1
公开(公告)日：2008-02-14
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G06F19/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively. Based on each data (representing the Hb concentration changes), two or more Hb concentration changes (for example, the oxidized Hb concentration change and deoxidized Hb concentration change) are classified according to whether the changes are increases or decreases, and indicated in the form of symbols, an image, or a graph. Thus, an examining person is provided with compressed and simplified information and supported in diagnosis.
摘要翻译：在过去，从多个受试者相互测量的平均值或差异的比较已经成为使用脑活动信号来实现的诊断支持的主流。然而，在这种情况下，难以吸收个体差异，诊断支持技术的精度低。为了提高诊断支持技术的精度，利用光学生物测量系统获取的数据的属性来创建和显示表示每个人的状况变化的信息。因此，有效地支持每个人的诊断。测量光信号用于计算和记录氧化血红蛋白（Hb），脱氧Hb和总Hb的浓度变化。基于每个数据（表示Hb浓度变化），根据变化是增加还是减少来分类两种或更多种Hb浓度变化（例如，氧化的Hb浓度变化和脱氧的Hb浓度变化），并以表格的符号，图像或图形。因此，检查人员被提供压缩和简化的信息并且在诊断中被支持。

2. 发明申请

US20060178839A1 Optical measurement instrument and optical measurement method 有权
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US20060178839A1
公开(公告)日：2006-08-10
申请号：US11378448
申请日：2006-03-20
申请人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
发明人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
IPC分类号： G06F19/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method comprising an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program (S1); a process for inputting items of condition including a measurement mode (S2); a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode (S4); a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel (S10); and a process for displaying said signals for each channel detected according to said instructed result (S11).
摘要翻译：为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得所需物品的图像，光学测量方法包括初始显示处理用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个（S1）; 用于输入包括测量模式的条件项目的处理（S 2）; 用于显示光照射位置和光检测位置的处理以及表示测量位置关系的状态与所述模式（S 4）。用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件以从多波长多通道照射的被检体的内部检测光信号的步骤（S10）; 以及根据所述指示结果显示针对每个通道的所述信号的处理（S11）。

3. 发明申请

US20060100526A1 Optical bioinstrumentation for living body 有权
公开(公告)号：US20060100526A1
公开(公告)日：2006-05-11
申请号：US11205184
申请日：2005-08-17
申请人： Yukari Yamamoto , Atsushi Maki , Masashi Kiguchi , Tsuyoshi Yamamoto
发明人： Yukari Yamamoto , Atsushi Maki , Masashi Kiguchi , Tsuyoshi Yamamoto
IPC分类号： A61B6/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/064 , A61B5/6814 , A61B5/7425 , A61B5/743 , A61B34/20 , A61B2034/2051 , A61B2034/2055 , A61B2034/2063
摘要： In a probe positioning technology, an optical bioinstrumentation includes a region selecting unit that is used to delineate a region of interest in an anatomical image of a subject, a computing unit that determines a recommended probe position according to the region of interest, a probe position sensor that detects a current probe position, a computing unit that calculates the distance between the recommended probe position and the current probe position, and an alarm device that generates an alarm sound or the like when the distance falls within a predetermined range. Moreover, the optical bioinstrumentation for living body further includes a memory unit in which the probe position is saved together with measurement data.

4. 发明授权

US06723047B1 Volition induction apparatus and input/output apparatus which use optical measuring instrument, and recording medium 有权
标题翻译：使用光学测量仪器和记录介质的感应装置和输入/输出装置
公开(公告)号：US06723047B1
公开(公告)日：2004-04-20
申请号：US10009187
申请日：2001-12-07
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Yoshitoshi Ito , Yuichi Yamashita , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Yoshitoshi Ito , Yuichi Yamashita , Hideaki Koizumi
IPC分类号： A61B500
CPC分类号： G06F3/015 , A61B5/486 , A63F2250/26 , Y10S128/905
摘要： It has long been unclear in what degree the brain should be activated and how much the blood volume should be varied for controlling a signal by measuring the concentration of metabolic substance in the tissue or change of concentration thereof using the light and by using the result of measurement. The present invention provides an optical measuring system which can present the concentration of metabolic substance in the tissue which may be detected with a subject by itself or the target value of change of the concentration. Thereby, it is now possible for the subject by itself to more easily detect and control the concentration of metabolic substance in the tissue or change of concentration thereof. As a result, cerebral information can be extracted in direct to realize various applications such as control of the game machines and welfare facilities.
摘要翻译：长期以来，不清楚大脑应该被激活的程度以及通过使用光测量组织中代谢物质的浓度或其浓度的变化来控制信号来改变血容量，并且通过使用测量。本发明提供一种光学测量系统，其可以呈现组织中代谢物质的浓度，其可以由受试者自身检测或目标浓度变化值。因此，现在可以使受试者本身更容易地检测和控制组织中代谢物质的浓度或其浓度的变化。因此，可以直接提取脑信息，实现游戏机和福利设施的控制等各种应用。

