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1. 发明申请

US20100069792A1 BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, SAMPLE COLLECTING METHOD, MANUFACTURING METHOD OF BIOSENSOR CARTRIDGE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译：生物传感器盒，生物传感器装置，样品采集方法，生物传感器盒的制造方法和针状集成传感器
公开(公告)号：US20100069792A1
公开(公告)日：2010-03-18
申请号：US12513458
申请日：2007-11-01
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151 , H01R43/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B2562/0295 , Y10T29/49002
摘要： A biosensor cartridge capable of performing puncturing in an exact position, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When tip portion 11a of biosensor chip body 11 is pushed against a subject M, elastic body 20 protruding from a tip portion 11a of biosensor chip body 11 is compressed, and puncturing tool 12 for puncturing protrudes. Thus, the subject M can be punctured. Additionally, if a pushing force is weakened, puncturing tool 12 is extracted from the subject M by the restoring force of elastic body 20, and the sample R flows out of the puncture hole. Additionally, cover member 19 is provided around biosensor chip body 11. Thus, when puncturing is performed by thin plate-shaped biosensor cartridge 10, biosensor chip body 11 can be prevented from deforming, and puncturing can be accurately performed in a desired puncturing position.
摘要翻译：本发明提供一种生物传感器盒，其能够在精确位置进行穿刺，并且容易地收集和测量穿刺孔的样本，而不需要使样本收集开口靠近穿刺孔的操作。当生物传感器芯体11的尖端部分11a被压靠在被检体M上时，从生物传感器芯体11的尖端部分11a突出的弹性体20被压缩，并且用于穿刺的穿刺工具12突出。因此，可以对被检体M进行穿刺。此外，如果推力减弱，则通过弹性体20的恢复力从被检体M取出穿刺工具12，并且样本R流出穿刺孔。另外，盖体19设置在生物传感器芯体11周围。因此，当通过薄板状生物传感器盒10进行穿刺时，可以防止生物传感器芯体11变形，并且可以在期望的穿刺位置精确地进行穿刺。

2. 发明申请

US20100004559A1 BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译： BIOSENSOR CARTRIDGE，使用BIOSENSOR CARTRIDGE的方法，生物传感器设备和针式集成传感器
公开(公告)号：US20100004559A1
公开(公告)日：2010-01-07
申请号：US12519916
申请日：2007-12-17
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117
摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.
摘要翻译：一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作提供孔。当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

3. 发明申请

US20100228149A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20100228149A1
公开(公告)日：2010-09-09
申请号：US12528660
申请日：2008-02-25
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2562/0295
摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.
摘要翻译：传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件传感器芯片，刺针针固定到该传感器芯片上。传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧）在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

4. 发明申请

US20090299225A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090299225A1
公开(公告)日：2009-12-03
申请号：US12297387
申请日：2007-04-17
申请人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150511 , A61B5/150549 , A61B5/150717 , A61B5/15186
摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.
摘要翻译：提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作样品收集开口更靠近穿刺孔。当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集而不进行样品收集开口的定位。

5. 发明申请

US20090152127A1 Biosensor Measurement Machine , Biosensor Measurement System and Biosensor Measurement Method 有权
标题翻译：生物传感器测量机，生物传感器测量系统和生物传感器测量方法
公开(公告)号：US20090152127A1
公开(公告)日：2009-06-18
申请号：US11992102
申请日：2006-09-08
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： G01N27/327 , G01N27/26 , G01N27/04 , G01N27/416
CPC分类号： G01N27/3273
摘要： Provided are a biosensor chip measurement machine that can obtain accurate measurement results within a short period of time by employing only a tiny amount as a sample, and a measurement method therefor.A biosensor measurement machine 20 includes a power source 21, which is connected to a voltage regulator 22, a measurement instrument 23, and a controller 24 for supplying power. When a biosensor chip 1 is connected to the biosensor measurement machine 20 and a voltage is applied, the measurement instrument begins the measurement of a current value for a biosensor. When a measured current value or a measured charge value is greater than a reference value, the measurement is ended in accordance with an instruction issued by the controller 24, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.
摘要翻译：提供一种生物传感器芯片测量机，其可以通过仅使用微量作为样品而在短时间内获得准确的测量结果及其测量方法。生物传感器测量机20包括连接到电压调节器22的电源21，测量仪器23和用于供电的控制器24。当生物传感器芯片1连接到生物传感器测量机20并施加电压时，测量仪器开始测量生物传感器的当前值。当测量的电流值或测量的电荷值大于参考值时，根据控制器24发出的指令结束测量，并且当该值小于参考值时，根据控制器指令。

