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    • 1. 发明申请
    • Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist
    • 苯基或杂芳基氨基烷烃衍生物作为ip受体拮抗剂
    • US20060089371A1
    • 2006-04-27
    • US10534174
    • 2003-10-29
    • Toshiki MurataMasami UmedaSatoru YoshikawaKlaus UrbahnsJang GuptaOsamu Sakurai
    • Toshiki MurataMasami UmedaSatoru YoshikawaKlaus UrbahnsJang GuptaOsamu Sakurai
    • A61K31/506C07D403/02
    • C07D213/64C07C229/36C07D213/74C07D231/38C07D239/42C07D241/20C07D261/14C07D277/42C07D401/04C07D401/10C07D401/12C07D403/10C07D403/12C07D405/10
    • The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I) in which the groups Q1-Q4, Ar, and R1-R7 are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.
    • 本发明涉及式(I)的苯基或杂芳基氨基烷烃衍生物,其中基团Q 1,Q 4,Ar和R 1, SUP> -R 7如说明书和权利要求中所定义。 这些材料可用作药物制剂的活性成分。 本发明的苯基或杂芳基氨基烷烃具有IP受体拮抗活性,可用于预防和治疗与IP受体拮抗活性相关的疾病。 这些疾病包括泌尿系统疾病或疾病如下:膀胱出口阻塞,膀胱过度活动,尿失禁,逼尿肌反射反射,逼尿肌不稳定,膀胱容量减少,排尿频率,急迫性尿失禁,压力性尿失禁,膀胱高反应性,良性前列腺肥大 ),前列腺炎,尿频,夜尿症,尿急,盆腔超敏反应,尿道炎,盆腔疼痛综合征,前列腺痛,膀胱炎或自发性膀胱过敏。 本发明的化合物还可用于治疗疼痛,包括但不限于炎性疼痛,神经性疼痛,急性疼痛,慢性疼痛,牙痛,经前痛,内脏痛,头痛等; 低血压 血友病和出血; 和炎症,因为这些疾病也通过用IP受体拮抗剂治疗而缓解。 本申请要求化合物,含有它们的药物组合物和使用它们的治疗方法。
    • 3. 发明申请
    • Carboxamides derivatives
    • 甲酰胺衍生物
    • US20060135613A1
    • 2006-06-22
    • US10517646
    • 2003-06-12
    • Makoto ShimazakiOsamu SakuraiKanako HiraiKlaus UrbahnsNoriyuki YamamotoSatoru YoshikawaMasaomi UmedaMasaomi Tajimi
    • Makoto ShimazakiOsamu SakuraiKanako HiraiKlaus UrbahnsNoriyuki YamamotoSatoru YoshikawaMasaomi UmedaMasaomi Tajimi
    • A61K31/198A61K31/195C07C237/38
    • C07C235/34
    • The present invention relates to carboxamides which are useful as an active ingredient of pharmaceutical preparations. The carboxamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the diseases are alleviated by treatment with an IP receptor antagonist.
    • 本发明涉及可用作药物制剂活性成分的羧酰胺。 本发明的甲酰胺具有IP受体拮抗活性,可用于预防和治疗与IP受体拮抗活性相关的疾病。 这些疾病包括泌尿系统疾病或紊乱,如下:膀胱出口阻塞,膀胱过度活动,尿失禁,逼尿肌反射反射,逼尿肌不稳定,膀胱容量减少,排尿频率,急迫性尿失禁,压力性尿失禁,膀胱反应过度,前列腺肥大 ),前列腺炎,尿频,夜尿症,尿急,盆腔超敏反应,尿道炎,盆腔疼痛综合征,前列腺痛,膀胱炎或自发性膀胱过敏。 本发明的化合物还可用于治疗疼痛,包括但不限于炎性疼痛,神经性疼痛,急性疼痛,慢性疼痛,牙痛,经前痛,内脏痛,头痛等; 低血压 血友病和出血; 和炎症,因为通过用IP受体拮抗剂治疗来减轻疾病。
    • 5. 发明授权
    • Audio equipment and method of displaying operation thereof
    • 音频设备及其操作方法
    • US07388573B1
    • 2008-06-17
    • US08535791
    • 1995-09-28
    • Kaneaki FujishitaOsamu SakuraiJunichi Nagahara
    • Kaneaki FujishitaOsamu SakuraiJunichi Nagahara
    • G09G5/00
    • H04S7/40H04S3/00
    • The present invention is concerned with an audio equipment capable of processing video signals and a method of displaying operation of the acoustic equipment. An input selector switch 1 is supplied with reproduced audio signals from devices connected to a tuner unit 2 and input terminals 3, and supplies a signal to a sound field processing DSP unit 4. A signal processed by the DSP unit 4 is applied through a muting switch 5 to an output terminal 6. An input selector switch 7 is supplied with reproduced video signals from devices connected to input terminals 8, and supplies a signal to a graphic controller (GDC) 9 which generates a video signal to display an image. One of a signal generated by the GDC 9 and an original video signal are selected by a switch 10, and applied to an output terminal 11. The GDC 9 also generates an image simulating a control panel. When a key switch 13 is operated, the display corresponding to the operated key in the simulating image is varied.
    • 本发明涉及能够处理视频信号的音频设备和显示声学设备的操作的方法。 向输入选择开关1提供来自连接到调谐器单元2和输入端3的设备的再现音频信号,并将信号提供给声场处理DSP单元4。 由DSP单元4处理的信号通过静音开关5施加到输出端子6。 向输入选择开关7提供来自连接到输入端子8的装置的再现视频信号,并向图形控制器(GDC)9提供信号,图形控制器(GDC)9产生视频信号以显示图像。 由GDC9产生的信号和原始视频信号之一由开关10选择,并被施加到输出端子11。 GDC 9还生成模拟控制面板的图像。 当键开关13被操作时,与模拟图像中的操作键对应的显示被改变。
    • 10. 发明授权
    • Motor control apparatus and electric appliance using the same
    • 电机控制装置及使用电器的电器
    • US07026771B2
    • 2006-04-11
    • US11124139
    • 2005-05-09
    • Hiroyuki KushidaOsamu SakuraiAkihiro Ishizawa
    • Hiroyuki KushidaOsamu SakuraiAkihiro Ishizawa
    • H02P1/54H02P5/46H02P7/68H02P7/74H02P7/80
    • H02P25/14
    • A microprocessor of the motor control apparatus acquires a zero-cross detection signal from a zero-cross detection section and a load current from a current detection section at a prescribed sampling period. The processor obtains a load current instant value every sampling period and a corresponding sine-functional value from a sine-functional value table to calculate a compensation value for the load current instant value. The processor also calculates a load current compensation total value by adding the compensation value by the predetermined number of times of sampling and compares the load current compensation total value with a load current reference value to obtain a difference therebetween. In response to the difference, an instruction value for delay time that determines the output timing of a trigger signal to a switching element is changed so that power consumption of the motor falls within a prescribed range.
    • 马达控制装置的微处理器在规定的采样周期中从零交叉检测部分获取来自电流检测部分的负载电流的零交叉检测信号。 处理器每个采样周期获得负载电流即时值,并从正弦函数值表中获得相应的正弦函数值,以计算负载电流瞬时值的补偿值。 处理器还通过将补偿值加上预定的采样次数来计算负载电流补偿总值,并将负载电流补偿总值与负载电流参考值进行比较以获得它们之间的差。 响应于该差异,改变确定触发信号对开关元件的输出定时的延迟时间的指令值,使得电动机的功耗落在规定范围内。