5. 发明授权

US06321110B1 Device for controlling equipment by using signals from a living body 失效
标题翻译：通过使用生物体信号控制设备的装置
公开(公告)号：US06321110B1
公开(公告)日：2001-11-20
申请号：US09385419
申请日：1999-08-30
申请人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
发明人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
IPC分类号： A61B600
CPC分类号： G06F3/015
摘要： A device for controlling equipment includes a light projector adapted to project light onto a head of a living body, a light collecting device for collecting the light having passed through the head from the light projector, a light measuring device for measuring an intensity of the light collected by the light collecting device, a memory device for storing a previous history of changes of the intensity of the light measured by the light measuring device, a signal judging circuit for judging if both the intensity of the light measured by the light measuring device and the previous history of changes of the intensity of the light satisfy a predetermined condition, a display device for displaying the intensity of the light measured by the light measuring device and a result obtained by the signal judging circuit, and a control signal generating circuit for generating a control signal to be supplied to an external equipment if the predetermined condition is satisfied.
摘要翻译：一种用于控制设备的装置，包括适用于将光投射到生物体的头部上的光投射器，用于收集从光投影仪通过头部的光的光收集装置，用于测量光强度的光测量装置由光收集装置收集的存储装置，用于存储由光测量装置测量的光的强度变化的先前历史的存储装置，用于判断由光测量装置测量的光的强度和光的强度变化的先前历史满足预定条件，用于显示由光测量装置测量的光的强度的显示装置和由信号判断电路获得的结果的控制信号产生电路，如果满足预定条件，则提供给外部设备的控制信号。

6. 发明授权

US07974671B2 Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same 有权
标题翻译：生物体信息处理系统结合生物体光学测量装置和脑波测量装置以及用于其的探针装置
公开(公告)号：US07974671B2
公开(公告)日：2011-07-05
申请号：US10572357
申请日：2004-09-03
申请人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
发明人： Michiyuki Fujiwara , Tsuneaki Kawaguchi , Fumio Kawaguchi , Shingo Kawasaki , Atsushi Maki , Yukiko Hirabayashi , Yukari Yamamoto , Masashi Kiguchi , Hiroki Sato , Tsuyoshi Yamamoto , Takushige Katsura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/0059 , A61B5/0261 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/0484 , A61B5/0488 , A61B5/11 , A61B5/6822 , A61B5/742 , A61B2562/0209 , A61B2562/0233 , A61B2562/046
摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.
摘要翻译：一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光，通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

7. 发明授权

US07516021B2 Optical system for measuring metabolism in a body, method and program 有权
标题翻译：用于测量身体代谢的光学系统，方法和程序
公开(公告)号：US07516021B2
公开(公告)日：2009-04-07
申请号：US11570558
申请日：2005-06-08
申请人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
发明人： Hiroki Sato , Atsushi Maki , Tsuyoshi Yamamoto , Masashi Kiguchi
IPC分类号： G01N31/00
CPC分类号： A61B5/7264 , A61B5/0059 , A61B5/7425 , A61B5/743 , G06F19/00 , G16H40/63
摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.
摘要翻译：用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化血红蛋白对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

8. 发明授权

US07171250B2 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US07171250B2
公开(公告)日：2007-01-30
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

9. 发明授权

US06947779B2 Optical measurement device 失效
标题翻译：光学测量装置
公开(公告)号：US06947779B2
公开(公告)日：2005-09-20
申请号：US09873206
申请日：2001-06-05
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/17 , G01N21/31
CPC分类号： A61B5/7475 , A61B5/1455
摘要： Optical measurement that is optimum for improving spatial resolution is accomplished by making it possible to estimate a physical quantity of an object substance to be measured at any point on a subject. When any position to be evaluated, in an image shown in a window 1-1, is pointed and selected a mouse pointer 1-4, the value of the concentration or its change of the object substance at the point is displayed in the display area 1-7 of a window 1-3. The drawings represents an example in which one position is specified and there are two object substances to be measured. The value of the concentration or its change of each object substance to be measured is separately displayed.
摘要翻译：通过使得可以在对象的任何点估计待测物体的物理量来实现对于改善空间分辨率最佳的光学测量。当要评估的任何位置在窗口1至1所示的图像中被指向并选择了鼠标指针1-4时，该点处的物体的浓度值或其变化的值被显示在显示区域中 1 - 7的窗口1 - 3。附图表示其中指定了一个位置并且存在两个待测物体的示例。分别显示要测量的每种物质的浓度值或其变化值。

10. 发明授权

US06657183B2 Amusement system using living body measurement by light, head setter for the amusement system, and program for use in the amusement system 有权
标题翻译：娱乐系统使用活体测量的乐器，娱乐系统的头枕，以及娱乐系统中使用的节目
公开(公告)号：US06657183B2
公开(公告)日：2003-12-02
申请号：US09939601
申请日：2001-08-28
申请人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
发明人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
IPC分类号： H01J4014
CPC分类号： A63F13/212 , A63F13/10 , A63F13/213 , A63F2300/1012 , A63F2300/807
摘要： Disclosed herein is an amusement system that can be used and enjoyed by different persons without using the brain continuously and with little feeling of fatigue and which permits setting a probe at any spot on the head of the subject. The amusement system includes irradiators for irradiating the subject with light, light detectors for detection of the light that has been emitted from said irradiator and which has propagated through the living body, signal processors for processing the signal of light intensity detected by said detector and display units that show the processing results from the signal processor. The range of display of a change in intensity of said transmitted light according to the results of a test task carried out on said living body.
摘要翻译：本文公开了一种娱乐系统，其可以由不同的人使用和享用，而不用连续地使用大脑并且几乎没有疲劳的感觉，并且允许在受试者头部的任何位置设置探针。娱乐系统包括用于用光照射对象的照射器，用于检测已经从所述照射器发射并已经通过生物体传播的光的光检测器，用于处理由所述检测器检测的光强度的信号的信号处理器和显示器显示信号处理器处理结果的单位。根据在所述活体上进行的测试任务的结果，显示所述透射光的强度变化的范围。

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