6. 发明申请

US20090020420A1 Biosensor Chip and Biosensor Chip Production Method 审中-公开
标题翻译：生物传感器芯片和生物传感器芯片生产方法
公开(公告)号：US20090020420A1
公开(公告)日：2009-01-22
申请号：US11921166
申请日：2006-10-16
申请人： Takahiko Kitamura , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino , Hideaki Nakamura , Isao Karube , Masao Gotoh , Tomoko Ishikawa
发明人： Takahiko Kitamura , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino , Hideaki Nakamura , Isao Karube , Masao Gotoh , Tomoko Ishikawa
IPC分类号： G01N27/327 , B05D5/00
CPC分类号： C12Q1/002
摘要： It is intended to provide a biosensor chip capable of rapid and correct measurement, including a reaction chamber that enables a measurement of a very small amount of a measurement sample and has a small capacity and potassium ferricyanide having a very small crystal particle size disposed in the reaction chamber.In a biosensor chip 1, electrodes 3 and 4 are disposed on the lower substrate 2, and lower spacer 5 (7 and 8) is adhered on the electrodes 3 and 4. An upper spacer 11 (12 and 13) is adhered to an upper substrate 15, and a lower spacer 5 is attached to the upper spacer 11 by and adhesive agent 10. A lower groove 9 is formed between long and short lower spacers 7 and 8, and an upper groove 14 is formed between long and short spacers 12 and 13, so that a reaction chamber 17 is formed by the upper and lower grooves 9 and 14. A capacity of the reaction chamber is 0.3 μL, and an enzyme 18 and potassium ferricyanide are disposed in the reaction chamber 17 in such a fashion as to oppose to each other with a gap being defined therebetween. A crystal particle diameter of the potassium ferricyanide is 100 μm or less, and amount of the potassium ferricyanide is V×0.1 mg or more when the capacity of the reaction chamber 17 is V.
摘要翻译：旨在提供能够快速且正确测量的生物传感器芯片，其包括能够测量非常少量的测量样品并且具有小容量的反应室和具有非常小的晶粒度的铁氰化钾反应室。在生物传感器芯片1中，电极3和4设置在下基板2上，下隔片5（7和8）粘附在电极3和4上。上间隔件11（12和13）基板15和下隔板5通过粘合剂10附接到上间隔件11.下槽9形成在长和短下隔板7和8之间，并且上槽14形成在长间隔件12和短间隔件12之间和13，使得反应室17由上下槽9和14形成。反应室的容量为0.3微米，酶18和铁氰化钾以如下方式设置在反应室17中：彼此相对，在其间限定间隙。当反应室17的容量为V时，铁氰化钾的晶粒直径为100μm以下，铁氰化钾的量为Vx0.1mg以上。

7. 发明授权

US08282813B2 Biosensor measurement machine, biosensor measurement system and biosensor measurement method 有权
标题翻译：生物传感器测量机，生物传感器测量系统和生物传感器测量方法
公开(公告)号：US08282813B2
公开(公告)日：2012-10-09
申请号：US11992102
申请日：2006-09-08
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Takahiko Kitamura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： G01N27/416
CPC分类号： G01N27/3273
摘要： A biosensor measurement device for providing accurate measurement results within a short period of time by using only a very small amount of sample. The biosensor measurement device includes a power source, which is connected to a voltage regulator, a measurement instrument, and a controller for supplying power. When the biosensor chip is connected to the biosensor measurement device and a voltage is applied, the measurement instrument begins the measurement of a current value for the biosensor. When the measured current value or a measured charge value is greater than a reference value, the measurement is terminated in accordance with an instruction issued by the controller, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.
摘要翻译：一种生物传感器测量装置，其通过仅使用非常少量的样品在短时间内提供精确的测量结果。生物传感器测量装置包括连接到电压调节器的电源，测量仪器和用于供电的控制器。当生物传感器芯片连接到生物传感器测量装置并施加电压时，测量仪器开始测量生物传感器的当前值。当测量的电流值或测量的电荷值大于参考值时，根据控制器发出的指令来终止测量，并且当该值小于参考值时，根据a 控制器指令。

8. 发明申请

US20090123335A1 Sensor Chip and Sensor System 审中-公开
标题翻译：传感器芯片和传感器系统
公开(公告)号：US20090123335A1
公开(公告)日：2009-05-14
申请号：US11885945
申请日：2006-10-25
申请人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
发明人： Hideaki Nakamura , Masao Gotoh , Tomoko Ishikawa , Isao Karube , Toshifumi Hosoya , Shingo Kaimori , Moriyasu Ichino
IPC分类号： G01N31/22
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438
摘要： It is intended to provide a sensor chip that enables detection of a deterioration state of a reagent applied on a reaction portion when measuring a concentration of a measurement object substance and a sensor system that enables a correct measurement by using the sensor chip for detecting the reagent deterioration state. A sensor chip including two substrates opposed to each other, a spacer layer sandwiched between the substrates, a multiple reaction portions provided in the spacer layer, and detection electrode units disposed on surfaces of the substrates facing to the spacer layer and exposed to the reaction portions, wherein an identical reagent A is applied on two or more of the reaction portions, and another reagent B that reacts with the reagent A is applied on at least one of the two reaction portions and a sensor system including the sensor chip and a measurement unit for comparing current values from the two or more reaction portions on which the identical reagent A is applied.
摘要翻译：本发明旨在提供一种传感器芯片，其能够检测在测量对象物质的浓度的反应部分上施加的试剂的劣化状态，以及能够通过使用用于检测试剂的传感器芯片进行正确测量的传感器系统劣化状态。一种传感器芯片，包括彼此相对的两个基板，夹在基板之间的间隔层，设置在间隔层中的多个反作用部分和设置在面向间隔层的基板的表面上并暴露于反应部分的检测电极单元其中相同的试剂A施加在两个或更多个反应部分上，另一个与试剂A反应的试剂B施加在两个反应部分中的至少一个上，以及包括传感器芯片和测量单元的传感器系统用于比较来自施加相同试剂A的两个或更多个反应部分的电流值。

9. 发明申请

US20090050986A1 Method for Fabricating Sensor Chip, and Sensor Chip 审中-公开
标题翻译：制造传感器芯片和传感器芯片的方法
公开(公告)号：US20090050986A1
公开(公告)日：2009-02-26
申请号：US11795903
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： H01L29/00 , H01L21/50
CPC分类号： B01J19/0046 , B01J2219/00518 , B01J2219/00527 , B01J2219/00533 , B01J2219/00621 , B01J2219/00657 , B01J2219/0072 , B01J2219/00725
摘要： A method for fabricating a sensor chip having a substrate, a cover layer, a spacer layer interposed between the substrate and the cover layer, and a hollow reaction section provided in the spacer layer, the method comprising the steps of: affixing two or more adhesive or bonding tapes onto a sheet where a plurality of substrates are to be formed or onto a plurality of substrates, to thus form a spacer layer; and forming a hollow reaction section from one or a plurality of gaps between the tapes, whereby volumetric variations or positional displacements of the hollow reaction section can be reduced. A sensor chip which can be fabricated by this method.
摘要翻译：一种用于制造具有衬底，覆盖层，插入在衬底和覆盖层之间的间隔层的传感器芯片的方法和设置在间隔层中的中空反应部分，该方法包括以下步骤：将两个或更多个粘合剂或将带粘合到要形成多个基底的片上或多个基底上，从而形成间隔层; 并且从带之间的一个或多个间隙形成中空反应部分，从而可以减小中空反应部分的体积变化或位置位移。可通过该方法制造的传感器芯片。

10. 发明申请

US20080129280A1 Coupled Member Made of a Plurality of Sensor Chips and Manufacturing Method Thereof 审中-公开
标题翻译：传感器芯片制造的耦合构件及其制造方法
公开(公告)号：US20080129280A1
公开(公告)日：2008-06-05
申请号：US11795902
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： G01N27/327
CPC分类号： B82Y5/00 , G01N33/4875 , Y10T29/49002
摘要： A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed. More specifically, a method for manufacturing a coupled member made of the plurality of sensor chips is provided in which such sensor chips are coupled to each other under cuttable conditions, while each of these sensor chips includes: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer; a sensing member provided in the hollow reaction portion; an output terminal for outputting a signal sensed by the sensing member to the outside; and a sample introducing port for introducing a sample to the hollow reaction portion.
摘要翻译：由多个传感器芯片制成的耦合构件的特征在于相邻的传感器芯片在可切割的状态下彼此耦合; 相应的传感器芯片可以以更高的效率从耦合部件切割和分离; 并且即使在传感器芯片被分离之后，这些传感器芯片也可以容易且快速地存储在容器中; 此外，可以容易地检测传感器芯片，并且可以容易地去除故障芯片。更具体地说，提供了一种用于制造由多个传感器芯片制成的耦合构件的方法，其中这些传感器芯片在可切割的条件下彼此耦合，而这些传感器芯片中的每一个包括：基板; 覆盖层; 设置在所述基板和所述覆盖层之间的中空反应部; 设置在所述中空反应部中的检测部件; 输出端子，用于将由感测构件感测的信号输出到外部; 以及用于将样品引入中空反应部的样品引入口。

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